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GALR1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GALR1
Entrez Gene ID 2587
Full Name galanin receptor 1
Synonyms GALNR,GALNR1
General protein information
Preferred Names

galanin receptor 1

Names

galanin receptor type 1
GAL1-R
GALR-1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

18

18q23

Summary The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008].
Disorder MIM:

600377


mRNA and Protein(s)

mRNA Protein Name
NM_001480.3 NP_001471.2 galanin receptor type 1
XM_017025691.1 XP_016881180.1 galanin receptor type 1 isoform X1



Pan troglodytes (chimpanzee) GALR1 XP_523975.2
Bos taurus (cattle) GALR1 NP_001179170.1
Mus musculus (house mouse) Galr1 NP_032108.1
Gallus gallus (chicken) GALR1 NP_001121534.1
Danio rerio (zebrafish) galr1 XP_696215.1
Caenorhabditis elegans (roundworm) CELE_Y54E2A.1 NP_497057.2
Macaca mulatta (rhesus monkey) GALR1 XP_001086740.1
Xenopus tropicalis (tropical clawed frog) galr1 NP_001107355.1
Homo sapiens (human) GALR1 NP_001471.2
Canis lupus familiaris (dog) GALR1 XP_541048.2
Rattus norvegicus (Norway rat) Galr1 NP_037090.2


Related articles in PubMed

GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer.
Doufekas K, Hadwin R, Kandimalla R, Jones A, Mould T, Crowe S, Olaitan A, Macdonald N, Fiegl H, Wik E, Salvesen HB, Widschwendter M
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society23(6)1050-5(2013 Jul)

Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer.
Stevenson L, Allen WL, Turkington R, Jithesh PV, Proutski I, Stewart G, Lenz HJ, Van Schaeybroeck S, Longley DB, Johnston PG
Clinical cancer research : an official journal of the American Association for Cancer Research18(19)5412-26(2012 Oct)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.
Jackson KJ, Chen X, Miles MF, Harenza J, Damaj MI
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology36(11)2339-48(2011 Oct)

The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.
Lori A, Tang Y, O'Malley S, Picciotto MR, Wu R, Conneely KN, Cubells JF
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology36(7)1412-20(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma.
Title: Site-specific methylation patterns of the GAL and GALR1/2 genes in head and neck cancer: Potential utility as biomarkers for prognosis.

The MOR-Gal1R heteromer can explain previous results showing antagonistic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder
Title: Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.

GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis
Title: Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer.

Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
Title: Brain galanin system genes interact with life stresses in depression-related phenotypes.

GALR1 methylation is associated with endometrial cancer.
Title: GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer.

The following GALR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GALR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu17969 NM_001480.3
Latest version!
Homo sapiens galanin receptor 1 (GALR1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$144.50-$202.30
$289.00
OHu87840 XM_017025691.1
Latest version!
Homo sapiens galanin receptor 1 (GALR1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00

ORF Online Only Promotion

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1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17969
Clone ID Related Accession (Same CDS sequence) NM_001480.3
Accession Version NM_001480.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1050bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-02
Organism Homo sapiens(Human)
Product galanin receptor type 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC100863.2 and U23854.1. This sequence is a reference standard in the RefSeqGene project. On Feb 6, 2008 this sequence version replaced NM_001480.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.80604.1, BC095530.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGAGCTGG CGGTCGGGAA CCTCAGCGAG GGCAACGCGA GCTGGCCGGA GCCCCCCGCC 
CCGGAGCCCG GGCCGCTGTT CGGCATCGGC GTGGAGAACT TCGTCACGCT GGTGGTGTTC
GGCCTGATCT TCGCGCTGGG TGTGCTGGGC AACAGCCTAG TGATCACCGT GCTGGCGCGC
AGCAAGCCGG GCAAGCCGCG GAGCACCACC AACCTGTTCA TCCTCAACCT GAGCATCGCC
GACCTGGCCT ACCTGCTCTT CTGCATCCCC TTCCAGGCCA CCGTGTACGC GCTGCCCACC
TGGGTGCTGG GCGCCTTCAT CTGCAAGTTC ATCCACTACT TCTTCACCGT GTCCATGCTG
GTGAGCATCT TCACCCTGGC CGCGATGTCC GTGGACCGCT ACGTGGCCAT CGTGCACTCG
CGGCGCTCCT CCTCCCTCAG GGTGTCCCGC AACGCGCTGC TGGGCGTGGG CTGCATCTGG
GCGCTGTCCA TTGCCATGGC CTCGCCCGTG GCCTACCACC AGGGCCTCTT CCACCCGCGC
GCCAGCAACC AGACCTTCTG CTGGGAGCAG TGGCCCGACC CTCGCCACAA GAAGGCCTAC
GTGGTGTGCA CCTTCGTCTT CGGCTACCTG CTGCCGCTCC TGCTCATCTG CTTCTGCTAT
GCCAAGGTCC TTAATCACTT GCATAAAAAG TTGAAGAACA TGTCAAAGAA GTCTGAAGCA
TCCAAGAAAA AGACTGCACA GACAGTTCTG GTGGTGGTTG TGGTGTTTGG AATCTCCTGG
CTGCCGCACC ACATCATCCA TCTCTGGGCT GAGTTTGGAG TTTTCCCGCT GACGCCGGCT
TCCTTCCTCT TCAGAATCAC CGCCCACTGC CTGGCGTACA GCAATTCCTC CGTGAATCCT
ATCATTTATG CATTTCTCTC TGAAAATTTC AGGAAGGCCT ATAAACAAGT GTTCAAGTGT
CACATTCGCA AAGATTCACA CCTGAGTGAT ACTAAAGAAA GTAAAAGTCG AATAGACACC
CCACCATCAA CCAATTGTAC TCATGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001471.2
CDS498..1547
Misc Feature(1)606..668
Misc Feature(2)645..1406
Misc Feature(3)708..770
Misc Feature(4)825..890
Misc Feature(5)951..1013
Misc Feature(6)1098..1160
Misc Feature(7)1242..1304
Misc Feature(8)1311..1373
Exon (1)1..1163
Exon (2)1164..1229
Exon (3)1230..2787
Translation

Target ORF information:

RefSeq Version NM_001480.3
Organism Homo sapiens(Human)
Definition Homo sapiens galanin receptor 1 (GALR1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001480.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGAGCTGG CGGTCGGGAA CCTCAGCGAG GGCAACGCGA GCTGGCCGGA GCCCCCCGCC 
CCGGAGCCCG GGCCGCTGTT CGGCATCGGC GTGGAGAACT TCGTCACGCT GGTGGTGTTC
GGCCTGATCT TCGCGCTGGG TGTGCTGGGC AACAGCCTAG TGATCACCGT GCTGGCGCGC
AGCAAGCCGG GCAAGCCGCG GAGCACCACC AACCTGTTCA TCCTCAACCT GAGCATCGCC
GACCTGGCCT ACCTGCTCTT CTGCATCCCC TTCCAGGCCA CCGTGTACGC GCTGCCCACC
TGGGTGCTGG GCGCCTTCAT CTGCAAGTTC ATCCACTACT TCTTCACCGT GTCCATGCTG
GTGAGCATCT TCACCCTGGC CGCGATGTCC GTGGACCGCT ACGTGGCCAT CGTGCACTCG
CGGCGCTCCT CCTCCCTCAG GGTGTCCCGC AACGCGCTGC TGGGCGTGGG CTGCATCTGG
GCGCTGTCCA TTGCCATGGC CTCGCCCGTG GCCTACCACC AGGGCCTCTT CCACCCGCGC
GCCAGCAACC AGACCTTCTG CTGGGAGCAG TGGCCCGACC CTCGCCACAA GAAGGCCTAC
GTGGTGTGCA CCTTCGTCTT CGGCTACCTG CTGCCGCTCC TGCTCATCTG CTTCTGCTAT
GCCAAGGTCC TTAATCACTT GCATAAAAAG TTGAAGAACA TGTCAAAGAA GTCTGAAGCA
TCCAAGAAAA AGACTGCACA GACAGTTCTG GTGGTGGTTG TGGTGTTTGG AATCTCCTGG
CTGCCGCACC ACATCATCCA TCTCTGGGCT GAGTTTGGAG TTTTCCCGCT GACGCCGGCT
TCCTTCCTCT TCAGAATCAC CGCCCACTGC CTGGCGTACA GCAATTCCTC CGTGAATCCT
ATCATTTATG CATTTCTCTC TGAAAATTTC AGGAAGGCCT ATAAACAAGT GTTCAAGTGT
CACATTCGCA AAGATTCACA CCTGAGTGAT ACTAAAGAAA GTAAAAGTCG AATAGACACC
CCACCATCAA CCAATTGTAC TCATGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu87840
Clone ID Related Accession (Same CDS sequence) XM_017025691.1
Accession Version XM_017025691.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 810bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product galanin receptor type 1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGCTGG CGGTCGGGAA CCTCAGCGAG GGCAACGCGA GCTGGCCGGA GCCCCCCGCC 
CCGGAGCCCG GGCCGCTGTT CGGCATCGGC GTGGAGAACT TCGTCACGCT GGTGGTGTTC
GGCCTGATCT TCGCGCTGGG TGTGCTGGGC AACAGCCTAG TGATCACCGT GCTGGCGCGC
AGCAAGCCGG GCAAGCCGCG GAGCACCACC AACCTGTTCA TCCTCAACCT GAGCATCGCC
GACCTGGCCT ACCTGCTCTT CTGCATCCCC TTCCAGGCCA CCGTGTACGC GCTGCCCACC
TGGGTGCTGG GCGCCTTCAT CTGCAAGTTC ATCCACTACT TCTTCACCGT GTCCATGCTG
GTGAGCATCT TCACCCTGGC CGCGATGTCC GTGGACCGCT ACGTGGCCAT CGTGCACTCG
CGGCGCTCCT CCTCCCTCAG GGTGTCCCGC AACGCGCTGC TGGGCGTGGG CTGCATCTGG
GCGCTGTCCA TTGCCATGGC CTCGCCCGTG GCCTACCACC AGGGCCTCTT CCACCCGCGC
GCCAGCAACC AGACCTTCTG CTGGGAGCAG TGGCCCGACC CTCGCCACAA GAAGGCCTAC
GTGGTGTGCA CCTTCGTCTT CGGCTACCTG CTGCCGCTCC TGCTCATCTG CTTCTGCTAT
GCCAAGGTCC TTAATCACTT GCATAAAAAG TTGAAGAACA TGTCAAAGAA GTCTGAAGCA
TCCAAGAAAA AGGTGCAGGG TGCAAGCTTT GGATGGATCT ACCATTCTGG GGTCTGGAGG
ATGGTGGCCC TCTTCTCACA GATCCACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016881180.1
CDS498..1307
Translation

Target ORF information:

RefSeq Version XM_017025691.1
Organism Homo sapiens(Human)
Definition Homo sapiens galanin receptor 1 (GALR1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017025691.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGCTGG CGGTCGGGAA CCTCAGCGAG GGCAACGCGA GCTGGCCGGA GCCCCCCGCC 
CCGGAGCCCG GGCCGCTGTT CGGCATCGGC GTGGAGAACT TCGTCACGCT GGTGGTGTTC
GGCCTGATCT TCGCGCTGGG TGTGCTGGGC AACAGCCTAG TGATCACCGT GCTGGCGCGC
AGCAAGCCGG GCAAGCCGCG GAGCACCACC AACCTGTTCA TCCTCAACCT GAGCATCGCC
GACCTGGCCT ACCTGCTCTT CTGCATCCCC TTCCAGGCCA CCGTGTACGC GCTGCCCACC
TGGGTGCTGG GCGCCTTCAT CTGCAAGTTC ATCCACTACT TCTTCACCGT GTCCATGCTG
GTGAGCATCT TCACCCTGGC CGCGATGTCC GTGGACCGCT ACGTGGCCAT CGTGCACTCG
CGGCGCTCCT CCTCCCTCAG GGTGTCCCGC AACGCGCTGC TGGGCGTGGG CTGCATCTGG
GCGCTGTCCA TTGCCATGGC CTCGCCCGTG GCCTACCACC AGGGCCTCTT CCACCCGCGC
GCCAGCAACC AGACCTTCTG CTGGGAGCAG TGGCCCGACC CTCGCCACAA GAAGGCCTAC
GTGGTGTGCA CCTTCGTCTT CGGCTACCTG CTGCCGCTCC TGCTCATCTG CTTCTGCTAT
GCCAAGGTCC TTAATCACTT GCATAAAAAG TTGAAGAACA TGTCAAAGAA GTCTGAAGCA
TCCAAGAAAA AGGTGCAGGG TGCAAGCTTT GGATGGATCT ACCATTCTGG GGTCTGGAGG
ATGGTGGCCC TCTTCTCACA GATCCACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society23(6)1050-5(2013 Jul)
Doufekas K,Hadwin R,Kandimalla R,Jones A,Mould T,Crowe S,Olaitan A,Macdonald N,Fiegl H,Wik E,Salvesen HB,Widschwendter M


book

Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research18(19)5412-26(2012 Oct)
Stevenson L,Allen WL,Turkington R,Jithesh PV,Proutski I,Stewart G,Lenz HJ,Van Schaeybroeck S,Longley DB,Johnston PG


book

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF


book

The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology36(11)2339-48(2011 Oct)
Jackson KJ,Chen X,Miles MF,Harenza J,Damaj MI


book

The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology36(7)1412-20(2011 Jun)
Lori A,Tang Y,O'Malley S,Picciotto MR,Wu R,Conneely KN,Cubells JF


 
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