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CHMP2B cDNA ORF clone, Homo sapiens (human)

Gene Symbol CHMP2B
Entrez Gene ID 25978
Full Name charged multivesicular body protein 2B
Synonyms ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B
General protein information
Preferred Names
charged multivesicular body protein 2b
Names
charged multivesicular body protein 2b
VPS2 homolog B
chromatin modifying protein 2B
vacuolar protein-sorting-associated protein 2-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p11.2

Summary This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

609512

Disorder Html: Dementia, familial, nonspecific, 600795 (3); Amyotrophic lateral

mRNA and Protein(s)

mRNA Protein Name
XM_011533576 XP_011531878 charged multivesicular body protein 2b isoform X1
NM_014043 NP_054762 charged multivesicular body protein 2b isoform 1
NM_001244644 NP_001231573 charged multivesicular body protein 2b isoform 2



Homo sapiens (human) CHMP2B NP_054762.2
Pan troglodytes (chimpanzee) CHMP2B XP_003950194.1
Macaca mulatta (Rhesus monkey) CHMP2B XP_001104518.1
Canis lupus familiaris (dog) CHMP2B XP_544799.3
Bos taurus (cattle) CHMP2B NP_001030549.1
Mus musculus (house mouse) Chmp2b NP_081155.1
Rattus norvegicus (Norway rat) Chmp2b XP_343996.5
Gallus gallus (chicken) CHMP2B NP_001025963.1
Danio rerio (zebrafish) chmp2bb NP_998069.1
Drosophila melanogaster (fruit fly) CHMP2B NP_647947.1
Caenorhabditis elegans C01A2.4 NP_493357.2
Arabidopsis thaliana (thale cress) VPS2.3 NP_563696.1
Xenopus (Silurana) tropicalis (western clawed frog) chmp2b NP_998866.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CHMP2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHMP2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu66679 XM_011533576 PREDICTED: Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu18244 NM_014043 Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu18651 NM_001244644 Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu66679
Clone ID Related Accession (Same CDS sequence) XM_011533576
Accession Version XM_011533576.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 690bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product charged multivesicular body protein 2b isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_022517.19) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

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661
ATGATCTCGG CTCAACGCAA CCATCACCTC CCAGATTCAA GCGATTCTTC TACCTCAGCC 
TACCGAGTAG CTCGGATTAC AGATGTAATA AAGGAACAGA ATCGAGAGTT ACGAGGTACA
CAGAGGGCTA TAATCAGAGA TCGAGCAGCT TTAGAGAAAC AAGAAAAACA GCTGGAATTA
GAAATTAAGA AAATGGCCAA GATTGGTAAT AAGGAAGCTT GCAAAGTTTT AGCCAAACAA
CTTGTGCATC TACGGAAACA GAAGACGAGA ACTTTTGCTG TAAGTTCAAA AGTTACTTCT
ATGTCTACAC AAACAAAAGT GATGAATTCC CAAATGAAGA TGGCTGGAGC AATGTCTACT
ACAGCAAAAA CAATGCAGGC AGTTAACAAG AAGATGGATC CACAAAAGAC ATTACAAACA
ATGCAGAATT TCCAGAAGGA AAACATGAAA ATGGAAATGA CTGAAGAAAT GATCAATGAT
ACACTTGATG ACATCTTTGA CGGTTCTGAT GACGAAGAAG AAAGCCAGGA TATTGTGAAT
CAAGTTCTTG ATGAAATTGG AATTGAAATT TCTGGAAAGA TGGCCAAAGC TCCATCAGCT
GCTCGAAGCT TACCATCTGC CTCTACTTCA AAGGCTACAA TCTCAGATGA AGAGATTGAA
CGGCAACTCA AGGCTTTAGG AGTAGATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011531878.1
CDS40..729
Misc Feature(1)133..630(+)
Translation

Target ORF information:

RefSeq Version XM_011533576
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011533576

ORF Insert Sequence:

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121
181
241
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361
421
481
541
601
661
ATGATCTCGG CTCAACGCAA CCATCACCTC CCAGATTCAA GCGATTCTTC TACCTCAGCC 
TACCGAGTAG CTCGGATTAC AGATGTAATA AAGGAACAGA ATCGAGAGTT ACGAGGTACA
CAGAGGGCTA TAATCAGAGA TCGAGCAGCT TTAGAGAAAC AAGAAAAACA GCTGGAATTA
GAAATTAAGA AAATGGCCAA GATTGGTAAT AAGGAAGCTT GCAAAGTTTT AGCCAAACAA
CTTGTGCATC TACGGAAACA GAAGACGAGA ACTTTTGCTG TAAGTTCAAA AGTTACTTCT
ATGTCTACAC AAACAAAAGT GATGAATTCC CAAATGAAGA TGGCTGGAGC AATGTCTACT
ACAGCAAAAA CAATGCAGGC AGTTAACAAG AAGATGGATC CACAAAAGAC ATTACAAACA
ATGCAGAATT TCCAGAAGGA AAACATGAAA ATGGAAATGA CTGAAGAAAT GATCAATGAT
ACACTTGATG ACATCTTTGA CGGTTCTGAT GACGAAGAAG AAAGCCAGGA TATTGTGAAT
CAAGTTCTTG ATGAAATTGG AATTGAAATT TCTGGAAAGA TGGCCAAAGC TCCATCAGCT
GCTCGAAGCT TACCATCTGC CTCTACTTCA AAGGCTACAA TCTCAGATGA AGAGATTGAA
CGGCAACTCA AGGCTTTAGG AGTAGATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18244
Clone ID Related Accession (Same CDS sequence) NM_014043
Accession Version NM_014043.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 642bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product charged multivesicular body protein 2b isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM828410.1, BC001553.1, DA426159.1 and BM982148.1. This sequence is a reference standard in the RefSeqGene project. On Mar 21, 2008 this sequence version replaced gi:40254865. Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK002165.1, BC001553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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ATGGCGTCCC TCTTCAAGAA GAAAACCGTG GATGATGTAA TAAAGGAACA GAATCGAGAG 
TTACGAGGTA CACAGAGGGC TATAATCAGA GATCGAGCAG CTTTAGAGAA ACAAGAAAAA
CAGCTGGAAT TAGAAATTAA GAAAATGGCC AAGATTGGTA ATAAGGAAGC TTGCAAAGTT
TTAGCCAAAC AACTTGTGCA TCTACGGAAA CAGAAGACGA GAACTTTTGC TGTAAGTTCA
AAAGTTACTT CTATGTCTAC ACAAACAAAA GTGATGAATT CCCAAATGAA GATGGCTGGA
GCAATGTCTA CTACAGCAAA AACAATGCAG GCAGTTAACA AGAAGATGGA TCCACAAAAG
ACATTACAAA CAATGCAGAA TTTCCAGAAG GAAAACATGA AAATGGAAAT GACTGAAGAA
ATGATCAATG ATACACTTGA TGACATCTTT GACGGTTCTG ATGACGAAGA AGAAAGCCAG
GATATTGTGA ATCAAGTTCT TGATGAAATT GGAATTGAAA TTTCTGGAAA GATGGCCAAA
GCTCCATCAG CTGCTCGAAG CTTACCATCT GCCTCTACTT CAAAGGCTAC AATCTCAGAT
GAAGAGATTG AACGGCAACT CAAGGCTTTA GGAGTAGATT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_054762.2
CDS261..902
Misc Feature(1)75..77(+)
Misc Feature(2)264..266(+)
Misc Feature(3)306..803(+)
Misc Feature(4)855..857(+)
Misc Feature(5)855..857(+)
Misc Feature(6)855..857(+)
Misc Feature(7)861..893(+)
Exon (1)1..294
Gene:CHMP2B
Gene Synonym:
Exon (2)295..386
Gene:CHMP2B
Gene Synonym:
Exon (3)387..581
Gene:CHMP2B
Gene Synonym:
Exon (4)582..684
Gene:CHMP2B
Gene Synonym:
Exon (5)685..791
Gene:CHMP2B
Gene Synonym:
Exon (6)792..2628
Gene:CHMP2B
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_014043
Organism Homo sapiens (human)
Definition Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014043

ORF Insert Sequence:

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121
181
241
301
361
421
481
541
601
ATGGCGTCCC TCTTCAAGAA GAAAACCGTG GATGATGTAA TAAAGGAACA GAATCGAGAG 
TTACGAGGTA CACAGAGGGC TATAATCAGA GATCGAGCAG CTTTAGAGAA ACAAGAAAAA
CAGCTGGAAT TAGAAATTAA GAAAATGGCC AAGATTGGTA ATAAGGAAGC TTGCAAAGTT
TTAGCCAAAC AACTTGTGCA TCTACGGAAA CAGAAGACGA GAACTTTTGC TGTAAGTTCA
AAAGTTACTT CTATGTCTAC ACAAACAAAA GTGATGAATT CCCAAATGAA GATGGCTGGA
GCAATGTCTA CTACAGCAAA AACAATGCAG GCAGTTAACA AGAAGATGGA TCCACAAAAG
ACATTACAAA CAATGCAGAA TTTCCAGAAG GAAAACATGA AAATGGAAAT GACTGAAGAA
ATGATCAATG ATACACTTGA TGACATCTTT GACGGTTCTG ATGACGAAGA AGAAAGCCAG
GATATTGTGA ATCAAGTTCT TGATGAAATT GGAATTGAAA TTTCTGGAAA GATGGCCAAA
GCTCCATCAG CTGCTCGAAG CTTACCATCT GCCTCTACTT CAAAGGCTAC AATCTCAGAT
GAAGAGATTG AACGGCAACT CAAGGCTTTA GGAGTAGATT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18651
Clone ID Related Accession (Same CDS sequence) NM_001244644
Accession Version NM_001244644.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 519bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product charged multivesicular body protein 2b isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM828410.1, AK296072.1, BI821848.1, AK002165.1 and BM982148.1. Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting predicted protein (isoform 2) is shorter when it is compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK296072.1, BU857794.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

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ATGGAATTAG AAATTAAGAA AATGGCCAAG ATTGGTAATA AGGAAGCTTG CAAAGTTTTA 
GCCAAACAAC TTGTGCATCT ACGGAAACAG AAGACGAGAA CTTTTGCTGT AAGTTCAAAA
GTTACTTCTA TGTCTACACA AACAAAAGTG ATGAATTCCC AAATGAAGAT GGCTGGAGCA
ATGTCTACTA CAGCAAAAAC AATGCAGGCA GTTAACAAGA AGATGGATCC ACAAAAGACA
TTACAAACAA TGCAGAATTT CCAGAAGGAA AACATGAAAA TGGAAATGAC TGAAGAAATG
ATCAATGATA CACTTGATGA CATCTTTGAC GGTTCTGATG ACGAAGAAGA AAGCCAGGAT
ATTGTGAATC AAGTTCTTGA TGAAATTGGA ATTGAAATTT CTGGAAAGAT GGCCAAAGCT
CCATCAGCTG CTCGAAGCTT ACCATCTGCC TCTACTTCAA AGGCTACAAT CTCAGATGAA
GAGATTGAAC GGCAACTCAA GGCTTTAGGA GTAGATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001231573.1
CDS292..810
Misc Feature(1)256..258(+)
Misc Feature(2)295..711(+)
Exon (1)1..294
Gene:CHMP2B
Gene Synonym:
Exon (2)295..489
Gene:CHMP2B
Gene Synonym:
Exon (3)490..592
Gene:CHMP2B
Gene Synonym:
Exon (4)593..699
Gene:CHMP2B
Gene Synonym:
Exon (5)700..2536
Gene:CHMP2B
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001244644
Organism Homo sapiens (human)
Definition Homo sapiens charged multivesicular body protein 2B (CHMP2B), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001244644

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGAATTAG AAATTAAGAA AATGGCCAAG ATTGGTAATA AGGAAGCTTG CAAAGTTTTA 
GCCAAACAAC TTGTGCATCT ACGGAAACAG AAGACGAGAA CTTTTGCTGT AAGTTCAAAA
GTTACTTCTA TGTCTACACA AACAAAAGTG ATGAATTCCC AAATGAAGAT GGCTGGAGCA
ATGTCTACTA CAGCAAAAAC AATGCAGGCA GTTAACAAGA AGATGGATCC ACAAAAGACA
TTACAAACAA TGCAGAATTT CCAGAAGGAA AACATGAAAA TGGAAATGAC TGAAGAAATG
ATCAATGATA CACTTGATGA CATCTTTGAC GGTTCTGATG ACGAAGAAGA AAGCCAGGAT
ATTGTGAATC AAGTTCTTGA TGAAATTGGA ATTGAAATTT CTGGAAAGAT GGCCAAAGCT
CCATCAGCTG CTCGAAGCTT ACCATCTGCC TCTACTTCAA AGGCTACAAT CTCAGATGAA
GAGATTGAAC GGCAACTCAA GGCTTTAGGA GTAGATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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