FBXW2 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | FBXW2 |
Entrez Gene ID | 26190 |
Full Name | F-box and WD repeat domain containing 2 |
Synonyms | FBW2,Fwd2,Md6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
XM_005251913.2 | XP_005251970.1 | F-box/WD repeat-containing protein 2 isoform X5 |
NM_001375890.1 | NP_001362819.1 | F-box/WD repeat-containing protein 2 isoform 3 |
XM_006717049.3 | XP_006717112.1 | F-box/WD repeat-containing protein 2 isoform X1 |
XM_017014615.2 | XP_016870104.1 | F-box/WD repeat-containing protein 2 isoform X4 |
XM_005251910.2 | XP_005251967.1 | F-box/WD repeat-containing protein 2 isoform X1 |
XM_017014617.1 | XP_016870106.1 | F-box/WD repeat-containing protein 2 isoform X5 |
XM_006717051.2 | XP_006717114.1 | F-box/WD repeat-containing protein 2 isoform X3 |
NM_012164.3 | NP_036296.2 | F-box/WD repeat-containing protein 2 |
XM_017014615.1 | XP_016870104.1 | F-box/WD repeat-containing protein 2 isoform X4 |
XM_005251910.3 | XP_005251967.1 | F-box/WD repeat-containing protein 2 isoform X2 |
XM_011518518.1 | XP_011516820.1 | F-box/WD repeat-containing protein 2 isoform X1 |
XM_005251910.4 | XP_005251967.1 | F-box/WD repeat-containing protein 2 isoform X2 |
XM_024447509.1 | XP_024303277.1 | F-box/WD repeat-containing protein 2 isoform X4 |
NM_012164.4 | NP_036296.2 | F-box/WD repeat-containing protein 2 isoform 1 |
NM_001375888.1 | NP_001362817.1 | F-box/WD repeat-containing protein 2 isoform 1 |
NM_001375889.1 | NP_001362818.1 | F-box/WD repeat-containing protein 2 isoform 2 |
XM_017014616.1 | XP_016870105.1 | F-box/WD repeat-containing protein 2 isoform X5 |

FBXW2 | XP_001096310.2 | |
Mus musculus (house mouse) | Fbxw2 | NP_001158240.1 |
Homo sapiens (human) | FBXW2 | NP_036296.2 |
Canis lupus familiaris (dog) | FBXW2 | XP_853711.1 |
Pan troglodytes (chimpanzee) | FBXW2 | XP_520223.2 |
Gallus gallus (chicken) | FBXW2 | NP_001007843.1 |
Xenopus tropicalis (tropical clawed frog) | fbxw2 | NP_001011178.1 |
Bos taurus (cattle) | FBXW2 | NP_001070442.1 |
Rattus norvegicus (Norway rat) | Fbxw2 | NP_001101305.1 |
Danio rerio (zebrafish) | fbxw2 | NP_001018175.1 |

Related articles in PubMed
The ?-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.
Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y
Nature communications814002(2017 Jan)
A High-Density Map for Navigating the Human Polycomb Complexome.
Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C
Cell reports17(2)583-595(2016 10)
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC, Lindquist S
Cell158(2)434-448(2014 Jul)
RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion.
Wang CC, Lo HF, Lin SY, Chen H
The Biochemical journal453(2)201-8(2013 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
RACK1 competes with GCM1 for FBW2 and thereby prevents GCM1 ubiquitination, which is also supported by the observation that GCM1 is destabilized in RACK1-knockdown BeWo placental cells
Title: RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion.
UBE2D2 is required for GCMa ubiquitination and for association with the SCF(FBXW2) complex.
Title: Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation.
the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system
Title: FBW2 targets GCMa to the ubiquitin-proteasome degradation system.
The following FBXW2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXW2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu06088![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_005251910.2 , NM_012164.3 , XM_005251910.3 , XM_005251910.4 , NM_012164.4 , NM_001375888.1 | |
Accession Version | NM_012164.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-11-26 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA703966.1, BC110334.1, AL161911.17 and AL138836.15. On Nov 24, 2006 this sequence version replaced NM_012164.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.68383.1, SRR1660809.50075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_036296.2 |
CDS | 239..1603 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06088![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_005251910.2 , NM_012164.3 , XM_005251910.3 , XM_005251910.4 , NM_012164.4 , NM_001375888.1 | |
Accession Version | NM_012164.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA703966.1, BC110334.1, AL161911.17 and AL138836.15. On Nov 22, 2018 this sequence version replaced NM_012164.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.68383.1, SRR1660809.50075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000608872.6/ ENSP00000476369.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_036296.2 |
CDS | 193..1557 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06088![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_005251910.2 , NM_012164.3 , XM_005251910.3 , XM_005251910.4 , NM_012164.4 , NM_001375888.1 | |
Accession Version | NM_001375888.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL161911.17 and AL138836.15. On Nov 5, 2019 this sequence version replaced XM_005251910.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000239.1, SRR7346977.2235120.1 [ECO:0000332] ##Evidence-Data-END## |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001362817.1 |
CDS | 187..1551 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06088![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_005251910.2 , NM_012164.3 , XM_005251910.3 , XM_005251910.4 , NM_012164.4 , NM_001375888.1 | |
Accession Version | XM_005251910.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | F-box/WD repeat-containing protein 2 isoform X1 | |
Comment |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005251967.1 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06088![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_005251910.2 , NM_012164.3 , XM_005251910.3 , XM_005251910.4 , NM_012164.4 , NM_001375888.1 | |
Accession Version | XM_005251910.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005251910.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005251967.1 |
CDS | 242..1606 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu06088![]() |
|
Clone ID Related Accession (Same CDS sequence) | XM_005251910.2 , NM_012164.3 , XM_005251910.3 , XM_005251910.4 , NM_012164.4 , NM_001375888.1 | |
Accession Version | XM_005251910.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-12 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005251910.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END## |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005251967.1 |
CDS | 198..1562 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43183 | |
Clone ID Related Accession (Same CDS sequence) | XM_005251913.2 , XM_017014617.1 , NM_001375889.1 , XM_017014616.1 | |
Accession Version | XM_005251913.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-12 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005251913.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END## |
1 | ATGAAGCAAC TGGAGGACCA TGAAGCCTTT GAAACCTCGT CATTAATTGG ACACAGTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005251970.1 |
CDS | 528..1505 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAAGCAAC TGGAGGACCA TGAAGCCTTT GAAACCTCGT CATTAATTGG ACACAGTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43183 | |
Clone ID Related Accession (Same CDS sequence) | XM_005251913.2 , XM_017014617.1 , NM_001375889.1 , XM_017014616.1 | |
Accession Version | XM_017014617.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGCAAC TGGAGGACCA TGAAGCCTTT GAAACCTCGT CATTAATTGG ACACAGTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016870106.1 |
CDS | 749..1726 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAAGCAAC TGGAGGACCA TGAAGCCTTT GAAACCTCGT CATTAATTGG ACACAGTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43183 | |
Clone ID Related Accession (Same CDS sequence) | XM_005251913.2 , XM_017014617.1 , NM_001375889.1 , XM_017014616.1 | |
Accession Version | XM_017014616.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGCAAC TGGAGGACCA TGAAGCCTTT GAAACCTCGT CATTAATTGG ACACAGTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016870105.1 |
CDS | 725..1702 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAAGCAAC TGGAGGACCA TGAAGCCTTT GAAACCTCGT CATTAATTGG ACACAGTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43180 | |
Clone ID Related Accession (Same CDS sequence) | NM_001375890.1 , XM_006717049.3 , XM_011518518.1 | |
Accession Version | XM_006717049.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1461bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006717049.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGTGTG ATGAGGTGGT TTATGAAGTA CAAAGCGCTA TACTGCGCCA TAATTGTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006717112.1 |
CDS | 328..1788 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAAGTGTG ATGAGGTGGT TTATGAAGTA CAAAGCGCTA TACTGCGCCA TAATTGTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43180 | |
Clone ID Related Accession (Same CDS sequence) | NM_001375890.1 , XM_006717049.3 , XM_011518518.1 | |
Accession Version | XM_011518518.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1461bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-12 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END## |
1 | ATGAAGTGTG ATGAGGTGGT TTATGAAGTA CAAAGCGCTA TACTGCGCCA TAATTGTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011516820.1 |
CDS | 383..1843 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAAGTGTG ATGAGGTGGT TTATGAAGTA CAAAGCGCTA TACTGCGCCA TAATTGTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43181 | |
Clone ID Related Accession (Same CDS sequence) | XM_006717051.2 | |
Accession Version | XM_006717051.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006717051.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGTGTG ATGAGGTGGT TTATGAAGTA CAAAGCGCTA TACTGCGCCA TAATTGTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006717114.1 |
CDS | 383..1648 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAAGTGTG ATGAGGTGGT TTATGAAGTA CAAAGCGCTA TACTGCGCCA TAATTGTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43180 | |
Clone ID Related Accession (Same CDS sequence) | NM_001375890.1 , XM_006717049.3 , XM_011518518.1 | |
Accession Version | NM_001375890.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1461bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform 3 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL161911.17 and AL138836.15. On Nov 5, 2019 this sequence version replaced XM_011518518.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.156058.1, DRR138527.263274.1 [ECO:0000332] ##Evidence-Data-END## |
1 | ATGAAGTGTG ATGAGGTGGT TTATGAAGTA CAAAGCGCTA TACTGCGCCA TAATTGTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001362819.1 |
CDS | 359..1819 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAAGTGTG ATGAGGTGGT TTATGAAGTA CAAAGCGCTA TACTGCGCCA TAATTGTGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu43183 | |
Clone ID Related Accession (Same CDS sequence) | XM_005251913.2 , XM_017014617.1 , NM_001375889.1 , XM_017014616.1 | |
Accession Version | NM_001375889.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-04 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform 2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL161911.17 and AL138836.15. On Nov 5, 2019 this sequence version replaced XM_005251913.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300066.1, SRR1660809.210300.1 [ECO:0000332] ##Evidence-Data-END## |
1 | ATGAAGCAAC TGGAGGACCA TGAAGCCTTT GAAACCTCGT CATTAATTGG ACACAGTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001362818.1 |
CDS | 482..1459 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAAGCAAC TGGAGGACCA TGAAGCCTTT GAAACCTCGT CATTAATTGG ACACAGTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu98597 | |
Clone ID Related Accession (Same CDS sequence) | XM_017014615.2 , XM_017014615.1 , XM_024447509.1 | |
Accession Version | XM_017014615.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1170bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017014615.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016870104.1 |
CDS | 198..1367 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu98597 | |
Clone ID Related Accession (Same CDS sequence) | XM_017014615.2 , XM_017014615.1 , XM_024447509.1 | |
Accession Version | XM_017014615.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1170bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016870104.1 |
CDS | 242..1411 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu98597 | |
Clone ID Related Accession (Same CDS sequence) | XM_017014615.2 , XM_017014615.1 , XM_024447509.1 | |
Accession Version | XM_024447509.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1170bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | F-box/WD repeat-containing protein 2 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024303277.1 |
CDS | 189..1358 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGAGAGAA AGGACTTTGA GACATGGCTT GATAACATTT CTGTTACATT TCTTTCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
The ?-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. |
![]() |
A High-Density Map for Navigating the Human Polycomb Complexome. |
![]() |
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. |
![]() |
RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion. |