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GJB2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GJB2
Entrez Gene ID 2706
Full Name gap junction protein, beta 2, 26kDa
Synonyms CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK
General protein information
Preferred Names
gap junction beta-2 protein
Names
gap junction beta-2 protein
connexin 26
gap junction protein beta 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q11-q12

Summary This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]. lac of sum
Disorder MIM:

121011

Disorder Html: Deafness, autosomal recessive 1A, 220290 (3); Deafness, autosomal

mRNA and Protein(s)

mRNA Protein Name
XM_011535049 XP_011533351 gap junction beta-2 protein isoform X1
NM_004004 NP_003995 gap junction beta-2 protein



Homo sapiens (human) GJB2 NP_003995.2
Pan troglodytes (chimpanzee) GJB2 XP_522618.1
Macaca mulatta (Rhesus monkey) GJB2 NP_001038200.1
Canis lupus familiaris (dog) GJB2 NP_001184077.1
Bos taurus (cattle) GJB2 NP_001077106.1
Mus musculus (house mouse) Gjb2 NP_032151.1
Rattus norvegicus (Norway rat) Gjb2 NP_001004099.1
Gallus gallus (chicken) GJB2 NP_001257745.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GJB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GJB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27143
XM_011535049 PREDICTED: Homo sapiens gap junction protein, beta 2, 26kDa (GJB2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu27143
NM_004004 Homo sapiens gap junction protein, beta 2, 26kDa (GJB2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27143
Clone ID Related Accession (Same CDS sequence) NM_004004 , XM_011535049
Accession Version XM_011535049.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 681bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product gap junction beta-2 protein isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_024524.15) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
ATGGATTGGG GCACGCTGCA GACGATCCTG GGGGGTGTGA ACAAACACTC CACCAGCATT 
GGAAAGATCT GGCTCACCGT CCTCTTCATT TTTCGCATTA TGATCCTCGT TGTGGCTGCA
AAGGAGGTGT GGGGAGATGA GCAGGCCGAC TTTGTCTGCA ACACCCTGCA GCCAGGCTGC
AAGAACGTGT GCTACGATCA CTACTTCCCC ATCTCCCACA TCCGGCTATG GGCCCTGCAG
CTGATCTTCG TGTCCACGCC AGCGCTCCTA GTGGCCATGC ACGTGGCCTA CCGGAGACAT
GAGAAGAAGA GGAAGTTCAT CAAGGGGGAG ATAAAGAGTG AATTTAAGGA CATCGAGGAG
ATCAAAACCC AGAAGGTCCG CATCGAAGGC TCCCTGTGGT GGACCTACAC AAGCAGCATC
TTCTTCCGGG TCATCTTCGA AGCCGCCTTC ATGTACGTCT TCTATGTCAT GTACGACGGC
TTCTCCATGC AGCGGCTGGT GAAGTGCAAC GCCTGGCCTT GTCCCAACAC TGTGGACTGC
TTTGTGTCCC GGCCCACGGA GAAGACTGTC TTCACAGTGT TCATGATTGC AGTGTCTGGA
ATTTGCATCC TGCTGAATGT CACTGAATTG TGTTATTTGC TAATTAGATA TTGTTCTGGG
AAGTCAAAAA AGCCAGTTTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011533351.1
CDS207..887
Misc Feature(1)210..530(+)
Misc Feature(2)642..845(+)
Translation

Target ORF information:

RefSeq Version XM_011535049
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens gap junction protein, beta 2, 26kDa (GJB2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011535049

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGATTGGG GCACGCTGCA GACGATCCTG GGGGGTGTGA ACAAACACTC CACCAGCATT 
GGAAAGATCT GGCTCACCGT CCTCTTCATT TTTCGCATTA TGATCCTCGT TGTGGCTGCA
AAGGAGGTGT GGGGAGATGA GCAGGCCGAC TTTGTCTGCA ACACCCTGCA GCCAGGCTGC
AAGAACGTGT GCTACGATCA CTACTTCCCC ATCTCCCACA TCCGGCTATG GGCCCTGCAG
CTGATCTTCG TGTCCACGCC AGCGCTCCTA GTGGCCATGC ACGTGGCCTA CCGGAGACAT
GAGAAGAAGA GGAAGTTCAT CAAGGGGGAG ATAAAGAGTG AATTTAAGGA CATCGAGGAG
ATCAAAACCC AGAAGGTCCG CATCGAAGGC TCCCTGTGGT GGACCTACAC AAGCAGCATC
TTCTTCCGGG TCATCTTCGA AGCCGCCTTC ATGTACGTCT TCTATGTCAT GTACGACGGC
TTCTCCATGC AGCGGCTGGT GAAGTGCAAC GCCTGGCCTT GTCCCAACAC TGTGGACTGC
TTTGTGTCCC GGCCCACGGA GAAGACTGTC TTCACAGTGT TCATGATTGC AGTGTCTGGA
ATTTGCATCC TGCTGAATGT CACTGAATTG TGTTATTTGC TAATTAGATA TTGTTCTGGG
AAGTCAAAAA AGCCAGTTTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27143
Clone ID Related Accession (Same CDS sequence) NM_004004 , XM_011535049
Accession Version NM_004004.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 681bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product gap junction beta-2 protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA287424.1, BC017048.1, BC071703.1, AA962716.1 and BI491091.1. This sequence is a reference standard in the RefSeqGene project. On Aug 2, 2008 this sequence version replaced gi:118572604. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP220335.1, BC017048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGATTGGG GCACGCTGCA GACGATCCTG GGGGGTGTGA ACAAACACTC CACCAGCATT 
GGAAAGATCT GGCTCACCGT CCTCTTCATT TTTCGCATTA TGATCCTCGT TGTGGCTGCA
AAGGAGGTGT GGGGAGATGA GCAGGCCGAC TTTGTCTGCA ACACCCTGCA GCCAGGCTGC
AAGAACGTGT GCTACGATCA CTACTTCCCC ATCTCCCACA TCCGGCTATG GGCCCTGCAG
CTGATCTTCG TGTCCACGCC AGCGCTCCTA GTGGCCATGC ACGTGGCCTA CCGGAGACAT
GAGAAGAAGA GGAAGTTCAT CAAGGGGGAG ATAAAGAGTG AATTTAAGGA CATCGAGGAG
ATCAAAACCC AGAAGGTCCG CATCGAAGGC TCCCTGTGGT GGACCTACAC AAGCAGCATC
TTCTTCCGGG TCATCTTCGA AGCCGCCTTC ATGTACGTCT TCTATGTCAT GTACGACGGC
TTCTCCATGC AGCGGCTGGT GAAGTGCAAC GCCTGGCCTT GTCCCAACAC TGTGGACTGC
TTTGTGTCCC GGCCCACGGA GAAGACTGTC TTCACAGTGT TCATGATTGC AGTGTCTGGA
ATTTGCATCC TGCTGAATGT CACTGAATTG TGTTATTTGC TAATTAGATA TTGTTCTGGG
AAGTCAAAAA AGCCAGTTTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003995.2
CDS216..896
Misc Feature(1)210..212(+)
Misc Feature(2)219..539(+)
Misc Feature(3)276..335(+)
Misc Feature(4)441..509(+)
Misc Feature(5)609..677(+)
Misc Feature(6)651..854(+)
Misc Feature(7)792..860(+)
Exon (1)1..193
Gene:GJB2
Gene Synonym:
Exon (2)194..2334
Gene:GJB2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004004
Organism Homo sapiens (human)
Definition Homo sapiens gap junction protein, beta 2, 26kDa (GJB2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004004

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGATTGGG GCACGCTGCA GACGATCCTG GGGGGTGTGA ACAAACACTC CACCAGCATT 
GGAAAGATCT GGCTCACCGT CCTCTTCATT TTTCGCATTA TGATCCTCGT TGTGGCTGCA
AAGGAGGTGT GGGGAGATGA GCAGGCCGAC TTTGTCTGCA ACACCCTGCA GCCAGGCTGC
AAGAACGTGT GCTACGATCA CTACTTCCCC ATCTCCCACA TCCGGCTATG GGCCCTGCAG
CTGATCTTCG TGTCCACGCC AGCGCTCCTA GTGGCCATGC ACGTGGCCTA CCGGAGACAT
GAGAAGAAGA GGAAGTTCAT CAAGGGGGAG ATAAAGAGTG AATTTAAGGA CATCGAGGAG
ATCAAAACCC AGAAGGTCCG CATCGAAGGC TCCCTGTGGT GGACCTACAC AAGCAGCATC
TTCTTCCGGG TCATCTTCGA AGCCGCCTTC ATGTACGTCT TCTATGTCAT GTACGACGGC
TTCTCCATGC AGCGGCTGGT GAAGTGCAAC GCCTGGCCTT GTCCCAACAC TGTGGACTGC
TTTGTGTCCC GGCCCACGGA GAAGACTGTC TTCACAGTGT TCATGATTGC AGTGTCTGGA
ATTTGCATCC TGCTGAATGT CACTGAATTG TGTTATTTGC TAATTAGATA TTGTTCTGGG
AAGTCAAAAA AGCCAGTTTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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