Gene Symbol | RNF115 |
Entrez Gene ID | 27246 |
Full Name | ring finger protein 115 |
Synonyms | BCA2,ZNF364 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » RNF115 cDNA ORF clone
Gene Symbol | RNF115 |
Entrez Gene ID | 27246 |
Full Name | ring finger protein 115 |
Synonyms | BCA2,ZNF364 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_005272952.4 | XP_005273009.1 | E3 ubiquitin-protein ligase RNF115 isoform X1 |
NM_014455.3 | NP_055270.1 | E3 ubiquitin-protein ligase RNF115 |
NM_014455.4 | NP_055270.1 | E3 ubiquitin-protein ligase RNF115 |
XM_005272952.5 | XP_005273009.1 | E3 ubiquitin-protein ligase RNF115 isoform X1 |
Homo sapiens (human) | RNF115 | NP_055270.1 |
Bos taurus (cattle) | RNF115 | NP_001069776.1 |
Pan troglodytes (chimpanzee) | RNF115 | XP_514416.2 |
Mus musculus (house mouse) | Rnf115 | NP_080682.3 |
Rattus norvegicus (Norway rat) | Rnf115 | NP_001102030.1 |
Xenopus tropicalis (tropical clawed frog) | rnf115 | NP_001135621.1 |
RNF115 | XP_001089703.1 | |
Danio rerio (zebrafish) | rnf115 | NP_001073542.1 |
Canis lupus familiaris (dog) | RNF115 | XP_850302.2 |
BCA2/Rabring7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of I?B?.
Colomer-Lluch M, Serra-Moreno R
Journal of virology91(8)(2017 Apr)
Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrent? L, Mar JC
PLoS genetics11(8)e1005428(2015 Aug)
BCA2/Rabring7 targets HIV-1 Gag for lysosomal degradation in a tetherin-independent manner.
Nityanandam R, Serra-Moreno R
PLoS pathogens10(5)e1004151(2014 May)
Regulation of metformin response by breast cancer associated gene 2.
Buac D, Kona FR, Seth AK, Dou QP
Neoplasia (New York, N.Y.)15(12)1379-90(2013 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Specifically, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB components in the cytoplasm. Since HIV-1 utilizes NF-kappaB to promote proviral transcription, the BCA2-mediated inhibition of NF-kappaB significantly decreases the transcriptional activity of HIV-1.
Title: BCA2/Rabring7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of I?B?.
BCA2 functions as an antiviral factor that targets HIV-1 Gag for degradation, impairing virus assembly and release.
Title: BCA2/Rabring7 targets HIV-1 Gag for lysosomal degradation in a tetherin-independent manner.
BCA2 is an endogenous inhibitor of AMPK activation in breast cancer cells and BCA2 inhibition increases the efficacy of metformin.
Title: Regulation of metformin response by breast cancer associated gene 2.
BCA2, a potential oncogenic E3 ubiquitin ligase, promotes breast cancer cell proliferation partially through targeting p21 for ubiquitination and proteasomal degradation.
Title: RNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation.
RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors.
Title: The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.
The following RNF115 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNF115 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
CloneID | OHu14931 | |
Clone ID Related Accession (Same CDS sequence) | NM_014455.3 , NM_014455.4 | |
Accession Version | NM_014455.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase RNF115 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG684824.1, AF419857.1, AC242845.1 and HY099262.1. On Jul 12, 2013 this sequence version replaced NM_014455.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.7849.1, SRR1803616.19144.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCGGAGG CTTCGGCGGC CGGGGCGGAC TCGGGCGCCG CTGTAGCCGC CCACCGGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055270.1 |
CDS | 251..1165 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014455.3 |
1 | ATGGCGGAGG CTTCGGCGGC CGGGGCGGAC TCGGGCGCCG CTGTAGCCGC CCACCGGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu14931 | |
Clone ID Related Accession (Same CDS sequence) | NM_014455.3 , NM_014455.4 | |
Accession Version | NM_014455.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 915bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase RNF115 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG684824.1, AF419857.1, AC242845.1 and HY099262.1. On Nov 22, 2018 this sequence version replaced NM_014455.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.91383.1, SRR1803611.197630.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000582693.5/ ENSP00000463650.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCGGAGG CTTCGGCGGC CGGGGCGGAC TCGGGCGCCG CTGTAGCCGC CCACCGGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055270.1 |
CDS | 223..1137 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014455.4 |
1 | ATGGCGGAGG CTTCGGCGGC CGGGGCGGAC TCGGGCGCCG CTGTAGCCGC CCACCGGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34317 | |
Clone ID Related Accession (Same CDS sequence) | XM_005272952.4 , XM_005272952.5 | |
Accession Version | XM_005272952.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase RNF115 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005272952.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATTCCAG AATCTAAAGT TGAAGGTCCC TTCCACAACC AGGAAAAACT ACACATTTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005273009.1 |
CDS | 398..1213 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005272952.4 |
1 | ATGATTCCAG AATCTAAAGT TGAAGGTCCC TTCCACAACC AGGAAAAACT ACACATTTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu34317 | |
Clone ID Related Accession (Same CDS sequence) | XM_005272952.4 , XM_005272952.5 | |
Accession Version | XM_005272952.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | E3 ubiquitin-protein ligase RNF115 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005272952.4. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATTCCAG AATCTAAAGT TGAAGGTCCC TTCCACAACC AGGAAAAACT ACACATTTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005273009.1 |
CDS | 340..1155 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005272952.5 |
1 | ATGATTCCAG AATCTAAAGT TGAAGGTCCC TTCCACAACC AGGAAAAACT ACACATTTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
BCA2/Rabring7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of I?B?. |
Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. |
BCA2/Rabring7 targets HIV-1 Gag for lysosomal degradation in a tetherin-independent manner. |
Regulation of metformin response by breast cancer associated gene 2. |