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MAGEH1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MAGEH1
Entrez Gene ID 28986
Full Name MAGE family member H1
Synonyms APR-1,APR1,MAGEH
General protein information
Preferred Names

MAGE family member H1

Names

melanoma-associated antigen H1
apoptosis-related protein 1
melanoma antigen family H, 1
melanoma antigen family H1
restin

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

X

Xp11.21

Summary This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013].
Disorder MIM:

300548


mRNA and Protein(s)

mRNA Protein Name
NM_014061.4 NP_054780.2 melanoma-associated antigen H1



Homo sapiens (human) MAGEH1 NP_054780.2
Canis lupus familiaris (dog) MAGEH1 XP_549024.1
Bos taurus (cattle) MAGEH1 NP_001074197.1
Mus musculus (house mouse) Mageh1 NP_076277.1
Rattus norvegicus (Norway rat) Mageh1 NP_001013268.1
Macaca mulatta (rhesus monkey) MAGEH1 XP_001093392.1


Related articles in PubMed

A proteome-scale map of the human interactome network.
Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M
Cell159(5)1212-1226(2014 Nov)

Neonatal detection of Turner syndrome by real-time PCR gene quantification of the ARSE and MAGEH1 genes.
Corrêa SC, Rocha MN, Richeti F, Kochi C, Silva E Lima LA, Magalhães M, Longui CA
Genetics and molecular research : GMR13(4)9068-76(2014 Oct)

Genome-wide association study of smoking behaviours among Bangladeshi adults.
Argos M, Tong L, Pierce BL, Rakibuz-Zaman M, Ahmed A, Islam T, Rahman M, Paul-Brutus R, Rahaman R, Roy S, Jasmine F, Kibriya MG, Ahsan H
Journal of medical genetics51(5)327-33(2014 May)

Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor.
Selimovic D, Sprenger A, Hannig M, Haïkel Y, Hassan M
Journal of cellular and molecular medicine16(2)349-61(2012 Feb)

Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment.
Ojima H, Yoshikawa D, Ino Y, Shimizu H, Miyamoto M, Kokubu A, Hiraoka N, Morofuji N, Kondo T, Onaya H, Okusaka T, Shimada K, Sakamoto Y, Esaki M, Nara S, Kosuge T, Hirohashi S, Kanai Y, Shibata T
Cancer science101(4)882-8(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our data showed that Apr-1 plays a crucial role in cell proliferation by controlling cell cycle progression, implying a tumor-suppressor function of Apr-1 in cholangiocarcinoma carcinogenesis
Title: Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits.

Data indicate that the neonatal detection test sensitivity obtained was 95% with a positive predictive value of 1 in the analyses for both the arylsulfatase E (ARSE) and melanoma antigen family H1 (MAGEH1) genes.
Title: Neonatal detection of Turner syndrome by real-time PCR gene quantification of the ARSE and MAGEH1 genes.

The induction of APR-1 expression caused apoptosis of melanoma cells via the interaction with the juxtamembrane region of p75 neurotrophin receptor.
Title: Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor.

The following MAGEH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGEH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu21244 NM_014061.4
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Homo sapiens MAGE family member H1 (MAGEH1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21244
Clone ID Related Accession (Same CDS sequence) NM_014061.4
Accession Version NM_014061.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 660bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-11-15
Organism Homo sapiens(Human)
Product melanoma-associated antigen H1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI916425.1, AF143235.4, AA634056.1 and AI191172.1. This sequence is a reference standard in the RefSeqGene project. On Aug 2, 2013 this sequence version replaced NM_014061.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGCCTCGGG GACGAAAGAG TCGGCGCCGC CGTAATGCGA GAGCCGCAGA AGAGAACCGC 
AACAATCGCA AAATCCAGGC CTCAGAGGCC TCCGAGACCC CTATGGCCGC CTCTGTGGTA
GCGAGCACCC CCGAAGACGA CCTGAGCGGC CCCGAGGAAG ACCCGAGCAC TCCAGAGGAG
GCCTCTACCA CCCCTGAAGA AGCCTCGAGC ACTGCCCAAG CACAAAAGCC TTCAGTGCCC
CGGAGCAATT TTCAGGGCAC CAAGAAAAGT CTCCTGATGT CTATATTAGC GCTCATCTTC
ATCATGGGCA ACAGCGCCAA GGAAGCTCTG GTCTGGAAAG TGCTGGGGAA GTTAGGAATG
CAGCCTGGAC GTCAGCACAG CATCTTTGGA GATCCGAAGA AGATCGTCAC AGAAGAGTTT
GTGCGCAGAG GGTACCTGAT TTATAAACCG GTGCCCCGTA GCAGTCCGGT GGAGTATGAG
TTCTTCTGGG GGCCCCGAGC ACACGTGGAA TCGAGCAAAC TGAAAGTCAT GCATTTTGTG
GCAAGGGTTC GTAACCGATG CTCTAAAGAC TGGCCTTGTA ATTATGACTG GGATTCGGAC
GATGATGCAG AGGTTGAGGC TATCCTCAAT TCAGGTGCTA GGGGTTATTC CGCCCCTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_054780.2
CDS287..946
Misc Feature(1)209..211
Misc Feature(2)<470..796
Misc Feature(3)869..871
Exon (1)1..1480
Translation

Target ORF information:

RefSeq Version NM_014061.4
Organism Homo sapiens(Human)
Definition Homo sapiens MAGE family member H1 (MAGEH1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014061.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGCCTCGGG GACGAAAGAG TCGGCGCCGC CGTAATGCGA GAGCCGCAGA AGAGAACCGC 
AACAATCGCA AAATCCAGGC CTCAGAGGCC TCCGAGACCC CTATGGCCGC CTCTGTGGTA
GCGAGCACCC CCGAAGACGA CCTGAGCGGC CCCGAGGAAG ACCCGAGCAC TCCAGAGGAG
GCCTCTACCA CCCCTGAAGA AGCCTCGAGC ACTGCCCAAG CACAAAAGCC TTCAGTGCCC
CGGAGCAATT TTCAGGGCAC CAAGAAAAGT CTCCTGATGT CTATATTAGC GCTCATCTTC
ATCATGGGCA ACAGCGCCAA GGAAGCTCTG GTCTGGAAAG TGCTGGGGAA GTTAGGAATG
CAGCCTGGAC GTCAGCACAG CATCTTTGGA GATCCGAAGA AGATCGTCAC AGAAGAGTTT
GTGCGCAGAG GGTACCTGAT TTATAAACCG GTGCCCCGTA GCAGTCCGGT GGAGTATGAG
TTCTTCTGGG GGCCCCGAGC ACACGTGGAA TCGAGCAAAC TGAAAGTCAT GCATTTTGTG
GCAAGGGTTC GTAACCGATG CTCTAAAGAC TGGCCTTGTA ATTATGACTG GGATTCGGAC
GATGATGCAG AGGTTGAGGC TATCCTCAAT TCAGGTGCTA GGGGTTATTC CGCCCCTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A proteome-scale map of the human interactome network.
Cell159(5)1212-1226(2014 Nov)
Rolland T,Taşan M,Charloteaux B,Pevzner SJ,Zhong Q,Sahni N,Yi S,Lemmens I,Fontanillo C,Mosca R,Kamburov A,Ghiassian SD,Yang X,Ghamsari L,Balcha D,Begg BE,Braun P,Brehme M,Broly MP,Carvunis AR,Convery-Zupan D,Corominas R,Coulombe-Huntington J,Dann E,Dreze M,Dricot A,Fan C,Franzosa E,Gebreab F,Gutierrez BJ,Hardy MF,Jin M,Kang S,Kiros R,Lin GN,Luck K,MacWilliams A,Menche J,Murray RR,Palagi A,Poulin MM,Rambout X,Rasla J,Reichert P,Romero V,Ruyssinck E,Sahalie JM,Scholz A,Shah AA,Sharma A,Shen Y,Spirohn K,Tam S,Tejeda AO,Trigg SA,Twizere JC,Vega K,Walsh J,Cusick ME,Xia Y,Barabási AL,Iakoucheva LM,Aloy P,De Las Rivas J,Tavernier J,Calderwood MA,Hill DE,Hao T,Roth FP,Vidal M


book

Neonatal detection of Turner syndrome by real-time PCR gene quantification of the ARSE and MAGEH1 genes.
Genetics and molecular research : GMR13(4)9068-76(2014 Oct)
Corrêa SC,Rocha MN,Richeti F,Kochi C,Silva E Lima LA,Magalhães M,Longui CA


book

Genome-wide association study of smoking behaviours among Bangladeshi adults.
Journal of medical genetics51(5)327-33(2014 May)
Argos M,Tong L,Pierce BL,Rakibuz-Zaman M,Ahmed A,Islam T,Rahman M,Paul-Brutus R,Rahaman R,Roy S,Jasmine F,Kibriya MG,Ahsan H


book

Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor.
Journal of cellular and molecular medicine16(2)349-61(2012 Feb)
Selimovic D,Sprenger A,Hannig M,Haïkel Y,Hassan M


book

Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment.
Cancer science101(4)882-8(2010 Apr)
Ojima H,Yoshikawa D,Ino Y,Shimizu H,Miyamoto M,Kokubu A,Hiraoka N,Morofuji N,Kondo T,Onaya H,Okusaka T,Shimada K,Sakamoto Y,Esaki M,Nara S,Kosuge T,Hirohashi S,Kanai Y,Shibata T


 
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