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MAGEH1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAGEH1
Entrez Gene ID 28986
Full Name melanoma antigen family H1
Synonyms APR-1, APR1, MAGEH
General protein information
Preferred Names
melanoma-associated antigen H1
Names
melanoma-associated antigen H1
restin
apoptosis-related protein 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp11.21

Summary This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013]. COMPLETENESS: complete on the 3' end. lac of sum
Disorder MIM:

300548


mRNA and Protein(s)

mRNA Protein Name
NM_014061 NP_054780 melanoma-associated antigen H1



Homo sapiens (human) MAGEH1 NP_054780.2
Macaca mulatta (Rhesus monkey) MAGEH1 XP_001093392.1
Canis lupus familiaris (dog) MAGEH1 XP_549024.1
Bos taurus (cattle) MAGEH1 NP_001074197.1
Mus musculus (house mouse) Mageh1 NP_076277.1
Rattus norvegicus (Norway rat) Mageh1 NP_001013268.1


The following MAGEH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGEH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu21244
NM_014061 Homo sapiens melanoma antigen family H1 (MAGEH1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21244
Clone ID Related Accession (Same CDS sequence) NM_014061
Accession Version NM_014061.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 660bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 08-FEB-2015
Organism Homo sapiens (human)
Product melanoma-associated antigen H1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI916425.1, AF143235.4, AA634056.1 and AI191172.1. This sequence is a reference standard in the RefSeqGene project. On Aug 2, 2013 this sequence version replaced gi:18105051. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGCCTCGGG GACGAAAGAG TCGGCGCCGC CGTAATGCGA GAGCCGCAGA AGAGAACCGC 
AACAATCGCA AAATCCAGGC CTCAGAGGCC TCCGAGACCC CTATGGCCGC CTCTGTGGTA
GCGAGCACCC CCGAAGACGA CCTGAGCGGC CCCGAGGAAG ACCCGAGCAC TCCAGAGGAG
GCCTCTACCA CCCCTGAAGA AGCCTCGAGC ACTGCCCAAG CACAAAAGCC TTCAGTGCCC
CGGAGCAATT TTCAGGGCAC CAAGAAAAGT CTCCTGATGT CTATATTAGC GCTCATCTTC
ATCATGGGCA ACAGCGCCAA GGAAGCTCTG GTCTGGAAAG TGCTGGGGAA GTTAGGAATG
CAGCCTGGAC GTCAGCACAG CATCTTTGGA GATCCGAAGA AGATCGTCAC AGAAGAGTTT
GTGCGCAGAG GGTACCTGAT TTATAAACCG GTGCCCCGTA GCAGTCCGGT GGAGTATGAG
TTCTTCTGGG GGCCCCGAGC ACACGTGGAA TCGAGCAAAC TGAAAGTCAT GCATTTTGTG
GCAAGGGTTC GTAACCGATG CTCTAAAGAC TGGCCTTGTA ATTATGACTG GGATTCGGAC
GATGATGCAG AGGTTGAGGC TATCCTCAAT TCAGGTGCTA GGGGTTATTC CGCCCCTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_054780.2
CDS287..946
Misc Feature(1)209..211(+)
Misc Feature(2)548..814(+)
Misc Feature(3)869..871(+)
Exon (1)1..1480
Gene:MAGEH1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_014061
Organism Homo sapiens (human)
Definition Homo sapiens melanoma antigen family H1 (MAGEH1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014061

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGCCTCGGG GACGAAAGAG TCGGCGCCGC CGTAATGCGA GAGCCGCAGA AGAGAACCGC 
AACAATCGCA AAATCCAGGC CTCAGAGGCC TCCGAGACCC CTATGGCCGC CTCTGTGGTA
GCGAGCACCC CCGAAGACGA CCTGAGCGGC CCCGAGGAAG ACCCGAGCAC TCCAGAGGAG
GCCTCTACCA CCCCTGAAGA AGCCTCGAGC ACTGCCCAAG CACAAAAGCC TTCAGTGCCC
CGGAGCAATT TTCAGGGCAC CAAGAAAAGT CTCCTGATGT CTATATTAGC GCTCATCTTC
ATCATGGGCA ACAGCGCCAA GGAAGCTCTG GTCTGGAAAG TGCTGGGGAA GTTAGGAATG
CAGCCTGGAC GTCAGCACAG CATCTTTGGA GATCCGAAGA AGATCGTCAC AGAAGAGTTT
GTGCGCAGAG GGTACCTGAT TTATAAACCG GTGCCCCGTA GCAGTCCGGT GGAGTATGAG
TTCTTCTGGG GGCCCCGAGC ACACGTGGAA TCGAGCAAAC TGAAAGTCAT GCATTTTGTG
GCAAGGGTTC GTAACCGATG CTCTAAAGAC TGGCCTTGTA ATTATGACTG GGATTCGGAC
GATGATGCAG AGGTTGAGGC TATCCTCAAT TCAGGTGCTA GGGGTTATTC CGCCCCTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

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J. Med. Genet. 51 (5), 327-333 (2014)
Argos M, Tong L, Pierce BL, Rakibuz-Zaman M, Ahmed A, Islam T, Rahman M, Paul-Brutus R, Rahaman R, Roy S, Jasmine F, Kibriya MG and Ahsan H.


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Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor
J. Cell. Mol. Med. 16 (2), 349-361 (2012)
Selimovic D, Sprenger A, Hannig M, Haikel Y and Hassan M.


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Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment
Cancer Sci. 101 (4), 882-888 (2010)
Ojima H, Yoshikawa D, Ino Y, Shimizu H, Miyamoto M, Kokubu A, Hiraoka N, Morofuji N, Kondo T, Onaya H, Okusaka T, Shimada K, Sakamoto Y, Esaki M, Nara S, Kosuge T, Hirohashi S, Kanai Y and Shibata T.


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Transcriptional up-regulation of restin by all-trans retinoic acid through STAT1 in cancer cell differentiation process
Biochem. Biophys. Res. Commun. 343 (4), 1009-1016 (2006)
Fu H, Yang G, Lu F, Wang R, Yao L and Lu Z.


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[Cloning and subcellular localization of apr-1--a new gene of tumor specific antigen family]
Ai Zheng 24 (2), 129-134 (2005)
Yan W, Wang WL, Zhu F, Cheng SQ, Li QL, Wang L and Wang CJ.


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A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease
Mol. Cell 15 (6), 853-865 (2004)
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Bussow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H and Wanker EE.


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The p75 neurotrophin receptor interacts with multiple MAGE proteins
J. Biol. Chem. 277 (51), 49101-49104 (2002)
Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E and Fainzilber M.


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Cloning and biological comparison of Restin, novel member of Mage superfamily
Sci. China, C, Life Sci. 45 (4), 412-420 (2002)
Zhao Z, Lu F, Zhu F, Yang H, Chai Y and Chen S.


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An overview of the MAGE gene family with the identification of all human members of the family
Cancer Res. 61 (14), 5544-5551 (2001)
Chomez P, De Backer O, Bertrand M, De Plaen E, Boon T and Lucas S.


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Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes
BioTechniques 29 (2), 310-313 (2000)
Zhu F, Yan W, Zhao ZL, Chai YB, Lu F, Wang Q, Peng WD, Yang AG and Wang CJ.


 
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