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COMMD5 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol COMMD5
Entrez Gene ID 28991
Full Name COMM domain containing 5
Synonyms HCARG,HT002
General protein information
Preferred Names

COMM domain containing 5

Names

COMM domain-containing protein 5
hypertension-related calcium-regulated gene protein
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

8

8q24.3
Disorder MIM:

608216


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001287237.1 NP_001274166.1 COMM domain-containing protein 5
NM_014066.3 NP_054785.2 COMM domain-containing protein 5
NM_001081003.2 NP_001074472.1 COMM domain-containing protein 5
NM_001081004.2 NP_001074473.1 COMM domain-containing protein 5

Pathways from BioSystems


Homologies


Homo sapiens (human) COMMD5 NP_001074473.1
Canis lupus familiaris (dog) COMMD5 XP_539226.3
Rattus norvegicus (Norway rat) LOC100910472 XP_006241977.1
COMMD5 XP_001095902.1
Mus musculus (house mouse) Commd5 NP_079812.1
Pan troglodytes (chimpanzee) COMMD5 XP_001160283.1
Rattus norvegicus (Norway rat) Commd5 NP_620808.1
Gallus gallus (chicken) COMMD5 NP_001008465.1
Bos taurus (cattle) COMMD5 NP_001014850.1
Danio rerio (zebrafish) commd5 NP_001003553.1
Xenopus tropicalis (tropical clawed frog) commd5 XP_002934589.2

Gene Ontology


Bibliography

Related articles in PubMed

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, Sluis Bv, Billadeau DD, Burstein E
Molecular biology of the cell26(1)91-103(2015 Jan)

Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair.
Matsuda H, Hamet P, Tremblay J
Journal of nephrology27(4)351-60(2014 Aug)

CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E
The Journal of clinical investigation123(5)2244-56(2013 May)

HCaRG accelerates tubular repair after ischemic kidney injury.
Matsuda H, Lavoie JL, Gaboury L, Hamet P, Tremblay J
Journal of the American Society of Nephrology : JASN22(11)2077-89(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the hypertension-related, calcium-regulated gene (HCaRG/COMMD5) is involved in renal repair.
Title: Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair.

HCaRG accelerates repair of renal proximal tubules by modulating cell proliferation of resident tubular epithelial cells and by facilitating redifferentiation.
Title: HCaRG accelerates tubular repair after ischemic kidney injury.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.

The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.
Title: Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression.

The gene for human HCaRG is located on chromosome 8q24.3.
Title: Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene.

The following COMMD5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMMD5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu01007 NM_001081004.2
Latest version!		 Homo sapiens COMM domain containing 5 (COMMD5), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu01007 NM_001287237.1
Latest version!		 Homo sapiens COMM domain containing 5 (COMMD5), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu01007 NM_001081003.2
Latest version!		 Homo sapiens COMM domain containing 5 (COMMD5), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu01007 NM_014066.3
Latest version!		 Homo sapiens COMM domain containing 5 (COMMD5), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu01007
Clone ID Related Accession (Same CDS sequence) NM_001287237.1 , NM_014066.3 , NM_001081003.2 , NM_001081004.2
Accession Version NM_001287237.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 675bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-09-10
Organism Homo sapiens(human)
Product COMM domain-containing protein 5
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG705627.1, BQ680339.1, BM013651.1, BC003055.1 and AW137480.1. Transcript Variant: This variant (4) represents the longest transcript. Variants 1 through 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM013651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155770, SAMN01820689 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCTGCTG TGGGGGCTGC AACTCCATAC CTGCATCATC CTGGTGATAG TCACAGTGGC 
CGAGTGAGTT TCTTGGGGGC CCAGCTTCCT CCAGAGGTGG CAGCAATGGC CCGGCTACTA 
GGGGACCTAG ACAGGAGCAC GTTCAGAAAG TTGCTGAAGT TTGTGGTCAG CAGCCTGCAG 
GGGGAGGACT GCCGAGAGGC TGTGCAGCGT CTTGGGGTCA GCGCCAACCT GCCGGAGGAG 
CAGCTGGGTG CCCTGCTGGC AGGCATGCAC ACACTGCTCC AGCAGGCCCT CCGTCTGCCC 
CCCACCAGCC TGAAGCCTGA CACCTTCAGG GACCAGCTCC AGGAGCTCTG CATCCCCCAA 
GACCTGGTCG GGGACTTGGC CAGCGTGGTA TTTGGGAGCC AGCGGCCCCT CCTTGATTCT 
GTGGCCCAGC AGCAGGGGGC CTGGCTGCCG CATGTTGCTG ACTTTCGGTG GCGGGTGGAT 
GTAGCAATCT CCACCAGTGC CCTGGCTCGC TCCCTGCAGC CGAGCGTCCT GATGCAGCTG 
AAGCTTTCAG ATGGGTCAGC ATACCGCTTT GAGGTCCCCA CAGCCAAGTT CCAGGAGCTG 
CGGTACAGCG TGGCCCTGGT CCTAAAGGAG ATGGCAGATC TGGAGAAGAG GTGTGAGCGC 
AGACTGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001274166.1
CDS400..1074
Misc Feature(1)277..279
Misc Feature(2)403..405
Misc Feature(3)742..1071
Exon (1)1..342
Exon (2)343..1572
Translation

Target ORF information:

RefSeq Version NM_001287237.1
Organism Homo sapiens(human)
Definition Homo sapiens COMM domain containing 5 (COMMD5), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001287237.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCTGCTG TGGGGGCTGC AACTCCATAC CTGCATCATC CTGGTGATAG TCACAGTGGC 
CGAGTGAGTT TCTTGGGGGC CCAGCTTCCT CCAGAGGTGG CAGCAATGGC CCGGCTACTA 
GGGGACCTAG ACAGGAGCAC GTTCAGAAAG TTGCTGAAGT TTGTGGTCAG CAGCCTGCAG 
GGGGAGGACT GCCGAGAGGC TGTGCAGCGT CTTGGGGTCA GCGCCAACCT GCCGGAGGAG 
CAGCTGGGTG CCCTGCTGGC AGGCATGCAC ACACTGCTCC AGCAGGCCCT CCGTCTGCCC 
CCCACCAGCC TGAAGCCTGA CACCTTCAGG GACCAGCTCC AGGAGCTCTG CATCCCCCAA 
GACCTGGTCG GGGACTTGGC CAGCGTGGTA TTTGGGAGCC AGCGGCCCCT CCTTGATTCT 
GTGGCCCAGC AGCAGGGGGC CTGGCTGCCG CATGTTGCTG ACTTTCGGTG GCGGGTGGAT 
GTAGCAATCT CCACCAGTGC CCTGGCTCGC TCCCTGCAGC CGAGCGTCCT GATGCAGCTG 
AAGCTTTCAG ATGGGTCAGC ATACCGCTTT GAGGTCCCCA CAGCCAAGTT CCAGGAGCTG 
CGGTACAGCG TGGCCCTGGT CCTAAAGGAG ATGGCAGATC TGGAGAAGAG GTGTGAGCGC 
AGACTGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu01007
Clone ID Related Accession (Same CDS sequence) NM_001287237.1 , NM_014066.3 , NM_001081003.2 , NM_001081004.2
Accession Version NM_014066.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 675bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-09-10
Organism Homo sapiens(human)
Product COMM domain-containing protein 5
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG705627.1, BC065729.1 and AW137480.1. On Feb 6, 2007 this sequence version replaced NM_014066.2. Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.437782.1, SRR1163658.465009.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCTGCTG TGGGGGCTGC AACTCCATAC CTGCATCATC CTGGTGATAG TCACAGTGGC 
CGAGTGAGTT TCTTGGGGGC CCAGCTTCCT CCAGAGGTGG CAGCAATGGC CCGGCTACTA 
GGGGACCTAG ACAGGAGCAC GTTCAGAAAG TTGCTGAAGT TTGTGGTCAG CAGCCTGCAG 
GGGGAGGACT GCCGAGAGGC TGTGCAGCGT CTTGGGGTCA GCGCCAACCT GCCGGAGGAG 
CAGCTGGGTG CCCTGCTGGC AGGCATGCAC ACACTGCTCC AGCAGGCCCT CCGTCTGCCC 
CCCACCAGCC TGAAGCCTGA CACCTTCAGG GACCAGCTCC AGGAGCTCTG CATCCCCCAA 
GACCTGGTCG GGGACTTGGC CAGCGTGGTA TTTGGGAGCC AGCGGCCCCT CCTTGATTCT 
GTGGCCCAGC AGCAGGGGGC CTGGCTGCCG CATGTTGCTG ACTTTCGGTG GCGGGTGGAT 
GTAGCAATCT CCACCAGTGC CCTGGCTCGC TCCCTGCAGC CGAGCGTCCT GATGCAGCTG 
AAGCTTTCAG ATGGGTCAGC ATACCGCTTT GAGGTCCCCA CAGCCAAGTT CCAGGAGCTG 
CGGTACAGCG TGGCCCTGGT CCTAAAGGAG ATGGCAGATC TGGAGAAGAG GTGTGAGCGC 
AGACTGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_054785.2
CDS287..961
Misc Feature(1)116..118
Misc Feature(2)290..292
Misc Feature(3)629..958
Exon (1)1..229
Exon (2)230..1459
Translation

Target ORF information:

RefSeq Version NM_014066.3
Organism Homo sapiens(human)
Definition Homo sapiens COMM domain containing 5 (COMMD5), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_014066.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCTGCTG TGGGGGCTGC AACTCCATAC CTGCATCATC CTGGTGATAG TCACAGTGGC 
CGAGTGAGTT TCTTGGGGGC CCAGCTTCCT CCAGAGGTGG CAGCAATGGC CCGGCTACTA 
GGGGACCTAG ACAGGAGCAC GTTCAGAAAG TTGCTGAAGT TTGTGGTCAG CAGCCTGCAG 
GGGGAGGACT GCCGAGAGGC TGTGCAGCGT CTTGGGGTCA GCGCCAACCT GCCGGAGGAG 
CAGCTGGGTG CCCTGCTGGC AGGCATGCAC ACACTGCTCC AGCAGGCCCT CCGTCTGCCC 
CCCACCAGCC TGAAGCCTGA CACCTTCAGG GACCAGCTCC AGGAGCTCTG CATCCCCCAA 
GACCTGGTCG GGGACTTGGC CAGCGTGGTA TTTGGGAGCC AGCGGCCCCT CCTTGATTCT 
GTGGCCCAGC AGCAGGGGGC CTGGCTGCCG CATGTTGCTG ACTTTCGGTG GCGGGTGGAT 
GTAGCAATCT CCACCAGTGC CCTGGCTCGC TCCCTGCAGC CGAGCGTCCT GATGCAGCTG 
AAGCTTTCAG ATGGGTCAGC ATACCGCTTT GAGGTCCCCA CAGCCAAGTT CCAGGAGCTG 
CGGTACAGCG TGGCCCTGGT CCTAAAGGAG ATGGCAGATC TGGAGAAGAG GTGTGAGCGC 
AGACTGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu01007
Clone ID Related Accession (Same CDS sequence) NM_001287237.1 , NM_014066.3 , NM_001081003.2 , NM_001081004.2
Accession Version NM_001081003.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 675bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-09-10
Organism Homo sapiens(human)
Product COMM domain-containing protein 5
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from H92104.1, BU600590.1, BI753202.1, BC002672.2 and AW137480.1. On Dec 11, 2013 this sequence version replaced NM_001081003.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF113540.1, ERR279867.2582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCTGCTG TGGGGGCTGC AACTCCATAC CTGCATCATC CTGGTGATAG TCACAGTGGC 
CGAGTGAGTT TCTTGGGGGC CCAGCTTCCT CCAGAGGTGG CAGCAATGGC CCGGCTACTA 
GGGGACCTAG ACAGGAGCAC GTTCAGAAAG TTGCTGAAGT TTGTGGTCAG CAGCCTGCAG 
GGGGAGGACT GCCGAGAGGC TGTGCAGCGT CTTGGGGTCA GCGCCAACCT GCCGGAGGAG 
CAGCTGGGTG CCCTGCTGGC AGGCATGCAC ACACTGCTCC AGCAGGCCCT CCGTCTGCCC 
CCCACCAGCC TGAAGCCTGA CACCTTCAGG GACCAGCTCC AGGAGCTCTG CATCCCCCAA 
GACCTGGTCG GGGACTTGGC CAGCGTGGTA TTTGGGAGCC AGCGGCCCCT CCTTGATTCT 
GTGGCCCAGC AGCAGGGGGC CTGGCTGCCG CATGTTGCTG ACTTTCGGTG GCGGGTGGAT 
GTAGCAATCT CCACCAGTGC CCTGGCTCGC TCCCTGCAGC CGAGCGTCCT GATGCAGCTG 
AAGCTTTCAG ATGGGTCAGC ATACCGCTTT GAGGTCCCCA CAGCCAAGTT CCAGGAGCTG 
CGGTACAGCG TGGCCCTGGT CCTAAAGGAG ATGGCAGATC TGGAGAAGAG GTGTGAGCGC 
AGACTGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001074472.1
CDS265..939
Misc Feature(1)133..135
Misc Feature(2)268..270
Misc Feature(3)607..936
Exon (1)1..207
Exon (2)208..1437
Translation

Target ORF information:

RefSeq Version NM_001081003.2
Organism Homo sapiens(human)
Definition Homo sapiens COMM domain containing 5 (COMMD5), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001081003.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCTGCTG TGGGGGCTGC AACTCCATAC CTGCATCATC CTGGTGATAG TCACAGTGGC 
CGAGTGAGTT TCTTGGGGGC CCAGCTTCCT CCAGAGGTGG CAGCAATGGC CCGGCTACTA 
GGGGACCTAG ACAGGAGCAC GTTCAGAAAG TTGCTGAAGT TTGTGGTCAG CAGCCTGCAG 
GGGGAGGACT GCCGAGAGGC TGTGCAGCGT CTTGGGGTCA GCGCCAACCT GCCGGAGGAG 
CAGCTGGGTG CCCTGCTGGC AGGCATGCAC ACACTGCTCC AGCAGGCCCT CCGTCTGCCC 
CCCACCAGCC TGAAGCCTGA CACCTTCAGG GACCAGCTCC AGGAGCTCTG CATCCCCCAA 
GACCTGGTCG GGGACTTGGC CAGCGTGGTA TTTGGGAGCC AGCGGCCCCT CCTTGATTCT 
GTGGCCCAGC AGCAGGGGGC CTGGCTGCCG CATGTTGCTG ACTTTCGGTG GCGGGTGGAT 
GTAGCAATCT CCACCAGTGC CCTGGCTCGC TCCCTGCAGC CGAGCGTCCT GATGCAGCTG 
AAGCTTTCAG ATGGGTCAGC ATACCGCTTT GAGGTCCCCA CAGCCAAGTT CCAGGAGCTG 
CGGTACAGCG TGGCCCTGGT CCTAAAGGAG ATGGCAGATC TGGAGAAGAG GTGTGAGCGC 
AGACTGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu01007
Clone ID Related Accession (Same CDS sequence) NM_001287237.1 , NM_014066.3 , NM_001081003.2 , NM_001081004.2
Accession Version NM_001081004.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 675bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-09-10
Organism Homo sapiens(human)
Product COMM domain-containing protein 5
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG705627.1, BQ680339.1, BC002672.2 and AW137480.1. On Dec 11, 2013 this sequence version replaced NM_001081004.1. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.157642.1, SRR1163658.260170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCTGCTG TGGGGGCTGC AACTCCATAC CTGCATCATC CTGGTGATAG TCACAGTGGC 
CGAGTGAGTT TCTTGGGGGC CCAGCTTCCT CCAGAGGTGG CAGCAATGGC CCGGCTACTA 
GGGGACCTAG ACAGGAGCAC GTTCAGAAAG TTGCTGAAGT TTGTGGTCAG CAGCCTGCAG 
GGGGAGGACT GCCGAGAGGC TGTGCAGCGT CTTGGGGTCA GCGCCAACCT GCCGGAGGAG 
CAGCTGGGTG CCCTGCTGGC AGGCATGCAC ACACTGCTCC AGCAGGCCCT CCGTCTGCCC 
CCCACCAGCC TGAAGCCTGA CACCTTCAGG GACCAGCTCC AGGAGCTCTG CATCCCCCAA 
GACCTGGTCG GGGACTTGGC CAGCGTGGTA TTTGGGAGCC AGCGGCCCCT CCTTGATTCT 
GTGGCCCAGC AGCAGGGGGC CTGGCTGCCG CATGTTGCTG ACTTTCGGTG GCGGGTGGAT 
GTAGCAATCT CCACCAGTGC CCTGGCTCGC TCCCTGCAGC CGAGCGTCCT GATGCAGCTG 
AAGCTTTCAG ATGGGTCAGC ATACCGCTTT GAGGTCCCCA CAGCCAAGTT CCAGGAGCTG 
CGGTACAGCG TGGCCCTGGT CCTAAAGGAG ATGGCAGATC TGGAGAAGAG GTGTGAGCGC 
AGACTGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001074473.1
CDS133..807
Misc Feature(1)136..138
Misc Feature(2)475..804
Exon (1)1..75
Exon (2)76..1305
Translation

Target ORF information:

RefSeq Version NM_001081004.2
Organism Homo sapiens(human)
Definition Homo sapiens COMM domain containing 5 (COMMD5), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001081004.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGTCTGCTG TGGGGGCTGC AACTCCATAC CTGCATCATC CTGGTGATAG TCACAGTGGC 
CGAGTGAGTT TCTTGGGGGC CCAGCTTCCT CCAGAGGTGG CAGCAATGGC CCGGCTACTA 
GGGGACCTAG ACAGGAGCAC GTTCAGAAAG TTGCTGAAGT TTGTGGTCAG CAGCCTGCAG 
GGGGAGGACT GCCGAGAGGC TGTGCAGCGT CTTGGGGTCA GCGCCAACCT GCCGGAGGAG 
CAGCTGGGTG CCCTGCTGGC AGGCATGCAC ACACTGCTCC AGCAGGCCCT CCGTCTGCCC 
CCCACCAGCC TGAAGCCTGA CACCTTCAGG GACCAGCTCC AGGAGCTCTG CATCCCCCAA 
GACCTGGTCG GGGACTTGGC CAGCGTGGTA TTTGGGAGCC AGCGGCCCCT CCTTGATTCT 
GTGGCCCAGC AGCAGGGGGC CTGGCTGCCG CATGTTGCTG ACTTTCGGTG GCGGGTGGAT 
GTAGCAATCT CCACCAGTGC CCTGGCTCGC TCCCTGCAGC CGAGCGTCCT GATGCAGCTG 
AAGCTTTCAG ATGGGTCAGC ATACCGCTTT GAGGTCCCCA CAGCCAAGTT CCAGGAGCTG 
CGGTACAGCG TGGCCCTGGT CCTAAAGGAG ATGGCAGATC TGGAGAAGAG GTGTGAGCGC 
AGACTGCAGG ACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M


book

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
Molecular biology of the cell26(1)91-103(2015 Jan)
Phillips-Krawczak CA,Singla A,Starokadomskyy P,Deng Z,Osborne DG,Li H,Dick CJ,Gomez TS,Koenecke M,Zhang JS,Dai H,Sifuentes-Dominguez LF,Geng LN,Kaufmann SH,Hein MY,Wallis M,McGaughran J,Gecz J,Sluis Bv,Billadeau DD,Burstein E


book

Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair.
Journal of nephrology27(4)351-60(2014 Aug)
Matsuda H,Hamet P,Tremblay J


book

CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
The Journal of clinical investigation123(5)2244-56(2013 May)
Starokadomskyy P,Gluck N,Li H,Chen B,Wallis M,Maine GN,Mao X,Zaidi IW,Hein MY,McDonald FJ,Lenzner S,Zecha A,Ropers HH,Kuss AW,McGaughran J,Gecz J,Burstein E


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HCaRG accelerates tubular repair after ischemic kidney injury.
Journal of the American Society of Nephrology : JASN22(11)2077-89(2011 Nov)
Matsuda H,Lavoie JL,Gaboury L,Hamet P,Tremblay J