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MACROD1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MACROD1
Entrez Gene ID 28992
Full Name MACRO domain containing 1
Synonyms LRP16
General protein information
Preferred Names

MACRO domain containing 1

Names

O-acetyl-ADP-ribose deacetylase MACROD1
MACRO domain-containing protein 1
[Protein ADP-ribosylglutamate] hydrolase

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

11

11q13.1

Disorder MIM:

610400


mRNA and Protein(s)

mRNA Protein Name
NM_014067.3 NP_054786.2 O-acetyl-ADP-ribose deacetylase MACROD1
XM_005273939.4 XP_005273996.1 O-acetyl-ADP-ribose deacetylase MACROD1 isoform X1
XM_006718521.3 XP_006718584.1 O-acetyl-ADP-ribose deacetylase MACROD1 isoform X3
XM_005273940.2 XP_005273997.1 O-acetyl-ADP-ribose deacetylase MACROD1 isoform X4
XM_011544970.2 XP_011543272.1 O-acetyl-ADP-ribose deacetylase MACROD1 isoform X2
XM_006718522.2 XP_006718585.1 O-acetyl-ADP-ribose deacetylase MACROD1 isoform X5



Bos taurus (cattle) MACROD1 NP_001039974.1
Pan troglodytes (chimpanzee) MACROD1 XP_001162785.2
Rattus norvegicus (Norway rat) Macrod1 NP_647553.1
Macaca mulatta (rhesus monkey) MACROD1 XP_001115435.1
Homo sapiens (human) MACROD1 NP_054786.2
Canis lupus familiaris (dog) MACROD1 XP_854964.2
Mus musculus (house mouse) Macrod1 NP_598908.2
Danio rerio (zebrafish) macrod1 NP_001004573.2


Related articles in PubMed

An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.
Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, Wang Y, Fu X, Luo G, Han W
Nucleic acids research43(6)3167-79(2015 Mar)

Aberrant LRP16 protein expression in primary neuroendocrine lung tumors.
Shao Y, Li X, Lu Y, Liu L, Zhao P
International journal of clinical and experimental pathology8(6)6560-5(2015)

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.
Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG
Nature structural & molecular biology20(4)508-14(2013 Apr)

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.
Chen D, Vollmar M, Rossi MN, Phillips C, Kraehenbuehl R, Slade D, Mehrotra PV, von Delft F, Crosthwaite SK, Gileadi O, Denu JM, Ahel I
The Journal of biological chemistry286(15)13261-71(2011 Apr)

LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation.
Wu Z, Li Y, Li X, Ti D, Zhao Y, Si Y, Mei Q, Zhao P, Fu X, Han W
PloS one6(3)e18157(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LRP16, through its constitutive interactions with PARP1 and IKKgamma, functions to facilitate the lesion-specific recruitment of PARP1 and IKKgamma and, ultimately, the concomitant recruitment of PIASy to IKKgamma in response to DNA damage.
Title: An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.

The results indicate that abnormal LRP16 expression is noted in neuroendocrine lung tumors and the expression can give insight into the pathogenesis of the disease.
Title: Aberrant LRP16 protein expression in primary neuroendocrine lung tumors.

Findings not only indicate that LRP16 is a crucial regulator for NF-kappaB activation inside the nucleus, but also suggest that LRP16 may be an important contributor to the aberrant activation of NF-kappaB in tumors.
Title: LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation.

LRP16 expression is related to the degree of differentiation, invasiveness, metastasis and prognosis of colorectal carcinoma.
Title: Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma.

K18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm.
Title: Keratin 18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm.

The following MACROD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MACROD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27375 NM_014067.3
Latest version!
Homo sapiens MACRO domain containing 1 (MACROD1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $69.30
$99.00
OHu45295 XM_005273939.4
Latest version!
Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
OHu45296 XM_006718521.3
Latest version!
Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $69.30
$99.00
OHu45297 XM_005273940.2
Latest version!
Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $69.30
$99.00
OHu45299 XM_006718522.2
Latest version!
Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $69.30
$99.00
OHu67298 XM_011544970.2
Latest version!
Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00

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Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27375
Clone ID Related Accession (Same CDS sequence) NM_014067.3
Accession Version NM_014067.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 978bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-05
Organism Homo sapiens(Human)
Product O-acetyl-ADP-ribose deacetylase MACROD1
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ637198.1, AF202922.2 and BC003188.1. On Nov 13, 2008 this sequence version replaced NM_014067.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279858.814.1, SRR1163658.302629.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGCCA ACAGCTCCCT GCTCGGAGGC
GGTGGCGTGG ACGGCTGCAT TCATCGGGCC GCCGGCCCCC TGCTTACCGA CGAGTGCCGG
ACCCTGCAGA GCTGTAAGAC TGGCAAGGCC AAGATCACCG GCGGCTATCG GCTCCCGGCC
AAGTACGTCA TCCACACAGT GGGGCCCATC GCCTACGGGG AGCCCAGCGC CAGTCAGGCT
GCCGAGCTCC GCAGCTGCTA CCTGAGCAGT CTGGACCTGC TGCTGGAGCA CCGGCTCCGC
TCGGTGGCGT TCCCCTGCAT CTCCACCGGC GTGTTTGGCT ACCCCTGTGA GGCGGCCGCC
GAGATCGTGC TGGCCACGCT GCGAGAGTGG CTGGAGCAGC ACAAGGACAA GGTGGACCGG
CTGATCATCT GCGTGTTCCT CGAGAAGGAC GAGGACATCT ACCGGAGCCG GCTCCCCCAC
TACTTCCCCG TGGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_054786.2
CDS120..1097
Misc Feature(1)78..80
Misc Feature(2)405..407
Misc Feature(3)417..419
Misc Feature(4)426..428
Misc Feature(5)504..506
Misc Feature(6)573..1061
Misc Feature(7)576..1076
Misc Feature(8)594..602
Misc Feature(9)order(597..602,639..641,660..662,666..671,921..923,927..935)
Misc Feature(10)606..608
Misc Feature(11)order(630..632,639..641,657..659,669..671,792..794)
Misc Feature(12)633..641
Misc Feature(13)654..671
Misc Feature(14)918..938
Exon (1)1..417
Exon (2)418..519
Exon (3)520..636
Exon (4)637..666
Exon (5)667..783
Exon (6)784..905
Exon (7)906..936
Exon (8)937..1010
Exon (9)1011..1092
Exon (10)1093..1127
Exon (11)1128..1257
Translation

Target ORF information:

RefSeq Version NM_014067.3
Organism Homo sapiens(Human)
Definition Homo sapiens MACRO domain containing 1 (MACROD1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_014067.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGCCA ACAGCTCCCT GCTCGGAGGC
GGTGGCGTGG ACGGCTGCAT TCATCGGGCC GCCGGCCCCC TGCTTACCGA CGAGTGCCGG
ACCCTGCAGA GCTGTAAGAC TGGCAAGGCC AAGATCACCG GCGGCTATCG GCTCCCGGCC
AAGTACGTCA TCCACACAGT GGGGCCCATC GCCTACGGGG AGCCCAGCGC CAGTCAGGCT
GCCGAGCTCC GCAGCTGCTA CCTGAGCAGT CTGGACCTGC TGCTGGAGCA CCGGCTCCGC
TCGGTGGCGT TCCCCTGCAT CTCCACCGGC GTGTTTGGCT ACCCCTGTGA GGCGGCCGCC
GAGATCGTGC TGGCCACGCT GCGAGAGTGG CTGGAGCAGC ACAAGGACAA GGTGGACCGG
CTGATCATCT GCGTGTTCCT CGAGAAGGAC GAGGACATCT ACCGGAGCCG GCTCCCCCAC
TACTTCCCCG TGGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu45295
Clone ID Related Accession (Same CDS sequence) XM_005273939.4
Accession Version XM_005273939.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1005bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product O-acetyl-ADP-ribose deacetylase MACROD1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005273939.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGCCA ACAGCTCCCT GCTCGGAGGC
GGTGGCGTGG ACGGCTGCAT TCATCGGGCC GCCGGCCCCC TGCTTACCGA CGAGTGCCGG
ACCCTGCAGA GCTGTAAGAC TGGCAAGGCC AAGATCACCG GCGGCTATCG GCTCCCGGCC
AAGTACGTCA TCCACACAGT GGGGCCCATC GCCTACGGGG AGCCCAGCGC CAGTCAGGCT
GCCGAGCTCC GCAGCTGCTA CCTGAGCAGT CTGGACCTGC TGCTGGAGCA CCGGCTCCGC
TCGGTGGCGT TCCCCTGCAT CTCCACCGGC GTGTTTGGCT ACCCCTGTGA GGCGGCCGCC
GAGATCGTGC TGGCCACGCT GCGAGAGTGG CTGGAGCAGC ACAAGGACAA GGTGGACCGG
CTGATCATCT GCGTGTTCCT CGAGAAGGAC GAGGACATCT ACCGGAGCCG GCTCCCCCAC
TACTTCCCCG TGGACCCGCC TTCGGGACCC CGCTCCCAGC TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005273996.1
CDS659..1663
Misc Feature(1)1112..1600
Misc Feature(2)1115..1615
Misc Feature(3)order(1136..1141,1178..1180,1199..1201,1205..1210,1460..1462,1466..1474)
Misc Feature(4)order(1169..1171,1178..1180,1196..1198,1208..1210,1331..1333)
Translation

Target ORF information:

RefSeq Version XM_005273939.4
Organism Homo sapiens(Human)
Definition Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005273939.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGCCA ACAGCTCCCT GCTCGGAGGC
GGTGGCGTGG ACGGCTGCAT TCATCGGGCC GCCGGCCCCC TGCTTACCGA CGAGTGCCGG
ACCCTGCAGA GCTGTAAGAC TGGCAAGGCC AAGATCACCG GCGGCTATCG GCTCCCGGCC
AAGTACGTCA TCCACACAGT GGGGCCCATC GCCTACGGGG AGCCCAGCGC CAGTCAGGCT
GCCGAGCTCC GCAGCTGCTA CCTGAGCAGT CTGGACCTGC TGCTGGAGCA CCGGCTCCGC
TCGGTGGCGT TCCCCTGCAT CTCCACCGGC GTGTTTGGCT ACCCCTGTGA GGCGGCCGCC
GAGATCGTGC TGGCCACGCT GCGAGAGTGG CTGGAGCAGC ACAAGGACAA GGTGGACCGG
CTGATCATCT GCGTGTTCCT CGAGAAGGAC GAGGACATCT ACCGGAGCCG GCTCCCCCAC
TACTTCCCCG TGGACCCGCC TTCGGGACCC CGCTCCCAGC TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu45296
Clone ID Related Accession (Same CDS sequence) XM_006718521.3
Accession Version XM_006718521.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 597bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product O-acetyl-ADP-ribose deacetylase MACROD1 isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006718521.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGGAG CCAAGAGGCT GCGCATTAAT
GAGACCCGTG CTGCCGCGGC CCTCCTGGAA TGTGATCCGG AGCCTCAGGG AGGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006718584.1
CDS659..1255
Misc Feature(1)1115..>1192
Translation

Target ORF information:

RefSeq Version XM_006718521.3
Organism Homo sapiens(Human)
Definition Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006718521.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGGAG CCAAGAGGCT GCGCATTAAT
GAGACCCGTG CTGCCGCGGC CCTCCTGGAA TGTGATCCGG AGCCTCAGGG AGGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu45297
Clone ID Related Accession (Same CDS sequence) XM_005273940.2
Accession Version XM_005273940.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 567bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product O-acetyl-ADP-ribose deacetylase MACROD1 isoform X4
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005273940.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGACT CTCACAGCCA GGAGGACCCG
GTACCCGCCT GGAATCCCAG GGAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005273997.1
CDS659..1225
Misc Feature(1)1115..>1174
Translation

Target ORF information:

RefSeq Version XM_005273940.2
Organism Homo sapiens(Human)
Definition Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005273940.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGACT CTCACAGCCA GGAGGACCCG
GTACCCGCCT GGAATCCCAG GGAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu45299
Clone ID Related Accession (Same CDS sequence) XM_006718522.2
Accession Version XM_006718522.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 525bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product O-acetyl-ADP-ribose deacetylase MACROD1 isoform X5
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006718522.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGGAG CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006718585.1
CDS659..1183
Misc Feature(1)1115..>1174
Translation

Target ORF information:

RefSeq Version XM_006718522.2
Organism Homo sapiens(Human)
Definition Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006718522.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGGAG CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu67298
Clone ID Related Accession (Same CDS sequence) XM_011544970.2
Accession Version XM_011544970.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 975bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product O-acetyl-ADP-ribose deacetylase MACROD1 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011544970.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGTGG ACGGCTGCAT TCATCGGGCC
GCCGGCCCCC TGCTTACCGA CGAGTGCCGG ACCCTGCAGA GCTGTAAGAC TGGCAAGGCC
AAGATCACCG GCGGCTATCG GCTCCCGGCC AAGTACGTCA TCCACACAGT GGGGCCCATC
GCCTACGGGG AGCCCAGCGC CAGTCAGGCT GCCGAGCTCC GCAGCTGCTA CCTGAGCAGT
CTGGACCTGC TGCTGGAGCA CCGGCTCCGC TCGGTGGCGT TCCCCTGCAT CTCCACCGGC
GTGTTTGGCT ACCCCTGTGA GGCGGCCGCC GAGATCGTGC TGGCCACGCT GCGAGAGTGG
CTGGAGCAGC ACAAGGACAA GGTGGACCGG CTGATCATCT GCGTGTTCCT CGAGAAGGAC
GAGGACATCT ACCGGAGCCG GCTCCCCCAC TACTTCCCCG TGGACCCGCC TTCGGGACCC
CGCTCCCAGC TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011543272.1
CDS659..1633
Misc Feature(1)1112..1570
Misc Feature(2)1115..1585
Misc Feature(3)order(1136..1141,1175..1180,1430..1432,1436..1444)
Translation

Target ORF information:

RefSeq Version XM_011544970.2
Organism Homo sapiens(Human)
Definition Homo sapiens MACRO domain containing 1 (MACROD1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011544970.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCTAC AGAGCCGACT GTCCGGCCGC CTGGCACAGC TGCGCGCGGC GGGGCAGCTG 
CTCGTCCCCC CGCGCCCCCG GCCCGGACAC TTGGCGGGTG CCACGAGGAC CCGCAGCAGC
ACGTGCGGTC CCCCGGCGTT CCTGGGCGTG TTCGGCCGCC GTGCGCGGAC CTCGGCGGGA
GTTGGGGCGT GGGGGGCGGC GGCGGTGGGG CGGACAGCCG GGGTGCGCAC TTGGGCCCCC
CTGGCCATGG CGGCGAAGGT GGACCTGAGC ACCTCCACCG ACTGGAAGGA GGCGAAATCC
TTTCTGAAGG GCCTGAGTGA CAAGCAGCGG GAGGAACATT ACTTCTGCAA GGACTTTGTC
AGGCTGAAGA AGATCCCGAC ATGGAAGGAG ATGGCGAAAG GGGTGGCTGT GAAGGTGGAG
GAGCCCAGGT ATAAAAAGGA CAAGCAGCTC AATGAGAAAA TCTCCCTGCT CCGCAGCGAC
ATCACCAAGC TGGAGGTGGA CGCCATCGTC AACGCCGTGG ACGGCTGCAT TCATCGGGCC
GCCGGCCCCC TGCTTACCGA CGAGTGCCGG ACCCTGCAGA GCTGTAAGAC TGGCAAGGCC
AAGATCACCG GCGGCTATCG GCTCCCGGCC AAGTACGTCA TCCACACAGT GGGGCCCATC
GCCTACGGGG AGCCCAGCGC CAGTCAGGCT GCCGAGCTCC GCAGCTGCTA CCTGAGCAGT
CTGGACCTGC TGCTGGAGCA CCGGCTCCGC TCGGTGGCGT TCCCCTGCAT CTCCACCGGC
GTGTTTGGCT ACCCCTGTGA GGCGGCCGCC GAGATCGTGC TGGCCACGCT GCGAGAGTGG
CTGGAGCAGC ACAAGGACAA GGTGGACCGG CTGATCATCT GCGTGTTCCT CGAGAAGGAC
GAGGACATCT ACCGGAGCCG GCTCCCCCAC TACTTCCCCG TGGACCCGCC TTCGGGACCC
CGCTCCCAGC TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.
Nucleic acids research43(6)3167-79(2015 Mar)
Wu Z,Wang C,Bai M,Li X,Mei Q,Li X,Wang Y,Fu X,Luo G,Han W


book

Aberrant LRP16 protein expression in primary neuroendocrine lung tumors.
International journal of clinical and experimental pathology8(6)6560-5(2015)
Shao Y,Li X,Lu Y,Liu L,Zhao P


book

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.
Nature structural & molecular biology20(4)508-14(2013 Apr)
Jankevicius G,Hassler M,Golia B,Rybin V,Zacharias M,Timinszky G,Ladurner AG


book

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.
The Journal of biological chemistry286(15)13261-71(2011 Apr)
Chen D,Vollmar M,Rossi MN,Phillips C,Kraehenbuehl R,Slade D,Mehrotra PV,von Delft F,Crosthwaite SK,Gileadi O,Denu JM,Ahel I


book

LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation.
PloS one6(3)e18157(2011 Mar)
Wu Z,Li Y,Li X,Ti D,Zhao Y,Si Y,Mei Q,Zhao P,Fu X,Han W


 
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