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CXCL3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CXCL3
Entrez Gene ID 2921
Full Name chemokine (C-X-C motif) ligand 3
Synonyms CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3
General protein information
Preferred Names
C-X-C motif chemokine 3
Names
C-X-C motif chemokine 3
GRO-gamma
MIP2-beta
MGSA gamma
GRO3 oncogene
GRO-gamma(1-73)
growth-regulated protein gamma
macrophage inflammatory protein 2-beta
melanoma growth stimulatory activity gamma
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

139111


mRNA and Protein(s)

mRNA Protein Name
NM_002090 NP_002081 C-X-C motif chemokine 3 precursor



Homo sapiens (human) CXCL3 NP_002081.2
Pan troglodytes (chimpanzee) CXCL3 XP_517228.2
Macaca mulatta (Rhesus monkey) CXCL3 NP_001028051.1
Macaca mulatta (Rhesus monkey) LOC100424064 XP_002804334.1
Mus musculus (house mouse) Cxcl2 NP_033166.1
Rattus norvegicus (Norway rat) Cxcl2 NP_446099.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CXCL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu03827
NM_002090 Homo sapiens chemokine (C-X-C motif) ligand 3 (CXCL3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu03827
Clone ID Related Accession (Same CDS sequence) NM_002090
Accession Version NM_002090.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 324bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-X-C motif chemokine 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM828712.1, BC065743.1 and AW079760.1. On Oct 15, 2004 this sequence version replaced gi:4504156. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: CN263767.1, BC065743.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGCCCACG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGTCCGT GGTCACTGAA
CTGCGCTGCC AGTGCTTGCA GACACTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG
AATGTAAGGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT
GGGAAGAAAG CTTGTCTCAA CCCCGCATCC CCCATGGTTC AGAAAATCAT CGAAAAGATA
CTGAACAAGG GGAGCACCAA CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002081.2
CDS163..486
Misc Feature(1)280..468(+)
Misc Feature(2)280..447(+)
Misc Feature(3)280..288(+)
Misc Feature(4)283..465(+)
Misc Feature(5)283..411(+)
Misc Feature(6)286..297(+)
Misc Feature(7)292..333(+)
Misc Feature(8)298..414(+)
Misc Feature(9)319..468(+)
Misc Feature(10)325..411(+)
Misc Feature(11)331..465(+)
Misc Feature(12)358..366(+)
Misc Feature(13)358..366(+)
Misc Feature(14)397..405(+)
Exon (1)1..262
Gene:CXCL3
Gene Synonym:
Exon (2)263..386
Gene:CXCL3
Gene Synonym:
Exon (3)387..470
Gene:CXCL3
Gene Synonym:
Exon (4)471..1159
Gene:CXCL3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002090
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-X-C motif) ligand 3 (CXCL3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002090

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCACG CCACGCTCTC CGCCGCCCCC AGCAATCCCC GGCTCCTGCG GGTGGCGCTG 
CTGCTCCTGC TCCTGGTGGC CGCCAGCCGG CGCGCAGCAG GAGCGTCCGT GGTCACTGAA
CTGCGCTGCC AGTGCTTGCA GACACTGCAG GGAATTCACC TCAAGAACAT CCAAAGTGTG
AATGTAAGGT CCCCCGGACC CCACTGCGCC CAAACCGAAG TCATAGCCAC ACTCAAGAAT
GGGAAGAAAG CTTGTCTCAA CCCCGCATCC CCCATGGTTC AGAAAATCAT CGAAAAGATA
CTGAACAAGG GGAGCACCAA CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration
J. Immunol. 191 (5), 2731-2741 (2013)
Al-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, Rousseau S, Eidelman DH and Hamid Q.


book

Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines
J. Immunol. 190 (10), 5065-5077 (2013)
Chen HW, Chen HY, Wang LT, Wang FH, Fang LW, Lai HY, Chen HH, Lu J, Hung MS, Cheng Y, Chen MY, Liu SJ, Chong P, Lee OK and Hsu SC.


book

Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis
Muscle Nerve 46 (6), 917-925 (2012)
De Paepe B, Creus KK, Martin JJ and De Bleecker JL.


book

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature 491 (7422), 119-124 (2012)
Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and Cho JH.


book

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity
J. Leukoc. Biol. 74 (3), 448-455 (2003)
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and Oppenheim JJ.


book

Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms
Eur. J. Biochem. 260 (2), 421-429 (1999)
Wuyts A, Govaerts C, Struyf S, Lenaerts JP, Put W, Conings R, Proost P and Van Damme J.


book

An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha induction of gro in human fibroblasts
J. Immunol. 147 (2), 520-527 (1991)
Anisowicz A, Messineo M, Lee SW and Sager R.


book

Nucleotide sequence of the human melanoma growth stimulatory activity (MGSA) gene
Nucleic Acids Res. 18 (21), 6453 (1990)
Baker NE, Kucera G and Richmond A.


book

Identification of three related human GRO genes encoding cytokine functions
Proc. Natl. Acad. Sci. U.S.A. 87 (19), 7732-7736 (1990)
Haskill S, Peace A, Morris J, Sporn SA, Anisowicz A, Lee SW, Smith T, Martin G, Ralph P and Sager R.


book

Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues
J. Exp. Med. 172 (3), 911-919 (1990)
Tekamp-Olson P, Gallegos C, Bauer D, McClain J, Sherry B, Fabre M, van Deventer S and Cerami A.


 
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