GTF3A cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | GTF3A |
| Entrez Gene ID | 2971 |
| Full Name | general transcription factor IIIA |
| Synonyms | AP2,TFIIIA |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_002097.2 | NP_002088.2 | transcription factor IIIA |
| NM_002097.3 | NP_002088.2 | transcription factor IIIA |
| Homo sapiens (human) | GTF3A | NP_002088.2 |
| Mus musculus (house mouse) | Gtf3a | NP_079928.2 |
| Rattus norvegicus (Norway rat) | Gtf3a | NP_001107042.1 |
| Gallus gallus (chicken) | GTF3A | NP_001107043.1 |
| Drosophila melanogaster (fruit fly) | CG9609 | NP_573161.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_05322 | XP_003712886.1 |
| Pan troglodytes (chimpanzee) | GTF3A | XP_522641.3 |
| GTF3A | XP_001095556.1 | |
| Canis lupus familiaris (dog) | GTF3A | XP_534523.3 |
| Bos taurus (cattle) | GTF3A | NP_001107044.1 |
| Danio rerio (zebrafish) | gtf3aa | NP_001003866.1 |
| Schizosaccharomyces pombe (fission yeast) | sfc2 | NP_594670.1 |
| Xenopus tropicalis (tropical clawed frog) | gtf3a | XP_002941582.2 |
Related articles in PubMed
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.
Sloan KE, Bohnsack MT, Watkins NJ
Cell reports5(1)237-47(2013 Oct)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, M?gi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segr? AV, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpel?inen TO, Yang J, Bouatia-Naji N, Esko T, Feitosa MF, Kutalik Z, Mangino M, Raychaudhuri S, Scherag A, Smith AV, Welch R, Zhao JH, Aben KK, Absher DM, Amin N, Dixon AL, Fisher E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ, Johansson A, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers RH, Narisu N, Perry JR, Peters MJ, Preuss M, Ripatti S, Rivadeneira F, Sandholt C, Scott LJ, Timpson NJ, Tyrer JP, van Wingerden S, Watanabe RM, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper MN, Jansson JO, Lawrence RW, Pellikka N, Prokopenko I, Shi J, Thiering E, Alavere H, Alibrandi MT, Almgren P, Arnold AM, Aspelund T, Atwood LD, Balkau B, Balmforth AJ, Bennett AJ, Ben-Shlomo Y, Bergman RN, Bergmann S, Biebermann H, Blakemore AI, Boes T, Bonnycastle LL, Bornstein SR, Brown MJ, Buchanan TA, Busonero F, Campbell H, Cappuccio FP, Cavalcanti-Proen?a C, Chen YD, Chen CM, Chines PS, Clarke R, Coin L, Connell J, Day IN, den Heijer M, Duan J, Ebrahim S, Elliott P, Elosua R, Eiriksdottir G, Erdos MR, Eriksson JG, Facheris MF, Felix SB, Fischer-Posovszky P, Folsom AR, Friedrich N, Freimer NB, Fu M, Gaget S, Gejman PV, Geus EJ, Gieger C, Gjesing AP, Goel A, Goyette P, Grallert H, Gr?ssler J, Greenawalt DM, Groves CJ, Gudnason V, Guiducci C, Hartikainen AL, Hassanali N, Hall AS, Havulinna AS, Hayward C, Heath AC, Hengstenberg C, Hicks AA, Hinney A, Hofman A, Homuth G, Hui J, Igl W, Iribarren C, Isomaa B, Jacobs KB, Jarick I, Jewell E, John U, J?rgensen T, Jousilahti P, Jula A, Kaakinen M, Kajantie E, Kaplan LM, Kathiresan S, Kettunen J, Kinnunen L, Knowles JW, Kolcic I, K?nig IR, Koskinen S, Kovacs P, Kuusisto J, Kraft P, Kval?y K, Laitinen J, Lantieri O, Lanzani C, Launer LJ, Lecoeur C, Lehtim?ki T, Lettre G, Liu J, Lokki ML, Lorentzon M, Luben RN, Ludwig B, , Manunta P, Marek D, Marre M, Martin NG, McArdle WL, McCarthy A, McKnight B, Meitinger T, Melander O, Meyre D, Midthjell K, Montgomery GW, Morken MA, Morris AP, Mulic R, Ngwa JS, Nelis M, Neville MJ, Nyholt DR, O'Donnell CJ, O'Rahilly S, Ong KK, Oostra B, Par? G, Parker AN, Perola M, Pichler I, Pietil?inen KH, Platou CG, Polasek O, Pouta A, Rafelt S, Raitakari O, Rayner NW, Ridderstr?le M, Rief W, Ruokonen A, Robertson NR, Rzehak P, Salomaa V, Sanders AR, Sandhu MS, Sanna S, Saramies J, Savolainen MJ, Scherag S, Schipf S, Schreiber S, Schunkert H, Silander K, Sinisalo J, Siscovick DS, Smit JH, Soranzo N, Sovio U, Stephens J, Surakka I, Swift AJ, Tammesoo ML, Tardif JC, Teder-Laving M, Teslovich TM, Thompson JR, Thomson B, T?njes A, Tuomi T, van Meurs JB, van Ommen GJ, Vatin V, Viikari J, Visvikis-Siest S, Vitart V, Vogel CI, Voight BF, Waite LL, Wallaschofski H, Walters GB, Widen E, Wiegand S, Wild SH, Willemsen G, Witte DR, Witteman JC, Xu J, Zhang Q, Zgaga L, Ziegler A, Zitting P, Beilby JP, Farooqi IS, Hebebrand J, Huikuri HV, James AL, K?h?nen M, Levinson DF, Macciardi F, Nieminen MS, Ohlsson C, Palmer LJ, Ridker PM, Stumvoll M, Beckmann JS, Boeing H, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Collins FS, Cupples LA, Smith GD, Erdmann J, Froguel P, Gr?nberg H, Gyllensten U, Hall P, Hansen T, Harris TB, Hattersley AT, Hayes RB, Heinrich J, Hu FB, Hveem K, Illig T, Jarvelin MR, Kaprio J, Karpe F, Khaw KT, Kiemeney LA, Krude H, Laakso M, Lawlor DA, Metspalu A, Munroe PB, Ouwehand WH, Pedersen O, Penninx BW, Peters A, Pramstaller PP, Quertermous T, Reinehr T, Rissanen A, Rudan I, Samani NJ, Schwarz PE, Shuldiner AR, Spector TD, Tuomilehto J, Uda M, Uitterlinden A, Valle TT, Wabitsch M, Waeber G, Wareham NJ, Watkins H, , Wilson JF, Wright AF, Zillikens MC, Chatterjee N, McCarroll SA, Purcell S, Schadt EE, Visscher PM, Assimes TL, Borecki IB, Deloukas P, Fox CS, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, Mohlke KL, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, van Duijn CM, Wichmann HE, Frayling TM, Thorsteinsdottir U, Abecasis GR, Barroso I, Boehnke M, Stefansson K, North KE, McCarthy MI, Hirschhorn JN, Ingelsson E, Loos RJ
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Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene.
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cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA.
Hanas JS, Hocker JR, Cheng YG, Lerner MR, Brackett DJ, Lightfoot SA, Hanas RJ, Madhusudhan KT, Moreland RJ
Gene282(1-2)43-52(2002 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following GTF3A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GTF3A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu32111 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_002097.2 , NM_002097.3 | |
| Accession Version | NM_002097.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-01 | |
| Organism | Homo sapiens(human) | |
| Product | transcription factor IIIA | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D32257.1, BP254755.1, U20272.1 and AW627732.1. On or before Mar 29, 2008 this sequence version replaced XM_001716951.1, XM_001715623.1, XM_001717641.1, NM_002097.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D32257.1, SRR1163655.444445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | CTGGATCCGC CGGCCGTGGT CGCCGAGTCG GTGTCGTCCT TGACCATCGC CGACGCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_002088.2 |
| CDS | 195..1292 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_002097.2 |
ORF Insert Sequence:
1 | CTGGATCCGC CGGCCGTGGT CGCCGAGTCG GTGTCGTCCT TGACCATCGC CGACGCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu32111 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_002097.2 , NM_002097.3 | |
| Accession Version | NM_002097.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-05 | |
| Organism | Homo sapiens(human) | |
| Product | transcription factor IIIA | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D32257.1, BP254755.1, U20272.1, AW627732.1 and AL137059.20. On Nov 23, 2018 this sequence version replaced NM_002097.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.289034.1, SRR3476690.656735.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | CTGGATCCGC CGGCCGTGGT CGCCGAGTCG GTGTCGTCCT TGACCATCGC CGACGCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_002088.2 |
| CDS | 120..1217 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_002097.3 |
ORF Insert Sequence:
1 | CTGGATCCGC CGGCCGTGGT CGCCGAGTCG GTGTCGTCCT TGACCATCGC CGACGCGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. |
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. |
|
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. |
|
Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene. |
|
cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA. |