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GYS2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GYS2
Entrez Gene ID 2998
Full Name glycogen synthase 2
General protein information
Preferred Names

glycogen synthase 2

Names

glycogen [starch] synthase, liver
glycogen synthase 2 (liver)

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

12

12p12.1

Summary The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009].
Disorder MIM:

138571

Disorder Html: Glycogen storage disease, type 0, 240600 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_021957.3 NP_068776.2 glycogen [starch] synthase, liver
XM_006719063.3 XP_006719126.1 glycogen [starch] synthase, liver isoform X1
XM_017019245.1 XP_016874734.1 glycogen [starch] synthase, liver isoform X2



Bos taurus (cattle) GYS2 NP_001179834.1
Mus musculus (house mouse) Gys2 NP_663547.2
Danio rerio (zebrafish) gys2 NP_001018199.1
Pan troglodytes (chimpanzee) GYS2 XP_520790.2
Gallus gallus (chicken) GYS2 XP_004938048.1
Canis lupus familiaris (dog) GYS2 XP_534869.2
Homo sapiens (human) GYS2 NP_068776.2
Rattus norvegicus (Norway rat) Gys2 NP_037221.1
Macaca mulatta (rhesus monkey) GYS2 XP_001098578.1


Related articles in PubMed

Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition.
Hwang JY, Lee EJ, Jin Go M, Sung YA, Lee HJ, Heon Kwak S, Jang HC, Soo Park K, Lee HJ, Byul Jang H, Song J, Park KH, Kim HL, Cho MC, Lee JY
Journal of human genetics57(10)660-4(2012 Oct)

Mutational analysis of the GYS2 gene in patients diagnosed with ketotic hypoglycaemia.
Nessa A, Kumaran A, Kirk R, Dalton A, Ismail D, Hussain K
Journal of pediatric endocrinology & metabolism : JPEM25(9-10)963-7(2012)

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A
Mutation research694(1-2)13-9(2010 Dec)

Genetic associations of brain structural networks in schizophrenia: a preliminary study.
Jagannathan K, Calhoun VD, Gelernter J, Stevens MC, Liu J, Bolognani F, Windemuth A, Ruaño G, Assaf M, Pearlson GD
Biological psychiatry68(7)657-66(2010 Oct)

Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH
Pharmacogenomics11(7)959-71(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The GYS2 gene is a new susceptibility gene that significantly affects the risk for ovary syndrome through obesity-related conditions.
Title: Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition.

Sequencing of the GYS2 gene is more likely to be positive in patients with fasting ketotic hypoglycaemia and concomitant postprandial hyperglycaemia with hyperlactataemia.
Title: Mutational analysis of the GYS2 gene in patients diagnosed with ketotic hypoglycaemia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic associations of brain structural networks in schizophrenia: a preliminary study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?

The following GYS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GYS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu46092 XM_006719063.3
Latest version!
Homo sapiens glycogen synthase 2 (GYS2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu83744 XM_017019245.1
Latest version!
Homo sapiens glycogen synthase 2 (GYS2), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $223.30
$319.00
OHu24235 NM_021957.3
Latest version!
Homo sapiens glycogen synthase 2 (GYS2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
$559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu46092
Clone ID Related Accession (Same CDS sequence) XM_006719063.3
Accession Version XM_006719063.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1881bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product glycogen [starch] synthase, liver isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006719063.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGGAAAAA AGACTGTAAC TAACATGAAC TCACAAGAGA AGACCATTCA CTTACTTAAG 
GAAAACTTTC AGGTGCATTT TGGAAGATGG CTGATAGAAG GAAGTCCTTA TGTGGTACTT
TTTGACATAG GCTATTCAGC TTGGAATCTG GACAGGTGGA AGGGTGACCT CTGGGAAGCA
TGCAGTGTCG GCATTCCTTA TCATGACCGA GAAGCCAATG ATATGCTGAT ATTTGGATCT
TTAACTGCCT GGTTCTTAAA AGAGGTGACA GATCATGCAG ATGGTAAATA TGTCGTTGCC
CAATTCCATG AATGGCAGGC TGGAATTGGA CTGATCCTTT CTCGAGCCAG GAAACTTCCT
ATTGCCACAA TATTTACAAC CCACGCTACA CTACTTGGGA GGTATCTCTG TGCAGCAAAT
ATTGATTTCT ACAACCATCT TGATAAGTTT AACATTGACA AAGAGGCTGG GGAAAGGCAG
ATTTACCACC GGTACTGCAT GGAGCGAGCT TCCGTTCATT GCGCTCACGT GTTCACCACG
GTTTCTGAAA TAACAGCAAT AGAAGCTGAA CATATGCTGA AGAGAAAGCC TGATGTAGTT
ACTCCAAACG GCTTGAATGT TAAGAAATTT TCAGCAGTGC ATGAGTTTCA AAATCTACAT
GCCATGTACA AGGCCAGAAT CCAAGATTTT GTTCGAGGTC ATTTCTATGG TCATCTCGAC
TTTGATCTTG AAAAGACTTT GTTCCTTTTC ATTGCTGGGA GGTATGAGTT TTCAAACAAA
GGAGCTGACA TCTTCCTAGA ATCCTTATCC AGGCTAAATT TCCTGCTGAG GATGCATAAA
AGTGACATCA CAGTGATGGT GTTTTTCATT ATGCCTGCCA AGACAAATAA TTTCAACGTG
GAAACCCTGA AAGGACAAGC AGTGCGAAAA CAGCTGTGGG ATGTTGCACA TTCTGTGAAG
GAAAAGTTTG GAAAAAAACT CTATGATGCA TTATTAAGAG GAGAAATTCC TGACCTGAAC
GATATTTTAG ATCGAGATGA TCTAACAATT ATGAAAAGAG CCATCTTTTC AACTCAGCGA
CAGTCATTGC CCCCAGTGAC CACGCACAAC ATGATTGATG ACTCCACCGA CCCCATCCTC
AGCACCATTA GACGGATTGG ACTTTTCAAC AACCGCACAG ATAGAGTCAA GGTGATTTTG
CACCCAGAGT TTCTATCCTC CACCAGTCCC TTACTACCCA TGGACTATGA AGAGTTTGTT
AGAGGTTGTC ATCTTGGAGT ATTTCCATCA TACTATGAAC CCTGGGGTTA TACTCCAGCT
GAATGCACTG TGATGGGTAT CCCCAGTGTG ACCACGAATC TCTCCGGGTT TGGCTGTTTC
ATGCAGGAGC ACGTGGCTGA TCCTACTGCT TACGGTATTT ACATCGTTGA CAGGCGGTTC
CGTTCTCCAG ATGATTCTTG CAATCAGCTG ACTAAGTTTC TCTATGGATT TTGCAAACAG
TCACGCCGCC AAAGGATTAT CCAGAGGAAC AGAACTGAGA GGCTCTCAGA TCTTCTGGAT
TGGAGATACT TAGGCAGATA TTACCAGCAT GCCAGACACC TGACATTAAG CAGAGCTTTT
CCAGATAAAT TCCATGTGGA ACTAACATCA CCACCAACGA CAGAAGGATT TAAATATCCC
AGGCCTTCCT CAGTACCACC TTCTCCTTCA GGGTCTCAGG CCTCCAGTCC TCAGAGCAGT
GATGTGGAAG ATGAAGTGGA GGATGAGAGA TACGATGAGG AAGAGGAGGC TGAAAGGGAT
CGGTTAAATA TCAAGTCACC ATTTTCACTG AGCCACGTTC CTCATGGGAA GAAAAAGCTG
CATGGTGAAT ATAAGAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006719126.1
CDS19..1899
Misc Feature(1)25..1761
Misc Feature(2)25..1632
Translation

Target ORF information:

RefSeq Version XM_006719063.3
Organism Homo sapiens(Human)
Definition Homo sapiens glycogen synthase 2 (GYS2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006719063.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGGAAAAA AGACTGTAAC TAACATGAAC TCACAAGAGA AGACCATTCA CTTACTTAAG 
GAAAACTTTC AGGTGCATTT TGGAAGATGG CTGATAGAAG GAAGTCCTTA TGTGGTACTT
TTTGACATAG GCTATTCAGC TTGGAATCTG GACAGGTGGA AGGGTGACCT CTGGGAAGCA
TGCAGTGTCG GCATTCCTTA TCATGACCGA GAAGCCAATG ATATGCTGAT ATTTGGATCT
TTAACTGCCT GGTTCTTAAA AGAGGTGACA GATCATGCAG ATGGTAAATA TGTCGTTGCC
CAATTCCATG AATGGCAGGC TGGAATTGGA CTGATCCTTT CTCGAGCCAG GAAACTTCCT
ATTGCCACAA TATTTACAAC CCACGCTACA CTACTTGGGA GGTATCTCTG TGCAGCAAAT
ATTGATTTCT ACAACCATCT TGATAAGTTT AACATTGACA AAGAGGCTGG GGAAAGGCAG
ATTTACCACC GGTACTGCAT GGAGCGAGCT TCCGTTCATT GCGCTCACGT GTTCACCACG
GTTTCTGAAA TAACAGCAAT AGAAGCTGAA CATATGCTGA AGAGAAAGCC TGATGTAGTT
ACTCCAAACG GCTTGAATGT TAAGAAATTT TCAGCAGTGC ATGAGTTTCA AAATCTACAT
GCCATGTACA AGGCCAGAAT CCAAGATTTT GTTCGAGGTC ATTTCTATGG TCATCTCGAC
TTTGATCTTG AAAAGACTTT GTTCCTTTTC ATTGCTGGGA GGTATGAGTT TTCAAACAAA
GGAGCTGACA TCTTCCTAGA ATCCTTATCC AGGCTAAATT TCCTGCTGAG GATGCATAAA
AGTGACATCA CAGTGATGGT GTTTTTCATT ATGCCTGCCA AGACAAATAA TTTCAACGTG
GAAACCCTGA AAGGACAAGC AGTGCGAAAA CAGCTGTGGG ATGTTGCACA TTCTGTGAAG
GAAAAGTTTG GAAAAAAACT CTATGATGCA TTATTAAGAG GAGAAATTCC TGACCTGAAC
GATATTTTAG ATCGAGATGA TCTAACAATT ATGAAAAGAG CCATCTTTTC AACTCAGCGA
CAGTCATTGC CCCCAGTGAC CACGCACAAC ATGATTGATG ACTCCACCGA CCCCATCCTC
AGCACCATTA GACGGATTGG ACTTTTCAAC AACCGCACAG ATAGAGTCAA GGTGATTTTG
CACCCAGAGT TTCTATCCTC CACCAGTCCC TTACTACCCA TGGACTATGA AGAGTTTGTT
AGAGGTTGTC ATCTTGGAGT ATTTCCATCA TACTATGAAC CCTGGGGTTA TACTCCAGCT
GAATGCACTG TGATGGGTAT CCCCAGTGTG ACCACGAATC TCTCCGGGTT TGGCTGTTTC
ATGCAGGAGC ACGTGGCTGA TCCTACTGCT TACGGTATTT ACATCGTTGA CAGGCGGTTC
CGTTCTCCAG ATGATTCTTG CAATCAGCTG ACTAAGTTTC TCTATGGATT TTGCAAACAG
TCACGCCGCC AAAGGATTAT CCAGAGGAAC AGAACTGAGA GGCTCTCAGA TCTTCTGGAT
TGGAGATACT TAGGCAGATA TTACCAGCAT GCCAGACACC TGACATTAAG CAGAGCTTTT
CCAGATAAAT TCCATGTGGA ACTAACATCA CCACCAACGA CAGAAGGATT TAAATATCCC
AGGCCTTCCT CAGTACCACC TTCTCCTTCA GGGTCTCAGG CCTCCAGTCC TCAGAGCAGT
GATGTGGAAG ATGAAGTGGA GGATGAGAGA TACGATGAGG AAGAGGAGGC TGAAAGGGAT
CGGTTAAATA TCAAGTCACC ATTTTCACTG AGCCACGTTC CTCATGGGAA GAAAAAGCTG
CATGGTGAAT ATAAGAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu83744
Clone ID Related Accession (Same CDS sequence) XM_017019245.1
Accession Version XM_017019245.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1179bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product glycogen [starch] synthase, liver isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCTTCGAG GCCGATCCCT CTCTGTAACA TCCCTGGGTG GGCTTCCCCA GTGGGAAGTC 
GAAGAACTTC CTGTGGAGGA GTTACTGCTC TTTGAAGTTG CTTGGGAAGT GACCAATAAA
GTTGGAGGCA TCTATACTGT GATTCAGACA AAGGCCAAAA CAACAGCAGA TGAATGGGGA
GAGAACTATT TTCTGATAGG TCCATATTTT GAGCATAATA TGAAGACTCA GGTGGAACAG
TGTGAACCTG TAAATGATGC TGTCAGAAGA GCAGTGGACG CAATGAATAA GCATGGCTGC
CAGGTGCATT TTGGAAGATG GCTGATAGAA GGAAGTCCTT ATGTGGTACT TTTTGACATA
GGCTATTCAG CTTGGAATCT GGACAGGTGG AAGGGTGACC TCTGGGAAGC ATGCAGTGTC
GGCATTCCTT ATCATGACCG AGAAGCCAAT GATATGCTGA TATTTGGATC TTTAACTGCC
TGGTTCTTAA AAGAGGTGAC AGATCATGCA GATGGTAAAT ATGTCGTTGC CCAATTCCAT
GAATGGCAGG CTGGAATTGG ACTGATCCTT TCTCGAGCCA GGAAACTTCC TATTGCCACA
ATATTTACAA CCCACGCTAC ACTACTTGGG AGGTATCTCT GTGCAGCAAA TATTGATTTC
TACAACCATC TTGATAAGTT TAACATTGAC AAAGAGGCTG GGGAAAGGCA GATTTACCAC
CGGTACTGCA TGGAGCGAGC TTCCGTTCAT TGCGCTCACG TGTTCACCAC GGTTTCTGAA
ATAACAGCAA TAGAAGCTGA ACATATGCTG AAGAGAAAGC CTGATGTAGT TACTCCAAAC
GGCTTGAATG TTAAGAAATT TTCAGCAGTG CATGAGTTTC AAAATCTACA TGCCATGTAC
AAGGCCAGAA TCCAAGATTT TGTTCGAGGT CATTTCTATG GTCATCTCGA CTTTGATCTT
GAAAAGACTT TGTTCCTTTT CATTGCTGGG AGGTATGAGT TTTCAAACAA AGGAGCTGAC
ATCTTCCTAG AATCCTTATC CAGGCTAAAT TTCCTGCTGA GGATGCATAA AAGTGACATC
ACAGTGATGG TGTTTTTCAT TATGCCTGCC AAGACAAATA ATTTCAACGT GGAAACCCTG
AAAGGACAAG CAGTGCGAAA ACAGCTGTGG TTATCGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016874734.1
CDS267..1445
Translation

Target ORF information:

RefSeq Version XM_017019245.1
Organism Homo sapiens(Human)
Definition Homo sapiens glycogen synthase 2 (GYS2), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017019245.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCTTCGAG GCCGATCCCT CTCTGTAACA TCCCTGGGTG GGCTTCCCCA GTGGGAAGTC 
GAAGAACTTC CTGTGGAGGA GTTACTGCTC TTTGAAGTTG CTTGGGAAGT GACCAATAAA
GTTGGAGGCA TCTATACTGT GATTCAGACA AAGGCCAAAA CAACAGCAGA TGAATGGGGA
GAGAACTATT TTCTGATAGG TCCATATTTT GAGCATAATA TGAAGACTCA GGTGGAACAG
TGTGAACCTG TAAATGATGC TGTCAGAAGA GCAGTGGACG CAATGAATAA GCATGGCTGC
CAGGTGCATT TTGGAAGATG GCTGATAGAA GGAAGTCCTT ATGTGGTACT TTTTGACATA
GGCTATTCAG CTTGGAATCT GGACAGGTGG AAGGGTGACC TCTGGGAAGC ATGCAGTGTC
GGCATTCCTT ATCATGACCG AGAAGCCAAT GATATGCTGA TATTTGGATC TTTAACTGCC
TGGTTCTTAA AAGAGGTGAC AGATCATGCA GATGGTAAAT ATGTCGTTGC CCAATTCCAT
GAATGGCAGG CTGGAATTGG ACTGATCCTT TCTCGAGCCA GGAAACTTCC TATTGCCACA
ATATTTACAA CCCACGCTAC ACTACTTGGG AGGTATCTCT GTGCAGCAAA TATTGATTTC
TACAACCATC TTGATAAGTT TAACATTGAC AAAGAGGCTG GGGAAAGGCA GATTTACCAC
CGGTACTGCA TGGAGCGAGC TTCCGTTCAT TGCGCTCACG TGTTCACCAC GGTTTCTGAA
ATAACAGCAA TAGAAGCTGA ACATATGCTG AAGAGAAAGC CTGATGTAGT TACTCCAAAC
GGCTTGAATG TTAAGAAATT TTCAGCAGTG CATGAGTTTC AAAATCTACA TGCCATGTAC
AAGGCCAGAA TCCAAGATTT TGTTCGAGGT CATTTCTATG GTCATCTCGA CTTTGATCTT
GAAAAGACTT TGTTCCTTTT CATTGCTGGG AGGTATGAGT TTTCAAACAA AGGAGCTGAC
ATCTTCCTAG AATCCTTATC CAGGCTAAAT TTCCTGCTGA GGATGCATAA AAGTGACATC
ACAGTGATGG TGTTTTTCAT TATGCCTGCC AAGACAAATA ATTTCAACGT GGAAACCCTG
AAAGGACAAG CAGTGCGAAA ACAGCTGTGG TTATCGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24235
Clone ID Related Accession (Same CDS sequence) NM_021957.3
Accession Version NM_021957.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2112bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-06
Organism Homo sapiens(Human)
Product glycogen [starch] synthase, liver
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB185936.1, BC126310.1, AV653197.1 and AC006559.6. This sequence is a reference standard in the RefSeqGene project. On Dec 13, 2006 this sequence version replaced NM_021957.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S70004.1, BC126310.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGCTTCGAG GCCGATCCCT CTCTGTAACA TCCCTGGGTG GGCTTCCCCA GTGGGAAGTC 
GAAGAACTTC CTGTGGAGGA GTTACTGCTC TTTGAAGTTG CTTGGGAAGT GACCAATAAA
GTTGGAGGCA TCTATACTGT GATTCAGACA AAGGCCAAAA CAACAGCAGA TGAATGGGGA
GAGAACTATT TTCTGATAGG TCCATATTTT GAGCATAATA TGAAGACTCA GGTGGAACAG
TGTGAACCTG TAAATGATGC TGTCAGAAGA GCAGTGGACG CAATGAATAA GCATGGCTGC
CAGGTGCATT TTGGAAGATG GCTGATAGAA GGAAGTCCTT ATGTGGTACT TTTTGACATA
GGCTATTCAG CTTGGAATCT GGACAGGTGG AAGGGTGACC TCTGGGAAGC ATGCAGTGTC
GGCATTCCTT ATCATGACCG AGAAGCCAAT GATATGCTGA TATTTGGATC TTTAACTGCC
TGGTTCTTAA AAGAGGTGAC AGATCATGCA GATGGTAAAT ATGTCGTTGC CCAATTCCAT
GAATGGCAGG CTGGAATTGG ACTGATCCTT TCTCGAGCCA GGAAACTTCC TATTGCCACA
ATATTTACAA CCCACGCTAC ACTACTTGGG AGGTATCTCT GTGCAGCAAA TATTGATTTC
TACAACCATC TTGATAAGTT TAACATTGAC AAAGAGGCTG GGGAAAGGCA GATTTACCAC
CGGTACTGCA TGGAGCGAGC TTCCGTTCAT TGCGCTCACG TGTTCACCAC GGTTTCTGAA
ATAACAGCAA TAGAAGCTGA ACATATGCTG AAGAGAAAGC CTGATGTAGT TACTCCAAAC
GGCTTGAATG TTAAGAAATT TTCAGCAGTG CATGAGTTTC AAAATCTACA TGCCATGTAC
AAGGCCAGAA TCCAAGATTT TGTTCGAGGT CATTTCTATG GTCATCTCGA CTTTGATCTT
GAAAAGACTT TGTTCCTTTT CATTGCTGGG AGGTATGAGT TTTCAAACAA AGGAGCTGAC
ATCTTCCTAG AATCCTTATC CAGGCTAAAT TTCCTGCTGA GGATGCATAA AAGTGACATC
ACAGTGATGG TGTTTTTCAT TATGCCTGCC AAGACAAATA ATTTCAACGT GGAAACCCTG
AAAGGACAAG CAGTGCGAAA ACAGCTGTGG GATGTTGCAC ATTCTGTGAA GGAAAAGTTT
GGAAAAAAAC TCTATGATGC ATTATTAAGA GGAGAAATTC CTGACCTGAA CGATATTTTA
GATCGAGATG ATCTAACAAT TATGAAAAGA GCCATCTTTT CAACTCAGCG ACAGTCATTG
CCCCCAGTGA CCACGCACAA CATGATTGAT GACTCCACCG ACCCCATCCT CAGCACCATT
AGACGGATTG GACTTTTCAA CAACCGCACA GATAGAGTCA AGGTGATTTT GCACCCAGAG
TTTCTATCCT CCACCAGTCC CTTACTACCC ATGGACTATG AAGAGTTTGT TAGAGGTTGT
CATCTTGGAG TATTTCCATC ATACTATGAA CCCTGGGGTT ATACTCCAGC TGAATGCACT
GTGATGGGTA TCCCCAGTGT GACCACGAAT CTCTCCGGGT TTGGCTGTTT CATGCAGGAG
CACGTGGCTG ATCCTACTGC TTACGGTATT TACATCGTTG ACAGGCGGTT CCGTTCTCCA
GATGATTCTT GCAATCAGCT GACTAAGTTT CTCTATGGAT TTTGCAAACA GTCACGCCGC
CAAAGGATTA TCCAGAGGAA CAGAACTGAG AGGCTCTCAG ATCTTCTGGA TTGGAGATAC
TTAGGCAGAT ATTACCAGCA TGCCAGACAC CTGACATTAA GCAGAGCTTT TCCAGATAAA
TTCCATGTGG AACTAACATC ACCACCAACG ACAGAAGGAT TTAAATATCC CAGGCCTTCC
TCAGTACCAC CTTCTCCTTC AGGGTCTCAG GCCTCCAGTC CTCAGAGCAG TGATGTGGAA
GATGAAGTGG AGGATGAGAG ATACGATGAG GAAGAGGAGG CTGAAAGGGA TCGGTTAAAT
ATCAAGTCAC CATTTTCACT GAGCCACGTT CCTCATGGGA AGAAAAAGCT GCATGGTGAA
TATAAGAACT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_068776.2
CDS256..2367
Misc Feature(1)214..216
Misc Feature(2)277..279
Misc Feature(3)286..288
Misc Feature(4)352..2229
Misc Feature(5)352..2100
Misc Feature(6)2134..2136
Misc Feature(7)2176..2178
Misc Feature(8)2188..2190
Misc Feature(9)2200..2202
Misc Feature(10)2212..2214
Misc Feature(11)2224..2226
Misc Feature(12)2302..2304
Exon (1)1..376
Exon (2)377..558
Exon (3)559..750
Exon (4)751..933
Exon (5)934..1078
Exon (6)1079..1196
Exon (7)1197..1317
Exon (8)1318..1424
Exon (9)1425..1484
Exon (10)1485..1563
Exon (11)1564..1677
Exon (12)1678..1804
Exon (13)1805..1900
Exon (14)1901..2064
Exon (15)2065..2145
Exon (16)2146..3132
Translation

Target ORF information:

RefSeq Version NM_021957.3
Organism Homo sapiens(Human)
Definition Homo sapiens glycogen synthase 2 (GYS2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021957.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
ATGCTTCGAG GCCGATCCCT CTCTGTAACA TCCCTGGGTG GGCTTCCCCA GTGGGAAGTC 
GAAGAACTTC CTGTGGAGGA GTTACTGCTC TTTGAAGTTG CTTGGGAAGT GACCAATAAA
GTTGGAGGCA TCTATACTGT GATTCAGACA AAGGCCAAAA CAACAGCAGA TGAATGGGGA
GAGAACTATT TTCTGATAGG TCCATATTTT GAGCATAATA TGAAGACTCA GGTGGAACAG
TGTGAACCTG TAAATGATGC TGTCAGAAGA GCAGTGGACG CAATGAATAA GCATGGCTGC
CAGGTGCATT TTGGAAGATG GCTGATAGAA GGAAGTCCTT ATGTGGTACT TTTTGACATA
GGCTATTCAG CTTGGAATCT GGACAGGTGG AAGGGTGACC TCTGGGAAGC ATGCAGTGTC
GGCATTCCTT ATCATGACCG AGAAGCCAAT GATATGCTGA TATTTGGATC TTTAACTGCC
TGGTTCTTAA AAGAGGTGAC AGATCATGCA GATGGTAAAT ATGTCGTTGC CCAATTCCAT
GAATGGCAGG CTGGAATTGG ACTGATCCTT TCTCGAGCCA GGAAACTTCC TATTGCCACA
ATATTTACAA CCCACGCTAC ACTACTTGGG AGGTATCTCT GTGCAGCAAA TATTGATTTC
TACAACCATC TTGATAAGTT TAACATTGAC AAAGAGGCTG GGGAAAGGCA GATTTACCAC
CGGTACTGCA TGGAGCGAGC TTCCGTTCAT TGCGCTCACG TGTTCACCAC GGTTTCTGAA
ATAACAGCAA TAGAAGCTGA ACATATGCTG AAGAGAAAGC CTGATGTAGT TACTCCAAAC
GGCTTGAATG TTAAGAAATT TTCAGCAGTG CATGAGTTTC AAAATCTACA TGCCATGTAC
AAGGCCAGAA TCCAAGATTT TGTTCGAGGT CATTTCTATG GTCATCTCGA CTTTGATCTT
GAAAAGACTT TGTTCCTTTT CATTGCTGGG AGGTATGAGT TTTCAAACAA AGGAGCTGAC
ATCTTCCTAG AATCCTTATC CAGGCTAAAT TTCCTGCTGA GGATGCATAA AAGTGACATC
ACAGTGATGG TGTTTTTCAT TATGCCTGCC AAGACAAATA ATTTCAACGT GGAAACCCTG
AAAGGACAAG CAGTGCGAAA ACAGCTGTGG GATGTTGCAC ATTCTGTGAA GGAAAAGTTT
GGAAAAAAAC TCTATGATGC ATTATTAAGA GGAGAAATTC CTGACCTGAA CGATATTTTA
GATCGAGATG ATCTAACAAT TATGAAAAGA GCCATCTTTT CAACTCAGCG ACAGTCATTG
CCCCCAGTGA CCACGCACAA CATGATTGAT GACTCCACCG ACCCCATCCT CAGCACCATT
AGACGGATTG GACTTTTCAA CAACCGCACA GATAGAGTCA AGGTGATTTT GCACCCAGAG
TTTCTATCCT CCACCAGTCC CTTACTACCC ATGGACTATG AAGAGTTTGT TAGAGGTTGT
CATCTTGGAG TATTTCCATC ATACTATGAA CCCTGGGGTT ATACTCCAGC TGAATGCACT
GTGATGGGTA TCCCCAGTGT GACCACGAAT CTCTCCGGGT TTGGCTGTTT CATGCAGGAG
CACGTGGCTG ATCCTACTGC TTACGGTATT TACATCGTTG ACAGGCGGTT CCGTTCTCCA
GATGATTCTT GCAATCAGCT GACTAAGTTT CTCTATGGAT TTTGCAAACA GTCACGCCGC
CAAAGGATTA TCCAGAGGAA CAGAACTGAG AGGCTCTCAG ATCTTCTGGA TTGGAGATAC
TTAGGCAGAT ATTACCAGCA TGCCAGACAC CTGACATTAA GCAGAGCTTT TCCAGATAAA
TTCCATGTGG AACTAACATC ACCACCAACG ACAGAAGGAT TTAAATATCC CAGGCCTTCC
TCAGTACCAC CTTCTCCTTC AGGGTCTCAG GCCTCCAGTC CTCAGAGCAG TGATGTGGAA
GATGAAGTGG AGGATGAGAG ATACGATGAG GAAGAGGAGG CTGAAAGGGA TCGGTTAAAT
ATCAAGTCAC CATTTTCACT GAGCCACGTT CCTCATGGGA AGAAAAAGCT GCATGGTGAA
TATAAGAACT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition.
Journal of human genetics57(10)660-4(2012 Oct)
Hwang JY,Lee EJ,Jin Go M,Sung YA,Lee HJ,Heon Kwak S,Jang HC,Soo Park K,Lee HJ,Byul Jang H,Song J,Park KH,Kim HL,Cho MC,Lee JY


book

Mutational analysis of the GYS2 gene in patients diagnosed with ketotic hypoglycaemia.
Journal of pediatric endocrinology & metabolism : JPEM25(9-10)963-7(2012)
Nessa A,Kumaran A,Kirk R,Dalton A,Ismail D,Hussain K


book

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Mutation research694(1-2)13-9(2010 Dec)
Flachsbart F,Franke A,Kleindorp R,Caliebe A,Blanché H,Schreiber S,Nebel A


book

Genetic associations of brain structural networks in schizophrenia: a preliminary study.
Biological psychiatry68(7)657-66(2010 Oct)
Jagannathan K,Calhoun VD,Gelernter J,Stevens MC,Liu J,Bolognani F,Windemuth A,Ruaño G,Assaf M,Pearlson GD


book

Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Pharmacogenomics11(7)959-71(2010 Jul)
Ruaño G,Thompson PD,Kane JP,Pullinger CR,Windemuth A,Seip RL,Kocherla M,Holford TR,Wu AH


 
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