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HSD17B10 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol HSD17B10
Entrez Gene ID 3028
Full Name hydroxysteroid 17-beta dehydrogenase 10
Synonyms 17b-HSD10,ABAD,CAMR,DUPXp11.22,ERAB,HADH2,HCD2,HSD10MD,MHBD,MRPP2,MRX17,MRX31,MRXS10,SCHAD,SDR5C1
General protein information
Preferred Names

hydroxysteroid 17-beta dehydrogenase 10

Names

3-hydroxyacyl-CoA dehydrogenase type-2
3-hydroxy-2-methylbutyryl-CoA dehydrogenase
AB-binding alcohol dehydrogenase
amyloid-beta peptide binding alcohol dehydrogenase
endoplasmic reticulum-associated amyloid beta-peptide-binding protein
mitochondrial RNase P subunit 2
mitochondrial ribonuclease P protein 2
short chain L-3-hydroxyacyl-CoA dehydrogenase type 2
short chain type dehydrogenase/reductase XH98G2

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

X

Xp11.22

Summary This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014].
Disorder MIM:

300256

Disorder Html: 17-beta-hydroxysteroid dehydrogenase X deficiency, 300438 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_004493.2 NP_004484.1 3-hydroxyacyl-CoA dehydrogenase type-2 isoform 1
NM_001037811.2 NP_001032900.1 3-hydroxyacyl-CoA dehydrogenase type-2 isoform 2



Canis lupus familiaris (dog) HSD17B10 XP_538051.2
Mus musculus (house mouse) Hsd17b10 NP_058043.3
Drosophila melanogaster (fruit fly) scu NP_523396.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP003414 XP_003436472.1
Xenopus tropicalis (tropical clawed frog) hsd17b10 NP_001016511.1
Rattus norvegicus (Norway rat) Hsd17b10 NP_113870.1
Pan troglodytes (chimpanzee) HSD17B10 XP_003317521.1
Bos taurus (cattle) HSD17B10 NP_776759.1
Caenorhabditis elegans (roundworm) ard-1 NP_502083.1
Magnaporthe oryzae (rice blast fungus) MGG_01180 XP_003714064.1
Neurospora crassa NCU11196 XP_001728478.1
Macaca mulatta (rhesus monkey) HSD17B10 XP_001087982.1
Homo sapiens (human) HSD17B10 NP_004484.1
Danio rerio (zebrafish) hsd17b10 NP_001006098.1


Related articles in PubMed

17β-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content.
Amberger A, Deutschmann AJ, Traunfellner P, Moser P, Feichtinger RG, Kofler B, Zschocke J
Cancer letters374(1)149-155(2016 Apr)

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases.
Boynton TO, Shimkets LJ
Genes & development29(18)1903-14(2015 Sep)

Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex.
Vilardo E, Rossmanith W
Nucleic acids research43(10)5112-9(2015 May)

Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death.
Carlson EA, Marquez RT, Du F, Wang Y, Xu L, Yan SS
BMC cancer15166(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A computational study and enzyme inhibition assay with full length human 17-beta-HSD10 identifies risperidone as enzyme inhibitor and possible antineoplastic agent.
Title: A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment.

Data suggest that HSD10 plays a role in alterations of energy metabolism by regulating mtDNA content in colorectal carcinomas.
Title: 17β-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content.

Three HSD10 variants associated with neurodegenerative disorders are inactive with cardiolipin
Title: Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases.

The study showed that pathogenic mutations impair SDR5C1-dependent dehydrogenation, tRNA processing and methylation.
Title: Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex.

Our findings demonstrate that overexpression of HSD10 accelerates pheochromocytoma cell growth, enhances cell respiration, and increases cellular resistance to cell death induction.
Title: Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death.

The following HSD17B10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSD17B10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18260 NM_001037811.2
Latest version!
Homo sapiens hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu18855 NM_004493.2
Latest version!
Homo sapiens hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18260
Clone ID Related Accession (Same CDS sequence) NM_001037811.2
Accession Version NM_001037811.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 759bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product 3-hydroxyacyl-CoA dehydrogenase type-2 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU132847.1, BC008708.1 and Z97054.1. This sequence is a reference standard in the RefSeqGene project. On Apr 11, 2006 this sequence version replaced NM_001037811.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.75693.1, BC008708.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCAGCAG CGTGTCGGAG CGTGAAGGGC CTGGTGGCGG TAATAACCGG AGGAGCCTCG 
GGCCTGGGCC TGGCCACGGC GGAGCGACTT GTGGGGCAGG GAGCCTCTGC TGTGCTTCTG
GACCTGCCCA ACTCGGGTGG GGAGGCCCAA GCCAAGAAGT TAGGAAACAA CTGCGTTTTC
GCCCCAGCCG ACGTGACCTC TGAGAAGGAT GTGCAAACAG CTCTGGCTCT AGCAAAAGGA
AAGTTTGGCC GTGTGGATGT AGCTGTCAAC TGTGCAGGCA TCGCGGTGGC TAGCAAGACG
TACAACTTAA AGAAGGGCCA GACCCATACC TTGGAAGACT TCCAGCGAGT TCTTGATGTG
AATCTCATGG GCACCTTCAA TGTGATCCGC CTGGTGGCTG GTGAGATGGG CCAGAATGAA
CCAGACCAGG GAGGCCAACG TGGGGTCATC ATCAACACTG CCAGTGTGGC TGCCTTCGAG
GGTCAGGTTG GACAAGCTGC ATACTCTGCT TCCAAGGGGG GAATAGTGGG CATGACACTG
CCCATTGCTC GGGATCTGGC TCCCATAGGT CTGTTTGGCA CCCCACTGCT GACCAGCCTC
CCAGAGAAAG TGTGCAACTT CTTGGCCAGC CAAGTGCCCT TCCCTAGCCG ACTGGGTGAC
CCTGCTGAGT ATGCTCACCT CGTACAGGCC ATCATCGAGA ACCCATTCCT CAATGGAGAG
GTCATCCGGC TGGATGGGGC CATTCGTATG CAGCCTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001032900.1
CDS32..790
Misc Feature(1)50..784
Misc Feature(2)56..787
Misc Feature(3)order(80..82,89..97,152..157,218..226,302..310,389..391,488..496,533..535,545..547,599..607,611..622)
Misc Feature(4)order(326..334,338..340,353..358,362..364,371..376,383..385,395..400,407..412,419..421,428..433,440..442,461..469,503..523,527..529,536..541,548..553,560..565,569..577,581..586,590..598,605..607,668..676,680..688,698..700,707..712,719..721,725..772,776..787)
Misc Feature(5)order(326..334,353..358,362..364,371..373,383..385,398..400,407..412,419..421,503..523,527..529,536..541,548..553,560..565,572..577,581..586,779..787)
Misc Feature(6)order(392..394,494..496,533..535,545..547)
Exon (1)1..58
Exon (2)59..223
Exon (3)224..388
Exon (4)389..517
Exon (5)518..599
Exon (6)600..936
Translation

Target ORF information:

RefSeq Version NM_001037811.2
Organism Homo sapiens(Human)
Definition Homo sapiens hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001037811.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCAGCAG CGTGTCGGAG CGTGAAGGGC CTGGTGGCGG TAATAACCGG AGGAGCCTCG 
GGCCTGGGCC TGGCCACGGC GGAGCGACTT GTGGGGCAGG GAGCCTCTGC TGTGCTTCTG
GACCTGCCCA ACTCGGGTGG GGAGGCCCAA GCCAAGAAGT TAGGAAACAA CTGCGTTTTC
GCCCCAGCCG ACGTGACCTC TGAGAAGGAT GTGCAAACAG CTCTGGCTCT AGCAAAAGGA
AAGTTTGGCC GTGTGGATGT AGCTGTCAAC TGTGCAGGCA TCGCGGTGGC TAGCAAGACG
TACAACTTAA AGAAGGGCCA GACCCATACC TTGGAAGACT TCCAGCGAGT TCTTGATGTG
AATCTCATGG GCACCTTCAA TGTGATCCGC CTGGTGGCTG GTGAGATGGG CCAGAATGAA
CCAGACCAGG GAGGCCAACG TGGGGTCATC ATCAACACTG CCAGTGTGGC TGCCTTCGAG
GGTCAGGTTG GACAAGCTGC ATACTCTGCT TCCAAGGGGG GAATAGTGGG CATGACACTG
CCCATTGCTC GGGATCTGGC TCCCATAGGT CTGTTTGGCA CCCCACTGCT GACCAGCCTC
CCAGAGAAAG TGTGCAACTT CTTGGCCAGC CAAGTGCCCT TCCCTAGCCG ACTGGGTGAC
CCTGCTGAGT ATGCTCACCT CGTACAGGCC ATCATCGAGA ACCCATTCCT CAATGGAGAG
GTCATCCGGC TGGATGGGGC CATTCGTATG CAGCCTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu18855
Clone ID Related Accession (Same CDS sequence) NM_004493.2
Accession Version NM_004493.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 786bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product 3-hydroxyacyl-CoA dehydrogenase type-2 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU132847.1, BC000372.2 and Z97054.1. This sequence is a reference standard in the RefSeqGene project. On Apr 11, 2006 this sequence version replaced NM_004493.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.288612.1, AF035555.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGCAG CGTGTCGGAG CGTGAAGGGC CTGGTGGCGG TAATAACCGG AGGAGCCTCG 
GGCCTGGGCC TGGCCACGGC GGAGCGACTT GTGGGGCAGG GAGCCTCTGC TGTGCTTCTG
GACCTGCCCA ACTCGGGTGG GGAGGCCCAA GCCAAGAAGT TAGGAAACAA CTGCGTTTTC
GCCCCAGCCG ACGTGACCTC TGAGAAGGAT GTGCAAACAG CTCTGGCTCT AGCAAAAGGA
AAGTTTGGCC GTGTGGATGT AGCTGTCAAC TGTGCAGGCA TCGCGGTGGC TAGCAAGACG
TACAACTTAA AGAAGGGCCA GACCCATACC TTGGAAGACT TCCAGCGAGT TCTTGATGTG
AATCTCATGG GCACCTTCAA TGTGATCCGC CTGGTGGCTG GTGAGATGGG CCAGAATGAA
CCAGACCAGG GAGGCCAACG TGGGGTCATC ATCAACACTG CCAGTGTGGC TGCCTTCGAG
GGTCAGGTTG GACAAGCTGC ATACTCTGCT TCCAAGGGGG GAATAGTGGG CATGACACTG
CCCATTGCTC GGGATCTGGC TCCCATAGGT ATCCGGGTGA TGACCATTGC CCCAGGTCTG
TTTGGCACCC CACTGCTGAC CAGCCTCCCA GAGAAAGTGT GCAACTTCTT GGCCAGCCAA
GTGCCCTTCC CTAGCCGACT GGGTGACCCT GCTGAGTATG CTCACCTCGT ACAGGCCATC
ATCGAGAACC CATTCCTCAA TGGAGAGGTC ATCCGGCTGG ATGGGGCCAT TCGTATGCAG
CCTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004484.1
CDS32..817
Misc Feature(1)35..37
Misc Feature(2)50..811
Misc Feature(3)56..814
Misc Feature(4)order(80..82,89..97,152..157,218..226,302..310,389..391,488..496,533..535,545..547,623..634,638..649)
Misc Feature(5)188..190
Misc Feature(6)188..190
Misc Feature(7)236..238
Misc Feature(8)order(326..334,338..340,353..358,362..364,371..376,383..385,395..400,407..412,419..421,428..433,440..442,461..469,503..523,527..529,536..541,548..553,560..565,569..577,581..586,590..601,605..607,632..634,695..703,707..715,725..727,734..739,746..748,752..799,803..814)
Misc Feature(9)order(326..334,353..358,362..364,371..373,383..385,398..400,407..412,419..421,503..523,527..529,536..541,548..553,560..565,572..577,581..586,806..814)
Misc Feature(10)326..328
Misc Feature(11)344..346
Misc Feature(12)order(392..394,494..496,533..535,545..547)
Misc Feature(13)665..667
Misc Feature(14)665..667
Exon (1)1..58
Exon (2)59..223
Exon (3)224..388
Exon (4)389..517
Exon (5)518..626
Exon (6)627..963
Translation

Target ORF information:

RefSeq Version NM_004493.2
Organism Homo sapiens(Human)
Definition Homo sapiens hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004493.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCAGCAG CGTGTCGGAG CGTGAAGGGC CTGGTGGCGG TAATAACCGG AGGAGCCTCG 
GGCCTGGGCC TGGCCACGGC GGAGCGACTT GTGGGGCAGG GAGCCTCTGC TGTGCTTCTG
GACCTGCCCA ACTCGGGTGG GGAGGCCCAA GCCAAGAAGT TAGGAAACAA CTGCGTTTTC
GCCCCAGCCG ACGTGACCTC TGAGAAGGAT GTGCAAACAG CTCTGGCTCT AGCAAAAGGA
AAGTTTGGCC GTGTGGATGT AGCTGTCAAC TGTGCAGGCA TCGCGGTGGC TAGCAAGACG
TACAACTTAA AGAAGGGCCA GACCCATACC TTGGAAGACT TCCAGCGAGT TCTTGATGTG
AATCTCATGG GCACCTTCAA TGTGATCCGC CTGGTGGCTG GTGAGATGGG CCAGAATGAA
CCAGACCAGG GAGGCCAACG TGGGGTCATC ATCAACACTG CCAGTGTGGC TGCCTTCGAG
GGTCAGGTTG GACAAGCTGC ATACTCTGCT TCCAAGGGGG GAATAGTGGG CATGACACTG
CCCATTGCTC GGGATCTGGC TCCCATAGGT ATCCGGGTGA TGACCATTGC CCCAGGTCTG
TTTGGCACCC CACTGCTGAC CAGCCTCCCA GAGAAAGTGT GCAACTTCTT GGCCAGCCAA
GTGCCCTTCC CTAGCCGACT GGGTGACCCT GCTGAGTATG CTCACCTCGT ACAGGCCATC
ATCGAGAACC CATTCCTCAA TGGAGAGGTC ATCCGGCTGG ATGGGGCCAT TCGTATGCAG
CCTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

17β-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content.
Cancer letters374(1)149-155(2016 Apr)
Amberger A,Deutschmann AJ,Traunfellner P,Moser P,Feichtinger RG,Kofler B,Zschocke J


book

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M


book

Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases.
Genes & development29(18)1903-14(2015 Sep)
Boynton TO,Shimkets LJ


book

Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex.
Nucleic acids research43(10)5112-9(2015 May)
Vilardo E,Rossmanith W


book

Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death.
BMC cancer15166(2015 Mar)
Carlson EA,Marquez RT,Du F,Wang Y,Xu L,Yan SS


 
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