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FOXA3 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol FOXA3
Entrez Gene ID 3171
Full Name forkhead box A3
Synonyms FKHH3,HNF3G,TCF3G
General protein information
Preferred Names

forkhead box A3

Names

hepatocyte nuclear factor 3-gamma
HNF-3-gamma
HNF-3G
TCF-3G
fork head-related protein FKH H3
forkhead box protein A3
transcription factor 3G

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

19

19q13.32

Summary This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008].
Disorder MIM:

602295


mRNA and Protein(s)

mRNA Protein Name
NM_004497.2 NP_004488.2 hepatocyte nuclear factor 3-gamma



Canis lupus familiaris (dog) FOXA3 XP_541549.3
Mus musculus (house mouse) Foxa3 NP_032286.1
Pan troglodytes (chimpanzee) FOXA3 XP_512763.2
Rattus norvegicus (Norway rat) Foxa3 NP_058773.1
Macaca mulatta (rhesus monkey) FOXA3 XP_001111513.1
Homo sapiens (human) FOXA3 NP_004488.2
Bos taurus (cattle) FOXA3 NP_001028291.1
Danio rerio (zebrafish) foxa3 NP_571374.1


Related articles in PubMed

Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.
Adler-Wailes DC, Alberobello AT, Ma X, Hugendubler L, Stern EA, Mou Z, Han JC, Kim PW, Sumner AE, Yanovski JA, Mueller E
International journal of obesity (2005)39(6)888-92(2015 Jun)

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.
Chen G, Korfhagen TR, Karp CL, Impey S, Xu Y, Randell SH, Kitzmiller J, Maeda Y, Haitchi HM, Sridharan A, Senft AP, Whitsett JA
American journal of respiratory and critical care medicine189(3)301-13(2014 Feb)

The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.
Xu L, Panel V, Ma X, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E
Molecular and cellular biology33(17)3392-9(2013 Sep)

[Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3γ].
Liu Q, Li H, Chen HH, Wang J
Yi chuan = Hereditas34(5)573-83(2012 May)

Genetic predictors of interindividual variability in hepatic CYP3A4 expression.
Lamba V, Panetta JC, Strom S, Schuetz EG
The Journal of pharmacology and experimental therapeutics332(3)1088-99(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our study identified novel FOXA3 variants and mutations, assessed the adipogenic capacity of two novel missense alterations in vitro and demonstrated for the first time the associations between FOXA3 SNP rs28666870 with metabolic phenotypes in humans.
Title: Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity in asthma and chronic obstructive pulmonary disease.
Title: Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.

In obese subjects, FOXA3 is differentially expressed in visceral and subcutaneous adipose depots.
Title: The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.

low caloric intake decreases the production of intracellular reactive oxygen species and suppresses endothelial cells senescence through promoting HNF3gamma binging to NOX4 promoter region and inhibiting NOX4 gene expression induced by up-regulated HNF3gamma
Title: [Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3γ].

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic predictors of interindividual variability in hepatic CYP3A4 expression.

The following FOXA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25423
NM_004497.2
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Homo sapiens forkhead box A3 (FOXA3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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$379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25423
Clone ID Related Accession (Same CDS sequence) NM_004497.2
Accession Version NM_004497.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1053bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-09-01
Organism Homo sapiens(Human)
Product hepatocyte nuclear factor 3-gamma
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC016024.1. On Nov 3, 2002 this sequence version replaced NM_004497.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016024.1, AK223473.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGCTGGGCT CAGTGAAGAT GGAGGCCCAT GACCTGGCCG AGTGGAGCTA CTACCCGGAG 
GCGGGCGAGG TCTACTCGCC GGTGACCCCA GTGCCCACCA TGGCCCCCCT CAACTCCTAC
ATGACCCTGA ATCCTCTAAG CTCTCCCTAT CCCCCTGGGG GGCTCCCTGC CTCCCCACTG
CCCTCAGGAC CCCTGGCACC CCCAGCACCT GCAGCCCCCC TGGGGCCCAC TTTCCCAGGC
CTGGGTGTCA GCGGTGGCAG CAGCAGCTCC GGGTACGGGG CCCCGGGTCC TGGGCTGGTG
CACGGGAAGG AGATGCCGAA GGGGTATCGG CGGCCCCTGG CACACGCCAA GCCACCGTAT
TCCTATATCT CACTCATCAC CATGGCCATC CAGCAGGCGC CGGGCAAGAT GCTGACCTTG
AGTGAAATCT ACCAGTGGAT CATGGACCTC TTCCCTTACT ACCGGGAGAA TCAGCAGCGC
TGGCAGAACT CCATTCGCCA CTCGCTGTCT TTCAACGACT GCTTCGTCAA GGTGGCGCGT
TCCCCAGACA AGCCTGGCAA GGGCTCCTAC TGGGCCCTAC ACCCCAGCTC AGGGAACATG
TTTGAGAATG GCTGCTACCT GCGCCGCCAG AAACGCTTCA AGCTGGAGGA GAAGGTGAAA
AAAGGGGGCA GCGGGGCTGC CACCACCACC AGGAACGGGA CAGGGTCTGC TGCCTCGACC
ACCACCCCCG CGGCCACAGT CACCTCCCCG CCCCAGCCCC CGCCTCCAGC CCCTGAGCCT
GAGGCCCAGG GCGGGGAAGA TGTGGGGGCT CTGGACTGTG GCTCACCCGC TTCCTCCACA
CCCTATTTCA CTGGCCTGGA GCTCCCAGGG GAGCTGAAGC TGGACGCGCC CTACAACTTC
AACCACCCTT TCTCCATCAA CAACCTAATG TCAGAACAGA CACCAGCACC TCCCAAACTG
GACGTGGGGT TTGGGGGCTA CGGGGCTGAA GGTGGGGAGC CTGGAGTCTA CTACCAGGGC
CTCTATTCCC GCTCTTTGCT TAATGCATCC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004488.2
CDS198..1250
Misc Feature(1)186..188
Misc Feature(2)546..812
Misc Feature(3)order(654..659,684..686,693..698,756..758)
Exon (1)1..266
Exon (2)267..1989
Translation

Target ORF information:

RefSeq Version NM_004497.2
Organism Homo sapiens(Human)
Definition Homo sapiens forkhead box A3 (FOXA3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004497.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGCTGGGCT CAGTGAAGAT GGAGGCCCAT GACCTGGCCG AGTGGAGCTA CTACCCGGAG 
GCGGGCGAGG TCTACTCGCC GGTGACCCCA GTGCCCACCA TGGCCCCCCT CAACTCCTAC
ATGACCCTGA ATCCTCTAAG CTCTCCCTAT CCCCCTGGGG GGCTCCCTGC CTCCCCACTG
CCCTCAGGAC CCCTGGCACC CCCAGCACCT GCAGCCCCCC TGGGGCCCAC TTTCCCAGGC
CTGGGTGTCA GCGGTGGCAG CAGCAGCTCC GGGTACGGGG CCCCGGGTCC TGGGCTGGTG
CACGGGAAGG AGATGCCGAA GGGGTATCGG CGGCCCCTGG CACACGCCAA GCCACCGTAT
TCCTATATCT CACTCATCAC CATGGCCATC CAGCAGGCGC CGGGCAAGAT GCTGACCTTG
AGTGAAATCT ACCAGTGGAT CATGGACCTC TTCCCTTACT ACCGGGAGAA TCAGCAGCGC
TGGCAGAACT CCATTCGCCA CTCGCTGTCT TTCAACGACT GCTTCGTCAA GGTGGCGCGT
TCCCCAGACA AGCCTGGCAA GGGCTCCTAC TGGGCCCTAC ACCCCAGCTC AGGGAACATG
TTTGAGAATG GCTGCTACCT GCGCCGCCAG AAACGCTTCA AGCTGGAGGA GAAGGTGAAA
AAAGGGGGCA GCGGGGCTGC CACCACCACC AGGAACGGGA CAGGGTCTGC TGCCTCGACC
ACCACCCCCG CGGCCACAGT CACCTCCCCG CCCCAGCCCC CGCCTCCAGC CCCTGAGCCT
GAGGCCCAGG GCGGGGAAGA TGTGGGGGCT CTGGACTGTG GCTCACCCGC TTCCTCCACA
CCCTATTTCA CTGGCCTGGA GCTCCCAGGG GAGCTGAAGC TGGACGCGCC CTACAACTTC
AACCACCCTT TCTCCATCAA CAACCTAATG TCAGAACAGA CACCAGCACC TCCCAAACTG
GACGTGGGGT TTGGGGGCTA CGGGGCTGAA GGTGGGGAGC CTGGAGTCTA CTACCAGGGC
CTCTATTCCC GCTCTTTGCT TAATGCATCC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.
International journal of obesity (2005)39(6)888-92(2015 Jun)
Adler-Wailes DC,Alberobello AT,Ma X,Hugendubler L,Stern EA,Mou Z,Han JC,Kim PW,Sumner AE,Yanovski JA,Mueller E


book

Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.
American journal of respiratory and critical care medicine189(3)301-13(2014 Feb)
Chen G,Korfhagen TR,Karp CL,Impey S,Xu Y,Randell SH,Kitzmiller J,Maeda Y,Haitchi HM,Sridharan A,Senft AP,Whitsett JA


book

The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.
Molecular and cellular biology33(17)3392-9(2013 Sep)
Xu L,Panel V,Ma X,Du C,Hugendubler L,Gavrilova O,Liu A,McLaughlin T,Kaestner KH,Mueller E


book

[Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3γ].
Yi chuan = Hereditas34(5)573-83(2012 May)
Liu Q,Li H,Chen HH,Wang J


book

Genetic predictors of interindividual variability in hepatic CYP3A4 expression.
The Journal of pharmacology and experimental therapeutics332(3)1088-99(2010 Mar)
Lamba V,Panetta JC,Strom S,Schuetz EG


 
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