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HSPA1A cDNA ORF clone, Homo sapiens (human)

Gene Symbol HSPA1A
Entrez Gene ID 3303
Full Name heat shock 70kDa protein 1A
Synonyms HEL-S-103, HSP70-1, HSP70-1A, HSP70.1, HSP70I, HSP72, HSPA1
General protein information
Preferred Names
heat shock 70 kDa protein 1A/1B
Names
heat shock 70 kDa protein 1A/1B
HSP70-1/HSP70-2
HSP70.1/HSP70.2
heat shock 70kD protein 1A
heat shock-induced protein
heat shock 70 kDa protein 1/2
dnaK-type molecular chaperone HSP70-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

140550


mRNA and Protein(s)

mRNA Protein Name
NM_005345 NP_005336 heat shock 70 kDa protein 1A/1B



Homo sapiens (human) HSPA1A NP_005336.3
Homo sapiens (human) HSPA1B NP_005337.2
Pan troglodytes (chimpanzee) HSPA1A XP_003311223.1
Macaca mulatta (Rhesus monkey) HSPA1B XP_001115060.2
Canis lupus familiaris (dog) LOC102155697 XP_005627221.1
Bos taurus (cattle) HSPA1A NP_976067.2
Mus musculus (house mouse) Hspa1a NP_034609.2
Rattus norvegicus (Norway rat) Hspa1a NP_114177.2
Rattus norvegicus (Norway rat) Hspa1b NP_997669.1
Danio rerio (zebrafish) hsc70 NP_956908.1
Drosophila melanogaster (fruit fly) Hsp70Ba NP_731716.1
Drosophila melanogaster (fruit fly) Hsc70-2 NP_524339.1
Drosophila melanogaster (fruit fly) Hsp68 NP_524474.1
Drosophila melanogaster (fruit fly) Hsp70Bc NP_650209.1
Drosophila melanogaster (fruit fly) Hsp70Aa NP_731651.1
Drosophila melanogaster (fruit fly) Hsp70Ab NP_524798.2
Drosophila melanogaster (fruit fly) Hsp70Bb NP_524927.2
Drosophila melanogaster (fruit fly) Hsp70Bbb NP_788663.1
Arabidopsis thaliana (thale cress) AT5G02490 NP_195869.1
Xenopus (Silurana) tropicalis (western clawed frog) hspa1l NP_001072429.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100485441 XP_002937685.1
Xenopus (Silurana) tropicalis (western clawed frog) hsp70 NP_001106370.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following HSPA1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPA1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu15193
NM_005345 Homo sapiens heat shock 70kDa protein 1A (HSPA1A), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu15193
Clone ID Related Accession (Same CDS sequence) NM_005345
Accession Version NM_005345.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1926bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 06-APR-2014
Organism Homo sapiens (human)
Product heat shock 70 kDa protein 1A/1B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA486842.1, AK225692.1, DA256622.1, AK096017.1 and BC002453.2. On Jul 15, 2008 this sequence version replaced gi:26787973. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TTGGCCGCAA GTTCGGCGAC
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC
AAGATCAGCG AGGCGGACAA GAAGAAGGTG CTGGACAAGT GTCAAGAGGT CATCTCGTGG
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGG
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCCACCAT TGAGGAGGTA
GATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005336.3
CDS244..2169
Misc Feature(1)244..2076(+)
Misc Feature(2)247..249(+)
Misc Feature(3)259..1386(+)
Misc Feature(4)271..1341(+)
Misc Feature(5)310..1269(+)
Misc Feature(6)340..1125(+)
Misc Feature(7)565..567(+)
Misc Feature(8)697..1218(+)
Misc Feature(9)979..981(+)
Misc Feature(10)1285..1287(+)
Misc Feature(11)1924..1926(+)
Misc Feature(12)2134..2136(+)
Misc Feature(13)2140..2142(+)
Misc Feature(14)2149..2151(+)
Exon (1)1..2429
Gene:HSPA1A
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005345
Organism Homo sapiens (human)
Definition Homo sapiens heat shock 70kDa protein 1A (HSPA1A), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005345

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGCCAAAG CCGCGGCGAT CGGCATCGAC CTGGGCACCA CCTACTCCTG CGTGGGGGTG 
TTCCAACACG GCAAGGTGGA GATCATCGCC AACGACCAGG GCAACCGCAC CACCCCCAGC
TACGTGGCCT TCACGGACAC CGAGCGGCTC ATCGGGGATG CGGCCAAGAA CCAGGTGGCG
CTGAACCCGC AGAACACCGT GTTTGACGCG AAGCGGCTGA TTGGCCGCAA GTTCGGCGAC
CCGGTGGTGC AGTCGGACAT GAAGCACTGG CCTTTCCAGG TGATCAACGA CGGAGACAAG
CCCAAGGTGC AGGTGAGCTA CAAGGGGGAG ACCAAGGCAT TCTACCCCGA GGAGATCTCG
TCCATGGTGC TGACCAAGAT GAAGGAGATC GCCGAGGCGT ACCTGGGCTA CCCGGTGACC
AACGCGGTGA TCACCGTGCC GGCCTACTTC AACGACTCGC AGCGCCAGGC CACCAAGGAT
GCGGGTGTGA TCGCGGGGCT CAACGTGCTG CGGATCATCA ACGAGCCCAC GGCCGCCGCC
ATCGCCTACG GCCTGGACAG AACGGGCAAG GGGGAGCGCA ACGTGCTCAT CTTTGACCTG
GGCGGGGGCA CCTTCGACGT GTCCATCCTG ACGATCGACG ACGGCATCTT CGAGGTGAAG
GCCACGGCCG GGGACACCCA CCTGGGTGGG GAGGACTTTG ACAACAGGCT GGTGAACCAC
TTCGTGGAGG AGTTCAAGAG AAAACACAAG AAGGACATCA GCCAGAACAA GCGAGCCGTG
AGGCGGCTGC GCACCGCCTG CGAGAGGGCC AAGAGGACCC TGTCGTCCAG CACCCAGGCC
AGCCTGGAGA TCGACTCCCT GTTTGAGGGC ATCGACTTCT ACACGTCCAT CACCAGGGCG
AGGTTCGAGG AGCTGTGCTC CGACCTGTTC CGAAGCACCC TGGAGCCCGT GGAGAAGGCT
CTGCGCGACG CCAAGCTGGA CAAGGCCCAG ATTCACGACC TGGTCCTGGT CGGGGGCTCC
ACCCGCATCC CCAAGGTGCA GAAGCTGCTG CAGGACTTCT TCAACGGGCG CGACCTGAAC
AAGAGCATCA ACCCCGACGA GGCTGTGGCC TACGGGGCGG CGGTGCAGGC GGCCATCCTG
ATGGGGGACA AGTCCGAGAA CGTGCAGGAC CTGCTGCTGC TGGACGTGGC TCCCCTGTCG
CTGGGGCTGG AGACGGCCGG AGGCGTGATG ACTGCCCTGA TCAAGCGCAA CTCCACCATC
CCCACCAAGC AGACGCAGAT CTTCACCACC TACTCCGACA ACCAACCCGG GGTGCTGATC
CAGGTGTACG AGGGCGAGAG GGCCATGACG AAAGACAACA ATCTGTTGGG GCGCTTCGAG
CTGAGCGGCA TCCCTCCGGC CCCCAGGGGC GTGCCCCAGA TCGAGGTGAC CTTCGACATC
GATGCCAACG GCATCCTGAA CGTCACGGCC ACGGACAAGA GCACCGGCAA GGCCAACAAG
ATCACCATCA CCAACGACAA GGGCCGCCTG AGCAAGGAGG AGATCGAGCG CATGGTGCAG
GAGGCGGAGA AGTACAAAGC GGAGGACGAG GTGCAGCGCG AGAGGGTGTC AGCCAAGAAC
GCCCTGGAGT CCTACGCCTT CAACATGAAG AGCGCCGTGG AGGATGAGGG GCTCAAGGGC
AAGATCAGCG AGGCGGACAA GAAGAAGGTG CTGGACAAGT GTCAAGAGGT CATCTCGTGG
CTGGACGCCA ACACCTTGGC CGAGAAGGAC GAGTTTGAGC ACAAGAGGAA GGAGCTGGAG
CAGGTGTGTA ACCCCATCAT CAGCGGACTG TACCAGGGTG CCGGTGGTCC CGGGCCTGGG
GGCTTCGGGG CTCAGGGTCC CAAGGGAGGG TCTGGGTCAG GCCCCACCAT TGAGGAGGTA
GATTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic beta-cell dysfunction and death in vitro
Clin. Sci. 126 (10), 739-752 (2014)
Krause M, Keane K, Rodrigues-Krause J, Crognale D, Egan B, De Vito G, Murphy C and Newsholme P.


book

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro
J. Biol. Chem. 289 (3), 1402-1414 (2014)
Rauch JN and Gestwicki JE.


book

A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70
J. Biol. Chem. 288 (52), 37192-37203 (2013)
Ormsby AR, Ramdzan YM, Mok YF, Jovanoski KD and Hatters DM.


book

Holocarboxylase synthetase catalyzes biotinylation of heat shock protein 72, thereby inducing RANTES expression in HEK-293 cells
Am. J. Physiol., Cell Physiol. 305 (12), C1240-C1245 (2013)
Xue J, Zhou J and Zempleni J.


book

Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment
Toxicol. Appl. Pharmacol. 273 (3), 580-589 (2013)
Jakubowicz-Gil J, Langner E, Badziul D, Wertel I and Rzeski W.


book

Syntenic conservation of HSP70 genes in cattle and humans
Genomics 14 (4), 863-868 (1992)
Grosz MD, Womack JE and Skow LC.


book

The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression
Genes Dev. 6 (7), 1153-1164 (1992)
Abravaya K, Myers MP, Murphy SP and Morimoto RI.


book

Structure and expression of the three MHC-linked HSP70 genes
Immunogenetics 32 (4), 242-251 (1990)
Milner CM and Campbell RD.


book

Human major histocompatibility complex contains genes for the major heat shock protein HSP70
Proc. Natl. Acad. Sci. U.S.A. 86 (6), 1968-1972 (1989)
Sargent CA, Dunham I, Trowsdale J and Campbell RD.


book

Structure and expression of the human gene encoding major heat shock protein HSP70
Mol. Cell. Biol. 5 (2), 330-341 (1985)
Wu,B., Hunt,C. and Morimoto,R.


 
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