Gene Symbol | HSPA2 |
Entrez Gene ID | 3306 |
Full Name | heat shock protein family A (Hsp70) member 2 |
Synonyms | HSP70-2,HSP70-3 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » HSPA2 cDNA ORF clone
gRNAs
Gene Symbol | HSPA2 |
Entrez Gene ID | 3306 |
Full Name | heat shock protein family A (Hsp70) member 2 |
Synonyms | HSP70-2,HSP70-3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_021979.3 | NP_068814.2 | heat shock-related 70 kDa protein 2 |
Pan troglodytes (chimpanzee) | HSPA2 | XP_510002.3 |
Mus musculus (house mouse) | Hspa2 | NP_032327.2 |
Arabidopsis thaliana (thale cress) | ERD2 | NP_176036.1 |
Rattus norvegicus (Norway rat) | Hspa2 | NP_068635.1 |
Xenopus tropicalis (tropical clawed frog) | hspa2 | XP_004917261.1 |
Homo sapiens (human) | HSPA2 | NP_068814.2 |
Canis lupus familiaris (dog) | HSPA2 | XP_537479.1 |
Bos taurus (cattle) | HSPA2 | NP_776769.1 |
Gallus gallus (chicken) | HSPA2 | NP_001006686.1 |
Overexpressed HSPA2 correlates with tumor angiogenesis and unfavorable prognosis in pancreatic carcinoma.
Zhai LL, Xie Q, Zhou CH, Huang DW, Tang ZG, Ju TF
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]17(3)457-463(2017 May - Jun)
Novel role for the testis-enriched HSPA2 protein in regulating epidermal keratinocyte differentiation.
Gogler-Pig?owska A, Klarzy?ska K, Sojka DR, Habryka A, G?owala-Kosi?ska M, Herok M, Kryj M, Halczok M, Krawczyk Z, Scieglinska D
Journal of cellular physiology233(3)2629-2644(2018 Mar)
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis.
Boiocchi C, Monti MC, Osera C, Mallucci G, Pistono C, Ferraro OE, Nosari G, Romani A, Cuccia M, Govoni S, Pascale A, Montomoli C, Bergamaschi R
Journal of neuroimmunology298189-93(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
HSPA2 appears to be necessary for controlling development of properly stratified epidermis and thus for maintenance of skin homeostasis.
Title: Novel role for the testis-enriched HSPA2 protein in regulating epidermal keratinocyte differentiation.
This study showed that a strong association between rs2227956 polymorphism and MS risk, which is independent from the association with HSP70-2 rs1061581, and a significant link between hsp70-hom protein expression and multiple sclerosis severity.
Title: Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis.
The data suggest that seminal plasma HSPA2 Cell-free mRNA is different between asthenozoospermic and normozoospermic individuals and it might be an indicator for semen quality.
Title: Seminal plasma HSPA2 mRNA content is associated with semen quality.
ACE and PDIA6 were identified as potential HSPA2-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri-acrosomal region of the sperm head.
Title: Heat Shock Protein member A2 forms a stable complex with angiotensin converting enzyme and protein disulfide isomerase A6 in human spermatozoa.
HSPA2 expression increased under conditions that stimulated HIF-1alpha activity, whereas inhibition of HIF-1alpha abrogated hypoxia-induced up-regulation of HSPA2 expression
Title: Cell type-dependent modulation of the gene encoding heat shock protein HSPA2 by hypoxia-inducible factor HIF-1: Down-regulation in keratinocytes and up-regulation in HeLa cells.
The following HSPA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu19990![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_021979.3 | |
Accession Version | NM_021979.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1920bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | heat shock-related 70 kDa protein 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI461827.1, BG772858.1, DB042367.1, CN356507.1, CD300159.1, BC036107.1 and BC001752.1. On May 22, 2007 this sequence version replaced NM_021979.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTGCCC GTGGCCCGGC TATCGGCATC GACCTGGGCA CCACCTATTC GTGCGTCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_068814.2 |
CDS | 383..2302 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTCTGCCC GTGGCCCGGC TATCGGCATC GACCTGGGCA CCACCTATTC GTGCGTCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Overexpressed HSPA2 correlates with tumor angiogenesis and unfavorable prognosis in pancreatic carcinoma. |
Novel role for the testis-enriched HSPA2 protein in regulating epidermal keratinocyte differentiation. |
Architecture of the human interactome defines protein communities and disease networks. |
Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis. |