Gene Symbol | MSL1 |
Entrez Gene ID | 339287 |
Full Name | male specific lethal 1 homolog |
Synonyms | MSL-1,hMSL1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » MSL1 cDNA ORF clone
Gene Symbol | MSL1 |
Entrez Gene ID | 339287 |
Full Name | male specific lethal 1 homolog |
Synonyms | MSL-1,hMSL1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001365920.1 | NP_001352849.1 | male-specific lethal 1 homolog isoform 3 |
XM_005257299.4 | XP_005257356.3 | male-specific lethal 1 homolog isoform X2 |
NM_001012241.1 | NP_001012241.1 | male-specific lethal 1 homolog |
NM_001365919.1 | NP_001352848.1 | male-specific lethal 1 homolog isoform 2 |
NM_001365921.1 | NP_001352850.1 | male-specific lethal 1 homolog isoform 4 |
XM_005257298.4 | XP_005257355.1 | male-specific lethal 1 homolog isoform X1 |
NM_001012241.2 | NP_001012241.1 | male-specific lethal 1 homolog isoform 1 |
Canis lupus familiaris (dog) | MSL1 | XP_005624595.1 |
Rattus norvegicus (Norway rat) | Msl1 | NP_001100518.1 |
MSL1 | XP_001096195.1 | |
Bos taurus (cattle) | MSL1 | XP_002696009.3 |
Pan troglodytes (chimpanzee) | MSL1 | XP_511469.3 |
Mus musculus (house mouse) | Msl1 | NP_082998.2 |
Gallus gallus (chicken) | MSL1 | XP_001236664.3 |
Xenopus tropicalis (tropical clawed frog) | msl1 | XP_002940260.2 |
Homo sapiens (human) | MSL1 | NP_001012241.1 |
Two distinct nuclear localization signals in mammalian MSL1 regulate its function.
Dmitriev RI, Pestov NB, Shakhparonov MI, Okkelman IA
Journal of cellular biochemistry115(11)1967-73(2014 Nov)
Deciphering the binding between Nupr1 and MSL1 and their DNA-repairing activity.
Aguado-Llera D, Hamidi T, Dom?nech R, Pantoja-Uceda D, Gironella M, Santoro J, Vel?zquez-Campoy A, Neira JL, Iovanna JL
PloS one8(10)e78101(2013)
The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.
Wu L, Zee BM, Wang Y, Garcia BA, Dou Y
Molecular cell43(1)132-44(2011 Jul)
Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.
Cai Y, Jin J, Swanson SK, Cole MD, Choi SH, Florens L, Washburn MP, Conaway JW, Conaway RC
The Journal of biological chemistry285(7)4268-72(2010 Feb)
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.
Gironella M, Malicet C, Cano C, Sandi MJ, Hamidi T, Tauil RM, Baston M, Valaco P, Moreno S, Lopez F, Neira JL, Dagorn JC, Iovanna JL
Journal of cellular physiology221(3)594-602(2009 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Studies identi fi ed a novel signal of nuclear localization (NLS) in all MSL1 protein isoforms and found that the combination of both NLS allows for its intra-nuclear focal accumulation and nuclear transport of TTC4 while all MSL1 isoforms affect H4K16Ac.
Title: Two distinct nuclear localization signals in mammalian MSL1 regulate its function.
The MSL1 bound to Nupr1, with a moderate affinity (2.8 microM) in an entropically-driven process. MSL1 did not bind to non-damaged DNA, but it bound to chemically-damaged-DNA with a moderate affinity (1.2 microM) also in an entropically-driven process.
Title: Deciphering the binding between Nupr1 and MSL1 and their DNA-repairing activity.
MSL1 plays an important role in mediating irradiation-induced DNA repair through formation of HAT complexes and interaction with 53BP1. P8 acts as a negative regulator of this process by interacting with MSL1 and preventing its role on HAT activity.
Title: p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.
A multisubunit human histone acetylase complex that contains homologs of the Drosophila MSL proteins MOF, MSL1 (hampin A), MSL2, and MSL3 was described. This complex is responsible for histone H4 lysine-16 acetylation of all cellular chromosomes.
Title: A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.
The following MSL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu03968 | |
Clone ID Related Accession (Same CDS sequence) | NM_001012241.1 , NM_001012241.2 | |
Accession Version | NM_001012241.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-30 | |
Organism | Homo sapiens(human) | |
Product | male-specific lethal 1 homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from R23466.1, BC122543.1, BX647188.1 and AK125654.1. On or before Jun 29, 2007 this sequence version replaced XM_932097.2, XM_932082.2, XM_932107.2, XM_943695.2, XM_943702.2. ##Evidence-Data-START## Transcript exon combination :: BC118997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAAAGGC GGATGCAGCT GGTAAAGAAG GATAACGAGA AAGAAAGGCA CAAGCTGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001012241.1 |
CDS | 342..1397 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001012241.1 |
1 | ATGGAAAGGC GGATGCAGCT GGTAAAGAAG GATAACGAGA AAGAAAGGCA CAAGCTGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu03968 | |
Clone ID Related Accession (Same CDS sequence) | NM_001012241.1 , NM_001012241.2 | |
Accession Version | NM_001012241.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | male-specific lethal 1 homolog isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC068669.21, R23466.1, BC122543.1, BX647188.1 and AK125654.1. On Sep 15, 2018 this sequence version replaced NM_001012241.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC122543.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAAAGGC GGATGCAGCT GGTAAAGAAG GATAACGAGA AAGAAAGGCA CAAGCTGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001012241.1 |
CDS | 908..1963 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001012241.2 |
1 | ATGGAAAGGC GGATGCAGCT GGTAAAGAAG GATAACGAGA AAGAAAGGCA CAAGCTGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu107225 | |
Clone ID Related Accession (Same CDS sequence) | NM_001365921.1 | |
Accession Version | NM_001365921.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | male-specific lethal 1 homolog isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC068669.21. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.963356.1, SRR7346977.1193715.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001352850.1 |
CDS | 643..2028 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001365921.1 |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu50344 | |
Clone ID Related Accession (Same CDS sequence) | NM_001365919.1 , XM_005257298.4 | |
Accession Version | NM_001365919.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | male-specific lethal 1 homolog isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC068669.21. On Sep 15, 2018 this sequence version replaced XM_005257298.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.15410.1, SRR1803617.186120.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000398532.9/ ENSP00000381543.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001352848.1 |
CDS | 643..2487 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001365919.1 |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu86824 | |
Clone ID Related Accession (Same CDS sequence) | NM_001365920.1 , XM_005257299.4 | |
Accession Version | NM_001365920.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1797bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | male-specific lethal 1 homolog isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC068669.21. On Sep 15, 2018 this sequence version replaced XM_005257299.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.181912.1, SRR1660809.48127.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001352849.1 |
CDS | 643..2439 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001365920.1 |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu50344 | |
Clone ID Related Accession (Same CDS sequence) | NM_001365919.1 , XM_005257298.4 | |
Accession Version | XM_005257298.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | male-specific lethal 1 homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005257298.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005257355.1 |
CDS | 1205..3049 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005257298.4 |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu86824 | |
Clone ID Related Accession (Same CDS sequence) | NM_001365920.1 , XM_005257299.4 | |
Accession Version | XM_005257299.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1797bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | male-specific lethal 1 homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005257299.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005257356.3 |
CDS | 1205..3001 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005257299.4 |
1 | ATGACCATGA GATCCGCGGT GTTCAAGGCG GCCGCGGCCC CTGCCGGCGG CAATCCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Two distinct nuclear localization signals in mammalian MSL1 regulate its function. |
Deciphering the binding between Nupr1 and MSL1 and their DNA-repairing activity. |
The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. |
Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. |