Gene Symbol | TSPAN33 |
Entrez Gene ID | 340348 |
Full Name | tetraspanin 33 |
Synonyms | PEN,PEN.,TSPAN-33 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » TSPAN33 cDNA ORF clone
gRNAs
Gene Symbol | TSPAN33 |
Entrez Gene ID | 340348 |
Full Name | tetraspanin 33 |
Synonyms | PEN,PEN.,TSPAN-33 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_178562.4 | NP_848657.1 | tetraspanin-33 |
NM_178562.5 | NP_848657.1 | tetraspanin-33 |
XM_006715960.3 | XP_006716023.1 | tetraspanin-33 isoform X1 |
Danio rerio (zebrafish) | tspan33 | NP_001002617.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002257 | XP_307926.5 |
Xenopus tropicalis (tropical clawed frog) | tspan33 | XP_002931890.1 |
TSPAN33 | XP_001091336.2 | |
Bos taurus (cattle) | TSPAN33 | NP_001029844.1 |
Mus musculus (house mouse) | Tspan33 | NP_666285.1 |
Homo sapiens (human) | TSPAN33 | NP_848657.1 |
Drosophila melanogaster (fruit fly) | Tsp86D | NP_001262468.1 |
Pan troglodytes (chimpanzee) | TSPAN33 | XP_001155179.1 |
Canis lupus familiaris (dog) | TSPAN33 | XP_532430.2 |
Rattus norvegicus (Norway rat) | Tspan33 | NP_001102697.1 |
Drosophila melanogaster (fruit fly) | Tsp3A | NP_001245504.1 |
Tspan33 is Expressed in Transitional and Memory B Cells, but is not Responsible for High ADAM10 Expression.
P?rez-Mart?nez CA, Maravillas-Montero JL, Meza-Herrera I, Vences-Catal?n F, Zlotnik A, Santos-Argumedo L
Scandinavian journal of immunology86(1)23-30(2017 Jul)
The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling.
Ruiz-Garc?a A, L?pez-L?pez S, Garc?a-Ram?rez JJ, Baladr?n V, Ruiz-Hidalgo MJ, L?pez-Sanz L, Ballesteros ?, Laborda J, Monsalve EM, D?az-Guerra MJ
Journal of immunology (Baltimore, Md. : 1950)197(8)3371-3381(2016 Oct)
TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.
Jouannet S, Saint-Pol J, Fernandez L, Nguyen V, Charrin S, Boucheix C, Brou C, Milhiet PE, Rubinstein E
Cellular and molecular life sciences : CMLS73(9)1895-915(2016 May)
TSPAN33 is a novel marker of activated and malignant B cells.
Luu VP, Hevezi P, Vences-Catalan F, Maravillas-Montero JL, White CA, Casali P, Llorente L, Jakez-Ocampo J, Lima G, Vilches-Cisneros N, Flores-Guti?rrez JP, Santos-Argumedo L, Zlotnik A
Clinical immunology (Orlando, Fla.)149(3)388-99(2013 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that tetraspanin 33 (tspan33) is an early activation marker, and that disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) protein expression does not correlate with Tspan33 expression in B cells.
Title: Tspan33 is Expressed in Transitional and Memory B Cells, but is not Responsible for High ADAM10 Expression.
The results suggest that TSPAN33 represents a new control element in the development of inflammation by macrophages that could constitute a potential therapeutic target.
Title: The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling.
TSPAN33 is overexpressed in activated and malignant B cells.
Title: TSPAN33 is a novel marker of activated and malignant B cells.
The following TSPAN33 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSPAN33 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu17763![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_178562.4 , NM_178562.5 | |
Accession Version | NM_178562.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | tetraspanin-33 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY012137.1, BC044244.1, AC011005.7 and AW089489.1. On Apr 30, 2014 this sequence version replaced NM_178562.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.94650.1, SRR1163657.516374.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCGGA GACCCCGGGC GCCGGCCGCC TCCGGGGAGG AGTTCTCCTT CGTCAGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_848657.1 |
CDS | 266..1117 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCGGA GACCCCGGGC GCCGGCCGCC TCCGGGGAGG AGTTCTCCTT CGTCAGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu17763![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_178562.4 , NM_178562.5 | |
Accession Version | NM_178562.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | tetraspanin-33 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from ABBA01057643.1, HY012137.1, BC044244.1, AC011005.7 and AW089489.1. On Nov 23, 2018 this sequence version replaced NM_178562.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.94650.1, SRR1163657.516374.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000486685.3/ ENSP00000483872.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCGCGGA GACCCCGGGC GCCGGCCGCC TCCGGGGAGG AGTTCTCCTT CGTCAGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_848657.1 |
CDS | 275..1126 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCGGA GACCCCGGGC GCCGGCCGCC TCCGGGGAGG AGTTCTCCTT CGTCAGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu41514 | |
Clone ID Related Accession (Same CDS sequence) | XM_006715960.3 | |
Accession Version | XM_006715960.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | tetraspanin-33 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006715960.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGCGGA GACCCCGGGC GCCGGCCGCC TCCGGGGAGG AGTTCTCCTT CGTCAGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006716023.1 |
CDS | 97..945 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGCGGA GACCCCGGGC GCCGGCCGCC TCCGGGGAGG AGTTCTCCTT CGTCAGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Tspan33 is Expressed in Transitional and Memory B Cells, but is not Responsible for High ADAM10 Expression. |
The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling. |
TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization. |
TSPAN33 is a novel marker of activated and malignant B cells. |