NANOS3 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | NANOS3 |
| Entrez Gene ID | 342977 |
| Full Name | nanos C2HC-type zinc finger 3 |
| Synonyms | NANOS1L,NOS3,ZC2HC12C |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001098622.2 | NP_001092092.1 | nanos homolog 3 |
| XM_011527964.2 | XP_011526266.1 | nanos homolog 3 isoform X1 |
| Homo sapiens (human) | NANOS3 | NP_001092092.1 |
| Pan troglodytes (chimpanzee) | NANOS3 | XP_001171060.1 |
| Mus musculus (house mouse) | Nanos3 | NP_918948.1 |
| Rattus norvegicus (Norway rat) | Nanos3 | NP_001099415.1 |
| Danio rerio (zebrafish) | nanos3 | NP_571953.1 |
| NANOS3 | XP_001111100.2 | |
| Canis lupus familiaris (dog) | NANOS3 | XP_003432960.1 |
Related articles in PubMed
Mutation analysis of NANOS3 in Brazilian women with primary ovarian failure.
Sousa BL, Nishi MY, Santos MG, Brito VN, Domenice S, Mendonca BB
Clinics (Sao Paulo, Brazil)71(12)695-698(2016 Dec)
Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells.
Panula S, Reda A, Stukenborg JB, Ramathal C, Sukhwani M, Albalushi H, Edsg?rd D, Nakamura M, S?der O, Orwig KE, Yamanaka S, Reijo Pera RA, Hovatta O
PloS one11(10)e0165268(2016)
The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition.
Grelet S, Andries V, Polette M, Gilles C, Staes K, Martin AP, Kileztky C, Terryn C, Dalstein V, Cheng CW, Shen CY, Birembaut P, Van Roy F, Nawrocki-Raby B
The Journal of pathology237(1)25-37(2015 Sep)
Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression.
Bhandari D, Raisch T, Weichenrieder O, Jonas S, Izaurralde E
Genes & development28(8)888-901(2014 Apr)
Homozygous inactivating mutation in NANOS3 in two sisters with primary ovarian insufficiency.
Santos MG, Machado AZ, Martins CN, Domenice S, Costa EM, Nishi MY, Ferraz-de-Souza B, Jorge SA, Pereira CA, Soardi FC, de Mello MP, Maciel-Guerra AT, Guerra-Junior G, Mendonca BB
BioMed research international2014787465(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
despite the prominent role of NANOS3 in ovarian development, our findings suggest that NANOS3 mutations were not associated with POF in the present cohort of Brazilian women.
Title: Mutation analysis of NANOS3 in Brazilian women with primary ovarian failure.
data can be used to further elucidate the role of NANOS3 and DAZL in germ cell development both in vitro and in vivo
Title: Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells.
NANOS3 has role in the acquisition of invasiveness by human lung tumour cells and propose a new mechanism of post-transcriptional regulation of epithelial-mesenchymal transition.
Title: The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition.
an inactivating missense mutation in NANOS3 has a role in primary ovarian insufficiency that involves increased primordial germ cell apoptosis during embryonic cell migration
Title: Homozygous inactivating mutation in NANOS3 in two sisters with primary ovarian insufficiency.
NANOS3 mutation is one possible cause of primary ovarian insufficiency.
Title: A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency.
The following NANOS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NANOS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu11814 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001098622.2 | |
| Accession Version | NM_001098622.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-22 | |
| Organism | Homo sapiens(human) | |
| Product | nanos homolog 3 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC101209.2 and CK821051.1. On Jun 7, 2011 this sequence version replaced NM_001098622.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK821051.1, SRR1803617.229030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGGGACCT TTGACCTGTG GACAGATTAC CTGGGTTTGG CACACCTGGT TAGGGCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001092092.1 |
| CDS | 1..579 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001098622.2 |
ORF Insert Sequence:
1 | ATGGGGACCT TTGACCTGTG GACAGATTAC CTGGGTTTGG CACACCTGGT TAGGGCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu79412 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011527964.2 | |
| Accession Version | XM_011527964.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-05 | |
| Organism | Homo sapiens(human) | |
| Product | nanos homolog 3 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011527964.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGGACCT TTGACCTGTG GACAGATTAC CTGGGTTTGG CACACCTGGT TAGGGCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011526266.1 |
| CDS | 867..1457 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011527964.2 |
ORF Insert Sequence:
1 | ATGGGGACCT TTGACCTGTG GACAGATTAC CTGGGTTTGG CACACCTGGT TAGGGCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Mutation analysis of NANOS3 in Brazilian women with primary ovarian failure. |
|
Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. |
|
The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition. |
|
Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. |
|
Homozygous inactivating mutation in NANOS3 in two sisters with primary ovarian insufficiency. |