IL2RG cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | IL2RG |
| Entrez Gene ID | 3561 |
| Full Name | interleukin 2 receptor subunit gamma |
| Synonyms | CD132,CIDX,IL-2RG,IMD4,P64,SCIDX,SCIDX1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]. |
| Disorder MIM: | |
| Disorder Html: | Severe combined immunodeficiency, X-linked, 300400 (3); Combined immunodeficiency, X-linked, moderate, 312863 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_000206.2 | NP_000197.1 | cytokine receptor common subunit gamma precursor |
| NM_000206.3 | NP_000197.1 | cytokine receptor common subunit gamma precursor |
| Rattus norvegicus (Norway rat) | Il2rg | NP_543165.1 |
| Gallus gallus (chicken) | IL2RG | NP_989858.1 |
| Danio rerio (zebrafish) | il2rgb | NP_001116522.1 |
| Pan troglodytes (chimpanzee) | LOC101059843 | XP_003954068.1 |
| Canis lupus familiaris (dog) | IL2RG | NP_001003201.1 |
| IL2RG | NP_001030606.1 | |
| Homo sapiens (human) | IL2RG | NP_000197.1 |
| Mus musculus (house mouse) | Il2rg | NP_038591.1 |
| Danio rerio (zebrafish) | il2rga | NP_001121743.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100492995 | XP_002934932.1 |
| Bos taurus (cattle) | IL2RG | NP_776784.1 |
Related articles in PubMed
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Alzubi J, Pallant C, Mussolino C, Howe SJ, Thrasher AJ, Cathomen T
Scientific reports7(1)12475(2017 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
systematic scoping review highlights the many potential uses of soluble interleukin-2 receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
Title: Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review.
A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype
Title: A novel deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype.
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported.
Title: Characterization of Receptor-Associated Protein Complex Assembly in Interleukin (IL)-2- and IL-15-Activated T-Cell Lines.
this study shows that downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines
Title: Downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines.
analysis of the contribution of IL2Rgamma to the dynamic formation of IL2-IL2R complexes
Title: Quantitative Contribution of IL2R? to the Dynamic Formation of IL2-IL2R Complexes.
The following IL2RG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL2RG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu18193 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_000206.2 , NM_000206.3 | |
| Accession Version | NM_000206.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-01 | |
| Organism | Homo sapiens(human) | |
| Product | cytokine receptor common subunit gamma precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC345219.1 and BC014972.1. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2010 this sequence version replaced NM_000206.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.9136.1, SRR1163657.310776.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGTTGAAGC CATCATTACC ATTCACATCC CTCTTATTCC TGCAGCTGCC CCTGCTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000197.1 |
| CDS | 93..1202 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_000206.2 |
ORF Insert Sequence:
1 | ATGTTGAAGC CATCATTACC ATTCACATCC CTCTTATTCC TGCAGCTGCC CCTGCTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu18193 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_000206.2 , NM_000206.3 | |
| Accession Version | NM_000206.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2020-01-04 | |
| Organism | Homo sapiens(human) | |
| Product | cytokine receptor common subunit gamma precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC345219.1 and BC014972.1. On Dec 4, 2019 this sequence version replaced NM_000206.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014972.1, D11086.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGTTGAAGC CATCATTACC ATTCACATCC CTCTTATTCC TGCAGCTGCC CCTGCTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000197.1 |
| CDS | 39..1148 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_000206.3 |
ORF Insert Sequence:
1 | ATGTTGAAGC CATCATTACC ATTCACATCC CTCTTATTCC TGCAGCTGCC CCTGCTGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. |