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IL7R cDNA ORF clone, Homo sapiens(Human)

Gene Symbol IL7R
Entrez Gene ID 3575
Full Name interleukin 7 receptor
Synonyms CD127,CDW127,IL-7R-alpha,IL7RA,ILRA
General protein information
Preferred Names

interleukin 7 receptor

Names

interleukin-7 receptor subunit alpha
CD127 antigen
IL-7 receptor subunit alpha
IL-7R subunit alpha
interleukin 7 receptor alpha chain
interleukin 7 receptor isoform H5-6

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

5

5p13.2

Summary The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015].
Disorder MIM:

146661

Disorder Html: Severe combined immunodeficiency, T-cell negative, B-cell/natural

mRNA and Protein(s)

mRNA Protein Name
NM_002185.3 NP_002176.2 interleukin-7 receptor subunit alpha precursor
XM_005248299.3 XP_005248356.1 interleukin-7 receptor subunit alpha isoform X1



Canis lupus familiaris (dog) IL7R XP_855408.1
Bos taurus (cattle) IL7R NP_001192816.1
Mus musculus (house mouse) Il7r NP_032398.3
Pan troglodytes (chimpanzee) IL7R XP_517807.2
Macaca mulatta (rhesus monkey) IL7R XP_001092582.1
Gallus gallus (chicken) IL7R NP_001073575.1
Homo sapiens (human) IL7R NP_002176.2
Rattus norvegicus (Norway rat) Il7r NP_001099888.1


Related articles in PubMed

Association between the IL7R T244I polymorphism and multiple sclerosis risk: a meta analysis.
Wu S, Liu Q, Zhu JM, Wang MR, Li J, Sun MG
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology37(9)1467-74(2016 Sep)

Interleukin 7 receptor polymorphisms and the risk of multiple sclerosis: A meta-analysis.
Tavakolpour S
Multiple sclerosis and related disorders866-73(2016 Jul)

Upregulated thymic stromal lymphopoietin receptor expression in children with asthma.
Lin SC, Huang JJ, Wang JY, Chuang HC, Chiang BL, Ye YL
European journal of clinical investigation46(6)511-9(2016 Jun)

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
Cheng Y, Chikwava K, Wu C, Zhang H, Bhagat A, Pei D, Choi JK, Tong W
The Journal of clinical investigation126(4)1267-81(2016 Apr)

Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.
Noronha EP, Andrade FG, Zampier C, de Andrade CF, Terra-Granado E, Pombo-de-Oliveira MS,
Blood cells, molecules & diseases5774-80(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 c.1858C>T (rs2476601), TLR4 c.896A>G (rs4986790) and TLR4 c.1196C>T (rs4986791), IL7R c.197T>C (rs1494555) and IL7R c.412G>A (rs1494558).
Title: [Allelic variants of immune response genes in children with infectious complications during the treatment of acute leukemia].

Study showed that a genetic variant in the 5' UTR of DDX39B reduces translation of DDX39B mRNAs and increases multiple sclerosis (MS) risk. Importantly, this DDX39B variant showed strong genetic & functional epistasis with allelic variants in IL7R exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R exon 6 splicing & its impact on MS risk.
Title: Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.

CD45RA distinguishes CD4+CD25+CD127-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus-mediated immunosuppression.
Title: CD45RA Distinguishes CD4+CD25+CD127-/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression.

IL-7 has a role inducing epitope masking of gammac protein in IL-7 receptor signaling complex
Title: IL-7 Induces an Epitope Masking of

In summary, our study demonstrates that IL-7/IL-7R axis promotes the invasion and migration of prostate cancer cells, through activation of AKT/NF-kappaB pathway and upregulation of MMP-3 and MMP-7 expression
Title: IL-7/IL-7 receptor axis stimulates prostate cancer cell invasion and migration via AKT/NF-κB pathway.

The following IL7R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL7R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu24651
NM_002185.3
Latest version!
Homo sapiens interleukin 7 receptor (IL7R), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OHu39321 XM_005248299.3
Latest version!
Homo sapiens interleukin 7 receptor (IL7R), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu24651
Clone ID Related Accession (Same CDS sequence) NM_002185.3
Accession Version NM_002185.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1380bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product interleukin-7 receptor subunit alpha precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD703890.1, BC020717.1, BC067540.1, AC112204.2 and AF373204.1. On Jun 14, 2012 this sequence version replaced NM_002185.2. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29696.1, BC067537.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGACAATTC TAGGTACAAC TTTTGGCATG GTTTTTTCTT TACTTCAAGT CGTTTCTGGA 
GAAAGTGGCT ATGCTCAAAA TGGAGACTTG GAAGATGCAG AACTGGATGA CTACTCATTC
TCATGCTATA GCCAGTTGGA AGTGAATGGA TCGCAGCACT CACTGACCTG TGCTTTTGAG
GACCCAGATG TCAACATCAC CAATCTGGAA TTTGAAATAT GTGGGGCCCT CGTGGAGGTA
AAGTGCCTGA ATTTCAGGAA ACTACAAGAG ATATATTTCA TCGAGACAAA GAAATTCTTA
CTGATTGGAA AGAGCAATAT ATGTGTGAAG GTTGGAGAAA AGAGTCTAAC CTGCAAAAAA
ATAGACCTAA CCACTATAGT TAAACCTGAG GCTCCTTTTG ACCTGAGTGT CGTCTATCGG
GAAGGAGCCA ATGACTTTGT GGTGACATTT AATACATCAC ACTTGCAAAA GAAGTATGTA
AAAGTTTTAA TGCACGATGT AGCTTACCGC CAGGAAAAGG ATGAAAACAA ATGGACGCAT
GTGAATTTAT CCAGCACAAA GCTGACACTC CTGCAGAGAA AGCTCCAACC GGCAGCAATG
TATGAGATTA AAGTTCGATC CATCCCTGAT CACTATTTTA AAGGCTTCTG GAGTGAATGG
AGTCCAAGTT ATTACTTCAG AACTCCAGAG ATCAATAATA GCTCAGGGGA GATGGATCCT
ATCTTACTAA CCATCAGCAT TTTGAGTTTT TTCTCTGTCG CTCTGTTGGT CATCTTGGCC
TGTGTGTTAT GGAAAAAAAG GATTAAGCCT ATCGTATGGC CCAGTCTCCC CGATCATAAG
AAGACTCTGG AACATCTTTG TAAGAAACCA AGAAAAAATT TAAATGTGAG TTTCAATCCT
GAAAGTTTCC TGGACTGCCA GATTCATAGG GTGGATGACA TTCAAGCTAG AGATGAAGTG
GAAGGTTTTC TGCAAGATAC GTTTCCTCAG CAACTAGAAG AATCTGAGAA GCAGAGGCTT
GGAGGGGATG TGCAGAGCCC CAACTGCCCA TCTGAGGATG TAGTCATCAC TCCAGAAAGC
TTTGGAAGAG ATTCATCCCT CACATGCCTG GCTGGGAATG TCAGTGCATG TGACGCCCCT
ATTCTCTCCT CTTCCAGGTC CCTAGACTGC AGGGAGAGTG GCAAGAATGG GCCTCATGTG
TACCAGGACC TCCTGCTTAG CCTTGGGACT ACAAACAGCA CGCTGCCCCC TCCATTTTCT
CTCCAATCTG GAATCCTGAC ATTGAACCCA GTTGCTCAGG GTCAGCCCAT TCTTACTTCC
CTGGGATCAA ATCAAGAAGA AGCATATGTC ACCATGTCCA GCTTCTACCA AAACCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002176.2
CDS104..1483
Misc Feature(1)494..757
Misc Feature(2)752..766
Misc Feature(3)order(752..757,761..766)
Misc Feature(4)821..895
Misc Feature(5)917..943
Misc Feature(6)947..949
Misc Feature(7)1448..1450
Exon (1)1..185
Exon (2)186..324
Exon (3)325..482
Exon (4)483..640
Exon (5)641..809
Exon (6)810..903
Exon (7)904..979
Exon (8)980..3819
Translation

Target ORF information:

RefSeq Version NM_002185.3
Organism Homo sapiens(Human)
Definition Homo sapiens interleukin 7 receptor (IL7R), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002185.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGACAATTC TAGGTACAAC TTTTGGCATG GTTTTTTCTT TACTTCAAGT CGTTTCTGGA 
GAAAGTGGCT ATGCTCAAAA TGGAGACTTG GAAGATGCAG AACTGGATGA CTACTCATTC
TCATGCTATA GCCAGTTGGA AGTGAATGGA TCGCAGCACT CACTGACCTG TGCTTTTGAG
GACCCAGATG TCAACATCAC CAATCTGGAA TTTGAAATAT GTGGGGCCCT CGTGGAGGTA
AAGTGCCTGA ATTTCAGGAA ACTACAAGAG ATATATTTCA TCGAGACAAA GAAATTCTTA
CTGATTGGAA AGAGCAATAT ATGTGTGAAG GTTGGAGAAA AGAGTCTAAC CTGCAAAAAA
ATAGACCTAA CCACTATAGT TAAACCTGAG GCTCCTTTTG ACCTGAGTGT CGTCTATCGG
GAAGGAGCCA ATGACTTTGT GGTGACATTT AATACATCAC ACTTGCAAAA GAAGTATGTA
AAAGTTTTAA TGCACGATGT AGCTTACCGC CAGGAAAAGG ATGAAAACAA ATGGACGCAT
GTGAATTTAT CCAGCACAAA GCTGACACTC CTGCAGAGAA AGCTCCAACC GGCAGCAATG
TATGAGATTA AAGTTCGATC CATCCCTGAT CACTATTTTA AAGGCTTCTG GAGTGAATGG
AGTCCAAGTT ATTACTTCAG AACTCCAGAG ATCAATAATA GCTCAGGGGA GATGGATCCT
ATCTTACTAA CCATCAGCAT TTTGAGTTTT TTCTCTGTCG CTCTGTTGGT CATCTTGGCC
TGTGTGTTAT GGAAAAAAAG GATTAAGCCT ATCGTATGGC CCAGTCTCCC CGATCATAAG
AAGACTCTGG AACATCTTTG TAAGAAACCA AGAAAAAATT TAAATGTGAG TTTCAATCCT
GAAAGTTTCC TGGACTGCCA GATTCATAGG GTGGATGACA TTCAAGCTAG AGATGAAGTG
GAAGGTTTTC TGCAAGATAC GTTTCCTCAG CAACTAGAAG AATCTGAGAA GCAGAGGCTT
GGAGGGGATG TGCAGAGCCC CAACTGCCCA TCTGAGGATG TAGTCATCAC TCCAGAAAGC
TTTGGAAGAG ATTCATCCCT CACATGCCTG GCTGGGAATG TCAGTGCATG TGACGCCCCT
ATTCTCTCCT CTTCCAGGTC CCTAGACTGC AGGGAGAGTG GCAAGAATGG GCCTCATGTG
TACCAGGACC TCCTGCTTAG CCTTGGGACT ACAAACAGCA CGCTGCCCCC TCCATTTTCT
CTCCAATCTG GAATCCTGAC ATTGAACCCA GTTGCTCAGG GTCAGCCCAT TCTTACTTCC
CTGGGATCAA ATCAAGAAGA AGCATATGTC ACCATGTCCA GCTTCTACCA AAACCAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu39321
Clone ID Related Accession (Same CDS sequence) XM_005248299.3
Accession Version XM_005248299.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 789bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product interleukin-7 receptor subunit alpha isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005248299.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGACAATTC TAGGTACAAC TTTTGGCATG GTTTTTTCTT TACTTCAAGT CGTTTCTGGA 
GAAAGTGGCT ATGCTCAAAA TGGAGACTTG GAAGATGCAG AACTGGATGA CTACTCATTC
TCATGCTATA GCCAGTTGGA AGTGAATGGA TCGCAGCACT CACTGACCTG TGCTTTTGAG
GACCCAGATG TCAACATCAC CAATCTGGAA TTTGAAATAT GTGGGGCCCT CGTGGAGGTA
AAGTGCCTGA ATTTCAGGAA ACTACAAGAG ATATATTTCA TCGAGACAAA GAAATTCTTA
CTGATTGGAA AGAGCAATAT ATGTGTGAAG GTTGGAGAAA AGAGTCTAAC CTGCAAAAAA
ATAGACCTAA CCACTATAGT TAAACCTGAG GCTCCTTTTG ACCTGAGTGT CGTCTATCGG
GAAGGAGCCA ATGACTTTGT GGTGACATTT AATACATCAC ACTTGCAAAA GAAGTATGTA
AAAGTTTTAA TGCACGATGT AGCTTACCGC CAGGAAAAGG ATGAAAACAA ATGGACGCAT
GTGAATTTAT CCAGCACAAA GCTGACACTC CTGCAGAGAA AGCTCCAACC GGCAGCAATG
TATGAGATTA AAGTTCGATC CATCCCTGAT CACTATTTTA AAGGCTTCTG GAGTGAATGG
AGTCCAAGTT ATTACTTCAG AACTCCAGAG ATCAATAATA GCTCAGGATT AAGCCTATCG
TATGGCCCAG TCTCCCCGAT CATAAGAAGA CTCTGGAACA TCTTTGTAAG AAACCAAGAA
AAAATTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005248356.1
CDS89..877
Misc Feature(1)479..742
Misc Feature(2)order(737..742,746..751)
Translation

Target ORF information:

RefSeq Version XM_005248299.3
Organism Homo sapiens(Human)
Definition Homo sapiens interleukin 7 receptor (IL7R), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005248299.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGACAATTC TAGGTACAAC TTTTGGCATG GTTTTTTCTT TACTTCAAGT CGTTTCTGGA 
GAAAGTGGCT ATGCTCAAAA TGGAGACTTG GAAGATGCAG AACTGGATGA CTACTCATTC
TCATGCTATA GCCAGTTGGA AGTGAATGGA TCGCAGCACT CACTGACCTG TGCTTTTGAG
GACCCAGATG TCAACATCAC CAATCTGGAA TTTGAAATAT GTGGGGCCCT CGTGGAGGTA
AAGTGCCTGA ATTTCAGGAA ACTACAAGAG ATATATTTCA TCGAGACAAA GAAATTCTTA
CTGATTGGAA AGAGCAATAT ATGTGTGAAG GTTGGAGAAA AGAGTCTAAC CTGCAAAAAA
ATAGACCTAA CCACTATAGT TAAACCTGAG GCTCCTTTTG ACCTGAGTGT CGTCTATCGG
GAAGGAGCCA ATGACTTTGT GGTGACATTT AATACATCAC ACTTGCAAAA GAAGTATGTA
AAAGTTTTAA TGCACGATGT AGCTTACCGC CAGGAAAAGG ATGAAAACAA ATGGACGCAT
GTGAATTTAT CCAGCACAAA GCTGACACTC CTGCAGAGAA AGCTCCAACC GGCAGCAATG
TATGAGATTA AAGTTCGATC CATCCCTGAT CACTATTTTA AAGGCTTCTG GAGTGAATGG
AGTCCAAGTT ATTACTTCAG AACTCCAGAG ATCAATAATA GCTCAGGATT AAGCCTATCG
TATGGCCCAG TCTCCCCGAT CATAAGAAGA CTCTGGAACA TCTTTGTAAG AAACCAAGAA
AAAATTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Association between the IL7R T244I polymorphism and multiple sclerosis risk: a meta analysis.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology37(9)1467-74(2016 Sep)
Wu S,Liu Q,Zhu JM,Wang MR,Li J,Sun MG


book

Interleukin 7 receptor polymorphisms and the risk of multiple sclerosis: A meta-analysis.
Multiple sclerosis and related disorders866-73(2016 Jul)
Tavakolpour S


book

Upregulated thymic stromal lymphopoietin receptor expression in children with asthma.
European journal of clinical investigation46(6)511-9(2016 Jun)
Lin SC,Huang JJ,Wang JY,Chuang HC,Chiang BL,Ye YL


book

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation126(4)1267-81(2016 Apr)
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W


book

Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia.
Blood cells, molecules & diseases5774-80(2016 Mar)
Noronha EP,Andrade FG,Zampier C,de Andrade CF,Terra-Granado E,Pombo-de-Oliveira MS,


 
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