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IL13 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol IL13
Entrez Gene ID 3596
Full Name interleukin 13
Synonyms IL-13,P600
General protein information
Preferred Names

interleukin 13

Names

interleukin-13

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

5

5q31.1

Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008].
Disorder MIM:

147683

Disorder Html: {Asthma, susceptibility to}, 600807 (3); {Allergic rhinitis,

mRNA and Protein(s)

mRNA Protein Name
NM_002188.2 NP_002179.2 interleukin-13 precursor



Homo sapiens (human) IL13 NP_002179.2
Canis lupus familiaris (dog) IL13 NP_001003384.1
Macaca mulatta (rhesus monkey) IL13 NP_001028101.1
Pan troglodytes (chimpanzee) IL13 NP_001008992.1
Bos taurus (cattle) IL13 NP_776514.1
Rattus norvegicus (Norway rat) Il13 NP_446280.1
Mus musculus (house mouse) Il13 NP_032381.1


Related articles in PubMed

Transforming growth factor β- and interleukin 13-producing mast cells are associated with fibrosis in bone marrow.
Nakayama S, Yokote T, Hiraoka N, Akioka T, Nishiwaki U, Miyoshi T, Iwaki K, Fumimoto A, Masuda Y, Hatooka J, Fujimoto M, Nishimura Y, Tsuji M
Human pathology62180-186(2017 Apr)

Role of IL-13 Genetic Variants in Signalling of Asthma.
Alasandagutti ML, Ansari MS, Sagurthi SR, Valluri V, Gaddam S
Inflammation40(2)566-577(2017 Apr)

Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with IL13 rs20541 Polymorphism in Finnish Adult Asthma Patients.
Ådjers K, Luukkainen A, Pekkanen J, Hurme M, Huhtala H, Renkonen R, Wang Y, Mäkelä MJ, Karjalainen J, Toppila-Salmi S
International archives of allergy and immunology172(2)123-128(2017)

Platycodin D inhibits interleukin-13-induced the expression of inflammatory cytokines and mucus in nasal epithelial cells.
Wang B, Gao Y, Zheng G, Ren X, Sun B, Zhu K, Luo H, Wang Z, Xu M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie841108-1112(2016 Dec)

Interleukin-13 stimulates MUC5AC expression via a STAT6-TMEM16A-ERK1/2 pathway in human airway epithelial cells.
Qin Y, Jiang Y, Sheikh AS, Shen S, Liu J, Jiang D
International immunopharmacology40106-114(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The presented data substantiate the hypothesis that claudin-18 is a central barrier-forming component of tight junctions and show that IL-13 downregulates claudin-18. These data also suggest that the loss of claudin-18 is associated with increased sensitization to aeroantigens and airway responsiveness
Title: Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.

STAT6-TMEM16A-ERK1/2 signal pathway and TMEM16A channel activity are required for the IL-13-induced TMEM16A mediated mucus production
Title: Interleukin-13 stimulates MUC5AC expression via a STAT6-TMEM16A-ERK1/2 pathway in human airway epithelial cells.

Our results indicated that the IL-3 and IL-13 polymorphisms were not associated with rheumatoid arthritis (RA). stratification analyses suggested that the IL-13 rs1800925 CT and CT/CC genotypes increased the risk of RA in patients with erythrocyte sedimentation rate (ESR) <25.00. these findings suggest that the IL-13 rs1800925 C/T polymorphism may be associated with increased risk of RA in ESR
Title: Correlation between IL-3 and IL-13 gene polymorphisms in Chinese patients and rheumatoid arthritis.

these data suggest that microRNA-143 suppresses IL-13 activity and inflammation through targeting of IL-13Ralpha1 in epidermal keratinocytes
Title: MicroRNA-143 inhibits IL-13-induced dysregulation of the epidermal barrier-related proteins in skin keratinocytes via targeting to IL-13Rα1.

Our results suggest that IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108, four SNPs with significant sole effect on asthma, interact to confer a higher risk for the disease in Chinese Han children.
Title: Four-locus gene interaction between IL13, IL4, FCER1B, and ADRB2 for asthma in Chinese Han children.

The following IL13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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OHu18161 NM_002188.2
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Homo sapiens interleukin 13 (IL13), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18161
Clone ID Related Accession (Same CDS sequence) NM_002188.2
Accession Version NM_002188.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product interleukin-13 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X69079.1. This sequence is a reference standard in the RefSeqGene project. On Dec 13, 2002 this sequence version replaced NM_002188.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X69079.1, SRR1163657.388945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGCATCCGC TCCTCAATCC TCTCCTGTTG GCACTGGGCC TCATGGCGCT TTTGTTGACC 
ACGGTCATTG CTCTCACTTG CCTTGGCGGC TTTGCCTCCC CAGGCCCTGT GCCTCCCTCT
ACAGCCCTCA GGGAGCTCAT TGAGGAGCTG GTCAACATCA CCCAGAACCA GAAGGCTCCG
CTCTGCAATG GCAGCATGGT ATGGAGCATC AACCTGACAG CTGGCATGTA CTGTGCAGCC
CTGGAATCCC TGATCAACGT GTCAGGCTGC AGTGCCATCG AGAAGACCCA GAGGATGCTG
AGCGGATTCT GCCCGCACAA GGTCTCAGCT GGGCAGTTTT CCAGCTTGCA TGTCCGAGAC
ACCAAAATCG AGGTGGCCCA GTTTGTAAAG GACCTGCTCT TACATTTAAA GAAACTTTTT
CGCGAGGGAC AGTTCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002179.2
CDS15..455
Misc Feature(1)117..446
Misc Feature(2)57..59
Exon (1)1..188
Exon (2)189..242
Exon (3)243..347
Exon (4)348..1282
Translation

Target ORF information:

RefSeq Version NM_002188.2
Organism Homo sapiens(Human)
Definition Homo sapiens interleukin 13 (IL13), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002188.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCATCCGC TCCTCAATCC TCTCCTGTTG GCACTGGGCC TCATGGCGCT TTTGTTGACC 
ACGGTCATTG CTCTCACTTG CCTTGGCGGC TTTGCCTCCC CAGGCCCTGT GCCTCCCTCT
ACAGCCCTCA GGGAGCTCAT TGAGGAGCTG GTCAACATCA CCCAGAACCA GAAGGCTCCG
CTCTGCAATG GCAGCATGGT ATGGAGCATC AACCTGACAG CTGGCATGTA CTGTGCAGCC
CTGGAATCCC TGATCAACGT GTCAGGCTGC AGTGCCATCG AGAAGACCCA GAGGATGCTG
AGCGGATTCT GCCCGCACAA GGTCTCAGCT GGGCAGTTTT CCAGCTTGCA TGTCCGAGAC
ACCAAAATCG AGGTGGCCCA GTTTGTAAAG GACCTGCTCT TACATTTAAA GAAACTTTTT
CGCGAGGGAC AGTTCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Transforming growth factor β- and interleukin 13-producing mast cells are associated with fibrosis in bone marrow.
Human pathology62180-186(2017 Apr)
Nakayama S,Yokote T,Hiraoka N,Akioka T,Nishiwaki U,Miyoshi T,Iwaki K,Fumimoto A,Masuda Y,Hatooka J,Fujimoto M,Nishimura Y,Tsuji M


book

Role of IL-13 Genetic Variants in Signalling of Asthma.
Inflammation40(2)566-577(2017 Apr)
Alasandagutti ML,Ansari MS,Sagurthi SR,Valluri V,Gaddam S


book

Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with IL13 rs20541 Polymorphism in Finnish Adult Asthma Patients.
International archives of allergy and immunology172(2)123-128(2017)
Ådjers K,Luukkainen A,Pekkanen J,Hurme M,Huhtala H,Renkonen R,Wang Y,Mäkelä MJ,Karjalainen J,Toppila-Salmi S


book

Platycodin D inhibits interleukin-13-induced the expression of inflammatory cytokines and mucus in nasal epithelial cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie841108-1112(2016 Dec)
Wang B,Gao Y,Zheng G,Ren X,Sun B,Zhu K,Luo H,Wang Z,Xu M


book

Interleukin-13 stimulates MUC5AC expression via a STAT6-TMEM16A-ERK1/2 pathway in human airway epithelial cells.
International immunopharmacology40106-114(2016 Nov)
Qin Y,Jiang Y,Sheikh AS,Shen S,Liu J,Jiang D


 
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