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ITGAV cDNA ORF clone, Homo sapiens(Human)

Gene Symbol ITGAV
Entrez Gene ID 3685
Full Name integrin subunit alpha V
Synonyms CD51,MSK8,VNRA,VTNR
General protein information
Preferred Names

integrin subunit alpha V

Names

integrin alpha-V
antigen identified by monoclonal antibody L230
integrin alphaVbeta3
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
vitronectin receptor subunit alpha

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

2

2q32.1

Summary The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015].
Disorder MIM:

193210


mRNA and Protein(s)

mRNA Protein Name
NM_002210.4 NP_002201.1 integrin alpha-V isoform 1 preproprotein
NM_001145000.2 NP_001138472.1 integrin alpha-V isoform 3 precursor
NM_001144999.2 NP_001138471.1 integrin alpha-V isoform 2 precursor



Macaca mulatta (rhesus monkey) ITGAV XP_001104012.1
Homo sapiens (human) ITGAV NP_002201.1
Canis lupus familiaris (dog) ITGAV XP_850989.2
Bos taurus (cattle) ITGAV NP_776792.1
Danio rerio (zebrafish) itgav NP_001028893.1
Rattus norvegicus (Norway rat) Itgav XP_006234499.1
Gallus gallus (chicken) ITGAV NP_990770.1
Mus musculus (house mouse) Itgav NP_032428.2
Pan troglodytes (chimpanzee) ITGAV XP_515967.3
Xenopus tropicalis (tropical clawed frog) itgav NP_001116921.1


Related articles in PubMed

Lack of association between integrin α
Chen XP, Xiong HR, Zhu N, Chen QZ, Wang H, Zhong CJ, Wang MR, Lu S, Luo F, Hou W
Virologica Sinica32(1)73-79(2017 Feb)

Priming Endothelial Cells With a Melanoma-Derived Extracellular Matrix Triggers the Activation of αvβ3/VEGFR2 Axis.
Helal-Neto E, Brandão-Costa RM, Saldanha-Gama R, Ribeiro-Pereira C, Midlej V, Benchimol M, Morandi V, Barja-Fidalgo C
Journal of cellular physiology231(11)2464-73(2016 Nov)

Use of αv Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice.
Tome Y, Yano S, Sugimoto N, Mii S, Uehara F, Miwa S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
Anticancer research36(8)3811-6(2016 Aug)

Integrin αvβ6 and matrix metalloproteinase 9 correlate with survival in gastric cancer.
Lian PL, Liu Z, Yang GY, Zhao R, Zhang ZY, Chen YG, Zhuang ZN, Xu KS
World journal of gastroenterology22(14)3852-9(2016 Apr)

Human Parechovirus 1 Infection Occurs via αVβ1 Integrin.
Merilahti P, Tauriainen S, Susi P
PloS one11(4)e0154769(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that dendritic cells (DCs) induced Th17 cell differentiation through miR-363/Integrin alphav/TGF-beta pathway in patients with rheumatoid arthritis (RA).
Title: Dendritic Cells from Rheumatoid Arthritis Patient Peripheral Blood Induce Th17 Cell Differentiation via miR-363/Integrin αv/TGF-β Axis.

Myocardial alphavbeta3 integrin expression represents a marker of ongoing cardiac repair following acute myocardial infarction.
Title: Cardiac α

The findings suggest that, in contrast with previous models, the ligand-binding site of integrin alphaVbeta3, binds to the constant region (helices A and B) of the EC2 domain of CD9, CD81, and CD151 antigens.
Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3.

sPLA2-IIA activates Integrin alphaVbeta3 and Integrin alpha4beta1 in an allosteric manner. (Review)
Title: Secreted Phospholipase A2 Type IIA (sPLA2-IIA) Activates Integrins in an Allosteric Manner.

Taken together, our findings suggested that HMGB1 enhances tumor cell migration ability by activating alphavbeta3/FAK through TLR4/NF-kappaB signaling, leading to metastasis of NSCLC.
Title: HMGB1 induces human non-small cell lung cancer cell motility by activating integrin αvβ3/FAK through TLR4/NF-κB signaling pathway.

The following ITGAV gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITGAV cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23508 NM_001144999.2
Latest version!
Homo sapiens integrin subunit alpha V (ITGAV), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 20 $713.30
$1019.00
OHu23663 NM_002210.4
Latest version!
Homo sapiens integrin subunit alpha V (ITGAV), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 20 $559.30
$799.00
OHu27622 NM_001145000.2
Latest version!
Homo sapiens integrin subunit alpha V (ITGAV), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 20 $384.30
$549.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23508
Clone ID Related Accession (Same CDS sequence) NM_001144999.2
Accession Version NM_001144999.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3009bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product integrin alpha-V isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK302990.1, BC047454.1, DA736912.1, CB962576.1, CN409399.1 and BQ101180.1. On May 10, 2013 this sequence version replaced NM_001144999.1. Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302990.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
ATGCTCCTAG GCACCCTCCT TCTGATCCTG TACATCTTAA TGTTGTGCCG GATGTTTCTT 
CTCGTGGGAG CTCCCAAAGC AAACACCACC CAGCCTGGGA TTGTGGAAGG AGGGCAGGTC
CTCAAATGTG ACTGGTCTTC TACCCGCCGG TGCCAGCCAA TTGAATTTGA TGCAACAGGC
AATAGAGATT ATGCCAAGGA TGATCCATTG GAATTTAAGT CCCATCAGTG GTTTGGAGCA
TCTGTGAGGT CGAAACAGGA TAAAATTTTG GCCTGTGCCC CATTGTACCA TTGGAGAACT
GAGATGAAAC AGGAGCGAGA GCCTGTTGGA ACATGCTTTC TTCAAGATGG AACAAAGACT
GTTGAGTATG CTCCATGTAG ATCACAAGAT ATTGATGCTG ATGGACAGGG ATTTTGTCAA
GGAGGATTCA GCATTGATTT TACTAAAGCT GACAGAGTAC TTCTTGGTGG TCCTGGTAGC
TTTTATTGGC AAGGTCAGCT TATTTCGGAT CAAGTGGCAG AAATCGTATC TAAATACGAC
CCCAATGTTT ACAGCATCAA GTATAATAAC CAATTAGCAA CTCGGACTGC ACAAGCTATT
TTTGATGACA GCTATTTGGG TTATTCTGTG GCTGTCGGAG ATTTCAATGG TGATGGCATA
GATGACTTTG TTTCAGGAGT TCCAAGAGCA GCAAGGACTT TGGGAATGGT TTATATTTAT
GATGGGAAGA ACATGTCCTC CTTATACAAT TTTACTGGCG AGCAGATGGC TGCATATTTC
GGATTTTCTG TAGCTGCCAC TGACATTAAT GGAGATGATT ATGCAGATGT GTTTATTGGA
GCACCTCTCT TCATGGATCG TGGCTCTGAT GGCAAACTCC AAGAGGTGGG GCAGGTCTCA
GTGTCTCTAC AGAGAGCTTC AGGAGACTTC CAGACGACAA AGCTGAATGG ATTTGAGGTC
TTTGCACGGT TTGGCAGTGC CATAGCTCCT TTGGGAGATC TGGACCAGGA TGGTTTCAAT
GATATTGCAA TTGCTGCTCC ATATGGGGGT GAAGATAAAA AAGGAATTGT TTATATCTTC
AATGGAAGAT CAACAGGCTT GAACGCAGTC CCATCTCAAA TCCTTGAAGG GCAGTGGGCT
GCTCGAAGCA TGCCACCAAG CTTTGGCTAT TCAATGAAAG GAGCCACAGA TATAGACAAA
AATGGATATC CAGACTTAAT TGTAGGAGCT TTTGGTGTAG ATCGAGCTAT CTTATACAGG
GCCAGACCAG TTATCACTGT AAATGCTGGT CTTGAAGTGT ACCCTAGCAT TTTAAATCAA
GACAATAAAA CCTGCTCACT GCCTGGAACA GCTCTCAAAG TTTCCTGTTT TAATGTTAGG
TTCTGCTTAA AGGCAGATGG CAAAGGAGTA CTTCCCAGGA AACTTAATTT CCAGGTGGAA
CTTCTTTTGG ATAAACTCAA GCAAAAGGGA GCAATTCGAC GAGCACTGTT TCTCTACAGC
AGGTCCCCAA GTCACTCCAA GAACATGACT ATTTCAAGGG GGGGACTGAT GCAGTGTGAG
GAATTGATAG CGTATCTGCG GGATGAATCT GAATTTAGAG ACAAACTCAC TCCAATTACT
ATTTTTATGG AATATCGGTT GGATTATAGA ACAGCTGCTG ATACAACAGG CTTGCAACCC
ATTCTTAACC AGTTCACGCC TGCTAACATT AGTCGACAGG CTCACATTCT ACTTGACTGT
GGTGAAGACA ATGTCTGTAA ACCCAAGCTG GAAGTTTCTG TAGATAGTGA TCAAAAGAAG
ATCTATATTG GGGATGACAA CCCTCTGACA TTGATTGTTA AGGCTCAGAA TCAAGGAGAA
GGTGCCTACG AAGCTGAGCT CATCGTTTCC ATTCCACTGC AGGCTGATTT CATCGGGGTT
GTCCGAAACA ATGAAGCCTT AGCAAGACTT TCCTGTGCAT TTAAGACAGA AAACCAAACT
CGCCAGGTGG TATGTGACCT TGGAAACCCA ATGAAGGCTG GAACTCAACT CTTAGCTGGT
CTTCGTTTCA GTGTGCACCA GCAGTCAGAG ATGGATACTT CTGTGAAATT TGACTTACAA
ATCCAAAGCT CAAATCTATT TGACAAAGTA AGCCCAGTTG TATCTCACAA AGTTGATCTT
GCTGTTTTAG CTGCAGTTGA GATAAGAGGA GTCTCGAGTC CTGATCATAT CTTTCTTCCG
ATTCCAAACT GGGAGCACAA GGAGAACCCT GAGACTGAAG AAGATGTTGG GCCAGTTGTT
CAGCACATCT ATGAGCTGAG AAACAATGGT CCAAGTTCAT TCAGCAAGGC AATGCTCCAT
CTTCAGTGGC CTTACAAATA TAATAATAAC ACTCTGTTGT ATATCCTTCA TTATGATATT
GATGGACCAA TGAACTGCAC TTCAGATATG GAGATCAACC CTTTGAGAAT TAAGATCTCA
TCTTTGCAAA CAACTGAAAA GAATGACACG GTTGCCGGGC AAGGTGAGCG GGACCATCTC
ATCACTAAGC GGGATCTTGC CCTCAGTGAA GGAGATATTC ACACTTTGGG TTGTGGAGTT
GCTCAGTGCT TGAAGATTGT CTGCCAAGTT GGGAGATTAG ACAGAGGAAA GAGTGCAATC
TTGTACGTAA AGTCATTACT GTGGACTGAG ACTTTTATGA ATAAAGAAAA TCAGAATCAT
TCCTATTCTC TGAAGTCGTC TGCTTCATTT AATGTCATAG AGTTTCCTTA TAAGAATCTT
CCAATTGAGG ATATCACCAA CTCCACATTG GTTACCACTA ATGTCACCTG GGGCATTCAG
CCAGCGCCCA TGCCTGTGCC TGTGTGGGTG ATCATTTTAG CAGTTCTAGC AGGATTGTTG
CTACTGGCTG TTTTGGTATT TGTAATGTAC AGGATGGGCT TTTTTAAACG GGTCCGGCCA
CCTCAAGAAG AACAAGAAAG GGAGCAGCTT CAACCTCATG AAAATGGTGA AGGAAACTCA
GAAACTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001138471.1
CDS131..3139
Misc Feature(1)368..541
Misc Feature(2)554..736
Misc Feature(3)653..805
Misc Feature(4)734..>856
Misc Feature(5)752..886
Misc Feature(6)896..1057
Misc Feature(7)911..1078
Misc Feature(8)1091..1255
Misc Feature(9)1103..1258
Misc Feature(10)1292..1420
Misc Feature(11)1391..2734
Exon (1)1..177
Exon (2)178..308
Exon (3)309..400
Exon (4)401..515
Exon (5)516..577
Exon (6)578..623
Exon (7)624..749
Exon (8)750..794
Exon (9)795..838
Exon (10)839..895
Exon (11)896..948
Exon (12)949..1151
Exon (13)1152..1343
Exon (14)1344..1389
Exon (15)1390..1497
Exon (16)1498..1556
Exon (17)1557..1711
Exon (18)1712..1849
Exon (19)1850..1917
Exon (20)1918..2065
Exon (21)2066..2158
Exon (22)2159..2238
Exon (23)2239..2319
Exon (24)2320..2425
Exon (25)2426..2584
Exon (26)2585..2698
Exon (27)2699..2812
Exon (28)2813..2920
Exon (29)2921..3043
Exon (30)3044..6749
Translation

Target ORF information:

RefSeq Version NM_001144999.2
Organism Homo sapiens(Human)
Definition Homo sapiens integrin subunit alpha V (ITGAV), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001144999.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
ATGCTCCTAG GCACCCTCCT TCTGATCCTG TACATCTTAA TGTTGTGCCG GATGTTTCTT 
CTCGTGGGAG CTCCCAAAGC AAACACCACC CAGCCTGGGA TTGTGGAAGG AGGGCAGGTC
CTCAAATGTG ACTGGTCTTC TACCCGCCGG TGCCAGCCAA TTGAATTTGA TGCAACAGGC
AATAGAGATT ATGCCAAGGA TGATCCATTG GAATTTAAGT CCCATCAGTG GTTTGGAGCA
TCTGTGAGGT CGAAACAGGA TAAAATTTTG GCCTGTGCCC CATTGTACCA TTGGAGAACT
GAGATGAAAC AGGAGCGAGA GCCTGTTGGA ACATGCTTTC TTCAAGATGG AACAAAGACT
GTTGAGTATG CTCCATGTAG ATCACAAGAT ATTGATGCTG ATGGACAGGG ATTTTGTCAA
GGAGGATTCA GCATTGATTT TACTAAAGCT GACAGAGTAC TTCTTGGTGG TCCTGGTAGC
TTTTATTGGC AAGGTCAGCT TATTTCGGAT CAAGTGGCAG AAATCGTATC TAAATACGAC
CCCAATGTTT ACAGCATCAA GTATAATAAC CAATTAGCAA CTCGGACTGC ACAAGCTATT
TTTGATGACA GCTATTTGGG TTATTCTGTG GCTGTCGGAG ATTTCAATGG TGATGGCATA
GATGACTTTG TTTCAGGAGT TCCAAGAGCA GCAAGGACTT TGGGAATGGT TTATATTTAT
GATGGGAAGA ACATGTCCTC CTTATACAAT TTTACTGGCG AGCAGATGGC TGCATATTTC
GGATTTTCTG TAGCTGCCAC TGACATTAAT GGAGATGATT ATGCAGATGT GTTTATTGGA
GCACCTCTCT TCATGGATCG TGGCTCTGAT GGCAAACTCC AAGAGGTGGG GCAGGTCTCA
GTGTCTCTAC AGAGAGCTTC AGGAGACTTC CAGACGACAA AGCTGAATGG ATTTGAGGTC
TTTGCACGGT TTGGCAGTGC CATAGCTCCT TTGGGAGATC TGGACCAGGA TGGTTTCAAT
GATATTGCAA TTGCTGCTCC ATATGGGGGT GAAGATAAAA AAGGAATTGT TTATATCTTC
AATGGAAGAT CAACAGGCTT GAACGCAGTC CCATCTCAAA TCCTTGAAGG GCAGTGGGCT
GCTCGAAGCA TGCCACCAAG CTTTGGCTAT TCAATGAAAG GAGCCACAGA TATAGACAAA
AATGGATATC CAGACTTAAT TGTAGGAGCT TTTGGTGTAG ATCGAGCTAT CTTATACAGG
GCCAGACCAG TTATCACTGT AAATGCTGGT CTTGAAGTGT ACCCTAGCAT TTTAAATCAA
GACAATAAAA CCTGCTCACT GCCTGGAACA GCTCTCAAAG TTTCCTGTTT TAATGTTAGG
TTCTGCTTAA AGGCAGATGG CAAAGGAGTA CTTCCCAGGA AACTTAATTT CCAGGTGGAA
CTTCTTTTGG ATAAACTCAA GCAAAAGGGA GCAATTCGAC GAGCACTGTT TCTCTACAGC
AGGTCCCCAA GTCACTCCAA GAACATGACT ATTTCAAGGG GGGGACTGAT GCAGTGTGAG
GAATTGATAG CGTATCTGCG GGATGAATCT GAATTTAGAG ACAAACTCAC TCCAATTACT
ATTTTTATGG AATATCGGTT GGATTATAGA ACAGCTGCTG ATACAACAGG CTTGCAACCC
ATTCTTAACC AGTTCACGCC TGCTAACATT AGTCGACAGG CTCACATTCT ACTTGACTGT
GGTGAAGACA ATGTCTGTAA ACCCAAGCTG GAAGTTTCTG TAGATAGTGA TCAAAAGAAG
ATCTATATTG GGGATGACAA CCCTCTGACA TTGATTGTTA AGGCTCAGAA TCAAGGAGAA
GGTGCCTACG AAGCTGAGCT CATCGTTTCC ATTCCACTGC AGGCTGATTT CATCGGGGTT
GTCCGAAACA ATGAAGCCTT AGCAAGACTT TCCTGTGCAT TTAAGACAGA AAACCAAACT
CGCCAGGTGG TATGTGACCT TGGAAACCCA ATGAAGGCTG GAACTCAACT CTTAGCTGGT
CTTCGTTTCA GTGTGCACCA GCAGTCAGAG ATGGATACTT CTGTGAAATT TGACTTACAA
ATCCAAAGCT CAAATCTATT TGACAAAGTA AGCCCAGTTG TATCTCACAA AGTTGATCTT
GCTGTTTTAG CTGCAGTTGA GATAAGAGGA GTCTCGAGTC CTGATCATAT CTTTCTTCCG
ATTCCAAACT GGGAGCACAA GGAGAACCCT GAGACTGAAG AAGATGTTGG GCCAGTTGTT
CAGCACATCT ATGAGCTGAG AAACAATGGT CCAAGTTCAT TCAGCAAGGC AATGCTCCAT
CTTCAGTGGC CTTACAAATA TAATAATAAC ACTCTGTTGT ATATCCTTCA TTATGATATT
GATGGACCAA TGAACTGCAC TTCAGATATG GAGATCAACC CTTTGAGAAT TAAGATCTCA
TCTTTGCAAA CAACTGAAAA GAATGACACG GTTGCCGGGC AAGGTGAGCG GGACCATCTC
ATCACTAAGC GGGATCTTGC CCTCAGTGAA GGAGATATTC ACACTTTGGG TTGTGGAGTT
GCTCAGTGCT TGAAGATTGT CTGCCAAGTT GGGAGATTAG ACAGAGGAAA GAGTGCAATC
TTGTACGTAA AGTCATTACT GTGGACTGAG ACTTTTATGA ATAAAGAAAA TCAGAATCAT
TCCTATTCTC TGAAGTCGTC TGCTTCATTT AATGTCATAG AGTTTCCTTA TAAGAATCTT
CCAATTGAGG ATATCACCAA CTCCACATTG GTTACCACTA ATGTCACCTG GGGCATTCAG
CCAGCGCCCA TGCCTGTGCC TGTGTGGGTG ATCATTTTAG CAGTTCTAGC AGGATTGTTG
CTACTGGCTG TTTTGGTATT TGTAATGTAC AGGATGGGCT TTTTTAAACG GGTCCGGCCA
CCTCAAGAAG AACAAGAAAG GGAGCAGCTT CAACCTCATG AAAATGGTGA AGGAAACTCA
GAAACTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23663
Clone ID Related Accession (Same CDS sequence) NM_002210.4
Accession Version NM_002210.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3147bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product integrin alpha-V isoform 1 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK309711.1, BC136442.1, DA736912.1, CB962576.1, CN409399.1, BC047454.1 and BQ101180.1. On May 10, 2013 this sequence version replaced NM_002210.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
ATGGCTTTTC CGCCGCGGCG ACGGCTGCGC CTCGGTCCCC GCGGCCTCCC GCTTCTTCTC 
TCGGGACTCC TGCTACCTCT GTGCCGCGCC TTCAACCTAG ACGTGGACAG TCCTGCCGAG
TACTCTGGCC CCGAGGGAAG TTACTTCGGC TTCGCCGTGG ATTTCTTCGT GCCCAGCGCG
TCTTCCCGGA TGTTTCTTCT CGTGGGAGCT CCCAAAGCAA ACACCACCCA GCCTGGGATT
GTGGAAGGAG GGCAGGTCCT CAAATGTGAC TGGTCTTCTA CCCGCCGGTG CCAGCCAATT
GAATTTGATG CAACAGGCAA TAGAGATTAT GCCAAGGATG ATCCATTGGA ATTTAAGTCC
CATCAGTGGT TTGGAGCATC TGTGAGGTCG AAACAGGATA AAATTTTGGC CTGTGCCCCA
TTGTACCATT GGAGAACTGA GATGAAACAG GAGCGAGAGC CTGTTGGAAC ATGCTTTCTT
CAAGATGGAA CAAAGACTGT TGAGTATGCT CCATGTAGAT CACAAGATAT TGATGCTGAT
GGACAGGGAT TTTGTCAAGG AGGATTCAGC ATTGATTTTA CTAAAGCTGA CAGAGTACTT
CTTGGTGGTC CTGGTAGCTT TTATTGGCAA GGTCAGCTTA TTTCGGATCA AGTGGCAGAA
ATCGTATCTA AATACGACCC CAATGTTTAC AGCATCAAGT ATAATAACCA ATTAGCAACT
CGGACTGCAC AAGCTATTTT TGATGACAGC TATTTGGGTT ATTCTGTGGC TGTCGGAGAT
TTCAATGGTG ATGGCATAGA TGACTTTGTT TCAGGAGTTC CAAGAGCAGC AAGGACTTTG
GGAATGGTTT ATATTTATGA TGGGAAGAAC ATGTCCTCCT TATACAATTT TACTGGCGAG
CAGATGGCTG CATATTTCGG ATTTTCTGTA GCTGCCACTG ACATTAATGG AGATGATTAT
GCAGATGTGT TTATTGGAGC ACCTCTCTTC ATGGATCGTG GCTCTGATGG CAAACTCCAA
GAGGTGGGGC AGGTCTCAGT GTCTCTACAG AGAGCTTCAG GAGACTTCCA GACGACAAAG
CTGAATGGAT TTGAGGTCTT TGCACGGTTT GGCAGTGCCA TAGCTCCTTT GGGAGATCTG
GACCAGGATG GTTTCAATGA TATTGCAATT GCTGCTCCAT ATGGGGGTGA AGATAAAAAA
GGAATTGTTT ATATCTTCAA TGGAAGATCA ACAGGCTTGA ACGCAGTCCC ATCTCAAATC
CTTGAAGGGC AGTGGGCTGC TCGAAGCATG CCACCAAGCT TTGGCTATTC AATGAAAGGA
GCCACAGATA TAGACAAAAA TGGATATCCA GACTTAATTG TAGGAGCTTT TGGTGTAGAT
CGAGCTATCT TATACAGGGC CAGACCAGTT ATCACTGTAA ATGCTGGTCT TGAAGTGTAC
CCTAGCATTT TAAATCAAGA CAATAAAACC TGCTCACTGC CTGGAACAGC TCTCAAAGTT
TCCTGTTTTA ATGTTAGGTT CTGCTTAAAG GCAGATGGCA AAGGAGTACT TCCCAGGAAA
CTTAATTTCC AGGTGGAACT TCTTTTGGAT AAACTCAAGC AAAAGGGAGC AATTCGACGA
GCACTGTTTC TCTACAGCAG GTCCCCAAGT CACTCCAAGA ACATGACTAT TTCAAGGGGG
GGACTGATGC AGTGTGAGGA ATTGATAGCG TATCTGCGGG ATGAATCTGA ATTTAGAGAC
AAACTCACTC CAATTACTAT TTTTATGGAA TATCGGTTGG ATTATAGAAC AGCTGCTGAT
ACAACAGGCT TGCAACCCAT TCTTAACCAG TTCACGCCTG CTAACATTAG TCGACAGGCT
CACATTCTAC TTGACTGTGG TGAAGACAAT GTCTGTAAAC CCAAGCTGGA AGTTTCTGTA
GATAGTGATC AAAAGAAGAT CTATATTGGG GATGACAACC CTCTGACATT GATTGTTAAG
GCTCAGAATC AAGGAGAAGG TGCCTACGAA GCTGAGCTCA TCGTTTCCAT TCCACTGCAG
GCTGATTTCA TCGGGGTTGT CCGAAACAAT GAAGCCTTAG CAAGACTTTC CTGTGCATTT
AAGACAGAAA ACCAAACTCG CCAGGTGGTA TGTGACCTTG GAAACCCAAT GAAGGCTGGA
ACTCAACTCT TAGCTGGTCT TCGTTTCAGT GTGCACCAGC AGTCAGAGAT GGATACTTCT
GTGAAATTTG ACTTACAAAT CCAAAGCTCA AATCTATTTG ACAAAGTAAG CCCAGTTGTA
TCTCACAAAG TTGATCTTGC TGTTTTAGCT GCAGTTGAGA TAAGAGGAGT CTCGAGTCCT
GATCATATCT TTCTTCCGAT TCCAAACTGG GAGCACAAGG AGAACCCTGA GACTGAAGAA
GATGTTGGGC CAGTTGTTCA GCACATCTAT GAGCTGAGAA ACAATGGTCC AAGTTCATTC
AGCAAGGCAA TGCTCCATCT TCAGTGGCCT TACAAATATA ATAATAACAC TCTGTTGTAT
ATCCTTCATT ATGATATTGA TGGACCAATG AACTGCACTT CAGATATGGA GATCAACCCT
TTGAGAATTA AGATCTCATC TTTGCAAACA ACTGAAAAGA ATGACACGGT TGCCGGGCAA
GGTGAGCGGG ACCATCTCAT CACTAAGCGG GATCTTGCCC TCAGTGAAGG AGATATTCAC
ACTTTGGGTT GTGGAGTTGC TCAGTGCTTG AAGATTGTCT GCCAAGTTGG GAGATTAGAC
AGAGGAAAGA GTGCAATCTT GTACGTAAAG TCATTACTGT GGACTGAGAC TTTTATGAAT
AAAGAAAATC AGAATCATTC CTATTCTCTG AAGTCGTCTG CTTCATTTAA TGTCATAGAG
TTTCCTTATA AGAATCTTCC AATTGAGGAT ATCACCAACT CCACATTGGT TACCACTAAT
GTCACCTGGG GCATTCAGCC AGCGCCCATG CCTGTGCCTG TGTGGGTGAT CATTTTAGCA
GTTCTAGCAG GATTGTTGCT ACTGGCTGTT TTGGTATTTG TAATGTACAG GATGGGCTTT
TTTAAACGGG TCCGGCCACC TCAAGAAGAA CAAGAAAGGG AGCAGCTTCA ACCTCATGAA
AATGGTGAAG GAAACTCAGA AACTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002201.1
CDS277..3423
Misc Feature(1)370..570
Misc Feature(2)412..585
Misc Feature(3)427..636
Misc Feature(4)601..786
Misc Feature(5)652..825
Misc Feature(6)793..951
Misc Feature(7)838..1020
Misc Feature(8)937..1089
Misc Feature(9)985..1149
Misc Feature(10)1018..>1140
Misc Feature(11)1036..1170
Misc Feature(12)1150..1347
Misc Feature(13)1180..1341
Misc Feature(14)1195..1362
Misc Feature(15)1348..1521
Misc Feature(16)1375..1539
Misc Feature(17)1387..1542
Misc Feature(18)1531..1722
Misc Feature(19)1576..1704
Misc Feature(20)1675..3018
Misc Feature(21)3253..3324
Misc Feature(22)3331..3345
Misc Feature(23)3418..3420
Exon (1)1..461
Exon (2)462..592
Exon (3)593..684
Exon (4)685..799
Exon (5)800..861
Exon (6)862..907
Exon (7)908..1033
Exon (8)1034..1078
Exon (9)1079..1122
Exon (10)1123..1179
Exon (11)1180..1232
Exon (12)1233..1435
Exon (13)1436..1627
Exon (14)1628..1673
Exon (15)1674..1781
Exon (16)1782..1840
Exon (17)1841..1995
Exon (18)1996..2133
Exon (19)2134..2201
Exon (20)2202..2349
Exon (21)2350..2442
Exon (22)2443..2522
Exon (23)2523..2603
Exon (24)2604..2709
Exon (25)2710..2868
Exon (26)2869..2982
Exon (27)2983..3096
Exon (28)3097..3204
Exon (29)3205..3327
Exon (30)3328..7033
Translation

Target ORF information:

RefSeq Version NM_002210.4
Organism Homo sapiens(Human)
Definition Homo sapiens integrin subunit alpha V (ITGAV), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002210.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
ATGGCTTTTC CGCCGCGGCG ACGGCTGCGC CTCGGTCCCC GCGGCCTCCC GCTTCTTCTC 
TCGGGACTCC TGCTACCTCT GTGCCGCGCC TTCAACCTAG ACGTGGACAG TCCTGCCGAG
TACTCTGGCC CCGAGGGAAG TTACTTCGGC TTCGCCGTGG ATTTCTTCGT GCCCAGCGCG
TCTTCCCGGA TGTTTCTTCT CGTGGGAGCT CCCAAAGCAA ACACCACCCA GCCTGGGATT
GTGGAAGGAG GGCAGGTCCT CAAATGTGAC TGGTCTTCTA CCCGCCGGTG CCAGCCAATT
GAATTTGATG CAACAGGCAA TAGAGATTAT GCCAAGGATG ATCCATTGGA ATTTAAGTCC
CATCAGTGGT TTGGAGCATC TGTGAGGTCG AAACAGGATA AAATTTTGGC CTGTGCCCCA
TTGTACCATT GGAGAACTGA GATGAAACAG GAGCGAGAGC CTGTTGGAAC ATGCTTTCTT
CAAGATGGAA CAAAGACTGT TGAGTATGCT CCATGTAGAT CACAAGATAT TGATGCTGAT
GGACAGGGAT TTTGTCAAGG AGGATTCAGC ATTGATTTTA CTAAAGCTGA CAGAGTACTT
CTTGGTGGTC CTGGTAGCTT TTATTGGCAA GGTCAGCTTA TTTCGGATCA AGTGGCAGAA
ATCGTATCTA AATACGACCC CAATGTTTAC AGCATCAAGT ATAATAACCA ATTAGCAACT
CGGACTGCAC AAGCTATTTT TGATGACAGC TATTTGGGTT ATTCTGTGGC TGTCGGAGAT
TTCAATGGTG ATGGCATAGA TGACTTTGTT TCAGGAGTTC CAAGAGCAGC AAGGACTTTG
GGAATGGTTT ATATTTATGA TGGGAAGAAC ATGTCCTCCT TATACAATTT TACTGGCGAG
CAGATGGCTG CATATTTCGG ATTTTCTGTA GCTGCCACTG ACATTAATGG AGATGATTAT
GCAGATGTGT TTATTGGAGC ACCTCTCTTC ATGGATCGTG GCTCTGATGG CAAACTCCAA
GAGGTGGGGC AGGTCTCAGT GTCTCTACAG AGAGCTTCAG GAGACTTCCA GACGACAAAG
CTGAATGGAT TTGAGGTCTT TGCACGGTTT GGCAGTGCCA TAGCTCCTTT GGGAGATCTG
GACCAGGATG GTTTCAATGA TATTGCAATT GCTGCTCCAT ATGGGGGTGA AGATAAAAAA
GGAATTGTTT ATATCTTCAA TGGAAGATCA ACAGGCTTGA ACGCAGTCCC ATCTCAAATC
CTTGAAGGGC AGTGGGCTGC TCGAAGCATG CCACCAAGCT TTGGCTATTC AATGAAAGGA
GCCACAGATA TAGACAAAAA TGGATATCCA GACTTAATTG TAGGAGCTTT TGGTGTAGAT
CGAGCTATCT TATACAGGGC CAGACCAGTT ATCACTGTAA ATGCTGGTCT TGAAGTGTAC
CCTAGCATTT TAAATCAAGA CAATAAAACC TGCTCACTGC CTGGAACAGC TCTCAAAGTT
TCCTGTTTTA ATGTTAGGTT CTGCTTAAAG GCAGATGGCA AAGGAGTACT TCCCAGGAAA
CTTAATTTCC AGGTGGAACT TCTTTTGGAT AAACTCAAGC AAAAGGGAGC AATTCGACGA
GCACTGTTTC TCTACAGCAG GTCCCCAAGT CACTCCAAGA ACATGACTAT TTCAAGGGGG
GGACTGATGC AGTGTGAGGA ATTGATAGCG TATCTGCGGG ATGAATCTGA ATTTAGAGAC
AAACTCACTC CAATTACTAT TTTTATGGAA TATCGGTTGG ATTATAGAAC AGCTGCTGAT
ACAACAGGCT TGCAACCCAT TCTTAACCAG TTCACGCCTG CTAACATTAG TCGACAGGCT
CACATTCTAC TTGACTGTGG TGAAGACAAT GTCTGTAAAC CCAAGCTGGA AGTTTCTGTA
GATAGTGATC AAAAGAAGAT CTATATTGGG GATGACAACC CTCTGACATT GATTGTTAAG
GCTCAGAATC AAGGAGAAGG TGCCTACGAA GCTGAGCTCA TCGTTTCCAT TCCACTGCAG
GCTGATTTCA TCGGGGTTGT CCGAAACAAT GAAGCCTTAG CAAGACTTTC CTGTGCATTT
AAGACAGAAA ACCAAACTCG CCAGGTGGTA TGTGACCTTG GAAACCCAAT GAAGGCTGGA
ACTCAACTCT TAGCTGGTCT TCGTTTCAGT GTGCACCAGC AGTCAGAGAT GGATACTTCT
GTGAAATTTG ACTTACAAAT CCAAAGCTCA AATCTATTTG ACAAAGTAAG CCCAGTTGTA
TCTCACAAAG TTGATCTTGC TGTTTTAGCT GCAGTTGAGA TAAGAGGAGT CTCGAGTCCT
GATCATATCT TTCTTCCGAT TCCAAACTGG GAGCACAAGG AGAACCCTGA GACTGAAGAA
GATGTTGGGC CAGTTGTTCA GCACATCTAT GAGCTGAGAA ACAATGGTCC AAGTTCATTC
AGCAAGGCAA TGCTCCATCT TCAGTGGCCT TACAAATATA ATAATAACAC TCTGTTGTAT
ATCCTTCATT ATGATATTGA TGGACCAATG AACTGCACTT CAGATATGGA GATCAACCCT
TTGAGAATTA AGATCTCATC TTTGCAAACA ACTGAAAAGA ATGACACGGT TGCCGGGCAA
GGTGAGCGGG ACCATCTCAT CACTAAGCGG GATCTTGCCC TCAGTGAAGG AGATATTCAC
ACTTTGGGTT GTGGAGTTGC TCAGTGCTTG AAGATTGTCT GCCAAGTTGG GAGATTAGAC
AGAGGAAAGA GTGCAATCTT GTACGTAAAG TCATTACTGT GGACTGAGAC TTTTATGAAT
AAAGAAAATC AGAATCATTC CTATTCTCTG AAGTCGTCTG CTTCATTTAA TGTCATAGAG
TTTCCTTATA AGAATCTTCC AATTGAGGAT ATCACCAACT CCACATTGGT TACCACTAAT
GTCACCTGGG GCATTCAGCC AGCGCCCATG CCTGTGCCTG TGTGGGTGAT CATTTTAGCA
GTTCTAGCAG GATTGTTGCT ACTGGCTGTT TTGGTATTTG TAATGTACAG GATGGGCTTT
TTTAAACGGG TCCGGCCACC TCAAGAAGAA CAAGAAAGGG AGCAGCTTCA ACCTCATGAA
AATGGTGAAG GAAACTCAGA AACTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27622
Clone ID Related Accession (Same CDS sequence) NM_001145000.2
Accession Version NM_001145000.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3039bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product integrin alpha-V isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK309711.1, BC144100.1, BC136442.1, DA736912.1, CB962576.1, CN409399.1, BC047454.1 and BQ101180.1. On May 10, 2013 this sequence version replaced NM_001145000.1. Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1. It is not known whether this isoform (3) is proteolytically processed in the same manner as isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
ATGGCTTTTC CGCCGCGGCG ACGGCTGCGC CTCGGTCCCC GCGGCCTCCC GCTTCTTCTC 
TCGGGACTCC TGCTACCTCT GTGCCGCGCC TTCAACCTAG ACGTGGACAG TCCTGCCGAG
TACTCTGGCC CCGAGGGAAG TTACTTCGGC TTCGCCGTGG ATTTCTTCGT GCCCAGCGCG
TCTTCCCGGA TGTTTCTTCT CGTGGGAGCT CCCAAAGCAA ACACCACCCA GCCTGGGATT
GTGGAAGGAG GGCAGGTCCT CAAATGTGAC TGGTCTTCTA CCCGCCGGTG CCAGCCAATT
GAATTTGATG CAACAGGCAA TAGAGATTAT GCCAAGGATG ATCCATTGGA ATTTAAGTCC
CATCAGTGGT TTGGAGCATC TGTGAGGTCG AAACAGGATA AAATTTTGGC CTGTGCCCCA
TTGTACCATT GGAGAACTGA GATGAAACAG GAGCGAGAGC CTGTTGGAAC ATGCTTTCTT
CAAGATGGAA CAAAGACTGT TGAGTATGCT CCATGTAGAT CACGTCAGCT TATTTCGGAT
CAAGTGGCAG AAATCGTATC TAAATACGAC CCCAATGTTT ACAGCATCAA GTATAATAAC
CAATTAGCAA CTCGGACTGC ACAAGCTATT TTTGATGACA GCTATTTGGG TTATTCTGTG
GCTGTCGGAG ATTTCAATGG TGATGGCATA GATGACTTTG TTTCAGGAGT TCCAAGAGCA
GCAAGGACTT TGGGAATGGT TTATATTTAT GATGGGAAGA ACATGTCCTC CTTATACAAT
TTTACTGGCG AGCAGATGGC TGCATATTTC GGATTTTCTG TAGCTGCCAC TGACATTAAT
GGAGATGATT ATGCAGATGT GTTTATTGGA GCACCTCTCT TCATGGATCG TGGCTCTGAT
GGCAAACTCC AAGAGGTGGG GCAGGTCTCA GTGTCTCTAC AGAGAGCTTC AGGAGACTTC
CAGACGACAA AGCTGAATGG ATTTGAGGTC TTTGCACGGT TTGGCAGTGC CATAGCTCCT
TTGGGAGATC TGGACCAGGA TGGTTTCAAT GATATTGCAA TTGCTGCTCC ATATGGGGGT
GAAGATAAAA AAGGAATTGT TTATATCTTC AATGGAAGAT CAACAGGCTT GAACGCAGTC
CCATCTCAAA TCCTTGAAGG GCAGTGGGCT GCTCGAAGCA TGCCACCAAG CTTTGGCTAT
TCAATGAAAG GAGCCACAGA TATAGACAAA AATGGATATC CAGACTTAAT TGTAGGAGCT
TTTGGTGTAG ATCGAGCTAT CTTATACAGG GCCAGACCAG TTATCACTGT AAATGCTGGT
CTTGAAGTGT ACCCTAGCAT TTTAAATCAA GACAATAAAA CCTGCTCACT GCCTGGAACA
GCTCTCAAAG TTTCCTGTTT TAATGTTAGG TTCTGCTTAA AGGCAGATGG CAAAGGAGTA
CTTCCCAGGA AACTTAATTT CCAGGTGGAA CTTCTTTTGG ATAAACTCAA GCAAAAGGGA
GCAATTCGAC GAGCACTGTT TCTCTACAGC AGGTCCCCAA GTCACTCCAA GAACATGACT
ATTTCAAGGG GGGGACTGAT GCAGTGTGAG GAATTGATAG CGTATCTGCG GGATGAATCT
GAATTTAGAG ACAAACTCAC TCCAATTACT ATTTTTATGG AATATCGGTT GGATTATAGA
ACAGCTGCTG ATACAACAGG CTTGCAACCC ATTCTTAACC AGTTCACGCC TGCTAACATT
AGTCGACAGG CTCACATTCT ACTTGACTGT GGTGAAGACA ATGTCTGTAA ACCCAAGCTG
GAAGTTTCTG TAGATAGTGA TCAAAAGAAG ATCTATATTG GGGATGACAA CCCTCTGACA
TTGATTGTTA AGGCTCAGAA TCAAGGAGAA GGTGCCTACG AAGCTGAGCT CATCGTTTCC
ATTCCACTGC AGGCTGATTT CATCGGGGTT GTCCGAAACA ATGAAGCCTT AGCAAGACTT
TCCTGTGCAT TTAAGACAGA AAACCAAACT CGCCAGGTGG TATGTGACCT TGGAAACCCA
ATGAAGGCTG GAACTCAACT CTTAGCTGGT CTTCGTTTCA GTGTGCACCA GCAGTCAGAG
ATGGATACTT CTGTGAAATT TGACTTACAA ATCCAAAGCT CAAATCTATT TGACAAAGTA
AGCCCAGTTG TATCTCACAA AGTTGATCTT GCTGTTTTAG CTGCAGTTGA GATAAGAGGA
GTCTCGAGTC CTGATCATAT CTTTCTTCCG ATTCCAAACT GGGAGCACAA GGAGAACCCT
GAGACTGAAG AAGATGTTGG GCCAGTTGTT CAGCACATCT ATGAGCTGAG AAACAATGGT
CCAAGTTCAT TCAGCAAGGC AATGCTCCAT CTTCAGTGGC CTTACAAATA TAATAATAAC
ACTCTGTTGT ATATCCTTCA TTATGATATT GATGGACCAA TGAACTGCAC TTCAGATATG
GAGATCAACC CTTTGAGAAT TAAGATCTCA TCTTTGCAAA CAACTGAAAA GAATGACACG
GTTGCCGGGC AAGGTGAGCG GGACCATCTC ATCACTAAGC GGGATCTTGC CCTCAGTGAA
GGAGATATTC ACACTTTGGG TTGTGGAGTT GCTCAGTGCT TGAAGATTGT CTGCCAAGTT
GGGAGATTAG ACAGAGGAAA GAGTGCAATC TTGTACGTAA AGTCATTACT GTGGACTGAG
ACTTTTATGA ATAAAGAAAA TCAGAATCAT TCCTATTCTC TGAAGTCGTC TGCTTCATTT
AATGTCATAG AGTTTCCTTA TAAGAATCTT CCAATTGAGG ATATCACCAA CTCCACATTG
GTTACCACTA ATGTCACCTG GGGCATTCAG CCAGCGCCCA TGCCTGTGCC TGTGTGGGTG
ATCATTTTAG CAGTTCTAGC AGGATTGTTG CTACTGGCTG TTTTGGTATT TGTAATGTAC
AGGATGGGCT TTTTTAAACG GGTCCGGCCA CCTCAAGAAG AACAAGAAAG GGAGCAGCTT
CAACCTCATG AAAATGGTGA AGGAAACTCA GAAACTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001138472.1
CDS277..3315
Misc Feature(1)412..585
Misc Feature(2)427..636
Misc Feature(3)652..753
Misc Feature(4)766..912
Misc Feature(5)829..981
Misc Feature(6)910..>1032
Misc Feature(7)928..1062
Misc Feature(8)1072..1233
Misc Feature(9)1087..1254
Misc Feature(10)1267..1431
Misc Feature(11)1279..1434
Misc Feature(12)1468..1596
Misc Feature(13)1567..2910
Exon (1)1..461
Exon (2)462..592
Exon (3)593..684
Exon (4)685..799
Exon (5)800..925
Exon (6)926..970
Exon (7)971..1014
Exon (8)1015..1071
Exon (9)1072..1124
Exon (10)1125..1327
Exon (11)1328..1519
Exon (12)1520..1565
Exon (13)1566..1673
Exon (14)1674..1732
Exon (15)1733..1887
Exon (16)1888..2025
Exon (17)2026..2093
Exon (18)2094..2241
Exon (19)2242..2334
Exon (20)2335..2414
Exon (21)2415..2495
Exon (22)2496..2601
Exon (23)2602..2760
Exon (24)2761..2874
Exon (25)2875..2988
Exon (26)2989..3096
Exon (27)3097..3219
Exon (28)3220..6925
Translation

Target ORF information:

RefSeq Version NM_001145000.2
Organism Homo sapiens(Human)
Definition Homo sapiens integrin subunit alpha V (ITGAV), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001145000.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
ATGGCTTTTC CGCCGCGGCG ACGGCTGCGC CTCGGTCCCC GCGGCCTCCC GCTTCTTCTC 
TCGGGACTCC TGCTACCTCT GTGCCGCGCC TTCAACCTAG ACGTGGACAG TCCTGCCGAG
TACTCTGGCC CCGAGGGAAG TTACTTCGGC TTCGCCGTGG ATTTCTTCGT GCCCAGCGCG
TCTTCCCGGA TGTTTCTTCT CGTGGGAGCT CCCAAAGCAA ACACCACCCA GCCTGGGATT
GTGGAAGGAG GGCAGGTCCT CAAATGTGAC TGGTCTTCTA CCCGCCGGTG CCAGCCAATT
GAATTTGATG CAACAGGCAA TAGAGATTAT GCCAAGGATG ATCCATTGGA ATTTAAGTCC
CATCAGTGGT TTGGAGCATC TGTGAGGTCG AAACAGGATA AAATTTTGGC CTGTGCCCCA
TTGTACCATT GGAGAACTGA GATGAAACAG GAGCGAGAGC CTGTTGGAAC ATGCTTTCTT
CAAGATGGAA CAAAGACTGT TGAGTATGCT CCATGTAGAT CACGTCAGCT TATTTCGGAT
CAAGTGGCAG AAATCGTATC TAAATACGAC CCCAATGTTT ACAGCATCAA GTATAATAAC
CAATTAGCAA CTCGGACTGC ACAAGCTATT TTTGATGACA GCTATTTGGG TTATTCTGTG
GCTGTCGGAG ATTTCAATGG TGATGGCATA GATGACTTTG TTTCAGGAGT TCCAAGAGCA
GCAAGGACTT TGGGAATGGT TTATATTTAT GATGGGAAGA ACATGTCCTC CTTATACAAT
TTTACTGGCG AGCAGATGGC TGCATATTTC GGATTTTCTG TAGCTGCCAC TGACATTAAT
GGAGATGATT ATGCAGATGT GTTTATTGGA GCACCTCTCT TCATGGATCG TGGCTCTGAT
GGCAAACTCC AAGAGGTGGG GCAGGTCTCA GTGTCTCTAC AGAGAGCTTC AGGAGACTTC
CAGACGACAA AGCTGAATGG ATTTGAGGTC TTTGCACGGT TTGGCAGTGC CATAGCTCCT
TTGGGAGATC TGGACCAGGA TGGTTTCAAT GATATTGCAA TTGCTGCTCC ATATGGGGGT
GAAGATAAAA AAGGAATTGT TTATATCTTC AATGGAAGAT CAACAGGCTT GAACGCAGTC
CCATCTCAAA TCCTTGAAGG GCAGTGGGCT GCTCGAAGCA TGCCACCAAG CTTTGGCTAT
TCAATGAAAG GAGCCACAGA TATAGACAAA AATGGATATC CAGACTTAAT TGTAGGAGCT
TTTGGTGTAG ATCGAGCTAT CTTATACAGG GCCAGACCAG TTATCACTGT AAATGCTGGT
CTTGAAGTGT ACCCTAGCAT TTTAAATCAA GACAATAAAA CCTGCTCACT GCCTGGAACA
GCTCTCAAAG TTTCCTGTTT TAATGTTAGG TTCTGCTTAA AGGCAGATGG CAAAGGAGTA
CTTCCCAGGA AACTTAATTT CCAGGTGGAA CTTCTTTTGG ATAAACTCAA GCAAAAGGGA
GCAATTCGAC GAGCACTGTT TCTCTACAGC AGGTCCCCAA GTCACTCCAA GAACATGACT
ATTTCAAGGG GGGGACTGAT GCAGTGTGAG GAATTGATAG CGTATCTGCG GGATGAATCT
GAATTTAGAG ACAAACTCAC TCCAATTACT ATTTTTATGG AATATCGGTT GGATTATAGA
ACAGCTGCTG ATACAACAGG CTTGCAACCC ATTCTTAACC AGTTCACGCC TGCTAACATT
AGTCGACAGG CTCACATTCT ACTTGACTGT GGTGAAGACA ATGTCTGTAA ACCCAAGCTG
GAAGTTTCTG TAGATAGTGA TCAAAAGAAG ATCTATATTG GGGATGACAA CCCTCTGACA
TTGATTGTTA AGGCTCAGAA TCAAGGAGAA GGTGCCTACG AAGCTGAGCT CATCGTTTCC
ATTCCACTGC AGGCTGATTT CATCGGGGTT GTCCGAAACA ATGAAGCCTT AGCAAGACTT
TCCTGTGCAT TTAAGACAGA AAACCAAACT CGCCAGGTGG TATGTGACCT TGGAAACCCA
ATGAAGGCTG GAACTCAACT CTTAGCTGGT CTTCGTTTCA GTGTGCACCA GCAGTCAGAG
ATGGATACTT CTGTGAAATT TGACTTACAA ATCCAAAGCT CAAATCTATT TGACAAAGTA
AGCCCAGTTG TATCTCACAA AGTTGATCTT GCTGTTTTAG CTGCAGTTGA GATAAGAGGA
GTCTCGAGTC CTGATCATAT CTTTCTTCCG ATTCCAAACT GGGAGCACAA GGAGAACCCT
GAGACTGAAG AAGATGTTGG GCCAGTTGTT CAGCACATCT ATGAGCTGAG AAACAATGGT
CCAAGTTCAT TCAGCAAGGC AATGCTCCAT CTTCAGTGGC CTTACAAATA TAATAATAAC
ACTCTGTTGT ATATCCTTCA TTATGATATT GATGGACCAA TGAACTGCAC TTCAGATATG
GAGATCAACC CTTTGAGAAT TAAGATCTCA TCTTTGCAAA CAACTGAAAA GAATGACACG
GTTGCCGGGC AAGGTGAGCG GGACCATCTC ATCACTAAGC GGGATCTTGC CCTCAGTGAA
GGAGATATTC ACACTTTGGG TTGTGGAGTT GCTCAGTGCT TGAAGATTGT CTGCCAAGTT
GGGAGATTAG ACAGAGGAAA GAGTGCAATC TTGTACGTAA AGTCATTACT GTGGACTGAG
ACTTTTATGA ATAAAGAAAA TCAGAATCAT TCCTATTCTC TGAAGTCGTC TGCTTCATTT
AATGTCATAG AGTTTCCTTA TAAGAATCTT CCAATTGAGG ATATCACCAA CTCCACATTG
GTTACCACTA ATGTCACCTG GGGCATTCAG CCAGCGCCCA TGCCTGTGCC TGTGTGGGTG
ATCATTTTAG CAGTTCTAGC AGGATTGTTG CTACTGGCTG TTTTGGTATT TGTAATGTAC
AGGATGGGCT TTTTTAAACG GGTCCGGCCA CCTCAAGAAG AACAAGAAAG GGAGCAGCTT
CAACCTCATG AAAATGGTGA AGGAAACTCA GAAACTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Lack of association between integrin α
Virologica Sinica32(1)73-79(2017 Feb)
Chen XP,Xiong HR,Zhu N,Chen QZ,Wang H,Zhong CJ,Wang MR,Lu S,Luo F,Hou W


book

Priming Endothelial Cells With a Melanoma-Derived Extracellular Matrix Triggers the Activation of αvβ3/VEGFR2 Axis.
Journal of cellular physiology231(11)2464-73(2016 Nov)
Helal-Neto E,Brandão-Costa RM,Saldanha-Gama R,Ribeiro-Pereira C,Midlej V,Benchimol M,Morandi V,Barja-Fidalgo C


book

Use of αv Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice.
Anticancer research36(8)3811-6(2016 Aug)
Tome Y,Yano S,Sugimoto N,Mii S,Uehara F,Miwa S,Bouvet M,Tsuchiya H,Kanaya F,Hoffman RM


book

Integrin αvβ6 and matrix metalloproteinase 9 correlate with survival in gastric cancer.
World journal of gastroenterology22(14)3852-9(2016 Apr)
Lian PL,Liu Z,Yang GY,Zhao R,Zhang ZY,Chen YG,Zhuang ZN,Xu KS


book

Human Parechovirus 1 Infection Occurs via αVβ1 Integrin.
PloS one11(4)e0154769(2016)
Merilahti P,Tauriainen S,Susi P


 
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