HES5 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | HES5 |
Entrez Gene ID | 388585 |
Full Name | hes family bHLH transcription factor 5 |
Synonyms | bHLHb38 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_001010926.4 | NP_001010926.1 | transcription factor HES-5 |
NM_001010926.3 | NP_001010926.1 | transcription factor HES-5 |
XM_005244751.4 | XP_005244808.1 | transcription factor HES-5 isoform X1 |

Danio rerio (zebrafish) | LOC100149066 | NP_001121862.1 |
Homo sapiens (human) | HES5 | NP_001010926.1 |
Mus musculus (house mouse) | Hes5 | NP_034549.1 |
Danio rerio (zebrafish) | her4.2 | NP_571165.3 |
Danio rerio (zebrafish) | her4.3 | NP_001154880.1 |
Xenopus tropicalis (tropical clawed frog) | hes5 | XP_004916212.1 |
Pan troglodytes (chimpanzee) | HES5 | XP_524847.2 |
Canis lupus familiaris (dog) | HES5 | XP_546734.2 |
Bos taurus (cattle) | HES5 | NP_001098937.1 |
Rattus norvegicus (Norway rat) | Hes5 | NP_077359.1 |
Gallus gallus (chicken) | HES5 | NP_001012713.1 |
Xenopus tropicalis (tropical clawed frog) | hes5.1 | NP_001037880.1 |
Danio rerio (zebrafish) | LOC100149863 | NP_001096598.1 |
Danio rerio (zebrafish) | LOC100148329 | NP_001154881.1 |

Related articles in PubMed
HES5 promotes cellular proliferation of non-small cell lung cancer through STAT3 signaling.
Gu S, Zhang R, Gu J, Li X, Lv L, Jiang J, Xu Z, Wang S, Shi C, Wang DP, Wu C
Oncology reports37(1)474-482(2017 Jan)
HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma.
Zhu G, Shi W, Fan H, Zhang X, Xu J, Chen Y, Xu Z, Tao T, Cheng C
Experimental and molecular pathology99(3)474-84(2015 Dec)
HES5 silencing is an early and recurrent change in prostate tumourigenesis.
Massie CE, Spiteri I, Ross-Adams H, Luxton H, Kay J, Whitaker HC, Dunning MJ, Lamb AD, Ramos-Montoya A, Brewer DS, Cooper CS, Eeles R, , Warren AY, Tavar? S, Neal DE, Lynch AG
Endocrine-related cancer22(2)131-44(2015 Apr)
HES5 is a key mediator of Wnt-3a-induced neuronal differentiation.
Mu?mann C, H?bner R, Trilck M, Rolfs A, Frech MJ
Stem cells and development23(12)1328-39(2014 Jun)
Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.
Sancho R, Blake SM, Tendeng C, Clurman BE, Lewis J, Behrens A
PLoS biology11(6)e1001586(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
HES5 might contribute to the proliferation of non-small cell lung cancer by STAT3 signaling.
Title: HES5 promotes cellular proliferation of non-small cell lung cancer through STAT3 signaling.
that suppression of the HES5 leading to inhibition of proliferation may be one of the mechanisms against Hepatocellular carcinoma
Title: HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma.
HES5 silencing is an early and recurrent change in prostate tumourigenesis
Title: HES5 silencing is an early and recurrent change in prostate tumourigenesis.
these data identify HES5 as a key mediator of the Wnt-3a proneurogenic effect occurring independently of the classical Wnt/beta-catenin signaling cascade thus further deciphering crosstalk mechanisms of Wnt and Notch signaling pathways regulating cell fate
Title: HES5 is a key mediator of Wnt-3a-induced neuronal differentiation.
the downstream Notch signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta.
Title: Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.
The following HES5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HES5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu29131![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_001010926.4 , NM_001010926.3 | |
Accession Version | NM_001010926.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-30 | |
Organism | Homo sapiens(human) | |
Product | transcription factor HES-5 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139246.21, DQ272660.1 and BX104111.1. On Nov 23, 2018 this sequence version replaced NM_001010926.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ272660.1, HY107217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378453.4/ ENSP00000367714.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCCCCCA GCACTGTGGC CGTGGAGCTG CTCAGCCCCA AAGAGAAAAA CCGACTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001010926.1 |
CDS | 100..600 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGCCCCCA GCACTGTGGC CGTGGAGCTG CTCAGCCCCA AAGAGAAAAA CCGACTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu29131![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_001010926.4 , NM_001010926.3 | |
Accession Version | NM_001010926.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | transcription factor HES-5 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DQ272660.1 and BX104111.1. On Dec 24, 2008 this sequence version replaced NM_001010926.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ272660.1, HY107217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCCCCA GCACTGTGGC CGTGGAGCTG CTCAGCCCCA AAGAGAAAAA CCGACTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001010926.1 |
CDS | 82..582 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGCCCCCA GCACTGTGGC CGTGGAGCTG CTCAGCCCCA AAGAGAAAAA CCGACTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu33432 | |
Clone ID Related Accession (Same CDS sequence) | XM_005244751.4 | |
Accession Version | XM_005244751.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | transcription factor HES-5 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005244751.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCCCCA GCACTGTGGC CGTGGAGCTG CTCAGCCCCA AAGAGAAAAA CCGACTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005244808.1 |
CDS | 391..987 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGCCCCCA GCACTGTGGC CGTGGAGCTG CTCAGCCCCA AAGAGAAAAA CCGACTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
HES5 promotes cellular proliferation of non-small cell lung cancer through STAT3 signaling. |
![]() |
HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival in hepatocellular carcinoma. |
![]() |
HES5 silencing is an early and recurrent change in prostate tumourigenesis. |
![]() |
HES5 is a key mediator of Wnt-3a-induced neuronal differentiation. |
![]() |
Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. |