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LAMTOR4 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol LAMTOR4
Entrez Gene ID 389541
Full Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Synonyms C7orf59
General protein information
Preferred Names

late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

Names

ragulator complex protein LAMTOR4
UPF0539 protein C7orf59
late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

7

7q22.1

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001008395.2 NP_001008396.1 ragulator complex protein LAMTOR4
NM_001008395.3 NP_001008396.1 ragulator complex protein LAMTOR4 isoform 1
XM_024446760.1 XP_024302528.1 ragulator complex protein LAMTOR4 isoform X1
NM_001318237.1 NP_001305166.1 ragulator complex protein LAMTOR4 isoform 3
XM_017012199.1 XP_016867688.1 ragulator complex protein LAMTOR4 isoform X2
XM_017012198.1 XP_016867687.1 ragulator complex protein LAMTOR4 isoform X1
NM_001318236.2 NP_001305165.1 ragulator complex protein LAMTOR4 isoform 2
NM_001318237.2 NP_001305166.1 ragulator complex protein LAMTOR4 isoform 3
NM_001318236.1 NP_001305165.1 ragulator complex protein LAMTOR4 isoform 2
XM_024446761.1 XP_024302529.1 ragulator complex protein LAMTOR4 isoform X2
NM_001008395.4 NP_001008396.1 ragulator complex protein LAMTOR4 isoform 1

Pathways from BioSystems


Homologies


Homo sapiens (human) LAMTOR4 NP_001008396.1
Rattus norvegicus (Norway rat) Lamtor4 NP_001101800.1
Canis lupus familiaris (dog) LAMTOR4 XP_536864.1
Mus musculus (house mouse) Lamtor4 NP_001074577.1
Bos taurus (cattle) LAMTOR4 NP_001160079.1
Danio rerio (zebrafish) si:dkey-159a18.7 NP_001038415.1

Gene Ontology


Bibliography

Related articles in PubMed

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Rebsamen M, Pochini L, Stasyk T, de Ara?jo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G
Nature519(7544)477-81(2015 Mar)

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM
Science (New York, N.Y.)347(6218)188-94(2015 Jan)

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Blandin G, Marchand S, Charton K, Dani?le N, Gicquel E, Boucheteil JB, Bentaib A, Barrault L, Stockholm D, Bartoli M, Richard I
Skeletal muscle3(1)3(2013 Feb)

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM
Cell150(6)1196-208(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study identified HBXIP and C7orf59 as two additional Ragulator components that are required for mTORC1 activation by amino acids.
Title: Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

The following LAMTOR4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAMTOR4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu11251 NM_001008395.4
Latest version!		 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu11251 XM_024446760.1
Latest version!		 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu11251 XM_017012198.1
Latest version!		 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu101816 NM_001318237.2
Latest version!		 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu97247 NM_001318236.2
Latest version!		 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu97247 XM_017012199.1
Latest version!		 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu97247 XM_024446761.1
Latest version!		 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
View Old Accession Versions >>
OHu11251 NM_001008395.2 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
OHu101816 NM_001318237.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu97247 NM_001318236.1 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu11251 NM_001008395.3 Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu11251
Clone ID Related Accession (Same CDS sequence) NM_001008395.2 , NM_001008395.3 , XM_024446760.1 , XM_017012198.1 , NM_001008395.4
Accession Version NM_001008395.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-03-14
Organism Homo sapiens(Human)
Product ragulator complex protein LAMTOR4
Comment 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001008396.1
Translation

Target ORF information:

RefSeq Version NM_001008395.2
Organism Homo sapiens(Human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001008395.2

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu11251
Clone ID Related Accession (Same CDS sequence) NM_001008395.2 , NM_001008395.3 , XM_024446760.1 , XM_017012198.1 , NM_001008395.4
Accession Version NM_001008395.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-24
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU450474.1, BI598677.1 and AA772120.1. On Dec 31, 2015 this sequence version replaced NM_001008395.2. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1163655.194234.1, SRR1163657.319544.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001008396.1
CDS75..374
Translation

Target ORF information:

RefSeq Version NM_001008395.3
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001008395.3

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu11251
Clone ID Related Accession (Same CDS sequence) NM_001008395.2 , NM_001008395.3 , XM_024446760.1 , XM_017012198.1 , NM_001008395.4
Accession Version NM_001008395.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2020-01-03
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU450474.1 and BI598677.1. On Jun 2, 2019 this sequence version replaced NM_001008395.3. Transcript Variant: This variant (1) encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC063401.1, BI754529.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001008396.1
CDS56..355
Translation

Target ORF information:

RefSeq Version NM_001008395.4
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001008395.4

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu11251
Clone ID Related Accession (Same CDS sequence) NM_001008395.2 , NM_001008395.3 , XM_024446760.1 , XM_017012198.1 , NM_001008395.4
Accession Version XM_024446760.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_024302528.1
CDS388..687
Translation

Target ORF information:

RefSeq Version XM_024446760.1
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_024446760.1

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu11251
Clone ID Related Accession (Same CDS sequence) NM_001008395.2 , NM_001008395.3 , XM_024446760.1 , XM_017012198.1 , NM_001008395.4
Accession Version XM_017012198.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016867687.1
CDS462..761
Translation

Target ORF information:

RefSeq Version XM_017012198.1
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017012198.1

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGTGGTCTTT GGAGAACACA CACTGCTGGT GACGGTGTCA 
GGACAGAGGG TGTTTGTGGT GAAGAGGCAG AACCGAGGTC GGGAGCCCAT TGATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101816
Clone ID Related Accession (Same CDS sequence) NM_001318237.1 , NM_001318237.2
Accession Version NM_001318237.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 219bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-30
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform 3
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU450474.1, BI771662.1 and AA772120.1. Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI771662.1, BY796807.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
ATGTCATCTG GGGACCTGGA GAATGATGAG CAGGCAGCCA GTGCCATCTC TGAGCTGGTC 
AGCACAGCCT GCGGTTTCCG GCTGCACCGC GGCATGAATG TGCCCTTCAA GCGCCTGTCT 
GTGGTCTTTG GAGAACACAC ACTGCTGGTG ACGGTGTCAG GACAGAGGGT GTTTGTGGTG 
AAGAGGCAGA ACCGAGGTCG GGAGCCCATT GATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305166.1
CDS75..293
Translation

Target ORF information:

RefSeq Version NM_001318237.1
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318237.1

ORF Insert Sequence:

1
61
121
181
ATGTCATCTG GGGACCTGGA GAATGATGAG CAGGCAGCCA GTGCCATCTC TGAGCTGGTC 
AGCACAGCCT GCGGTTTCCG GCTGCACCGC GGCATGAATG TGCCCTTCAA GCGCCTGTCT 
GTGGTCTTTG GAGAACACAC ACTGCTGGTG ACGGTGTCAG GACAGAGGGT GTTTGTGGTG 
AAGAGGCAGA ACCGAGGTCG GGAGCCCATT GATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu101816
Clone ID Related Accession (Same CDS sequence) NM_001318237.1 , NM_001318237.2
Accession Version NM_001318237.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 219bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-28
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform 3
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU450474.1 and BI771662.1. On Jun 2, 2019 this sequence version replaced NM_001318237.1. Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI771662.1, BY796807.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
ATGTCATCTG GGGACCTGGA GAATGATGAG CAGGCAGCCA GTGCCATCTC TGAGCTGGTC 
AGCACAGCCT GCGGTTTCCG GCTGCACCGC GGCATGAATG TGCCCTTCAA GCGCCTGTCT 
GTGGTCTTTG GAGAACACAC ACTGCTGGTG ACGGTGTCAG GACAGAGGGT GTTTGTGGTG 
AAGAGGCAGA ACCGAGGTCG GGAGCCCATT GATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305166.1
CDS56..274
Translation

Target ORF information:

RefSeq Version NM_001318237.2
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318237.2

ORF Insert Sequence:

1
61
121
181
ATGTCATCTG GGGACCTGGA GAATGATGAG CAGGCAGCCA GTGCCATCTC TGAGCTGGTC 
AGCACAGCCT GCGGTTTCCG GCTGCACCGC GGCATGAATG TGCCCTTCAA GCGCCTGTCT 
GTGGTCTTTG GAGAACACAC ACTGCTGGTG ACGGTGTCAG GACAGAGGGT GTTTGTGGTG 
AAGAGGCAGA ACCGAGGTCG GGAGCCCATT GATGTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu97247
Clone ID Related Accession (Same CDS sequence) XM_017012199.1 , NM_001318236.2 , NM_001318236.1 , XM_024446761.1
Accession Version NM_001318236.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 249bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2020-01-04
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform 2
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU450474.1, BG706819.1 and AA772120.1. On Jun 2, 2019 this sequence version replaced NM_001318236.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which introduces a frameshift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BU602608.1, DRR138524.848061.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGGTGTGTCT CTCCTCCAGT GGTCTTTGGA GAACACACAC 
TGCTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305165.1
CDS56..304
Translation

Target ORF information:

RefSeq Version NM_001318236.2
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318236.2

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGGTGTGTCT CTCCTCCAGT GGTCTTTGGA GAACACACAC 
TGCTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu97247
Clone ID Related Accession (Same CDS sequence) XM_017012199.1 , NM_001318236.2 , NM_001318236.1 , XM_024446761.1
Accession Version NM_001318236.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 249bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-24
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform 2
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CU450474.1, BG706819.1 and AA772120.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which introduces a frameshift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BU602608.1, DB562023.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGGTGTGTCT CTCCTCCAGT GGTCTTTGGA GAACACACAC 
TGCTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001305165.1
CDS75..323
Translation

Target ORF information:

RefSeq Version NM_001318236.1
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001318236.1

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGGTGTGTCT CTCCTCCAGT GGTCTTTGGA GAACACACAC 
TGCTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu97247
Clone ID Related Accession (Same CDS sequence) XM_017012199.1 , NM_001318236.2 , NM_001318236.1 , XM_024446761.1
Accession Version XM_017012199.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 249bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGGTGTGTCT CTCCTCCAGT GGTCTTTGGA GAACACACAC 
TGCTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016867688.1
CDS462..710
Translation

Target ORF information:

RefSeq Version XM_017012199.1
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017012199.1

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGGTGTGTCT CTCCTCCAGT GGTCTTTGGA GAACACACAC 
TGCTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu97247
Clone ID Related Accession (Same CDS sequence) XM_017012199.1 , NM_001318236.2 , NM_001318236.1 , XM_024446761.1
Accession Version XM_024446761.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 249bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product ragulator complex protein LAMTOR4 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGGTGTGTCT CTCCTCCAGT GGTCTTTGGA GAACACACAC 
TGCTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_024302529.1
CDS388..636
Translation

Target ORF information:

RefSeq Version XM_024446761.1
Organism Homo sapiens(human)
Definition Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 (LAMTOR4), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_024446761.1

ORF Insert Sequence:

1
61
121
181
241
ATGACTTCTG CGCTGACCCA GGGGCTGGAG CGAATCCCAG ACCAGCTCGG CTACCTGGTA 
CTGAGTGAAG GTGCAGTGCT GGCGTCATCT GGGGACCTGG AGAATGATGA GCAGGCAGCC 
AGTGCCATCT CTGAGCTGGT CAGCACAGCC TGCGGTTTCC GGCTGCACCG CGGCATGAAT 
GTGCCCTTCA AGCGCCTGTC TGGTGTGTCT CTCCTCCAGT GGTCTTTGGA GAACACACAC 
TGCTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Nature519(7544)477-81(2015 Mar)
Rebsamen M,Pochini L,Stasyk T,de Ara?jo ME,Galluccio M,Kandasamy RK,Snijder B,Fauster A,Rudashevskaya EL,Bruckner M,Scorzoni S,Filipek PA,Huber KV,Bigenzahn JW,Heinz LX,Kraft C,Bennett KL,Indiveri C,Huber LA,Superti-Furga G


book

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Science (New York, N.Y.)347(6218)188-94(2015 Jan)
Wang S,Tsun ZY,Wolfson RL,Shen K,Wyant GA,Plovanich ME,Yuan ED,Jones TD,Chantranupong L,Comb W,Wang T,Bar-Peled L,Zoncu R,Straub C,Kim C,Park J,Sabatini BL,Sabatini DM


book

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Skeletal muscle3(1)3(2013 Feb)
Blandin G,Marchand S,Charton K,Dani?le N,Gicquel E,Boucheteil JB,Bentaib A,Barrault L,Stockholm D,Bartoli M,Richard I


book

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Cell150(6)1196-208(2012 Sep)
Bar-Peled L,Schweitzer LD,Zoncu R,Sabatini DM