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LPL cDNA ORF clone, Homo sapiens(Human)

Gene Symbol LPL
Entrez Gene ID 4023
Full Name lipoprotein lipase
Synonyms HDLCQ11,LIPD
General protein information
Preferred Names

lipoprotein lipase

Names

lipoprotein lipase

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

8

8p21.3

Summary LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008].
Disorder MIM:

609708

Disorder Html: Lipoprotein lipase deficiency, 238600 (3); Combined hyperlipidemia,

mRNA and Protein(s)

mRNA Protein Name
NM_000237.2 NP_000228.1 lipoprotein lipase precursor



Homo sapiens (human) LPL NP_000228.1
Mus musculus (house mouse) Lpl NP_032535.2
Gallus gallus (chicken) LPL NP_990613.1
Danio rerio (zebrafish) LOC101884800 XP_005174466.1
Pan troglodytes (chimpanzee) LPL XP_001149804.1
Danio rerio (zebrafish) lpl NP_571202.1
Bos taurus (cattle) LPL NP_001068588.1
Xenopus tropicalis (tropical clawed frog) lpl XP_002934038.1
Canis lupus familiaris (dog) LPL XP_005635791.1
Rattus norvegicus (Norway rat) Lpl NP_036730.1


Related articles in PubMed

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S,
JAMA317(9)937-946(2017 03)

Lipoprotein lipase and phospholipid transfer protein overexpression in human glioma cells and their effect on cell growth, apoptosis, and migration.
Dong W, Gong H, Zhang G, Vuletic S, Albers J, Zhang J, Liang H, Sui Y, Zheng J
Acta biochimica et biophysica Sinica49(1)62-73(2017 Jan)

Lipoprotein lipase does not increase significantly in the postprandial plasma.
Ishiyama N, Sakamaki K, Shimomura Y, Kotani K, Tsuzaki K, Sakane N, Miyashita K, Fukamachi I, Kobayashi J, Stanhope KL, Havel PJ, Kamachi K, Tanaka A, Tokita Y, Machida T, Murakami M, Nakajima K
Clinica chimica acta; international journal of clinical chemistry464204-210(2017 Jan)

Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia.
Pingitore P, Lepore SM, Pirazzi C, Mancina RM, Motta BM, Valenti L, Berge KE, Retterstøl K, Leren TP, Wiklund O, Romeo S
Journal of clinical lipidology10(4)816-823(2016 Jul-Aug)

Gene Polymorphisms Affect the Effectiveness of Atorvastatin in Treating Ischemic Stroke Patients.
Yue YH, Bai XD, Zhang HJ, Li YM, Hu L, Liu LY, Mao JP, Yang XY, Dila NM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(2)630-8(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LPL and PLTP appear to be novel glioma-associated proteins and play a role in the progression of human glioma
Title: Lipoprotein lipase and phospholipid transfer protein overexpression in human glioma cells and their effect on cell growth, apoptosis, and migration.

Loss of Lipoprotein Lipase is associated with Pancreatitis.
Title: Long-Term Retrospective Analysis of Gene Therapy with Alipogene Tiparvovec and Its Effect on Lipoprotein Lipase Deficiency-Induced Pancreatitis.

The binding of both antibody 88B8 and GPIHBP1 to LPL depends on large segments of LPL's carboxyl-terminal domain.
Title: An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1.

S447X polymorphism is associated with postprandial triacylglycerol and glucose.
Title: Impact of Lipoprotein Lipase Gene Polymorphism, S447X, on Postprandial Triacylglycerol and Glucose Response to Sequential Meal Ingestion.

It can be suggested that the pronounced hypolipidemic effect of rosuvastatin in homozygotes +495GG of the LPL gene is associated with modulation of the LPL activity, as it has been previously reported for other statin drugs.
Title: [ESTIMATING THE EFFECTIVENESS OF HYPOLIPIDEMIC THERAPY WITH ROSUVASTATIN IN PATIENTS WITH CORONARY HEART DISEASE DEPENDING ON THE GENOTYPE OF LIPOPROTEIN LIPASE].

The following LPL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LPL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25014 NM_000237.2
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Homo sapiens lipoprotein lipase (LPL), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25014
Clone ID Related Accession (Same CDS sequence) NM_000237.2
Accession Version NM_000237.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1428bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product lipoprotein lipase precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA485210.1, M15856.1 and AC100802.2. This sequence is a reference standard in the RefSeqGene project. On Apr 13, 2007 this sequence version replaced NM_000237.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.54932.1, SRR1803614.109542.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGAGAGCA AAGCCCTGCT CGTGCTGACT CTGGCCGTGT GGCTCCAGAG TCTGACCGCC 
TCCCGCGGAG GGGTGGCCGC CGCCGACCAA AGAAGAGATT TTATCGACAT CGAAAGTAAA
TTTGCCCTAA GGACCCCTGA AGACACAGCT GAGGACACTT GCCACCTCAT TCCCGGAGTA
GCAGAGTCCG TGGCTACCTG TCATTTCAAT CACAGCAGCA AAACCTTCAT GGTGATCCAT
GGCTGGACGG TAACAGGAAT GTATGAGAGT TGGGTGCCAA AACTTGTGGC CGCCCTGTAC
AAGAGAGAAC CAGACTCCAA TGTCATTGTG GTGGACTGGC TGTCACGGGC TCAGGAGCAT
TACCCAGTGT CCGCGGGCTA CACCAAACTG GTGGGACAGG ATGTGGCCCG GTTTATCAAC
TGGATGGAGG AGGAGTTTAA CTACCCTCTG GACAATGTCC ATCTCTTGGG ATACAGCCTT
GGAGCCCATG CTGCTGGCAT TGCAGGAAGT CTGACCAATA AGAAAGTCAA CAGAATTACT
GGCCTCGATC CAGCTGGACC TAACTTTGAG TATGCAGAAG CCCCGAGTCG TCTTTCTCCT
GATGATGCAG ATTTTGTAGA CGTCTTACAC ACATTCACCA GAGGGTCCCC TGGTCGAAGC
ATTGGAATCC AGAAACCAGT TGGGCATGTT GACATTTACC CGAATGGAGG TACTTTTCAG
CCAGGATGTA ACATTGGAGA AGCTATCCGC GTGATTGCAG AGAGAGGACT TGGAGATGTG
GACCAGCTAG TGAAGTGCTC CCACGAGCGC TCCATTCATC TCTTCATCGA CTCTCTGTTG
AATGAAGAAA ATCCAAGTAA GGCCTACAGG TGCAGTTCCA AGGAAGCCTT TGAGAAAGGG
CTCTGCTTGA GTTGTAGAAA GAACCGCTGC AACAATCTGG GCTATGAGAT CAATAAAGTC
AGAGCCAAAA GAAGCAGCAA AATGTACCTG AAGACTCGTT CTCAGATGCC CTACAAAGTC
TTCCATTACC AAGTAAAGAT TCATTTTTCT GGGACTGAGA GTGAAACCCA TACCAATCAG
GCCTTTGAGA TTTCTCTGTA TGGCACCGTG GCCGAGAGTG AGAACATCCC ATTCACTCTG
CCTGAAGTTT CCACAAATAA GACCTACTCC TTCCTAATTT ACACAGAGGT AGATATTGGA
GAACTACTCA TGTTGAAGCT CAAATGGAAG AGTGATTCAT ACTTTAGCTG GTCAGACTGG
TGGAGCAGTC CCGGCTTCGC CATTCAGAAG ATCAGAGTAA AAGCAGGAGA GACTCAGAAA
AAGGTGATCT TCTGTTCTAG GGAGAAAGTG TCTCATTTGC AGAAAGGAAA GGCACCTGCG
GTATTTGTGA AATGCCATGA CAAGTCTCTG AATAAGAAGT CAGGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000228.1
CDS371..1798
Misc Feature(1)173..175
Misc Feature(2)467..1789
Misc Feature(3)479..1372
Misc Feature(4)731..733
Misc Feature(5)839..853
Misc Feature(6)order(845..847,917..919,1172..1174)
Misc Feature(7)941..943
Misc Feature(8)order(1097..1102,1163..1168)
Misc Feature(9)1391..1765
Misc Feature(10)1397..1399
Misc Feature(11)1406..1693
Exon (1)1..458
Exon (2)459..619
Exon (3)620..799
Exon (4)800..911
Exon (5)912..1145
Exon (6)1146..1388
Exon (7)1389..1509
Exon (8)1510..1692
Exon (9)1693..1797
Exon (10)1798..3747
Translation

Target ORF information:

RefSeq Version NM_000237.2
Organism Homo sapiens(Human)
Definition Homo sapiens lipoprotein lipase (LPL), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000237.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGAGAGCA AAGCCCTGCT CGTGCTGACT CTGGCCGTGT GGCTCCAGAG TCTGACCGCC 
TCCCGCGGAG GGGTGGCCGC CGCCGACCAA AGAAGAGATT TTATCGACAT CGAAAGTAAA
TTTGCCCTAA GGACCCCTGA AGACACAGCT GAGGACACTT GCCACCTCAT TCCCGGAGTA
GCAGAGTCCG TGGCTACCTG TCATTTCAAT CACAGCAGCA AAACCTTCAT GGTGATCCAT
GGCTGGACGG TAACAGGAAT GTATGAGAGT TGGGTGCCAA AACTTGTGGC CGCCCTGTAC
AAGAGAGAAC CAGACTCCAA TGTCATTGTG GTGGACTGGC TGTCACGGGC TCAGGAGCAT
TACCCAGTGT CCGCGGGCTA CACCAAACTG GTGGGACAGG ATGTGGCCCG GTTTATCAAC
TGGATGGAGG AGGAGTTTAA CTACCCTCTG GACAATGTCC ATCTCTTGGG ATACAGCCTT
GGAGCCCATG CTGCTGGCAT TGCAGGAAGT CTGACCAATA AGAAAGTCAA CAGAATTACT
GGCCTCGATC CAGCTGGACC TAACTTTGAG TATGCAGAAG CCCCGAGTCG TCTTTCTCCT
GATGATGCAG ATTTTGTAGA CGTCTTACAC ACATTCACCA GAGGGTCCCC TGGTCGAAGC
ATTGGAATCC AGAAACCAGT TGGGCATGTT GACATTTACC CGAATGGAGG TACTTTTCAG
CCAGGATGTA ACATTGGAGA AGCTATCCGC GTGATTGCAG AGAGAGGACT TGGAGATGTG
GACCAGCTAG TGAAGTGCTC CCACGAGCGC TCCATTCATC TCTTCATCGA CTCTCTGTTG
AATGAAGAAA ATCCAAGTAA GGCCTACAGG TGCAGTTCCA AGGAAGCCTT TGAGAAAGGG
CTCTGCTTGA GTTGTAGAAA GAACCGCTGC AACAATCTGG GCTATGAGAT CAATAAAGTC
AGAGCCAAAA GAAGCAGCAA AATGTACCTG AAGACTCGTT CTCAGATGCC CTACAAAGTC
TTCCATTACC AAGTAAAGAT TCATTTTTCT GGGACTGAGA GTGAAACCCA TACCAATCAG
GCCTTTGAGA TTTCTCTGTA TGGCACCGTG GCCGAGAGTG AGAACATCCC ATTCACTCTG
CCTGAAGTTT CCACAAATAA GACCTACTCC TTCCTAATTT ACACAGAGGT AGATATTGGA
GAACTACTCA TGTTGAAGCT CAAATGGAAG AGTGATTCAT ACTTTAGCTG GTCAGACTGG
TGGAGCAGTC CCGGCTTCGC CATTCAGAAG ATCAGAGTAA AAGCAGGAGA GACTCAGAAA
AAGGTGATCT TCTGTTCTAG GGAGAAAGTG TCTCATTTGC AGAAAGGAAA GGCACCTGCG
GTATTTGTGA AATGCCATGA CAAGTCTCTG AATAAGAAGT CAGGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
JAMA317(9)937-946(2017 03)
Khera AV,Won HH,Peloso GM,O'Dushlaine C,Liu D,Stitziel NO,Natarajan P,Nomura A,Emdin CA,Gupta N,Borecki IB,Asselta R,Duga S,Merlini PA,Correa A,Kessler T,Wilson JG,Bown MJ,Hall AS,Braund PS,Carey DJ,Murray MF,Kirchner HL,Leader JB,Lavage DR,Manus JN,Hartzel DN,Samani NJ,Schunkert H,Marrugat J,Elosua R,McPherson R,Farrall M,Watkins H,Lander ES,Rader DJ,Danesh J,Ardissino D,Gabriel S,Willer C,Abecasis GR,Saleheen D,Dewey FE,Kathiresan S,


book

Lipoprotein lipase and phospholipid transfer protein overexpression in human glioma cells and their effect on cell growth, apoptosis, and migration.
Acta biochimica et biophysica Sinica49(1)62-73(2017 Jan)
Dong W,Gong H,Zhang G,Vuletic S,Albers J,Zhang J,Liang H,Sui Y,Zheng J


book

Lipoprotein lipase does not increase significantly in the postprandial plasma.
Clinica chimica acta; international journal of clinical chemistry464204-210(2017 Jan)
Ishiyama N,Sakamaki K,Shimomura Y,Kotani K,Tsuzaki K,Sakane N,Miyashita K,Fukamachi I,Kobayashi J,Stanhope KL,Havel PJ,Kamachi K,Tanaka A,Tokita Y,Machida T,Murakami M,Nakajima K


book

Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia.
Journal of clinical lipidology10(4)816-823(2016 Jul-Aug)
Pingitore P,Lepore SM,Pirazzi C,Mancina RM,Motta BM,Valenti L,Berge KE,Retterstøl K,Leren TP,Wiklund O,Romeo S


book

Gene Polymorphisms Affect the Effectiveness of Atorvastatin in Treating Ischemic Stroke Patients.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(2)630-8(2016)
Yue YH,Bai XD,Zhang HJ,Li YM,Hu L,Liu LY,Mao JP,Yang XY,Dila NM


 
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