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MAB21L1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAB21L1
Entrez Gene ID 4081
Full Name mab-21-like 1 (C. elegans)
Synonyms CAGR1, Nbla00126
General protein information
Preferred Names
protein mab-21-like 1
Names
protein mab-21-like 1
mab-21-like protein 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q13

Summary This gene is similar to the MAB-21 cell fate-determining gene found in C. elegans. It may be involved in eye and cerebellum development, and it has been proposed that expansion of a trinucleotide repeat region in the 5' UTR may play a role in a variety of psychiatric disorders. [provided by RefSeq, Oct 2008]. lac of sum
Disorder MIM:

601280


mRNA and Protein(s)

mRNA Protein Name
NM_005584 NP_005575 protein mab-21-like 1


Homo sapiens (human) MAB21L1 NP_005575.1
Pan troglodytes (chimpanzee) MAB21L1 XP_522656.2
Macaca mulatta (Rhesus monkey) MAB21L1 XP_001102683.1
Canis lupus familiaris (dog) MAB21L1 XP_543137.1
Bos taurus (cattle) MAB21L1 NP_001091579.1
Mus musculus (house mouse) Mab21l1 NP_034880.1
Rattus norvegicus (Norway rat) Mab21l1 NP_001102967.1
Gallus gallus (chicken) MAB21L1 NP_989864.1
Danio rerio (zebrafish) mab21l1 NP_694506.2
Drosophila melanogaster (fruit fly) mab-21 NP_651971.2
Caenorhabditis elegans mab-21 NP_497940.2
Xenopus (Silurana) tropicalis (western clawed frog) mab21l1 NP_001072797.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAB21L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAB21L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu22840
NM_005584 Homo sapiens mab-21-like 1 (C. elegans) (MAB21L1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22840
Clone ID Related Accession (Same CDS sequence) NM_005584
Accession Version NM_005584.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1080bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 10-MAY-2014
Organism Homo sapiens (human)
Product protein mab-21-like 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA611205.1, AK313185.1 and AL390071.9. This sequence is a reference standard in the RefSeqGene project. On Mar 25, 2010 this sequence version replaced gi:209571544. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGATTGCGG CCCAGGCCAA GCTGGTCTAC CATCTGAATA AATACTACAA CGAAAAATGC 
CAAGCCAGGA AAGCTGCCAT TGCCAAAACT ATCCGGGAAG TCTGCAAAGT AGTTTCCGAC
GTACTGAAGG AAGTGGAAGT GCAGGAGCCG CGGTTCATCA GCTCTCTCAA CGAGATGGAC
AATCGCTACG AGGGCCTCGA GGTCATCTCC CCCACCGAAT TTGAAGTGGT GCTTTATCTC
AACCAAATGG GGGTGTTCAA CTTCGTGGAC GATGGCTCAC TGCCCGGCTG CGCGGTGCTG
AAGTTGAGCG ACGGGCGCAA GAGGAGCATG TCCCTCTGGG TGGAATTCAT TACCGCCTCC
GGCTACCTCT CGGCGCGCAA AATCCGGTCC AGGTTTCAGA CGCTGGTGGC TCAAGCGGTA
GACAAATGTA GCTACCGGGA TGTGGTAAAG ATGGTGGCAG ACACCAGCGA AGTGAAACTG
AGAATCCGAG ATAGGTACGT GGTGCAGATC ACGCCGGCCT TTAAATGCAC CGGGATCTGG
CCGAGGAGTG CTGCCCACTG GCCACTTCCC CACATCCCCT GGCCGGGACC CAACCGGGTG
GCGGAGGTCA AGGCGGAAGG TTTCAATCTC TTGTCCAAGG AGTGCCACTC CTTGGCCGGC
AAGCAGAGCT CGGCGGAGAG CGACGCCTGG GTGCTGCAGT TCGCGGAGGC AGAGAACAGA
CTGCAGATGG GGGGCTGCAG AAAGAAGTGC CTCTCCATCC TCAAAACCTT AAGGGATCGT
CACCTTGAAC TGCCGGGCCA GCCCTTGAAC AATTACCATA TGAAGACTCT GGTTTCCTAC
GAGTGTGAAA AGCATCCCCG AGAGTCGGAC TGGGACGAGT CTTGCCTGGG TGATCGGCTG
AACGGGATTT TGCTGCAACT TATCTCCTGC CTGCAGTGCC GGCGGTGTCC CCACTACTTT
CTACCGAACT TAGATCTGTT TCAAGGCAAA CCTCACTCAG CTCTGGAAAA CGCTGCCAAA
CAAACGTGGC GACTGGCAAG AGAGATCCTG ACCAACCCGA AAAGTTTGGA AAAACTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005575.1
CDS558..1637
Misc Feature(1)447..449(+)
Misc Feature(2)741..1598(+)
Exon (1)1..2907
Gene:MAB21L1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005584
Organism Homo sapiens (human)
Definition Homo sapiens mab-21-like 1 (C. elegans) (MAB21L1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005584

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGATTGCGG CCCAGGCCAA GCTGGTCTAC CATCTGAATA AATACTACAA CGAAAAATGC 
CAAGCCAGGA AAGCTGCCAT TGCCAAAACT ATCCGGGAAG TCTGCAAAGT AGTTTCCGAC
GTACTGAAGG AAGTGGAAGT GCAGGAGCCG CGGTTCATCA GCTCTCTCAA CGAGATGGAC
AATCGCTACG AGGGCCTCGA GGTCATCTCC CCCACCGAAT TTGAAGTGGT GCTTTATCTC
AACCAAATGG GGGTGTTCAA CTTCGTGGAC GATGGCTCAC TGCCCGGCTG CGCGGTGCTG
AAGTTGAGCG ACGGGCGCAA GAGGAGCATG TCCCTCTGGG TGGAATTCAT TACCGCCTCC
GGCTACCTCT CGGCGCGCAA AATCCGGTCC AGGTTTCAGA CGCTGGTGGC TCAAGCGGTA
GACAAATGTA GCTACCGGGA TGTGGTAAAG ATGGTGGCAG ACACCAGCGA AGTGAAACTG
AGAATCCGAG ATAGGTACGT GGTGCAGATC ACGCCGGCCT TTAAATGCAC CGGGATCTGG
CCGAGGAGTG CTGCCCACTG GCCACTTCCC CACATCCCCT GGCCGGGACC CAACCGGGTG
GCGGAGGTCA AGGCGGAAGG TTTCAATCTC TTGTCCAAGG AGTGCCACTC CTTGGCCGGC
AAGCAGAGCT CGGCGGAGAG CGACGCCTGG GTGCTGCAGT TCGCGGAGGC AGAGAACAGA
CTGCAGATGG GGGGCTGCAG AAAGAAGTGC CTCTCCATCC TCAAAACCTT AAGGGATCGT
CACCTTGAAC TGCCGGGCCA GCCCTTGAAC AATTACCATA TGAAGACTCT GGTTTCCTAC
GAGTGTGAAA AGCATCCCCG AGAGTCGGAC TGGGACGAGT CTTGCCTGGG TGATCGGCTG
AACGGGATTT TGCTGCAACT TATCTCCTGC CTGCAGTGCC GGCGGTGTCC CCACTACTTT
CTACCGAACT TAGATCTGTT TCAAGGCAAA CCTCACTCAG CTCTGGAAAA CGCTGCCAAA
CAAACGTGGC GACTGGCAAG AGAGATCCTG ACCAACCCGA AAAGTTTGGA AAAACTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method
Invest. Ophthalmol. Vis. Sci. 52 (9), 6662-6670 (2011)
Oshikawa M, Tsutsui C, Ikegami T, Fuchida Y, Matsubara M, Toyama S, Usami R, Ohtoko K and Kato S.


book

PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway
J. Cell. Biochem. 112 (8), 2051-2061 (2011)
Kim BG, Park YJ, Libermann TA and Cho JY.


book

Molecular genetic delineation of a deletion of chromosome 13q12-->q13 in a patient with autism and auditory processing deficits
Cytogenet. Genome Res. 98 (4), 233-239 (2002)
Smith M, Woodroffe A, Smith R, Holguin S, Martinez J, Filipek PA, Modahl C, Moore B, Bocian ME, Mays L, Laulhere T, Flodman P and Spence MA.


book

Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3
Mol. Psychiatry 6 (5), 565-569 (2001)
Meira-Lima IV, Zhao J, Sham P, Pereira AC, Krieger JE and Vallada H.


book

Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development
Hum. Mol. Genet. 8 (13), 2397-2406 (1999)
Mariani M, Baldessari D, Francisconi S, Viggiano L, Rocchi M, Zappavigna V, Malgaretti N and Consalez GG.


book

Unstable expansion of the CAG trinucleotide repeat in MAB21L1: report of a second pedigree and effect on protein expression
J. Med. Genet. 36 (1), 62-64 (1999)
Margolis RL, Stine OC, Ward CM, Franz ML, Rosenblatt A, Callahan C, Sherr M, Ross CA and Potter NT.


book

cDNA cloning of a human homologue of the Caenorhabditis elegans cell fate-determining gene mab-21: expression, chromosomal localization and analysis of a highly polymorphic (CAG)n trinucleotide repeat
Hum. Mol. Genet. 5 (5), 607-616 (1996)
Margolis RL, Stine OC, McInnis MG, Ranen NG, Rubinsztein DC, Leggo J, Brando LV, Kidwai AS, Loev SJ, Breschel TS, Callahan C, Simpson SG, DePaulo JR, McMahon FJ, Jain S, Paykel ES, Walsh C, DeLisi LE, Crow TJ, Torrey EF, Ashworth RG, Macke JP, Nathans J and Ross CA.


 
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