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MAG cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MAG
Entrez Gene ID 4099
Full Name myelin associated glycoprotein
Synonyms GMA,S-MAG,SIGLEC-4A,SIGLEC4A,SPG75
General protein information
Preferred Names

myelin associated glycoprotein

Names

myelin-associated glycoprotein
sialic acid binding Ig-like lectin 4A
sialic acid-binding immunoglobulin-like lectin 4A

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

19

19q13.12

Summary The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010].
Disorder MIM:

159460


mRNA and Protein(s)

mRNA Protein Name
NM_001199216.1 NP_001186145.1 myelin-associated glycoprotein isoform c
NM_080600.2 NP_542167.1 myelin-associated glycoprotein isoform b precursor
NM_002361.3 NP_002352.1 myelin-associated glycoprotein isoform a precursor



Rattus norvegicus (Norway rat) Mag NP_058886.1
Xenopus tropicalis (tropical clawed frog) mag XP_002943135.1
Bos taurus (cattle) MAG NP_001035660.2
Danio rerio (zebrafish) mag NP_001007063.1
Macaca mulatta (rhesus monkey) MAG XP_001111459.2
Homo sapiens (human) MAG NP_002352.1
Mus musculus (house mouse) Mag NP_034888.1
Canis lupus familiaris (dog) MAG XP_005616772.1


Related articles in PubMed

Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.
Lossos A, Elazar N, Lerer I, Schueler-Furman O, Fellig Y, Glick B, Zimmerman BE, Azulay H, Dotan S, Goldberg S, Gomori JM, Ponger P, Newman JP, Marreed H, Steck AJ, Schaeren-Wiemers N, Mor N, Harel M, Geiger T, Eshed-Eisenbach Y, Meiner V, Peles E
Brain : a journal of neurology138(Pt 9)2521-36(2015 Sep)

Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies.
Magy L, Kaboré R, Mathis S, Lebeau P, Ghorab K, Caudie C, Vallat JM
Journal of immunology research2015450391(2015)

LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
Mantuano E, Lam MS, Gonias SL
The Journal of biological chemistry288(47)34009-18(2013 Nov)

The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children.
Mostafa GA, Al-Ayadhi LY
Journal of neuroimmunology261(1-2)77-81(2013 Aug)

An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease.
Kinter J, Lazzati T, Schmid D, Zeis T, Erne B, Lützelschwab R, Steck AJ, Pareyson D, Peles E, Schaeren-Wiemers N
Neurobiology of disease49221-31(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study identify involvement of myelin-associated glycoprotein in this family with a disorder affecting the central and peripheral nervous system, and suggest that loss of the protein function is responsible for the unique clinical phenotype
Title: Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.

polyneuropathy associated with anti-MAG antibodies is less homogeneous.
Title: Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies.

LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
Title: LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.

Increased serum levels of MAG (and MBP) were found in autistic patients with allergic manifestations compared to those without these manifestations.
Title: The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children.

Results show that MAG is important for axon-glia contact in a model for Charcot-Marie-Tooth disease type 1A, and suggest that its increased expression in patients has a compensatory role in the disease pathology
Title: An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease.

The following MAG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu13781
NM_001199216.1
Latest version!
Homo sapiens myelin associated glycoprotein (MAG), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00
OHu13785
NM_002361.3
Latest version!
Homo sapiens myelin associated glycoprotein (MAG), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$204.50-$286.30
$409.00
OHu19652 NM_080600.2
Latest version!
Homo sapiens myelin associated glycoprotein (MAG), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00

ORF Online Only Promotion

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2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu13781
Clone ID Related Accession (Same CDS sequence) NM_001199216.1
Accession Version NM_001199216.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1806bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product myelin-associated glycoprotein isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC331168.1, AK308976.1 and BC093045.1. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294644.1, AK308976.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGCCCTCGT CCATCTCGGC CTTCGAAGGC ACGTGCGTCT CCATCCCCTG CCGCTTTGAC 
TTCCCGGATG AGCTGCGGCC CGCTGTGGTG CATGGTGTCT GGTACTTCAA TAGCCCCTAC
CCCAAGAACT ACCCCCCGGT GGTCTTCAAG TCGCGCACCC AAGTAGTCCA CGAGAGCTTC
CAGGGCCGCA GCCGCCTCCT GGGGGACCTG GGCCTGCGAA ACTGCACCCT CCTGCTCAGC
AACGTCAGCC CCGAGCTGGG CGGGAAGTAC TACTTCCGTG GGGACCTGGG CGGCTACAAC
CAGTACACCT TCTCAGAGCA CAGCGTCCTG GATATCGTCA ACACCCCCAA CATCGTGGTG
CCCCCAGAGG TGGTGGCAGG CACGGAGGTG GAGGTCAGCT GCATGGTGCC GGACAACTGC
CCAGAGCTGC GCCCTGAGCT GAGCTGGCTG GGCCACGAGG GGCTGGGGGA GCCCGCTGTG
CTGGGCCGGC TGCGGGAGGA CGAGGGCACC TGGGTGCAGG TGTCACTGCT GCACTTCGTG
CCCACGAGGG AGGCCAACGG CCACAGGCTG GGCTGCCAGG CCTCCTTCCC CAACACCACC
CTGCAGTTCG AGGGCTACGC CAGCATGGAC GTCAAGTACC CCCCGGTGAT TGTGGAGATG
AACTCCTCGG TGGAGGCCAT CGAGGGCTCC CACGTGAGCC TGCTCTGTGG GGCTGACAGC
AACCCCCCGC CGCTGCTGAC CTGGATGCGG GACGGGACAG TCCTCCGGGA GGCGGTGGCC
GAGAGCCTGC TCCTGGAGCT GGAGGAGGTG ACCCCCGCCG AAGACGGCGT CTATGCCTGC
CTGGCCGAGA ATGCCTATGG CCAGGACAAC CGCACCGTGG GGCTCAGTGT CATGTATGCA
CCCTGGAAGC CAACAGTGAA CGGGACAATG GTGGCCGTAG AGGGGGAGAC GGTCTCTATC
TTGTGCTCCA CACAGAGCAA CCCGGACCCT ATTCTCACCA TCTTCAAGGA GAAGCAGATC
CTGTCCACGG TCATCTACGA GAGCGAGCTG CAGCTGGAGC TGCCGGCCGT GTCACCCGAG
GATGATGGAG AGTACTGGTG TGTGGCTGAG AACCAGTATG GCCAGAGGGC CACCGCCTTC
AACCTGTCTG TGGAGTTCGC CCCTGTGCTC CTCCTGGAGT CCCACTGCGC GGCAGCCCGA
GACACGGTGC AGTGCCTGTG CGTGGTGAAG TCCAACCCGG AGCCGTCCGT GGCCTTTGAG
CTGCCATCGC GCAATGTGAC CGTGAACGAG AGCGAGCGGG AGTTCGTGTA CTCGGAGCGC
AGCGGCCTCG TGCTCACCAG CATCCTCACG CTGCGGGGGC AGGCCCAGGC CCCGCCCCGC
GTCATCTGCA CCGCGAGGAA CCTCTATGGC GCCAAGAGCC TGGAGCTGCC CTTCCAGGGA
GCCCATCGAC TGATGTGGGC CAAGATCGGG CCTGTGGGCG CCGTGGTCGC CTTTGCCATC
CTGATTGCCA TCGTCTGCTA CATTACCCAG ACACGCAGGA AAAAGAACGT GACAGAGAGC
CCCAGCTTCT CGGCAGGGGA CAACCCTCCC GTCCTGTTCA GCAGCGACTT CCGCATCTCT
GGGGCACCAG AGAAGTACGA GAGCGAGAGG CGCCTGGGAT CTGAGAGGAG GCTGCTGGGC
CTTCGGGGTG AGCCCCCAGA GCTGGACCTG AGCTATTCTC ACTCGGACCT GGGGAAACGG
CCCACCAAGG ACAGCTACAC GCTGACGGAG GAGCTAGCTG AGTATGCTGA AATCCGGGTC
AAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001186145.1
CDS261..2066
Misc Feature(1)177..179
Misc Feature(2)261..602
Misc Feature(3)264..>533
Misc Feature(4)order(537..539,564..569)
Misc Feature(5)606..854
Misc Feature(6)903..1151
Misc Feature(7)942..1121
Misc Feature(8)1182..1412
Misc Feature(9)1200..1382
Exon (1)1..119
Exon (2)120..175
Exon (3)176..231
Exon (4)232..600
Exon (5)601..897
Exon (6)898..1155
Exon (7)1156..1416
Exon (8)1417..1704
Exon (9)1705..1801
Exon (10)1802..1901
Exon (11)1902..2419
Translation

Target ORF information:

RefSeq Version NM_001199216.1
Organism Homo sapiens(Human)
Definition Homo sapiens myelin associated glycoprotein (MAG), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001199216.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGCCCTCGT CCATCTCGGC CTTCGAAGGC ACGTGCGTCT CCATCCCCTG CCGCTTTGAC 
TTCCCGGATG AGCTGCGGCC CGCTGTGGTG CATGGTGTCT GGTACTTCAA TAGCCCCTAC
CCCAAGAACT ACCCCCCGGT GGTCTTCAAG TCGCGCACCC AAGTAGTCCA CGAGAGCTTC
CAGGGCCGCA GCCGCCTCCT GGGGGACCTG GGCCTGCGAA ACTGCACCCT CCTGCTCAGC
AACGTCAGCC CCGAGCTGGG CGGGAAGTAC TACTTCCGTG GGGACCTGGG CGGCTACAAC
CAGTACACCT TCTCAGAGCA CAGCGTCCTG GATATCGTCA ACACCCCCAA CATCGTGGTG
CCCCCAGAGG TGGTGGCAGG CACGGAGGTG GAGGTCAGCT GCATGGTGCC GGACAACTGC
CCAGAGCTGC GCCCTGAGCT GAGCTGGCTG GGCCACGAGG GGCTGGGGGA GCCCGCTGTG
CTGGGCCGGC TGCGGGAGGA CGAGGGCACC TGGGTGCAGG TGTCACTGCT GCACTTCGTG
CCCACGAGGG AGGCCAACGG CCACAGGCTG GGCTGCCAGG CCTCCTTCCC CAACACCACC
CTGCAGTTCG AGGGCTACGC CAGCATGGAC GTCAAGTACC CCCCGGTGAT TGTGGAGATG
AACTCCTCGG TGGAGGCCAT CGAGGGCTCC CACGTGAGCC TGCTCTGTGG GGCTGACAGC
AACCCCCCGC CGCTGCTGAC CTGGATGCGG GACGGGACAG TCCTCCGGGA GGCGGTGGCC
GAGAGCCTGC TCCTGGAGCT GGAGGAGGTG ACCCCCGCCG AAGACGGCGT CTATGCCTGC
CTGGCCGAGA ATGCCTATGG CCAGGACAAC CGCACCGTGG GGCTCAGTGT CATGTATGCA
CCCTGGAAGC CAACAGTGAA CGGGACAATG GTGGCCGTAG AGGGGGAGAC GGTCTCTATC
TTGTGCTCCA CACAGAGCAA CCCGGACCCT ATTCTCACCA TCTTCAAGGA GAAGCAGATC
CTGTCCACGG TCATCTACGA GAGCGAGCTG CAGCTGGAGC TGCCGGCCGT GTCACCCGAG
GATGATGGAG AGTACTGGTG TGTGGCTGAG AACCAGTATG GCCAGAGGGC CACCGCCTTC
AACCTGTCTG TGGAGTTCGC CCCTGTGCTC CTCCTGGAGT CCCACTGCGC GGCAGCCCGA
GACACGGTGC AGTGCCTGTG CGTGGTGAAG TCCAACCCGG AGCCGTCCGT GGCCTTTGAG
CTGCCATCGC GCAATGTGAC CGTGAACGAG AGCGAGCGGG AGTTCGTGTA CTCGGAGCGC
AGCGGCCTCG TGCTCACCAG CATCCTCACG CTGCGGGGGC AGGCCCAGGC CCCGCCCCGC
GTCATCTGCA CCGCGAGGAA CCTCTATGGC GCCAAGAGCC TGGAGCTGCC CTTCCAGGGA
GCCCATCGAC TGATGTGGGC CAAGATCGGG CCTGTGGGCG CCGTGGTCGC CTTTGCCATC
CTGATTGCCA TCGTCTGCTA CATTACCCAG ACACGCAGGA AAAAGAACGT GACAGAGAGC
CCCAGCTTCT CGGCAGGGGA CAACCCTCCC GTCCTGTTCA GCAGCGACTT CCGCATCTCT
GGGGCACCAG AGAAGTACGA GAGCGAGAGG CGCCTGGGAT CTGAGAGGAG GCTGCTGGGC
CTTCGGGGTG AGCCCCCAGA GCTGGACCTG AGCTATTCTC ACTCGGACCT GGGGAAACGG
CCCACCAAGG ACAGCTACAC GCTGACGGAG GAGCTAGCTG AGTATGCTGA AATCCGGGTC
AAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu13785
Clone ID Related Accession (Same CDS sequence) NM_002361.3
Accession Version NM_002361.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1881bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product myelin-associated glycoprotein isoform a precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC331168.1, AK223562.1 and BC093045.1. On or before Aug 31, 2013 this sequence version replaced XM_005258946.1, NM_002361.2. Transcript Variant: This variant (1) lacks exon 11 and has the stop codon in exon 12, as compared to variant 2. Isoform a is 44 aa longer and contains a different carboxy terminus when compared to isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222649.1, AK223562.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGATATTCC TCACGGCACT GCCTCTGTTC TGGATTATGA TTTCAGCCTC CCGAGGGGGT 
CACTGGGGTG CCTGGATGCC CTCGTCCATC TCGGCCTTCG AAGGCACGTG CGTCTCCATC
CCCTGCCGCT TTGACTTCCC GGATGAGCTG CGGCCCGCTG TGGTGCATGG TGTCTGGTAC
TTCAATAGCC CCTACCCCAA GAACTACCCC CCGGTGGTCT TCAAGTCGCG CACCCAAGTA
GTCCACGAGA GCTTCCAGGG CCGCAGCCGC CTCCTGGGGG ACCTGGGCCT GCGAAACTGC
ACCCTCCTGC TCAGCAACGT CAGCCCCGAG CTGGGCGGGA AGTACTACTT CCGTGGGGAC
CTGGGCGGCT ACAACCAGTA CACCTTCTCA GAGCACAGCG TCCTGGATAT CGTCAACACC
CCCAACATCG TGGTGCCCCC AGAGGTGGTG GCAGGCACGG AGGTGGAGGT CAGCTGCATG
GTGCCGGACA ACTGCCCAGA GCTGCGCCCT GAGCTGAGCT GGCTGGGCCA CGAGGGGCTG
GGGGAGCCCG CTGTGCTGGG CCGGCTGCGG GAGGACGAGG GCACCTGGGT GCAGGTGTCA
CTGCTGCACT TCGTGCCCAC GAGGGAGGCC AACGGCCACA GGCTGGGCTG CCAGGCCTCC
TTCCCCAACA CCACCCTGCA GTTCGAGGGC TACGCCAGCA TGGACGTCAA GTACCCCCCG
GTGATTGTGG AGATGAACTC CTCGGTGGAG GCCATCGAGG GCTCCCACGT GAGCCTGCTC
TGTGGGGCTG ACAGCAACCC CCCGCCGCTG CTGACCTGGA TGCGGGACGG GACAGTCCTC
CGGGAGGCGG TGGCCGAGAG CCTGCTCCTG GAGCTGGAGG AGGTGACCCC CGCCGAAGAC
GGCGTCTATG CCTGCCTGGC CGAGAATGCC TATGGCCAGG ACAACCGCAC CGTGGGGCTC
AGTGTCATGT ATGCACCCTG GAAGCCAACA GTGAACGGGA CAATGGTGGC CGTAGAGGGG
GAGACGGTCT CTATCTTGTG CTCCACACAG AGCAACCCGG ACCCTATTCT CACCATCTTC
AAGGAGAAGC AGATCCTGTC CACGGTCATC TACGAGAGCG AGCTGCAGCT GGAGCTGCCG
GCCGTGTCAC CCGAGGATGA TGGAGAGTAC TGGTGTGTGG CTGAGAACCA GTATGGCCAG
AGGGCCACCG CCTTCAACCT GTCTGTGGAG TTCGCCCCTG TGCTCCTCCT GGAGTCCCAC
TGCGCGGCAG CCCGAGACAC GGTGCAGTGC CTGTGCGTGG TGAAGTCCAA CCCGGAGCCG
TCCGTGGCCT TTGAGCTGCC ATCGCGCAAT GTGACCGTGA ACGAGAGCGA GCGGGAGTTC
GTGTACTCGG AGCGCAGCGG CCTCGTGCTC ACCAGCATCC TCACGCTGCG GGGGCAGGCC
CAGGCCCCGC CCCGCGTCAT CTGCACCGCG AGGAACCTCT ATGGCGCCAA GAGCCTGGAG
CTGCCCTTCC AGGGAGCCCA TCGACTGATG TGGGCCAAGA TCGGGCCTGT GGGCGCCGTG
GTCGCCTTTG CCATCCTGAT TGCCATCGTC TGCTACATTA CCCAGACACG CAGGAAAAAG
AACGTGACAG AGAGCCCCAG CTTCTCGGCA GGGGACAACC CTCCCGTCCT GTTCAGCAGC
GACTTCCGCA TCTCTGGGGC ACCAGAGAAG TACGAGAGCG AGAGGCGCCT GGGATCTGAG
AGGAGGCTGC TGGGCCTTCG GGGTGAGCCC CCAGAGCTGG ACCTGAGCTA TTCTCACTCG
GACCTGGGGA AACGGCCCAC CAAGGACAGC TACACGCTGA CGGAGGAGCT AGCTGAGTAT
GCTGAAATCC GGGTCAAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002352.1
CDS199..2079
Misc Feature(1)256..1173
Misc Feature(2)262..615
Misc Feature(3)277..>546
Misc Feature(4)391..399
Misc Feature(5)493..495
Misc Feature(6)514..516
Misc Feature(7)order(550..552,577..582)
Misc Feature(8)568..582
Misc Feature(9)619..867
Misc Feature(10)865..867
Misc Feature(11)916..1164
Misc Feature(12)934..936
Misc Feature(13)955..1134
Misc Feature(14)1141..1143
Misc Feature(15)1192..1194
Misc Feature(16)1195..1425
Misc Feature(17)1213..1395
Misc Feature(18)1414..1416
Misc Feature(19)1546..1548
Misc Feature(20)1558..1560
Misc Feature(21)1747..1806
Misc Feature(22)1831..1833
Misc Feature(23)1837..1839
Misc Feature(24)1843..1845
Misc Feature(25)1927..2076
Misc Feature(26)2056..2058
Exon (1)1..119
Exon (2)120..175
Exon (3)176..244
Exon (4)245..613
Exon (5)614..910
Exon (6)911..1168
Exon (7)1169..1429
Exon (8)1430..1717
Exon (9)1718..1814
Exon (10)1815..1914
Exon (11)1915..2432
Translation

Target ORF information:

RefSeq Version NM_002361.3
Organism Homo sapiens(Human)
Definition Homo sapiens myelin associated glycoprotein (MAG), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002361.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGATATTCC TCACGGCACT GCCTCTGTTC TGGATTATGA TTTCAGCCTC CCGAGGGGGT 
CACTGGGGTG CCTGGATGCC CTCGTCCATC TCGGCCTTCG AAGGCACGTG CGTCTCCATC
CCCTGCCGCT TTGACTTCCC GGATGAGCTG CGGCCCGCTG TGGTGCATGG TGTCTGGTAC
TTCAATAGCC CCTACCCCAA GAACTACCCC CCGGTGGTCT TCAAGTCGCG CACCCAAGTA
GTCCACGAGA GCTTCCAGGG CCGCAGCCGC CTCCTGGGGG ACCTGGGCCT GCGAAACTGC
ACCCTCCTGC TCAGCAACGT CAGCCCCGAG CTGGGCGGGA AGTACTACTT CCGTGGGGAC
CTGGGCGGCT ACAACCAGTA CACCTTCTCA GAGCACAGCG TCCTGGATAT CGTCAACACC
CCCAACATCG TGGTGCCCCC AGAGGTGGTG GCAGGCACGG AGGTGGAGGT CAGCTGCATG
GTGCCGGACA ACTGCCCAGA GCTGCGCCCT GAGCTGAGCT GGCTGGGCCA CGAGGGGCTG
GGGGAGCCCG CTGTGCTGGG CCGGCTGCGG GAGGACGAGG GCACCTGGGT GCAGGTGTCA
CTGCTGCACT TCGTGCCCAC GAGGGAGGCC AACGGCCACA GGCTGGGCTG CCAGGCCTCC
TTCCCCAACA CCACCCTGCA GTTCGAGGGC TACGCCAGCA TGGACGTCAA GTACCCCCCG
GTGATTGTGG AGATGAACTC CTCGGTGGAG GCCATCGAGG GCTCCCACGT GAGCCTGCTC
TGTGGGGCTG ACAGCAACCC CCCGCCGCTG CTGACCTGGA TGCGGGACGG GACAGTCCTC
CGGGAGGCGG TGGCCGAGAG CCTGCTCCTG GAGCTGGAGG AGGTGACCCC CGCCGAAGAC
GGCGTCTATG CCTGCCTGGC CGAGAATGCC TATGGCCAGG ACAACCGCAC CGTGGGGCTC
AGTGTCATGT ATGCACCCTG GAAGCCAACA GTGAACGGGA CAATGGTGGC CGTAGAGGGG
GAGACGGTCT CTATCTTGTG CTCCACACAG AGCAACCCGG ACCCTATTCT CACCATCTTC
AAGGAGAAGC AGATCCTGTC CACGGTCATC TACGAGAGCG AGCTGCAGCT GGAGCTGCCG
GCCGTGTCAC CCGAGGATGA TGGAGAGTAC TGGTGTGTGG CTGAGAACCA GTATGGCCAG
AGGGCCACCG CCTTCAACCT GTCTGTGGAG TTCGCCCCTG TGCTCCTCCT GGAGTCCCAC
TGCGCGGCAG CCCGAGACAC GGTGCAGTGC CTGTGCGTGG TGAAGTCCAA CCCGGAGCCG
TCCGTGGCCT TTGAGCTGCC ATCGCGCAAT GTGACCGTGA ACGAGAGCGA GCGGGAGTTC
GTGTACTCGG AGCGCAGCGG CCTCGTGCTC ACCAGCATCC TCACGCTGCG GGGGCAGGCC
CAGGCCCCGC CCCGCGTCAT CTGCACCGCG AGGAACCTCT ATGGCGCCAA GAGCCTGGAG
CTGCCCTTCC AGGGAGCCCA TCGACTGATG TGGGCCAAGA TCGGGCCTGT GGGCGCCGTG
GTCGCCTTTG CCATCCTGAT TGCCATCGTC TGCTACATTA CCCAGACACG CAGGAAAAAG
AACGTGACAG AGAGCCCCAG CTTCTCGGCA GGGGACAACC CTCCCGTCCT GTTCAGCAGC
GACTTCCGCA TCTCTGGGGC ACCAGAGAAG TACGAGAGCG AGAGGCGCCT GGGATCTGAG
AGGAGGCTGC TGGGCCTTCG GGGTGAGCCC CCAGAGCTGG ACCTGAGCTA TTCTCACTCG
GACCTGGGGA AACGGCCCAC CAAGGACAGC TACACGCTGA CGGAGGAGCT AGCTGAGTAT
GCTGAAATCC GGGTCAAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19652
Clone ID Related Accession (Same CDS sequence) NM_080600.2
Accession Version NM_080600.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1749bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product myelin-associated glycoprotein isoform b precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC331168.1 and BC093045.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced XM_005258947.1, NM_080600.1. Transcript Variant: This variant (2) is a full-length transcript with the stop codon contained in exon 11. It encodes an isoform (b) that is 44 aa shorter and contains a different carboxy terminus when compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGATATTCC TCACGGCACT GCCTCTGTTC TGGATTATGA TTTCAGCCTC CCGAGGGGGT 
CACTGGGGTG CCTGGATGCC CTCGTCCATC TCGGCCTTCG AAGGCACGTG CGTCTCCATC
CCCTGCCGCT TTGACTTCCC GGATGAGCTG CGGCCCGCTG TGGTGCATGG TGTCTGGTAC
TTCAATAGCC CCTACCCCAA GAACTACCCC CCGGTGGTCT TCAAGTCGCG CACCCAAGTA
GTCCACGAGA GCTTCCAGGG CCGCAGCCGC CTCCTGGGGG ACCTGGGCCT GCGAAACTGC
ACCCTCCTGC TCAGCAACGT CAGCCCCGAG CTGGGCGGGA AGTACTACTT CCGTGGGGAC
CTGGGCGGCT ACAACCAGTA CACCTTCTCA GAGCACAGCG TCCTGGATAT CGTCAACACC
CCCAACATCG TGGTGCCCCC AGAGGTGGTG GCAGGCACGG AGGTGGAGGT CAGCTGCATG
GTGCCGGACA ACTGCCCAGA GCTGCGCCCT GAGCTGAGCT GGCTGGGCCA CGAGGGGCTG
GGGGAGCCCG CTGTGCTGGG CCGGCTGCGG GAGGACGAGG GCACCTGGGT GCAGGTGTCA
CTGCTGCACT TCGTGCCCAC GAGGGAGGCC AACGGCCACA GGCTGGGCTG CCAGGCCTCC
TTCCCCAACA CCACCCTGCA GTTCGAGGGC TACGCCAGCA TGGACGTCAA GTACCCCCCG
GTGATTGTGG AGATGAACTC CTCGGTGGAG GCCATCGAGG GCTCCCACGT GAGCCTGCTC
TGTGGGGCTG ACAGCAACCC CCCGCCGCTG CTGACCTGGA TGCGGGACGG GACAGTCCTC
CGGGAGGCGG TGGCCGAGAG CCTGCTCCTG GAGCTGGAGG AGGTGACCCC CGCCGAAGAC
GGCGTCTATG CCTGCCTGGC CGAGAATGCC TATGGCCAGG ACAACCGCAC CGTGGGGCTC
AGTGTCATGT ATGCACCCTG GAAGCCAACA GTGAACGGGA CAATGGTGGC CGTAGAGGGG
GAGACGGTCT CTATCTTGTG CTCCACACAG AGCAACCCGG ACCCTATTCT CACCATCTTC
AAGGAGAAGC AGATCCTGTC CACGGTCATC TACGAGAGCG AGCTGCAGCT GGAGCTGCCG
GCCGTGTCAC CCGAGGATGA TGGAGAGTAC TGGTGTGTGG CTGAGAACCA GTATGGCCAG
AGGGCCACCG CCTTCAACCT GTCTGTGGAG TTCGCCCCTG TGCTCCTCCT GGAGTCCCAC
TGCGCGGCAG CCCGAGACAC GGTGCAGTGC CTGTGCGTGG TGAAGTCCAA CCCGGAGCCG
TCCGTGGCCT TTGAGCTGCC ATCGCGCAAT GTGACCGTGA ACGAGAGCGA GCGGGAGTTC
GTGTACTCGG AGCGCAGCGG CCTCGTGCTC ACCAGCATCC TCACGCTGCG GGGGCAGGCC
CAGGCCCCGC CCCGCGTCAT CTGCACCGCG AGGAACCTCT ATGGCGCCAA GAGCCTGGAG
CTGCCCTTCC AGGGAGCCCA TCGACTGATG TGGGCCAAGA TCGGGCCTGT GGGCGCCGTG
GTCGCCTTTG CCATCCTGAT TGCCATCGTC TGCTACATTA CCCAGACACG CAGGAAAAAG
AACGTGACAG AGAGCCCCAG CTTCTCGGCA GGGGACAACC CTCCCGTCCT GTTCAGCAGC
GACTTCCGCA TCTCTGGGGC ACCAGAGAAG TACGAGTCCA AAGAGGTTTC TACCCTGGAA
TCTCACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_542167.1
CDS199..1947
Misc Feature(1)256..1173
Misc Feature(2)262..615
Misc Feature(3)277..>546
Misc Feature(4)391..399
Misc Feature(5)493..495
Misc Feature(6)514..516
Misc Feature(7)order(550..552,577..582)
Misc Feature(8)568..582
Misc Feature(9)619..867
Misc Feature(10)865..867
Misc Feature(11)916..1164
Misc Feature(12)934..936
Misc Feature(13)955..1134
Misc Feature(14)1141..1143
Misc Feature(15)1192..1194
Misc Feature(16)1195..1425
Misc Feature(17)1213..1395
Misc Feature(18)1414..1416
Misc Feature(19)1546..1548
Misc Feature(20)1558..1560
Misc Feature(21)1747..1806
Misc Feature(22)1831..1833
Misc Feature(23)1837..1839
Misc Feature(24)1843..1845
Exon (1)1..119
Exon (2)120..175
Exon (3)176..244
Exon (4)245..613
Exon (5)614..910
Exon (6)911..1168
Exon (7)1169..1429
Exon (8)1430..1717
Exon (9)1718..1814
Exon (10)1815..1914
Exon (11)1915..1959
Exon (12)1960..2477
Translation

Target ORF information:

RefSeq Version NM_080600.2
Organism Homo sapiens(Human)
Definition Homo sapiens myelin associated glycoprotein (MAG), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_080600.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGATATTCC TCACGGCACT GCCTCTGTTC TGGATTATGA TTTCAGCCTC CCGAGGGGGT 
CACTGGGGTG CCTGGATGCC CTCGTCCATC TCGGCCTTCG AAGGCACGTG CGTCTCCATC
CCCTGCCGCT TTGACTTCCC GGATGAGCTG CGGCCCGCTG TGGTGCATGG TGTCTGGTAC
TTCAATAGCC CCTACCCCAA GAACTACCCC CCGGTGGTCT TCAAGTCGCG CACCCAAGTA
GTCCACGAGA GCTTCCAGGG CCGCAGCCGC CTCCTGGGGG ACCTGGGCCT GCGAAACTGC
ACCCTCCTGC TCAGCAACGT CAGCCCCGAG CTGGGCGGGA AGTACTACTT CCGTGGGGAC
CTGGGCGGCT ACAACCAGTA CACCTTCTCA GAGCACAGCG TCCTGGATAT CGTCAACACC
CCCAACATCG TGGTGCCCCC AGAGGTGGTG GCAGGCACGG AGGTGGAGGT CAGCTGCATG
GTGCCGGACA ACTGCCCAGA GCTGCGCCCT GAGCTGAGCT GGCTGGGCCA CGAGGGGCTG
GGGGAGCCCG CTGTGCTGGG CCGGCTGCGG GAGGACGAGG GCACCTGGGT GCAGGTGTCA
CTGCTGCACT TCGTGCCCAC GAGGGAGGCC AACGGCCACA GGCTGGGCTG CCAGGCCTCC
TTCCCCAACA CCACCCTGCA GTTCGAGGGC TACGCCAGCA TGGACGTCAA GTACCCCCCG
GTGATTGTGG AGATGAACTC CTCGGTGGAG GCCATCGAGG GCTCCCACGT GAGCCTGCTC
TGTGGGGCTG ACAGCAACCC CCCGCCGCTG CTGACCTGGA TGCGGGACGG GACAGTCCTC
CGGGAGGCGG TGGCCGAGAG CCTGCTCCTG GAGCTGGAGG AGGTGACCCC CGCCGAAGAC
GGCGTCTATG CCTGCCTGGC CGAGAATGCC TATGGCCAGG ACAACCGCAC CGTGGGGCTC
AGTGTCATGT ATGCACCCTG GAAGCCAACA GTGAACGGGA CAATGGTGGC CGTAGAGGGG
GAGACGGTCT CTATCTTGTG CTCCACACAG AGCAACCCGG ACCCTATTCT CACCATCTTC
AAGGAGAAGC AGATCCTGTC CACGGTCATC TACGAGAGCG AGCTGCAGCT GGAGCTGCCG
GCCGTGTCAC CCGAGGATGA TGGAGAGTAC TGGTGTGTGG CTGAGAACCA GTATGGCCAG
AGGGCCACCG CCTTCAACCT GTCTGTGGAG TTCGCCCCTG TGCTCCTCCT GGAGTCCCAC
TGCGCGGCAG CCCGAGACAC GGTGCAGTGC CTGTGCGTGG TGAAGTCCAA CCCGGAGCCG
TCCGTGGCCT TTGAGCTGCC ATCGCGCAAT GTGACCGTGA ACGAGAGCGA GCGGGAGTTC
GTGTACTCGG AGCGCAGCGG CCTCGTGCTC ACCAGCATCC TCACGCTGCG GGGGCAGGCC
CAGGCCCCGC CCCGCGTCAT CTGCACCGCG AGGAACCTCT ATGGCGCCAA GAGCCTGGAG
CTGCCCTTCC AGGGAGCCCA TCGACTGATG TGGGCCAAGA TCGGGCCTGT GGGCGCCGTG
GTCGCCTTTG CCATCCTGAT TGCCATCGTC TGCTACATTA CCCAGACACG CAGGAAAAAG
AACGTGACAG AGAGCCCCAG CTTCTCGGCA GGGGACAACC CTCCCGTCCT GTTCAGCAGC
GACTTCCGCA TCTCTGGGGC ACCAGAGAAG TACGAGTCCA AAGAGGTTTC TACCCTGGAA
TCTCACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.
Brain : a journal of neurology138(Pt 9)2521-36(2015 Sep)
Lossos A,Elazar N,Lerer I,Schueler-Furman O,Fellig Y,Glick B,Zimmerman BE,Azulay H,Dotan S,Goldberg S,Gomori JM,Ponger P,Newman JP,Marreed H,Steck AJ,Schaeren-Wiemers N,Mor N,Harel M,Geiger T,Eshed-Eisenbach Y,Meiner V,Peles E


book

Heterogeneity of Polyneuropathy Associated with Anti-MAG Antibodies.
Journal of immunology research2015450391(2015)
Magy L,Kaboré R,Mathis S,Lebeau P,Ghorab K,Caudie C,Vallat JM


book

LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
The Journal of biological chemistry288(47)34009-18(2013 Nov)
Mantuano E,Lam MS,Gonias SL


book

The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children.
Journal of neuroimmunology261(1-2)77-81(2013 Aug)
Mostafa GA,Al-Ayadhi LY


book

An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease.
Neurobiology of disease49221-31(2013 Jan)
Kinter J,Lazzati T,Schmid D,Zeis T,Erne B,Lützelschwab R,Steck AJ,Pareyson D,Peles E,Schaeren-Wiemers N


 
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