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MAGOH cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MAGOH
Entrez Gene ID 4116
Full Name mago homolog, exon junction complex core component
Synonyms MAGOH1,MAGOHA
General protein information
Preferred Names

mago homolog, exon junction complex core component

Names

protein mago nashi homolog
mago-nashi homolog, proliferation-associated

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1p32.3

Summary Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008].
Disorder MIM:

602603


mRNA and Protein(s)

mRNA Protein Name
NM_002370.3 NP_002361.1 protein mago nashi homolog



Homo sapiens (human) MAGOH NP_002361.1
Pan troglodytes (chimpanzee) LOC100613301 XP_003308156.1
Canis lupus familiaris (dog) MAGOH XP_536702.1
Mus musculus (house mouse) Magoh NP_001269666.1
Bos taurus (cattle) MAGOH NP_001029417.1
Rattus norvegicus (Norway rat) Magoh NP_001094006.1
Gallus gallus (chicken) MAGOH2 NP_989656.1
Macaca mulatta (rhesus monkey) MAGOH XP_001112786.1


Related articles in PubMed

A proteome-scale map of the human interactome network.
Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M
Cell159(5)1212-1226(2014 Nov)

An atlas of genetic influences on human blood metabolites.
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, , Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenmüller G, Spector TD, Soranzo N
Nature genetics46(6)543-550(2014 Jun)

Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.
Singh KK, Wachsmuth L, Kulozik AE, Gehring NH
RNA biology10(8)1291-8(2013 Aug)

Structural basis for the nuclear export activity of Importin13.
Grünwald M, Lazzaretti D, Bono F
The EMBO journal32(6)899-913(2013 Mar)

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.
Singh G, Kucukural A, Cenik C, Leszyk JD, Shaffer SA, Weng Z, Moore MJ
Cell151(4)750-64(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay
Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

These results indicate that MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and Y14.
Title: The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.

crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase eukaryotic initiation factor 4AIII bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic
Title: Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.

The stable association of multiprotein exon junction complex core with RNA is maintained by inhibition of eIF4AIII ATPase activity by MAGOH-Y14.
Title: The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.

The following MAGOH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGOH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu17496
NM_002370.3
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Homo sapiens mago homolog, exon junction complex core component (MAGOH), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17496
Clone ID Related Accession (Same CDS sequence) NM_002370.3
Accession Version NM_002370.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-07-15
Organism Homo sapiens(Human)
Product protein mago nashi homolog
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX283982.1, AF067173.1 and AF035940.1. On Jan 28, 2011 this sequence version replaced NM_002370.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF035940.1, BM808411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
ATGGAGAGTG ACTTTTATCT GCGTTACTAC GTGGGGCACA AGGGCAAGTT CGGCCACGAG 
TTCCTGGAGT TTGAGTTTCG ACCGGACGGG AAGTTAAGAT ATGCCAACAA CAGCAATTAC
AAGAATGATG TCATGATCAG AAAAGAGGCT TATGTACATA AAAGCGTGAT GGAGGAACTG
AAGAGAATAA TTGACGACAG TGAAATTACC AAAGAGGATG ATGCATTGTG GCCTCCTCCT
GACCGAGTGG GCCGGCAGGA GCTTGAAATC GTCATTGGAG ATGAACACAT TTCTTTTACA
ACATCAAAAA TTGGTTCCCT TATTGATGTC AATCAATCCA AGGATCCAGA AGGCTTACGA
GTATTTTATT ATCTTGTCCA GGACCTGAAG TGTTTGGTCT TCAGTCTTAT TGGATTACAC
TTCAAGATTA AACCAATCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002361.1
CDS163..603
Misc Feature(1)61..63
Misc Feature(2)163..165
Misc Feature(3)172..600
Misc Feature(4)order(193..201,211..213,220..225,262..264,268..276,280..294,298..300,304..306,409..411,469..471,475..483,529..531,541..543,550..555,562..564,586..600)
Misc Feature(5)order(193..213,220..225,247..249,262..264,268..276,280..294,298..300,304..306,313..321,325..330,337..339,346..351,469..471,475..483,529..534,541..546,550..558,562..570,577..597)
Misc Feature(6)order(199..213,280..285,406..411,469..471)
Misc Feature(7)order(202..204,295..297,301..309,337..339,346..348,364..366,373..375,385..387,445..447,583..585)
Misc Feature(8)order(247..249,313..321,325..330,337..339,346..351,532..534,541..546,553..558,565..570,577..588)
Misc Feature(9)order(358..360,364..366,481..483)
Exon (1)1..250
Exon (2)251..309
Exon (3)310..420
Exon (4)421..503
Exon (5)504..756
Translation

Target ORF information:

RefSeq Version NM_002370.3
Organism Homo sapiens(Human)
Definition Homo sapiens mago homolog, exon junction complex core component (MAGOH), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002370.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGAGAGTG ACTTTTATCT GCGTTACTAC GTGGGGCACA AGGGCAAGTT CGGCCACGAG 
TTCCTGGAGT TTGAGTTTCG ACCGGACGGG AAGTTAAGAT ATGCCAACAA CAGCAATTAC
AAGAATGATG TCATGATCAG AAAAGAGGCT TATGTACATA AAAGCGTGAT GGAGGAACTG
AAGAGAATAA TTGACGACAG TGAAATTACC AAAGAGGATG ATGCATTGTG GCCTCCTCCT
GACCGAGTGG GCCGGCAGGA GCTTGAAATC GTCATTGGAG ATGAACACAT TTCTTTTACA
ACATCAAAAA TTGGTTCCCT TATTGATGTC AATCAATCCA AGGATCCAGA AGGCTTACGA
GTATTTTATT ATCTTGTCCA GGACCTGAAG TGTTTGGTCT TCAGTCTTAT TGGATTACAC
TTCAAGATTA AACCAATCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A proteome-scale map of the human interactome network.
Cell159(5)1212-1226(2014 Nov)
Rolland T,Taşan M,Charloteaux B,Pevzner SJ,Zhong Q,Sahni N,Yi S,Lemmens I,Fontanillo C,Mosca R,Kamburov A,Ghiassian SD,Yang X,Ghamsari L,Balcha D,Begg BE,Braun P,Brehme M,Broly MP,Carvunis AR,Convery-Zupan D,Corominas R,Coulombe-Huntington J,Dann E,Dreze M,Dricot A,Fan C,Franzosa E,Gebreab F,Gutierrez BJ,Hardy MF,Jin M,Kang S,Kiros R,Lin GN,Luck K,MacWilliams A,Menche J,Murray RR,Palagi A,Poulin MM,Rambout X,Rasla J,Reichert P,Romero V,Ruyssinck E,Sahalie JM,Scholz A,Shah AA,Sharma A,Shen Y,Spirohn K,Tam S,Tejeda AO,Trigg SA,Twizere JC,Vega K,Walsh J,Cusick ME,Xia Y,Barabási AL,Iakoucheva LM,Aloy P,De Las Rivas J,Tavernier J,Calderwood MA,Hill DE,Hao T,Roth FP,Vidal M


book

An atlas of genetic influences on human blood metabolites.
Nature genetics46(6)543-550(2014 Jun)
Shin SY,Fauman EB,Petersen AK,Krumsiek J,Santos R,Huang J,Arnold M,Erte I,Forgetta V,Yang TP,Walter K,Menni C,Chen L,Vasquez L,Valdes AM,Hyde CL,Wang V,Ziemek D,Roberts P,Xi L,Grundberg E,,Waldenberger M,Richards JB,Mohney RP,Milburn MV,John SL,Trimmer J,Theis FJ,Overington JP,Suhre K,Brosnan MJ,Gieger C,Kastenmüller G,Spector TD,Soranzo N


book

Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.
RNA biology10(8)1291-8(2013 Aug)
Singh KK,Wachsmuth L,Kulozik AE,Gehring NH


book

Structural basis for the nuclear export activity of Importin13.
The EMBO journal32(6)899-913(2013 Mar)
Grünwald M,Lazzaretti D,Bono F


book

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.
Cell151(4)750-64(2012 Nov)
Singh G,Kucukural A,Cenik C,Leszyk JD,Shaffer SA,Weng Z,Moore MJ


 
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