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MAL cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAL
Entrez Gene ID 4118
Full Name mal, T-cell differentiation protein
General protein information
Preferred Names
myelin and lymphocyte protein
Names
myelin and lymphocyte protein
T-lymphocyte maturation-associated protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q11.1

Summary The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]. lac of sum
Disorder MIM:

188860


mRNA and Protein(s)

mRNA Protein Name
NM_002371 NP_002362 myelin and lymphocyte protein isoform a
NM_022438 NP_071883 myelin and lymphocyte protein isoform b
NM_022439 NP_071884 myelin and lymphocyte protein isoform c
NM_022440 NP_071885 myelin and lymphocyte protein isoform d


Homo sapiens (human) MAL NP_002362.1
Pan troglodytes (chimpanzee) MAL XP_003949891.1
Macaca mulatta (Rhesus monkey) MAL XP_001095645.2
Canis lupus familiaris (dog) MAL NP_001003253.1
Bos taurus (cattle) MAL NP_001068896.1
Mus musculus (house mouse) Mal NP_034892.1
Rattus norvegicus (Norway rat) Mal NP_036930.1
Gallus gallus (chicken) MAL NP_001186320.1
Danio rerio (zebrafish) mal NP_001017686.1
Danio rerio (zebrafish) zgc:158773 NP_001075880.1
Danio rerio (zebrafish) zgc:153665 NP_001070931.1
Xenopus (Silurana) tropicalis (western clawed frog) mal NP_001006929.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu15983
NM_002371 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant a, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu16029 NM_022438 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant b, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu15772 NM_022439 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant c, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu15962
NM_022440 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant d, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu15983
Clone ID Related Accession (Same CDS sequence) NM_002371
Accession Version NM_002371.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 462bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myelin and lymphocyte protein isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76678.1 and BC000458.2. On May 9, 2012 this sequence version replaced gi:12408666. Transcript Variant: This variant (a) includes both alternatively spliced exons 2 and 3, resulting in the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000458.2, M15800.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA
GAGACTTCCT GGGTCACCTT GGACGCAGCC TACCACTGCA CCGCTGCCCT CTTTTACCTC
AGCGCCTCAG TCCTGGAGGC CCTGGCCACC ATCACGATGC AAGACGGCTT CACCTACAGG
CACTACCATG AAAACATTGC TGCCGTGGTG TTCTCCTACA TAGCCACTCT GCTCTACGTG
GTCCATGCGG TGTTCTCTTT AATCAGATGG AAGTCTTCAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002362.1
CDS139..600
Misc Feature(1)94..96(+)
Misc Feature(2)193..573(+)
Misc Feature(3)211..276(+)
Misc Feature(4)298..363(+)
Misc Feature(5)415..480(+)
Misc Feature(6)514..579(+)
Exon (1)1..231
Gene:MAL
Gene Synonym:
Exon (2)232..399
Gene:MAL
Gene Synonym:
Exon (3)400..525
Gene:MAL
Gene Synonym:
Exon (4)526..1137
Gene:MAL
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002371
Organism Homo sapiens (human)
Definition Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant a, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002371

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA
GAGACTTCCT GGGTCACCTT GGACGCAGCC TACCACTGCA CCGCTGCCCT CTTTTACCTC
AGCGCCTCAG TCCTGGAGGC CCTGGCCACC ATCACGATGC AAGACGGCTT CACCTACAGG
CACTACCATG AAAACATTGC TGCCGTGGTG TTCTCCTACA TAGCCACTCT GCTCTACGTG
GTCCATGCGG TGTTCTCTTT AATCAGATGG AAGTCTTCAT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16029
Clone ID Related Accession (Same CDS sequence) NM_022438
Accession Version NM_022438.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 336bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myelin and lymphocyte protein isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76679.1 and BC000458.2. On May 9, 2012 this sequence version replaced gi:12408660. Transcript Variant: This variant (b) includes alternatively spliced exon 2 but is missing exon 3, resulting in isoform b which is shorter than the predominant isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X76679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670, SAMEA962337 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA
GAGACTTCCT GGGTCACCTT GGTGTTCTCC TACATAGCCA CTCTGCTCTA CGTGGTCCAT
GCGGTGTTCT CTTTAATCAG ATGGAAGTCT TCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_071883.1
CDS139..474
Misc Feature(1)94..96(+)
Exon (1)1..231
Gene:MAL
Gene Synonym:
Exon (2)232..399
Gene:MAL
Gene Synonym:
Exon (3)400..1011
Gene:MAL
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_022438
Organism Homo sapiens (human)
Definition Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant b, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_022438

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA
GAGACTTCCT GGGTCACCTT GGTGTTCTCC TACATAGCCA CTCTGCTCTA CGTGGTCCAT
GCGGTGTTCT CTTTAATCAG ATGGAAGTCT TCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15772
Clone ID Related Accession (Same CDS sequence) NM_022439
Accession Version NM_022439.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 294bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myelin and lymphocyte protein isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76680.1 and BC000458.2. On May 9, 2012 this sequence version replaced gi:12408662. Transcript Variant: This variant (c) is missing alternatively spliced exon 2 but includes exon 3, resulting in isoform c which is shorter than the predominant isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX457478.2, X76680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145313, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGACGCAG CCTACCACTG CACCGCTGCC
CTCTTTTACC TCAGCGCCTC AGTCCTGGAG GCCCTGGCCA CCATCACGAT GCAAGACGGC
TTCACCTACA GGCACTACCA TGAAAACATT GCTGCCGTGG TGTTCTCCTA CATAGCCACT
CTGCTCTACG TGGTCCATGC GGTGTTCTCT TTAATCAGAT GGAAGTCTTC ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_071884.1
CDS139..432
Misc Feature(1)94..96(+)
Misc Feature(2)229..405(+)
Exon (1)1..231
Gene:MAL
Gene Synonym:
Exon (2)232..357
Gene:MAL
Gene Synonym:
Exon (3)358..969
Gene:MAL
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_022439
Organism Homo sapiens (human)
Definition Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant c, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_022439

ORF Insert Sequence:

1
61
121
181
241
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGACGCAG CCTACCACTG CACCGCTGCC
CTCTTTTACC TCAGCGCCTC AGTCCTGGAG GCCCTGGCCA CCATCACGAT GCAAGACGGC
TTCACCTACA GGCACTACCA TGAAAACATT GCTGCCGTGG TGTTCTCCTA CATAGCCACT
CTGCTCTACG TGGTCCATGC GGTGTTCTCT TTAATCAGAT GGAAGTCTTC ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15962
Clone ID Related Accession (Same CDS sequence) NM_022440
Accession Version NM_022440.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 168bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myelin and lymphocyte protein isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76681.1 and BC000458.2. On May 9, 2012 this sequence version replaced gi:12408664. Transcript Variant: This variant (d) is missing alternatively spliced exons 2 and 3, resulting in the shortest isoform (d). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X76681.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGTGTTCT CCTACATAGC CACTCTGCTC
TACGTGGTCC ATGCGGTGTT CTCTTTAATC AGATGGAAGT CTTCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_071885.1
CDS139..306
Misc Feature(1)94..96(+)
Exon (1)1..231
Gene:MAL
Gene Synonym:
Exon (2)232..843
Gene:MAL
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_022440
Organism Homo sapiens (human)
Definition Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant d, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_022440

ORF Insert Sequence:

1
61
121
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGTGTTCT CCTACATAGC CACTCTGCTC
TACGTGGTCC ATGCGGTGTT CTCTTTAATC AGATGGAAGT CTTCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB
J. Biol. Chem. 289 (2), 654-668 (2014)
Alaidarous M, Ve T, Casey LW, Valkov E, Ericsson DJ, Ullah MO, Schembri MA, Mansell A, Sweet MJ and Kobe B.


book

Suppression of MAL gene expression in gastric cancer correlates with metastasis and mortality
Fukuoka Igaku Zasshi 104 (10), 344-349 (2013)
Kurashige J, Sawada G, Takahashi Y, Eguchi H, Sudo T, Ikegami T, Yoshizumi T, Soejima Y, Ikeda T, Kawanaka H, Uchiyama H, Yamashita Y, Morita M, Oki E, Saeki H, Sugimachi K, Watanabe M, Mori M, Baba H and Mimori K.


book

CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease
Int. J. Cancer 133 (6), 1293-1299 (2013)
Bierkens M, Hesselink AT, Meijer CJ, Heideman DA, Wisman GB, van der Zee AG, Snijders PJ and Steenbergen RD.


book

Mal, more than a bridge to MyD88
IUBMB Life 65 (9), 777-786 (2013)
Bernard NJ and O'Neill LA.


book

The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1
J. Cell Biol. 202 (4), 653-666 (2013)
Dubash AD, Koetsier JL, Amargo EV, Najor NA, Harmon RM and Green KJ.


book

The MAL proteolipid is a component of the detergent-insoluble membrane subdomains of human T-lymphocytes
Biochem. J. 321 (PT 1), 247-252 (1997)
Millan J, Puertollano R, Fan L, Rancano C and Alonso MA.


book

Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene
Genomics 21 (2), 447-450 (1994)
Rancano C, Rubio T and Alonso MA.


book

Genomic structure and subcellular localization of MAL, a human T-cell-specific proteolipid protein
J. Biol. Chem. 269 (11), 8159-8164 (1994)
Rancano C, Rubio T, Correas I and Alonso MA.


book

Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen----q13
Immunogenetics 27 (2), 91-95 (1988)
Alonso MA, Barton DE and Francke U.


book

cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation
Proc. Natl. Acad. Sci. U.S.A. 84 (7), 1997-2001 (1987)
Alonso,M.A. and Weissman,S.M.


 
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