Gene Symbol | MAN2C1 |
Entrez Gene ID | 4123 |
Full Name | mannosidase alpha class 2C member 1 |
Synonyms | MAN6A8,MANA,MANA1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » MAN2C1 cDNA ORF clone
Gene Symbol | MAN2C1 |
Entrez Gene ID | 4123 |
Full Name | mannosidase alpha class 2C member 1 |
Synonyms | MAN6A8,MANA,MANA1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_017022186.1 | XP_016877675.1 | alpha-mannosidase 2C1 isoform X1 |
XM_005254384.3 | XP_005254441.1 | alpha-mannosidase 2C1 isoform X2 |
XM_017022187.1 | XP_016877676.1 | alpha-mannosidase 2C1 isoform X3 |
XM_017022188.2 | XP_016877677.1 | alpha-mannosidase 2C1 isoform X4 |
NM_001256494.1 | NP_001243423.1 | alpha-mannosidase 2C1 isoform 2 |
NM_001256495.1 | NP_001243424.1 | alpha-mannosidase 2C1 isoform 3 |
XM_005254384.2 | XP_005254441.1 | alpha-mannosidase 2C1 isoform X2 |
NM_006715.4 | NP_006706.2 | alpha-mannosidase 2C1 isoform 1 |
XM_017022188.1 | XP_016877677.1 | alpha-mannosidase 2C1 isoform X4 |
NM_006715.3 | NP_006706.2 | alpha-mannosidase 2C1 isoform 1 |
NM_001256496.1 | NP_001243425.1 | alpha-mannosidase 2C1 isoform 4 |
Rattus norvegicus (Norway rat) | Man2c1 | NP_640349.1 |
Saccharomyces cerevisiae (baker's yeast) | AMS1 | NP_011359.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_04464 | XP_003710997.1 |
MAN2C1 | XP_001102709.2 | |
Eremothecium gossypii | AGOS_AGR385C | NP_987051.2 |
Schizosaccharomyces pombe (fission yeast) | ams1 | NP_593979.1 |
Neurospora crassa | NCU07404 | XP_958488.1 |
Xenopus tropicalis (tropical clawed frog) | man2c1 | NP_001090678.1 |
Homo sapiens (human) | MAN2C1 | NP_006706.2 |
Mus musculus (house mouse) | Man2c1 | NP_082912.1 |
Danio rerio (zebrafish) | LOC569595 | XP_698084.4 |
Pan troglodytes (chimpanzee) | MAN2C1 | XP_003314839.1 |
Canis lupus familiaris (dog) | MAN2C1 | XP_005638775.1 |
Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence.
C?ceres A, Esko T, Pappa I, Guti?rrez A, Lopez-Espinosa MJ, Llop S, Bustamante M, Tiemeier H, Metspalu A, Joshi PK, Wilsonx JF, Reina-Castill?n J, Shin J, Pausova Z, Paus T, Sunyer J, P?rez-Jurado LA, Gonz?lez JR
PloS one11(6)e0157739(2016)
Dual functions for cytosolic ?-mannosidase (Man2C1): its down-regulation causes mitochondria-dependent apoptosis independently of its ?-mannosidase activity.
Wang L, Suzuki T
The Journal of biological chemistry288(17)11887-96(2013 Apr)
Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway.
Bernon C, Carr? Y, Kuokkanen E, Slomianny MC, Mir AM, Krzewinski F, Cacan R, Heikinheimo P, Morelle W, Michalski JC, Foulquier F, Duvet S
Glycobiology21(3)363-75(2011 Mar)
Gene expression and methylation signatures of MAN2C1 are associated with PTSD.
Uddin M, Galea S, Chang SC, Aiello AE, Wildman DE, de los Santos R, Koenen KC
Disease markers30(2-3)111-21(2011)
?-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.
He L, Fan C, Kapoor A, Ingram AJ, Rybak AP, Austin RC, Dickhout J, Cutz JC, Scholey J, Tang D
Nature communications2307(2011)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
MAN2C1 may contribute to the verbal difficulties observed in microduplications and to the intellectual disability of microdeletion syndromes
Title: Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence.
Man2C1 has dual functions: one in glycan catabolism and another in apoptotic signaling.
Title: Dual functions for cytosolic ?-mannosidase (Man2C1): its down-regulation causes mitochondria-dependent apoptosis independently of its ?-mannosidase activity.
regulation of Man2C1 expression is essential for maintaining efficient protein N-glycosylation
Title: Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway.
MAN2C1 methylation levels modify cumulative traumatic burden on risk of post traumatic stress disorder
Title: Gene expression and methylation signatures of MAN2C1 are associated with PTSD.
MAN2C1 binds PTEN thereby inhibiting its phosphatidylinositol 3,4,5 triphosphate phosphatase activity
Title: ?-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.
The following MAN2C1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAN2C1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu20040 | |
Clone ID Related Accession (Same CDS sequence) | NM_006715.4 , NM_006715.3 | |
Accession Version | NM_006715.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3123bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-06 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC342919.1 and BC050550.1. On Nov 23, 2018 this sequence version replaced NM_006715.3. Transcript Variant: This variant (1) encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005428.1, SRR1660803.59356.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000267978.10/ ENSP00000267978.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006706.2 |
CDS | 25..3147 |
Translation |
Target ORF information:
Target ORF information:
|
NM_006715.4 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu20040 | |
Clone ID Related Accession (Same CDS sequence) | NM_006715.4 , NM_006715.3 | |
Accession Version | NM_006715.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3123bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC342919.1 and BC050550.1. On Feb 3, 2012 this sequence version replaced NM_006715.2. Transcript Variant: This variant (1) encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050550.1, SRR1660809.239732.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006706.2 |
CDS | 45..3167 |
Translation |
Target ORF information:
Target ORF information:
|
NM_006715.3 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu20229 | |
Clone ID Related Accession (Same CDS sequence) | NM_001256496.1 | |
Accession Version | NM_001256496.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2826bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-04 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC342919.1, AK225145.1 and BC050550.1. Transcript Variant: This variant (4) lacks two exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK225145.1, SRR1803613.135278.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001243425.1 |
CDS | 45..2870 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001256496.1 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu85411 | |
Clone ID Related Accession (Same CDS sequence) | XM_017022188.2 , XM_017022188.1 | |
Accession Version | XM_017022188.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2757bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-03-25 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017022188.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016877677.1 |
CDS | 22..2778 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017022188.2 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu85411 | |
Clone ID Related Accession (Same CDS sequence) | XM_017022188.2 , XM_017022188.1 | |
Accession Version | XM_017022188.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2757bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016877677.1 |
CDS | 98..2854 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017022188.1 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu85409 | |
Clone ID Related Accession (Same CDS sequence) | XM_017022186.1 | |
Accession Version | XM_017022186.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3192bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-03-25 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACTGTG CCGCGGAGCG GCCAGGCAGC CCTCTTGGCG GAGGATCCAG GGAAAGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016877675.1 |
CDS | 348..3539 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017022186.1 |
1 | ATGGACTGTG CCGCGGAGCG GCCAGGCAGC CCTCTTGGCG GAGGATCCAG GGAAAGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu85410 | |
Clone ID Related Accession (Same CDS sequence) | XM_017022187.1 | |
Accession Version | XM_017022187.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3099bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-03-25 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACTGTG CCGCGGAGCG GCCAGGCAGC CCTCTTGGCG GAGGATCCAG GGAAAGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016877676.1 |
CDS | 348..3446 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017022187.1 |
1 | ATGGACTGTG CCGCGGAGCG GCCAGGCAGC CCTCTTGGCG GAGGATCCAG GGAAAGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu19830 | |
Clone ID Related Accession (Same CDS sequence) | NM_001256495.1 | |
Accession Version | NM_001256495.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3054bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-04 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC342919.1, BC080191.1 and BC050550.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC080191.1, SRR1660809.216332.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001243424.1 |
CDS | 45..3098 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001256495.1 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu20195 | |
Clone ID Related Accession (Same CDS sequence) | NM_001256494.1 | |
Accession Version | NM_001256494.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3174bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-05 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC396372.1 and BC038594.2. Transcript Variant: This variant (2) uses two alternate splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Isoform 2 also contains a short frame-shifted region compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC038594.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001243423.1 |
CDS | 45..3218 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001256494.1 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu48298 | |
Clone ID Related Accession (Same CDS sequence) | XM_005254384.3 , XM_005254384.2 | |
Accession Version | XM_005254384.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3147bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-03-25 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005254384.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005254441.1 |
CDS | 22..3168 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005254384.3 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu48298 | |
Clone ID Related Accession (Same CDS sequence) | XM_005254384.3 , XM_005254384.2 | |
Accession Version | XM_005254384.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3147bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | alpha-mannosidase 2C1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005254384.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005254441.1 |
CDS | 98..3244 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005254384.2 |
1 | ATGGCGGCTG CGCCGGCCTT GAAGCACTGG CGCACCACGC TGGAGCGGGT GGAGAAGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence. |
Dual functions for cytosolic ?-mannosidase (Man2C1): its down-regulation causes mitochondria-dependent apoptosis independently of its ?-mannosidase activity. |
Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway. |
Gene expression and methylation signatures of MAN2C1 are associated with PTSD. |
?-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells. |