×

MAS1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAS1
Entrez Gene ID 4142
Full Name MAS1 proto-oncogene, G protein-coupled receptor
Synonyms MAS, MGRA
General protein information
Preferred Names
proto-oncogene Mas
Names
proto-oncogene Mas
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q25.3-q26

Summary This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]. lac of sum
Disorder MIM:

165180


mRNA and Protein(s)

mRNA Protein Name
NM_002377 NP_002368 proto-oncogene Mas



Homo sapiens (human) MAS1 NP_002368.1
Pan troglodytes (chimpanzee) MAS1 XP_527553.1
Macaca mulatta (Rhesus monkey) MAS1 XP_001098523.1
Canis lupus familiaris (dog) MAS1 XP_005615616.1
Bos taurus (cattle) MAS1 XP_002690422.1
Mus musculus (house mouse) Mas1 NP_032578.2
Rattus norvegicus (Norway rat) Mas1 NP_036889.1
Gallus gallus (chicken) MAS1 XP_426151.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100494761 XP_002938917.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100492282 XP_002936476.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100492615 XP_002936478.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100492446 XP_002936477.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Free ORF Clone
for Every Scientist
More Detail >>

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu28585
NM_002377 Homo sapiens MAS1 proto-oncogene, G protein-coupled receptor (MAS1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu28585
Clone ID Related Accession (Same CDS sequence) NM_002377
Accession Version NM_002377.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 978bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 28-JUN-2014
Organism Homo sapiens (human)
Product proto-oncogene Mas
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M13150.1. On Oct 1, 1999 this sequence version replaced gi:4505104. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M13150.1 [ECO:0000332] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGATGGGT CAAACGTGAC ATCATTTGTT GTTGAGGAAC CCACGAACAT CTCAACTGGC 
AGGAACGCCT CAGTCGGGAA TGCACATCGG CAAATCCCCA TCGTGCACTG GGTCATTATG
AGCATCTCCC CAGTGGGGTT TGTTGAGAAT GGGATTCTCC TCTGGTTCCT GTGCTTCCGG
ATGAGAAGAA ATCCCTTCAC TGTCTACATC ACCCACCTGT CTATCGCAGA CATCTCACTG
CTCTTCTGTA TTTTCATCTT GTCTATCGAC TATGCTTTAG ATTATGAGCT TTCTTCTGGC
CATTACTACA CAATTGTCAC ATTATCAGTG ACTTTTCTGT TTGGCTACAA CACGGGCCTC
TATCTGCTGA CGGCCATTAG TGTGGAGAGG TGCCTGTCAG TCCTTTACCC CATCTGGTAC
CGATGCCATC GCCCCAAGTA CCAGTCGGCA TTGGTCTGTG CCCTTCTGTG GGCTCTTTCT
TGCTTGGTGA CCACCATGGA GTATGTCATG TGCATCGACA GAGAAGAAGA GAGTCACTCT
CGGAATGACT GCCGAGCAGT CATCATCTTT ATAGCCATCC TGAGCTTCCT GGTCTTCACG
CCCCTCATGC TGGTGTCCAG CACCATCTTG GTCGTGAAGA TCCGGAAGAA CACGTGGGCT
TCCCATTCCT CCAAGCTTTA CATAGTCATC ATGGTCACCA TCATTATATT CCTCATCTTC
GCTATGCCCA TGAGACTCCT TTACCTGCTG TACTATGAGT ATTGGTCGAC CTTTGGGAAC
CTACACCACA TTTCCCTGCT CTTCTCCACA ATCAACAGTA GCGCCAACCC TTTCATTTAC
TTCTTTGTGG GAAGCAGTAA GAAGAAGAGA TTCAAGGAGT CCTTAAAAGT TGTTCTGACC
AGGGCTTTCA AAGATGAAAT GCAACCTCGG CGCCAGAAAG ACAATTGTAA TACGGTCACA
GTTGAGACTG TCGTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002368.1
CDS15..992
Misc Feature(1)3..5(+)
Misc Feature(2)123..197(+)
Misc Feature(3)180..854(+)
Misc Feature(4)210..272(+)
Misc Feature(5)327..398(+)
Misc Feature(6)462..530(+)
Misc Feature(7)570..740(+)
Misc Feature(8)570..632(+)
Misc Feature(9)687..749(+)
Misc Feature(10)804..866(+)
Exon (1)1..1135
Gene:MAS1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002377
Organism Homo sapiens (human)
Definition Homo sapiens MAS1 proto-oncogene, G protein-coupled receptor (MAS1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002377

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGGATGGGT CAAACGTGAC ATCATTTGTT GTTGAGGAAC CCACGAACAT CTCAACTGGC 
AGGAACGCCT CAGTCGGGAA TGCACATCGG CAAATCCCCA TCGTGCACTG GGTCATTATG
AGCATCTCCC CAGTGGGGTT TGTTGAGAAT GGGATTCTCC TCTGGTTCCT GTGCTTCCGG
ATGAGAAGAA ATCCCTTCAC TGTCTACATC ACCCACCTGT CTATCGCAGA CATCTCACTG
CTCTTCTGTA TTTTCATCTT GTCTATCGAC TATGCTTTAG ATTATGAGCT TTCTTCTGGC
CATTACTACA CAATTGTCAC ATTATCAGTG ACTTTTCTGT TTGGCTACAA CACGGGCCTC
TATCTGCTGA CGGCCATTAG TGTGGAGAGG TGCCTGTCAG TCCTTTACCC CATCTGGTAC
CGATGCCATC GCCCCAAGTA CCAGTCGGCA TTGGTCTGTG CCCTTCTGTG GGCTCTTTCT
TGCTTGGTGA CCACCATGGA GTATGTCATG TGCATCGACA GAGAAGAAGA GAGTCACTCT
CGGAATGACT GCCGAGCAGT CATCATCTTT ATAGCCATCC TGAGCTTCCT GGTCTTCACG
CCCCTCATGC TGGTGTCCAG CACCATCTTG GTCGTGAAGA TCCGGAAGAA CACGTGGGCT
TCCCATTCCT CCAAGCTTTA CATAGTCATC ATGGTCACCA TCATTATATT CCTCATCTTC
GCTATGCCCA TGAGACTCCT TTACCTGCTG TACTATGAGT ATTGGTCGAC CTTTGGGAAC
CTACACCACA TTTCCCTGCT CTTCTCCACA ATCAACAGTA GCGCCAACCC TTTCATTTAC
TTCTTTGTGG GAAGCAGTAA GAAGAAGAGA TTCAAGGAGT CCTTAAAAGT TGTTCTGACC
AGGGCTTTCA AAGATGAAAT GCAACCTCGG CGCCAGAAAG ACAATTGTAA TACGGTCACA
GTTGAGACTG TCGTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

MAS promoter regulation: a role for Sry and tyrosine nitration of the KRAB domain of ZNF274 as a feedback mechanism
Clin. Sci. 126 (10), 727-738 (2014)
Prokop JW, Rauscher FJ 3rd, Peng H, Liu Y, Araujo FC, Watanabe I, Reis FM and Milsted A.


book

Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes
Gene 540 (1), 16-19 (2014)
Premzl M.


book

Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-kappaB pathway
Am. J. Respir. Cell Mol. Biol. 50 (4), 723-736 (2014)
Meng Y, Yu CH, Li W, Li T, Luo W, Huang S, Wu PS, Cai SX and Li X.


book

Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways
J. Biol. Chem. 288 (22), 15520-15531 (2013)
Than A, Leow MK and Chen P.


book

Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection
Am. J. Physiol. Heart Circ. Physiol. 302 (1), H299-H311 (2012)
Zhang T, Li Z, Dang H, Chen R, Liaw C, Tran TA, Boatman PD, Connolly DT and Adams JW.


book

Angiotensin converting enzyme 2, Angiotensin-(1-7), and receptor MAS axis in the kidney
Int J Hypertens 2012, 414128 (2012)
Pinheiro SV and Simoes E Silva AC.


book

Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
Proc. Natl. Acad. Sci. U.S.A. 100 (14), 8258-8263 (2003)
Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R and Walther T.


book

Molecular and cell biology of angiotensin receptors
J. Cardiovasc. Pharmacol. 18 (SUPPL 2), S7-S13 (1991)
Hanley MR.


book

The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action
Ciba Found. Symp. 150, 23-38 (1990)
Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR and Goedert M.


book

Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements
Oncogene Res. 1 (2), 169-178 (1987)
Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M and Ruddle FH.


 
*
*
*
*