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CXCL9 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CXCL9
Entrez Gene ID 4283
Full Name C-X-C motif chemokine ligand 9
Synonyms CMK,Humig,MIG,SCYB9,crg-10
General protein information
Preferred Names

C-X-C motif chemokine ligand 9

Names

C-X-C motif chemokine 9
chemokine (C-X-C motif) ligand 9
gamma-interferon-induced monokine
monokine induced by gamma interferon
monokine induced by interferon-gamma
small-inducible cytokine B9

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4q21.1

Disorder MIM:

601704


mRNA and Protein(s)

mRNA Protein Name
NM_002416.2 NP_002407.1 C-X-C motif chemokine 9 precursor



Macaca mulatta (rhesus monkey) CXCL9 NP_001028108.1
Homo sapiens (human) CXCL9 NP_002407.1
Pan troglodytes (chimpanzee) CXCL9 XP_526582.1
Bos taurus (cattle) CXCL9 NP_001106643.1


Related articles in PubMed

CD44 and CXCL9 serum protein levels predict the risk of clinically significant allograft rejection after liver transplantation.
Raschzok N, Reutzel-Selke A, Schmuck RB, Morgul MH, Gauger U, Prabowo KA, Tannus LM, Leder A, Struecker B, Boas-Knoop S, Bartels M, Jonas S, Lojewski C, Puhl G, Seehofer D, Bahra M, Pascher A, Pratschke J, Sauer IM
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society21(9)1195-207(2015 Sep)

CXCL9 Regulates TGF-β1-Induced Epithelial to Mesenchymal Transition in Human Alveolar Epithelial Cells.
O'Beirne SL, Walsh SM, Fabre A, Reviriego C, Worrell JC, Counihan IP, Lumsden RV, Cramton-Barnes J, Belperio JA, Donnelly SC, Boylan D, Marchal-Sommé J, Kane R, Keane MP
Journal of immunology (Baltimore, Md. : 1950)195(6)2788-96(2015 Sep)

Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells.
Kutty RK, Samuel W, Abay R, Cherukuri A, Nagineni CN, Duncan T, Jaworski C, Vijayasarathy C, Redmond TM
Cytokine74(2)335-8(2015 Aug)

Osteopontin, CCL5 and CXCL9 are independently associated with psoriasis, regardless of the presence of obesity.
Duarte GV, Boeira V, Correia T, Porto-Silva L, Cardoso T, Macedo MN, Oliveira MF, Carvalho E
Cytokine74(2)287-92(2015 Aug)

Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study.
Altara R, Gu YM, Struijker-Boudier HA, Thijs L, Staessen JA, Blankesteijn WM
PloS one10(10)e0141394(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

significant correlation between serum levels and the severity of coronary artery disease, quantified by the Gensini score
Title: Serum Monokine Induced by Gamma Interferon Is Associated With Severity of Coronary Artery Disease.

results support the notion that CXCL9 and CXCL10 exert tumour-suppressive function by TIL recruitment in human ovarian cancer
Title: CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer.

CXCL9 is a useful predictor of better clinical outcome in colorectal cancer patients.
Title: The chemokine CXCL9 expression is associated with better prognosis for colorectal carcinoma patients.

The mRNA expression and serum levels of CXCL9 were both increased.
Title: CXCL9 expression and polyomavirus BK infectivity in renal transplant patients with nephropathy.

Data show that asymptomatic patients with unstable plaques exhibited higher levels of endothelial microparticles (EMPs), CXCL9 chemokine and stem cell growth factor; lymphocyte secreted C-type lectin (SCGF-beta) compared to those with stable plaques.
Title: Elevated levels of endothelial-derived microparticles, and serum CXCL9 and SCGF-β are associated with unstable asymptomatic carotid plaques.

The following CXCL9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu26807 NM_002416.2
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Homo sapiens C-X-C motif chemokine ligand 9 (CXCL9), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26807
Clone ID Related Accession (Same CDS sequence) NM_002416.2
Accession Version NM_002416.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 378bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-08
Organism Homo sapiens(Human)
Product C-X-C motif chemokine 9 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB141449.1, X72755.1 and BC042178.1. On Oct 1, 2014 this sequence version replaced NM_002416.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042178.1, BC063122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGAAGAAAA GTGGTGTTCT TTTCCTCTTG GGCATCATCT TGCTGGTTCT GATTGGAGTG 
CAAGGAACCC CAGTAGTGAG AAAGGGTCGC TGTTCCTGCA TCAGCACCAA CCAAGGGACT
ATCCACCTAC AATCCTTGAA AGACCTTAAA CAATTTGCCC CAAGCCCTTC CTGCGAGAAA
ATTGAAATCA TTGCTACACT GAAGAATGGA GTTCAAACAT GTCTAAACCC AGATTCAGCA
GATGTGAAGG AACTGATTAA AAAGTGGGAG AAACAGGTCA GCCAAAAGAA AAAGCAAAAG
AATGGGAAAA AACATCAAAA AAAGAAAGTT CTGAAAGTTC GAAAATCTCA ACGTTCTCGT
CAAAAGAAGA CTACATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002407.1
CDS75..452
Misc Feature(1)144..146
Misc Feature(2)156..344
Misc Feature(3)order(156..164,180..182,195..212,237..245,273..278,285..293,309..311,324..326)
Misc Feature(4)156..164
Misc Feature(5)order(159..161,168..170,210..215,222..230,258..269,273..275,285..290,297..299,318..320,330..332,339..344)
Misc Feature(6)order(159..161,168..170,222..224,228..230,258..260,264..266,273..275,285..290)
Misc Feature(7)order(162..167,171..173)
Misc Feature(8)order(168..188,195..212)
Misc Feature(9)order(174..179,183..185,195..197,207..209,264..266,273..275,285..287,291..293)
Misc Feature(10)order(198..200,204..206,306..308,315..317,321..332,336..338)
Misc Feature(11)order(204..206,213..215,270..272,276..278,285..290)
Misc Feature(12)order(210..215,225..227,261..263,267..269,297..299,318..320,330..332,339..344)
Misc Feature(13)237..245
Misc Feature(14)237..245
Misc Feature(15)276..284
Exon (1)1..138
Exon (2)139..265
Exon (3)266..350
Exon (4)351..2708
Translation

Target ORF information:

RefSeq Version NM_002416.2
Organism Homo sapiens(Human)
Definition Homo sapiens C-X-C motif chemokine ligand 9 (CXCL9), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002416.2

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGAAAA GTGGTGTTCT TTTCCTCTTG GGCATCATCT TGCTGGTTCT GATTGGAGTG 
CAAGGAACCC CAGTAGTGAG AAAGGGTCGC TGTTCCTGCA TCAGCACCAA CCAAGGGACT
ATCCACCTAC AATCCTTGAA AGACCTTAAA CAATTTGCCC CAAGCCCTTC CTGCGAGAAA
ATTGAAATCA TTGCTACACT GAAGAATGGA GTTCAAACAT GTCTAAACCC AGATTCAGCA
GATGTGAAGG AACTGATTAA AAAGTGGGAG AAACAGGTCA GCCAAAAGAA AAAGCAAAAG
AATGGGAAAA AACATCAAAA AAAGAAAGTT CTGAAAGTTC GAAAATCTCA ACGTTCTCGT
CAAAAGAAGA CTACATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

CD44 and CXCL9 serum protein levels predict the risk of clinically significant allograft rejection after liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society21(9)1195-207(2015 Sep)
Raschzok N,Reutzel-Selke A,Schmuck RB,Morgul MH,Gauger U,Prabowo KA,Tannus LM,Leder A,Struecker B,Boas-Knoop S,Bartels M,Jonas S,Lojewski C,Puhl G,Seehofer D,Bahra M,Pascher A,Pratschke J,Sauer IM


book

CXCL9 Regulates TGF-β1-Induced Epithelial to Mesenchymal Transition in Human Alveolar Epithelial Cells.
Journal of immunology (Baltimore, Md. : 1950)195(6)2788-96(2015 Sep)
O'Beirne SL,Walsh SM,Fabre A,Reviriego C,Worrell JC,Counihan IP,Lumsden RV,Cramton-Barnes J,Belperio JA,Donnelly SC,Boylan D,Marchal-Sommé J,Kane R,Keane MP


book

Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells.
Cytokine74(2)335-8(2015 Aug)
Kutty RK,Samuel W,Abay R,Cherukuri A,Nagineni CN,Duncan T,Jaworski C,Vijayasarathy C,Redmond TM


book

Osteopontin, CCL5 and CXCL9 are independently associated with psoriasis, regardless of the presence of obesity.
Cytokine74(2)287-92(2015 Aug)
Duarte GV,Boeira V,Correia T,Porto-Silva L,Cardoso T,Macedo MN,Oliveira MF,Carvalho E


book

Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study.
PloS one10(10)e0141394(2015)
Altara R,Gu YM,Struijker-Boudier HA,Thijs L,Staessen JA,Blankesteijn WM


 
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