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MMP10 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MMP10
Entrez Gene ID 4319
Full Name matrix metallopeptidase 10
Synonyms SL-2, STMY2
General protein information
Preferred Names
stromelysin-2
Names
stromelysin-2
MMP-10
transin 2
transin-2
stromelysin 2
matrix metalloprotease 10
matrix metalloproteinase-10
matrix metalloproteinase 10 (stromelysin 2)
NP_002416.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q22.3

Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

185260


mRNA and Protein(s)

mRNA Protein Name
NM_002425 NP_002416 stromelysin-2 preproprotein



Homo sapiens (human) MMP10 NP_002416.1
Pan troglodytes (chimpanzee) MMP10 XP_001153881.1
Macaca mulatta (Rhesus monkey) MMP10 XP_001086245.1
Mus musculus (house mouse) Mmp10 NP_062344.1
Rattus norvegicus (Norway rat) Mmp10 NP_598198.1
Gallus gallus (chicken) MMP10 NP_001265018.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MMP10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23759
NM_002425 Homo sapiens matrix metallopeptidase 10 (MMP10), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23759
Clone ID Related Accession (Same CDS sequence) NM_002425
Accession Version NM_002425.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1431bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product stromelysin-2 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313960.1 and BC002591.2. On May 15, 2010 this sequence version replaced gi:4505204. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002591.2, X07820.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGCATC TTGCATTCCT TGTGCTGTTG TGTCTGCCAG TCTGCTCTGC CTATCCTCTG 
AGTGGGGCAG CAAAAGAGGA GGACTCCAAC AAGGATCTTG CCCAGCAATA CCTAGAAAAG
TACTACAACC TCGAAAAGGA TGTGAAACAG TTTAGAAGAA AGGACAGTAA TCTCATTGTT
AAAAAAATCC AAGGAATGCA GAAGTTCCTT GGGTTGGAGG TGACAGGGAA GCTAGACACT
GACACTCTGG AGGTGATGCG CAAGCCCAGG TGTGGAGTTC CTGACGTTGG TCACTTCAGC
TCCTTTCCTG GCATGCCGAA GTGGAGGAAA ACCCACCTTA CATACAGGAT TGTGAATTAT
ACACCAGATT TGCCAAGAGA TGCTGTTGAT TCTGCCATTG AGAAAGCTCT GAAAGTCTGG
GAAGAGGTGA CTCCACTCAC ATTCTCCAGG CTGTATGAAG GAGAGGCTGA TATAATGATC
TCTTTTGCAG TTAAAGAACA TGGAGACTTT TACTCTTTTG ATGGCCCAGG ACACAGTTTG
GCTCATGCCT ACCCACCTGG ACCTGGGCTT TATGGAGATA TTCACTTTGA TGATGATGAA
AAATGGACAG AAGATGCATC AGGCACCAAT TTATTCCTCG TTGCTGCTCA TGAACTTGGC
CACTCCCTGG GGCTCTTTCA CTCAGCCAAC ACTGAAGCTT TGATGTACCC ACTCTACAAC
TCATTCACAG AGCTCGCCCA GTTCCGCCTT TCGCAAGATG ATGTGAATGG CATTCAGTCT
CTCTACGGAC CTCCCCCTGC CTCTACTGAG GAACCCCTGG TGCCCACAAA ATCTGTTCCT
TCGGGATCTG AGATGCCAGC CAAGTGTGAT CCTGCTTTGT CCTTCGATGC CATCAGCACT
CTGAGGGGAG AATATCTGTT CTTTAAAGAC AGATATTTTT GGCGAAGATC CCACTGGAAC
CCTGAACCTG AATTTCATTT GATTTCTGCA TTTTGGCCCT CTCTTCCATC ATATTTGGAT
GCTGCATATG AAGTTAACAG CAGGGACACC GTTTTTATTT TTAAAGGAAA TGAGTTCTGG
GCCATCAGAG GAAATGAGGT ACAAGCAGGT TATCCAAGAG GCATCCATAC CCTGGGTTTT
CCTCCAACCA TAAGGAAAAT TGATGCAGCT GTTTCTGACA AGGAAAAGAA GAAAACATAC
TTCTTTGCAG CGGACAAATA CTGGAGATTT GATGAAAATA GCCAGTCCAT GGAGCAAGGC
TTCCCTAGAC TAATAGCTGA TGACTTTCCA GGAGTTGAGC CTAAGGTTGA TGCTGTATTA
CAGGCATTTG GATTTTTCTA CTTCTTCAGT GGATCATCAC AGTTTGAGTT TGACCCCAAT
GCCAGGATGG TGACACACAT ATTAAAGAGT AACAGCTGGT TACATTGCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002416.1
CDS38..1468
Misc Feature(1)11..13(+)
Misc Feature(2)134..295(+)
Misc Feature(3)302..325(+)
Misc Feature(4)356..826(+)
Misc Feature(5)356..826(+)
Misc Feature(6)512..754(+)
Misc Feature(7)686..718(+)
Misc Feature(8)893..1465(+)
Misc Feature(9)893..1042(+)
Misc Feature(10)923..1354(+)
Misc Feature(11)1043..1183(+)
Misc Feature(12)1187..1333(+)
Misc Feature(13)1334..1465(+)
Exon (1)1..142
Gene:MMP10
Gene Synonym:
Exon (2)143..384
Gene:MMP10
Gene Synonym:
Exon (3)385..533
Gene:MMP10
Gene Synonym:
Exon (4)534..659
Gene:MMP10
Gene Synonym:
Exon (5)660..824
Gene:MMP10
Gene Synonym:
Exon (6)825..969
Gene:MMP10
Gene Synonym:
Exon (7)970..1103
Gene:MMP10
Gene Synonym:
Exon (8)1104..1263
Gene:MMP10
Gene Synonym:
Exon (9)1264..1367
Gene:MMP10
Gene Synonym:
Exon (10)1368..1759
Gene:MMP10
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002425
Organism Homo sapiens (human)
Definition Homo sapiens matrix metallopeptidase 10 (MMP10), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002425

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGATGCATC TTGCATTCCT TGTGCTGTTG TGTCTGCCAG TCTGCTCTGC CTATCCTCTG 
AGTGGGGCAG CAAAAGAGGA GGACTCCAAC AAGGATCTTG CCCAGCAATA CCTAGAAAAG
TACTACAACC TCGAAAAGGA TGTGAAACAG TTTAGAAGAA AGGACAGTAA TCTCATTGTT
AAAAAAATCC AAGGAATGCA GAAGTTCCTT GGGTTGGAGG TGACAGGGAA GCTAGACACT
GACACTCTGG AGGTGATGCG CAAGCCCAGG TGTGGAGTTC CTGACGTTGG TCACTTCAGC
TCCTTTCCTG GCATGCCGAA GTGGAGGAAA ACCCACCTTA CATACAGGAT TGTGAATTAT
ACACCAGATT TGCCAAGAGA TGCTGTTGAT TCTGCCATTG AGAAAGCTCT GAAAGTCTGG
GAAGAGGTGA CTCCACTCAC ATTCTCCAGG CTGTATGAAG GAGAGGCTGA TATAATGATC
TCTTTTGCAG TTAAAGAACA TGGAGACTTT TACTCTTTTG ATGGCCCAGG ACACAGTTTG
GCTCATGCCT ACCCACCTGG ACCTGGGCTT TATGGAGATA TTCACTTTGA TGATGATGAA
AAATGGACAG AAGATGCATC AGGCACCAAT TTATTCCTCG TTGCTGCTCA TGAACTTGGC
CACTCCCTGG GGCTCTTTCA CTCAGCCAAC ACTGAAGCTT TGATGTACCC ACTCTACAAC
TCATTCACAG AGCTCGCCCA GTTCCGCCTT TCGCAAGATG ATGTGAATGG CATTCAGTCT
CTCTACGGAC CTCCCCCTGC CTCTACTGAG GAACCCCTGG TGCCCACAAA ATCTGTTCCT
TCGGGATCTG AGATGCCAGC CAAGTGTGAT CCTGCTTTGT CCTTCGATGC CATCAGCACT
CTGAGGGGAG AATATCTGTT CTTTAAAGAC AGATATTTTT GGCGAAGATC CCACTGGAAC
CCTGAACCTG AATTTCATTT GATTTCTGCA TTTTGGCCCT CTCTTCCATC ATATTTGGAT
GCTGCATATG AAGTTAACAG CAGGGACACC GTTTTTATTT TTAAAGGAAA TGAGTTCTGG
GCCATCAGAG GAAATGAGGT ACAAGCAGGT TATCCAAGAG GCATCCATAC CCTGGGTTTT
CCTCCAACCA TAAGGAAAAT TGATGCAGCT GTTTCTGACA AGGAAAAGAA GAAAACATAC
TTCTTTGCAG CGGACAAATA CTGGAGATTT GATGAAAATA GCCAGTCCAT GGAGCAAGGC
TTCCCTAGAC TAATAGCTGA TGACTTTCCA GGAGTTGAGC CTAAGGTTGA TGCTGTATTA
CAGGCATTTG GATTTTTCTA CTTCTTCAGT GGATCATCAC AGTTTGAGTT TGACCCCAAT
GCCAGGATGG TGACACACAT ATTAAAGAGT AACAGCTGGT TACATTGCTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors
BMC Cancer 14, 310 (2014)
Zhang G, Miyake M, Lawton A, Goodison S and Rosser CJ.


book

Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism
Mol. Cancer 13, 130 (2014)
Zhang JJ, Zhu Y, Xie KL, Peng YP, Tao JQ, Tang J, Li Z, Xu ZK, Dai CC, Qian ZY, Jiang KR, Wu JL, Gao WT, Du Q and Miao Y.


book

Genetic variations within metalloproteinases impact on the prophylaxis of depressive phases in bipolar patients
Neuropsychobiology 69 (2), 76-82 (2014)
Drago A, Monti B, De Ronchi D and Serretti A.


book

[Association between matrix metalloproteinase-10 gene polymorphisms and instability of carotid plaque]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30 (6), 711-715 (2013)
Zhu F, Jin XP, Huang MW, Zhu M, Chen QL, Wang F, Hu XF, Wang WF, Li WL, Li C, Zhu ZY and Zheng Z.


book

Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing
Invest. Ophthalmol. Vis. Sci. 54 (13), 8172-8180 (2013)
Saghizadeh M, Epifantseva I, Hemmati DM, Ghiam CA, Brunken WJ and Ljubimov AV.


book

Expression pattern of matrix metalloproteinases in human liver
Eur J Clin Chem Clin Biochem 33 (2), 65-71 (1995)
Lichtinghagen R, Helmbrecht T, Arndt B and Boker KH.


book

Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins
J. Biol. Chem. 266 (24), 15579-15582 (1991)
Fosang AJ, Neame PJ, Hardingham TE, Murphy G and Hamilton JA.


book

Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization
Ann. Genet. 33 (1), 21-23 (1990)
Jung JY, Warter S and Rumpler Y.


book

Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts
Biochemistry 28 (22), 8691-8698 (1989)
Sirum KL and Brinckerhoff CE.


book

The collagenase gene family in humans consists of at least four members
Biochem. J. 253 (1), 187-192 (1988)
Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J and Breathnach R.


 
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