MZT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	MZT1
Entrez Gene ID	440145
Full Name	mitotic spindle organizing protein 1
Synonyms	C13orf37,MOZART1
General protein information	Preferred Names mitotic spindle organizing protein 1 Names mitotic-spindle organizing protein 1 mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q21.33
Disorder MIM:	613448

mRNA and Protein(s)

mRNA Protein Name

NM_001071775.2 NP_001065243.1 mitotic-spindle organizing protein 1

NM_001071775.3 NP_001065243.1 mitotic-spindle organizing protein 1
Pathways from BioSystems

mRNA	Protein	Name
NM_001071775.2	NP_001065243.1	mitotic-spindle organizing protein 1
NM_001071775.3	NP_001065243.1	mitotic-spindle organizing protein 1

Homologies

Pan troglodytes (chimpanzee)	MZT1	XP_001136549.1
Bos taurus (cattle)	MZT1	NP_001193260.1
Rattus norvegicus (Norway rat)	Mzt1	XP_001081273.1
Xenopus tropicalis (tropical clawed frog)	mzt1	NP_001016381.1
Mus musculus (house mouse)	Mzt1	NP_780454.1
Danio rerio (zebrafish)	LOC100333194	XP_002660476.1
Homo sapiens (human)	MZT1	NP_001065243.1
Canis lupus familiaris (dog)	MZT1	XP_003433102.2
	LOC694901	XP_001083554.2
Gallus gallus (chicken)	MZT1	NP_001157822.1

Gene Ontology
Bibliography

Related articles in PubMed

NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex.
Cukier CD, Tourdes A, El-Mazouni D, Guillet V, Nomme J, Mourey L, Milon A, Merdes A, Gervais V
Protein science : a publication of the Protein Society26(11)2240-2248(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

MZT1 regulates microtubule nucleation by linking ?TuRC assembly to adapter-mediated targeting and activation.
Cota RR, Teixid?-Travesa N, Ezquerra A, Eibes S, Lacasa C, Roig J, L?ders J
Journal of cell science130(2)406-419(2017 01)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

Genome-wide association study of obsessive-compulsive disorder.
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH Jr, Kennedy JL, Rosenberg D, Stein DJ, Hemmings SM, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Uma?a P, Murphy DL, Wendland JR, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg HG, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Concei??o do Ros?rio M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A, , Hardy J, , Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL
Molecular psychiatry18(7)788-98(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NMR secondary structure and interactions of recombinant human MOZART1 protein with its binding partner, GCP3, has been presented.
Title: NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex.

MZT1 is a 'priming factor' for gamma-tubulin ring complex that allows spatial regulation of nucleation.
Title: MZT1 regulates microtubule nucleation by linking ?TuRC assembly to adapter-mediated targeting and activation.

The following MZT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MZT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24293	NM_001071775.3 Latest version!	Homo sapiens mitotic spindle organizing protein 1 (MZT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24293	NM_001071775.2	Homo sapiens mitotic spindle organizing protein 1 (MZT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MZT1 ( NM_001071775.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001065243.1 Homo sapiens mitotic spindle organizing protein 1 (MZT1), mRNA.

Price & Availability↑

CloneID	OHu24293
Clone ID Related Accession (Same CDS sequence)	NM_001071775.2 , NM_001071775.3
Accession Version	NM_001071775.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	mitotic-spindle organizing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC125183.1, AK025522.1 and AL356754.18. On Feb 15, 2008 this sequence version replaced NM_001071775.1. ##Evidence-Data-START## Transcript exon combination :: ERR279842.9114.1, SRR1660803.144999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END##

ATGGCGAGTA GCAGCGGTGC TGGGGCGGCG GCGGCGGCCG CGGCGGCGAA TCTGAATGCG 
GTGCGGGAGA CCATGGACGT TCTGCTTGAG ATTTCAAGAA TTTTGAATAC TGGCTTAGAT 
ATGGAAACTC TGTCTATTTG TGTACGGCTT TGTGAACAAG GAATTAACCC AGAAGCTTTA 
TCATCGGTTA TTAAGGAGCT TCGCAAGGCT ACTGAAGCAC TGAAGGCTGC TGAAAATATG 
ACAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001065243.1
CDS	199..447
Translation	MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEALSSVIKELRKATEALKAAENMTS

Target ORF information:

RefSeq Version	NM_001071775.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mitotic spindle organizing protein 1 (MZT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001071775.2

ORF Insert Sequence:

ATGGCGAGTA GCAGCGGTGC TGGGGCGGCG GCGGCGGCCG CGGCGGCGAA TCTGAATGCG 
GTGCGGGAGA CCATGGACGT TCTGCTTGAG ATTTCAAGAA TTTTGAATAC TGGCTTAGAT 
ATGGAAACTC TGTCTATTTG TGTACGGCTT TGTGAACAAG GAATTAACCC AGAAGCTTTA 
TCATCGGTTA TTAAGGAGCT TCGCAAGGCT ACTGAAGCAC TGAAGGCTGC TGAAAATATG 
ACAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MZT1 ( NM_001071775.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001065243.1 Homo sapiens mitotic spindle organizing protein 1 (MZT1), mRNA.

Price & Availability↑

CloneID	OHu24293
Clone ID Related Accession (Same CDS sequence)	NM_001071775.2 , NM_001071775.3
Accession Version	NM_001071775.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 249bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	mitotic-spindle organizing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC125183.1, AK025522.1 and AL356754.18. On Nov 22, 2018 this sequence version replaced NM_001071775.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.198352.1, SRR1660805.180025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000377818.4/ ENSP00000367049.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGAGTA GCAGCGGTGC TGGGGCGGCG GCGGCGGCCG CGGCGGCGAA TCTGAATGCG 
GTGCGGGAGA CCATGGACGT TCTGCTTGAG ATTTCAAGAA TTTTGAATAC TGGCTTAGAT 
ATGGAAACTC TGTCTATTTG TGTACGGCTT TGTGAACAAG GAATTAACCC AGAAGCTTTA 
TCATCGGTTA TTAAGGAGCT TCGCAAGGCT ACTGAAGCAC TGAAGGCTGC TGAAAATATG 
ACAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001065243.1
CDS	28..276
Translation	MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEALSSVIKELRKATEALKAAENMTS

Target ORF information:

RefSeq Version	NM_001071775.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mitotic spindle organizing protein 1 (MZT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001071775.3

ORF Insert Sequence:

ATGGCGAGTA GCAGCGGTGC TGGGGCGGCG GCGGCGGCCG CGGCGGCGAA TCTGAATGCG 
GTGCGGGAGA CCATGGACGT TCTGCTTGAG ATTTCAAGAA TTTTGAATAC TGGCTTAGAT 
ATGGAAACTC TGTCTATTTG TGTACGGCTT TGTGAACAAG GAATTAACCC AGAAGCTTTA 
TCATCGGTTA TTAAGGAGCT TCGCAAGGCT ACTGAAGCAC TGAAGGCTGC TGAAAATATG 
ACAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex.
Protein science : a publication of the Protein Society26(11)2240-2248(2017 Nov)
Cukier CD,Tourdes A,El-Mazouni D,Guillet V,Nomme J,Mourey L,Milon A,Merdes A,Gervais V

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

MZT1 regulates microtubule nucleation by linking ?TuRC assembly to adapter-mediated targeting and activation.
Journal of cell science130(2)406-419(2017 01)
Cota RR,Teixid?-Travesa N,Ezquerra A,Eibes S,Lacasa C,Roig J,L?ders J

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

Genome-wide association study of obsessive-compulsive disorder.
Molecular psychiatry18(7)788-98(2013 Jul)
Stewart SE,Yu D,Scharf JM,Neale BM,Fagerness JA,Mathews CA,Arnold PD,Evans PD,Gamazon ER,Davis LK,Osiecki L,McGrath L,Haddad S,Crane J,Hezel D,Illman C,Mayerfeld C,Konkashbaev A,Liu C,Pluzhnikov A,Tikhomirov A,Edlund CK,Rauch SL,Moessner R,Falkai P,Maier W,Ruhrmann S,Grabe HJ,Lennertz L,Wagner M,Bellodi L,Cavallini MC,Richter MA,Cook EH Jr,Kennedy JL,Rosenberg D,Stein DJ,Hemmings SM,Lochner C,Azzam A,Chavira DA,Fournier E,Garrido H,Sheppard B,Uma?a P,Murphy DL,Wendland JR,Veenstra-VanderWeele J,Denys D,Blom R,Deforce D,Van Nieuwerburgh F,Westenberg HG,Walitza S,Egberts K,Renner T,Miguel EC,Cappi C,Hounie AG,Concei??o do Ros?rio M,Sampaio AS,Vallada H,Nicolini H,Lanzagorta N,Camarena B,Delorme R,Leboyer M,Pato CN,Pato MT,Voyiaziakis E,Heutink P,Cath DC,Posthuma D,Smit JH,Samuels J,Bienvenu OJ,Cullen B,Fyer AJ,Grados MA,Greenberg BD,McCracken JT,Riddle MA,Wang Y,Coric V,Leckman JF,Bloch M,Pittenger C,Eapen V,Black DW,Ophoff RA,Strengman E,Cusi D,Turiel M,Frau F,Macciardi F,Gibbs JR,Cookson MR,Singleton A,,Hardy J,,Crenshaw AT,Parkin MA,Mirel DB,Conti DV,Purcell S,Nestadt G,Hanna GL,Jenike MA,Knowles JA,Cox N,Pauls DL

REQUEST A QUOTE

EMAIL

[email protected]

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

MZT1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM

SUPPORT

COMPANY

SUPPORT

COMPANY