PIWIL3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIWIL3
Entrez Gene ID	440822
Full Name	piwi like RNA-mediated gene silencing 3
Synonyms	HIWI3
General protein information	Preferred Names piwi like RNA-mediated gene silencing 3 Names piwi-like protein 3 piwi-like 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.23
Summary	This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Disorder MIM:	610314

mRNA and Protein(s)

mRNA	Protein	Name
NM_001255975.1	NP_001242904.1	piwi-like protein 3 isoform 2
NM_001008496.3	NP_001008496.2	piwi-like protein 3 isoform 1

Pathways from BioSystems

Homologies

	PIWIL3	XP_001099093.1
Canis lupus familiaris (dog)	LOC486307	XP_005636578.1
Homo sapiens (human)	PIWIL3	NP_001242904.1
Pan troglodytes (chimpanzee)	PIWIL3	XP_003317193.1
Drosophila melanogaster (fruit fly)	piwi	NP_476875.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of Piwil3 suppresses cell proliferation, migration and invasion in gastric cancer.
Jiang L, Wang WJ, Li ZW, Wang XZ
Cancer biomarkers : section A of Disease markers20(4)499-509(2017 Dec)

Expression of PIWIL3 in primary and metastatic melanoma.
Gambichler T, Kohsik C, H?h AK, Lang K, K?fferlein HU, Br?ning T, Stockfleth E, St?cker M, Drei?igacker M, Sand M
Journal of cancer research and clinical oncology143(3)433-437(2017 Mar)

Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.
Sivagurunathan S, Palanisamy K, Arunachalam JP, Chidambaram S
Molecular and cellular biochemistry427(1-2)145-156(2017 Mar)

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, D?ret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our data indicate that PIWIL3 protein expression is elevated in more aggressive primary malignant melanoma(MM )and metastatic disease. As also observed in other malignancies, PIWIL3 seems to play a role in MM progression.
Title: Expression of PIWIL3 in primary and metastatic melanoma.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.

PIWIL3 proteins were expressed in the cytoplasma of human astrocytic glioma and meningioma.
Title: [Preparation and distribution of polyclonal antibodies against human PIWIL3 protein in tumor tissues].

The following PIWIL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIWIL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20795	NM_001008496.3 Latest version!	Homo sapiens piwi like RNA-mediated gene silencing 3 (PIWIL3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu21459	NM_001255975.1 Latest version!	Homo sapiens piwi like RNA-mediated gene silencing 3 (PIWIL3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIWIL3 ( NM_001008496.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008496.2 Homo sapiens piwi like RNA-mediated gene silencing 3 (PIWIL3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20795
Clone ID Related Accession (Same CDS sequence)	NM_001008496.3
Accession Version	NM_001008496.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2649bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	piwi-like protein 3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP000359.1 and AB079368.1. On Dec 20, 2011 this sequence version replaced NM_001008496.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). ##Evidence-Data-START## Transcript exon combination :: AB079368.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2147596 [ECO:0000350] ##Evidence-Data-END##

ATGCCTGGTA GGGCAAGGAC TCGCGCCCGA GGCAGAGCCC GCCGCAGGGA GAGCTACCAA 
CAAGAGGCAC CTGGGGGACC CAGAGCACCT GGATCAGCTA CAACCCAGGA GCCCCCTCAG 
TTGCAGTCGA CACCCCGGCC GCTGCAGGAG GAAGTCCCAG TGGTTAGACC TCTGCAGCCA 
AGAGCAGCAA GAGGAGGAGC AGGAGGAGGA GCACAGTCTC AAGGGGTGAA GGAACCTGGA 
CCTGAGGCTG GGTTGCATAC AGCGCCCTTG CAGGAGAGAA GGATTGGTGG AGTTTTTCAA 
GACCTGGTGG TGAACACCAG GCAAGATATG AAGCATGTTA AAGACTCAAA AACAGGTTCA 
GAGGGTACAG TGGTACAGCT ACTCGCCAAC CACTTCCGAG TGATATCTCG TCCTCAGTGG 
GTTGCATATA AATACAACGT TGACTACAAA CCAGACATAG AAGATGGAAA TCTCCGTACA 
ATTTTACTTG ATCAACATAG AAGGAAATTT GGAGAGCGCC ATATATTTGA TGGAAACTCT 
TTATTATTAT CTCGGCCACT AAAAGAGCGG AGAGTGGAAT GGTTGAGCAC AACCAAAGAC 
AAAAACATCG TGAAGATTAC AGTTGAGTTT TCCAAAGAAC TCACGCCCAC GTCGCCAGAT 
TGCCTACGCT ATTACAACAT TCTCTTTAGA AGAACTTTCA AGCTGCTGGA TTTTGAACAA 
GTTGGTCGCA ACTATTATAC CAAAAAGAAG GCCATTCAGT TATACCGTCA TGGTACCAGT 
TTGGAAATCT GGCTTGGTTA TGTTACTTCT GTTCTTCAAT ACGAAAACAG CATTACCCTC 
TGTGCCGATG TGAGCCACAA ACTGCTCCGA ATAGAAACTG CTTATGATTT CATAAAGAGA 
ACATCTGCCC AGGCCCAGAC AGGAAACATC CGAGAGGAAG TAACTAATAA ATTAATTGGA 
TCAATTGTTC TGACAAAATA CAACAACAAA ACCTACAGAG TAGATGATAT TGATTGGAAG 
CAGAATCCTG AAGACACATT TAACAAATCA GATGGCAGCA AAATCACCTA TATAGACTAC 
TACAGGCAGC AACATAAAGA AATTGTCACA GTGAAGAAAC AGCCACTTTT GGTCAGCCAG 
GGCAGATGGA AAAAGGGCCT AACGGGTACA CAACGTGAAC CTATCCTGCT GATTCCTCAG 
CTGTGCCACA TGACAGGTCT AACAGATGAA ATATGTAAAG ATTATAGCAT TGTGAAAGAA 
TTGGCTAAAC ATACAAGATT GAGTCCAAGA AGAAGGCATC ATACATTAAA AGAATTCATC 
AATACTCTAC AAGATAATAA AAAAGTACGA GAGTTACTTC AACTCTGGGA TTTGAAATTT 
GATACCAATT TTTTGTCCGT CCCGGGAAGA GTTTTGAAAA ACGCAAACAT CGTGCAAGGC 
AGAAGAATGG TTAAAGCCAA TTCACAAGGA GACTGGTCAA GAGAAATAAG AGAATTACCC 
TTACTTAATG CAATGCCACT ACATAGTTGG CTCATACTCT ATAGCAGGAG CAGTCACAGA 
GAAGCCATGT CCTTAAAGGG TCATCTACAG AGTGTCACAG CCCCCATGGG CATAACTATG 
AAACCAGCAG AAATGATTGA AGTAGATGGT GATGCTAACT CCTATATAGA CACATTACGG 
AAATATACTA GACCAACACT GCAGATGGGA ATGTCATGTT TGCTGGTTTT CAAGGTGATT 
TGTATCCTGC CCAATGATGA CAAACGTAGA TATGACAGCA TAAAAAGATA CCTATGTACC 
AAATGCCCAA TTCCAAGCCA GTGTGTGGTG AAAAAGACCT TAGAAAAAGT CCAGGCAAGG 
ACCATCGTCA CCAAGATTGC CCAGCAGATG AATTGCAAGA TGGGAGGAGC CCTCTGGAAG 
GTGGAGACAG ACGTACAAAG AACAATGTTC GTTGGCATTG ATTGTTTCCA CGATATCGTA 
AATCGACAGA AATCAATAGC AGGATTTGTT GCAAGTACCA ATGCTGAATT AACAAAGTGG 
TACTCTCAAT GTGTCATCCA GAAAACAGGA GAAGAGCTTG TGAAAGAGCT GGAGATCTGC 
TTGAAAGCTG CCCTGGATGT CTGGTGTAAA AACGAATCAT CGATGCCACA TTCTGTTATT 
GTGTATCGGG ATGGAGTGGG AGATGGTCAG CTTCAAGCAT TGCTTGACCA TGAAGCGAAA 
AAGATGTCGA CCTACTTAAA AACCATCTCT CCTAACAATT TCACTCTAGC TTTCATTGTG 
GTGAAGAAAC GAATAAACAC TAGATTTTTT CTTAAACATG GAAGCAATTT TCAAAATCCA 
CCTCCAGGAA CAGTTATTGA TGTAGAGTTG ACTAGGAATG AATGGTATGA CTTTTTTATT 
GTGAGTCAGT CTGTGCAAGA TGGGACTGTT ACCCCCACTC ATTATAACGT CATCTATGAC 
ACGATTGGCT TGAGCCCAGA TACAGTACAG CGTTTAACAT ATTGTCTATG CCACATGTAT 
TATAATTTGC CAGGCATCAT CCGAGTTCCA GCGCCTTGCC ACTATGCCCA CAAGCTGGCT 
TACCTCGTGG GGCAGTCCAT TCACCAGGAA CCGAATCGTT CCTTGTCAAC TCGTCTCTTT 
TACCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008496.2
CDS	422..3070
Translation	MPGRARTRARGRARRRESYQQEAPGGPRAPGSATTQEPPQLQSTPRPLQEEVPVVRPLQPRAARGGAGGGAQSQGVKEPGPEAGLHTAPLQERRIGGVFQDLVVNTRQDMKHVKDSKTGSEGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNSLLLSRPLKERRVEWLSTTKDKNIVKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYRHGTSLEIWLGYVTSVLQYENSITLCADVSHKLLRIETAYDFIKRTSAQAQTGNIREEVTNKLIGSIVLTKYNNKTYRVDDIDWKQNPEDTFNKSDGSKITYIDYYRQQHKEIVTVKKQPLLVSQGRWKKGLTGTQREPILLIPQLCHMTGLTDEICKDYSIVKELAKHTRLSPRRRHHTLKEFINTLQDNKKVRELLQLWDLKFDTNFLSVPGRVLKNANIVQGRRMVKANSQGDWSREIRELPLLNAMPLHSWLILYSRSSHREAMSLKGHLQSVTAPMGITMKPAEMIEVDGDANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRRYDSIKRYLCTKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGALWKVETDVQRTMFVGIDCFHDIVNRQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDVWCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFTLAFIVVKKRINTRFFLKHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSPDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL

Target ORF information:

RefSeq Version	NM_001008496.3
Organism	Homo sapiens(human)
Definition	Homo sapiens piwi like RNA-mediated gene silencing 3 (PIWIL3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008496.3

ORF Insert Sequence:

ATGCCTGGTA GGGCAAGGAC TCGCGCCCGA GGCAGAGCCC GCCGCAGGGA GAGCTACCAA 
CAAGAGGCAC CTGGGGGACC CAGAGCACCT GGATCAGCTA CAACCCAGGA GCCCCCTCAG 
TTGCAGTCGA CACCCCGGCC GCTGCAGGAG GAAGTCCCAG TGGTTAGACC TCTGCAGCCA 
AGAGCAGCAA GAGGAGGAGC AGGAGGAGGA GCACAGTCTC AAGGGGTGAA GGAACCTGGA 
CCTGAGGCTG GGTTGCATAC AGCGCCCTTG CAGGAGAGAA GGATTGGTGG AGTTTTTCAA 
GACCTGGTGG TGAACACCAG GCAAGATATG AAGCATGTTA AAGACTCAAA AACAGGTTCA 
GAGGGTACAG TGGTACAGCT ACTCGCCAAC CACTTCCGAG TGATATCTCG TCCTCAGTGG 
GTTGCATATA AATACAACGT TGACTACAAA CCAGACATAG AAGATGGAAA TCTCCGTACA 
ATTTTACTTG ATCAACATAG AAGGAAATTT GGAGAGCGCC ATATATTTGA TGGAAACTCT 
TTATTATTAT CTCGGCCACT AAAAGAGCGG AGAGTGGAAT GGTTGAGCAC AACCAAAGAC 
AAAAACATCG TGAAGATTAC AGTTGAGTTT TCCAAAGAAC TCACGCCCAC GTCGCCAGAT 
TGCCTACGCT ATTACAACAT TCTCTTTAGA AGAACTTTCA AGCTGCTGGA TTTTGAACAA 
GTTGGTCGCA ACTATTATAC CAAAAAGAAG GCCATTCAGT TATACCGTCA TGGTACCAGT 
TTGGAAATCT GGCTTGGTTA TGTTACTTCT GTTCTTCAAT ACGAAAACAG CATTACCCTC 
TGTGCCGATG TGAGCCACAA ACTGCTCCGA ATAGAAACTG CTTATGATTT CATAAAGAGA 
ACATCTGCCC AGGCCCAGAC AGGAAACATC CGAGAGGAAG TAACTAATAA ATTAATTGGA 
TCAATTGTTC TGACAAAATA CAACAACAAA ACCTACAGAG TAGATGATAT TGATTGGAAG 
CAGAATCCTG AAGACACATT TAACAAATCA GATGGCAGCA AAATCACCTA TATAGACTAC 
TACAGGCAGC AACATAAAGA AATTGTCACA GTGAAGAAAC AGCCACTTTT GGTCAGCCAG 
GGCAGATGGA AAAAGGGCCT AACGGGTACA CAACGTGAAC CTATCCTGCT GATTCCTCAG 
CTGTGCCACA TGACAGGTCT AACAGATGAA ATATGTAAAG ATTATAGCAT TGTGAAAGAA 
TTGGCTAAAC ATACAAGATT GAGTCCAAGA AGAAGGCATC ATACATTAAA AGAATTCATC 
AATACTCTAC AAGATAATAA AAAAGTACGA GAGTTACTTC AACTCTGGGA TTTGAAATTT 
GATACCAATT TTTTGTCCGT CCCGGGAAGA GTTTTGAAAA ACGCAAACAT CGTGCAAGGC 
AGAAGAATGG TTAAAGCCAA TTCACAAGGA GACTGGTCAA GAGAAATAAG AGAATTACCC 
TTACTTAATG CAATGCCACT ACATAGTTGG CTCATACTCT ATAGCAGGAG CAGTCACAGA 
GAAGCCATGT CCTTAAAGGG TCATCTACAG AGTGTCACAG CCCCCATGGG CATAACTATG 
AAACCAGCAG AAATGATTGA AGTAGATGGT GATGCTAACT CCTATATAGA CACATTACGG 
AAATATACTA GACCAACACT GCAGATGGGA ATGTCATGTT TGCTGGTTTT CAAGGTGATT 
TGTATCCTGC CCAATGATGA CAAACGTAGA TATGACAGCA TAAAAAGATA CCTATGTACC 
AAATGCCCAA TTCCAAGCCA GTGTGTGGTG AAAAAGACCT TAGAAAAAGT CCAGGCAAGG 
ACCATCGTCA CCAAGATTGC CCAGCAGATG AATTGCAAGA TGGGAGGAGC CCTCTGGAAG 
GTGGAGACAG ACGTACAAAG AACAATGTTC GTTGGCATTG ATTGTTTCCA CGATATCGTA 
AATCGACAGA AATCAATAGC AGGATTTGTT GCAAGTACCA ATGCTGAATT AACAAAGTGG 
TACTCTCAAT GTGTCATCCA GAAAACAGGA GAAGAGCTTG TGAAAGAGCT GGAGATCTGC 
TTGAAAGCTG CCCTGGATGT CTGGTGTAAA AACGAATCAT CGATGCCACA TTCTGTTATT 
GTGTATCGGG ATGGAGTGGG AGATGGTCAG CTTCAAGCAT TGCTTGACCA TGAAGCGAAA 
AAGATGTCGA CCTACTTAAA AACCATCTCT CCTAACAATT TCACTCTAGC TTTCATTGTG 
GTGAAGAAAC GAATAAACAC TAGATTTTTT CTTAAACATG GAAGCAATTT TCAAAATCCA 
CCTCCAGGAA CAGTTATTGA TGTAGAGTTG ACTAGGAATG AATGGTATGA CTTTTTTATT 
GTGAGTCAGT CTGTGCAAGA TGGGACTGTT ACCCCCACTC ATTATAACGT CATCTATGAC 
ACGATTGGCT TGAGCCCAGA TACAGTACAG CGTTTAACAT ATTGTCTATG CCACATGTAT 
TATAATTTGC CAGGCATCAT CCGAGTTCCA GCGCCTTGCC ACTATGCCCA CAAGCTGGCT 
TACCTCGTGG GGCAGTCCAT TCACCAGGAA CCGAATCGTT CCTTGTCAAC TCGTCTCTTT 
TACCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIWIL3 ( NM_001255975.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001242904.1 Homo sapiens piwi like RNA-mediated gene silencing 3 (PIWIL3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21459
Clone ID Related Accession (Same CDS sequence)	NM_001255975.1
Accession Version	NM_001255975.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2622bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	piwi-like protein 3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK302409.1, AP000359.1 and AP000358.1. Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK302409.1, AK315806.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2147596 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGCCTGGTA GGGCAAGGAC TCGCGCCCGA GGCAGAGCCC GCCGCAGGGA GAGCTACCAA 
CAAGAGGCAC CTGGGGGACC CAGAGCACCT GGATCAGCTA CAACCCAGGA GCCCCCTCAG 
TTGCAGTCGA CACCCCGGCC GCTGCAGGAG GAAGTCCCAG TGGTTAGACC TCTGCAGCCA 
AGAGCAGCAA GAGGAGGAGC AGGAGGAGGA GCACAGTCTC AAGGGGTGAA GGAACCTGGA 
CCTGAGGCTG GGTTGCATAC AGCGCCCTTG CAGGAGAGAA GGATTGGTGG AGTTTTTCAA 
GACCTGGTGG TGAACACCAG GCAAGATATG AAGCATGTTA AAGACTCAAA AACAGGTTCA 
GAGGGTACAG TGGTACAGCT ACTCGCCAAC CACTTCCGAG TGATATCTCG TCCTCAGTGG 
GTTGCATATA AATACAACGT TGACTACAAA CCAGACATAG AAGATGGAAA TCTCCGTACA 
ATTTTACTTG ATCAACATAG AAGGAAATTT GGAGAGCGCC ATATATTTGA TGGAAACTCT 
TTATTATTAT CTCGGCCACT AAAAGAGCGG AGAGTGGAAT GGTTGAGCAC AACCAAAGAC 
AAAAACATCG TGAAGATTAC AGTTGAGTTT TCCAAAGAAC TCACGCCCAC GTCGCCAGAT 
TGCCTACGCT ATTACAACAT TCTCTTTAGA AGAACTTTCA AGCTGCTGGA TTTTGAACAA 
GTTGGTCGCA ACTATTATAC CAAAAAGAAG GCCATTCAGT TATACCGTCA TGGTACCAGT 
TTGGAAATCT GGCTTGGTTA TGTTACTTCT GTTCTTCAAT ACGAAAACAG CATTACCCTC 
TGTGCCGATG TGAGCCACAA ACTGCTCCGA ATAGAAACTG CTTATGATTT CATAAAGAGA 
ACATCTGCCC AGGCCCAGAC AGGAAACATC CGAGAGGAAG TAACTAATAA ATTAATTGGA 
TCAATTGTTC TGACAAAATA CAACAACAAA ACCTACAGAG TAGATGATAT TGATTGGAAG 
CAGAATCCTG AAGACACATT TAACAAATCA GATGGCAGCA AAATCACCTA TATAGACTAC 
TACAGGCAGC AACATAAAGA AATTGTCACA GTGAAGAAAC AGCCACTTTT GGTCAGCCAG 
GGCAGATGGA AAAAGGGCCT AACGGGTACA CAACGTGAAC CTATCCTGCT GATTCCTCAG 
CTGTGCCACA TGACAGGTCT AACAGATGAA ATATGTAAAG ATTATAGCAT TGTGAAAGAA 
TTGGCTAAAC ATACAAGATT GAGTCCAAGA AGAAGGCATC ATACATTAAA AGAATTCATC 
AATACTCTAC AAGATAATAA AAAAGTACGA GAGTTACTTC AACTCTGGGA TTTGAAATTT 
GATACCAATT TTTTGTCCGT CCCGGGAAGA GTTTTGAAAA ACGCAAACAT CGTGCAAGGC 
AGAAGAATGG TTAAAGCCAA TTCACAAGGA GACTGGTCAA GAGAAATAAG AGAATTACCC 
TTACTTAATG CAATGCCACT ACATAGTTGG CTCATACTCT ATAGCAGGAG CAGTCACAGA 
GAAGCCATGT CCTTAAAGGG TCATCTACAG AGTGTCACAG CCCCCATGGG CATAACTATG 
AAACCAGCAG AAATGATTGA AGTAGATGGT GATGCTAACT CCTATATAGA CACATTACGG 
AAATATACTA GACCAACACT GCAGATGGTG ATTTGTATCC TGCCCAATGA TGACAAACGT 
AGATATGACA GCATAAAAAG ATACCTATGT ACCAAATGCC CAATTCCAAG CCAGTGTGTG 
GTGAAAAAGA CCTTAGAAAA AGTCCAGGCA AGGACCATCG TCACCAAGAT TGCCCAGCAG 
ATGAATTGCA AGATGGGAGG AGCCCTCTGG AAGGTGGAGA CAGACGTACA AAGAACAATG 
TTCGTTGGCA TTGATTGTTT CCACGATATC GTAAATCGAC AGAAATCAAT AGCAGGATTT 
GTTGCAAGTA CCAATGCTGA ATTAACAAAG TGGTACTCTC AATGTGTCAT CCAGAAAACA 
GGAGAAGAGC TTGTGAAAGA GCTGGAGATC TGCTTGAAAG CTGCCCTGGA TGTCTGGTGT 
AAAAACGAAT CATCGATGCC ACATTCTGTT ATTGTGTATC GGGATGGAGT GGGAGATGGT 
CAGCTTCAAG CATTGCTTGA CCATGAAGCG AAAAAGATGT CGACCTACTT AAAAACCATC 
TCTCCTAACA ATTTCACTCT AGCTTTCATT GTGGTGAAGA AACGAATAAA CACTAGATTT 
TTTCTTAAAC ATGGAAGCAA TTTTCAAAAT CCACCTCCAG GAACAGTTAT TGATGTAGAG 
TTGACTAGGA ATGAATGGTA TGACTTTTTT ATTGTGAGTC AGTCTGTGCA AGATGGGACT 
GTTACCCCCA CTCATTATAA CGTCATCTAT GACACGATTG GCTTGAGCCC AGATACAGTA 
CAGCGTTTAA CATATTGTCT ATGCCACATG TATTATAATT TGCCAGGCAT CATCCGAGTT 
CCAGCGCCTT GCCACTATGC CCACAAGCTG GCTTACCTCG TGGGGCAGTC CATTCACCAG 
GAACCGAATC GTTCCTTGTC AACTCGTCTC TTTTACCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001242904.1
CDS	422..3043
Translation	MPGRARTRARGRARRRESYQQEAPGGPRAPGSATTQEPPQLQSTPRPLQEEVPVVRPLQPRAARGGAGGGAQSQGVKEPGPEAGLHTAPLQERRIGGVFQDLVVNTRQDMKHVKDSKTGSEGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNSLLLSRPLKERRVEWLSTTKDKNIVKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYRHGTSLEIWLGYVTSVLQYENSITLCADVSHKLLRIETAYDFIKRTSAQAQTGNIREEVTNKLIGSIVLTKYNNKTYRVDDIDWKQNPEDTFNKSDGSKITYIDYYRQQHKEIVTVKKQPLLVSQGRWKKGLTGTQREPILLIPQLCHMTGLTDEICKDYSIVKELAKHTRLSPRRRHHTLKEFINTLQDNKKVRELLQLWDLKFDTNFLSVPGRVLKNANIVQGRRMVKANSQGDWSREIRELPLLNAMPLHSWLILYSRSSHREAMSLKGHLQSVTAPMGITMKPAEMIEVDGDANSYIDTLRKYTRPTLQMVICILPNDDKRRYDSIKRYLCTKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGALWKVETDVQRTMFVGIDCFHDIVNRQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDVWCKNESSMPHSVIVYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFTLAFIVVKKRINTRFFLKHGSNFQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSPDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL

Target ORF information:

RefSeq Version	NM_001255975.1
Organism	Homo sapiens(human)
Definition	Homo sapiens piwi like RNA-mediated gene silencing 3 (PIWIL3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001255975.1

ORF Insert Sequence:

ATGCCTGGTA GGGCAAGGAC TCGCGCCCGA GGCAGAGCCC GCCGCAGGGA GAGCTACCAA 
CAAGAGGCAC CTGGGGGACC CAGAGCACCT GGATCAGCTA CAACCCAGGA GCCCCCTCAG 
TTGCAGTCGA CACCCCGGCC GCTGCAGGAG GAAGTCCCAG TGGTTAGACC TCTGCAGCCA 
AGAGCAGCAA GAGGAGGAGC AGGAGGAGGA GCACAGTCTC AAGGGGTGAA GGAACCTGGA 
CCTGAGGCTG GGTTGCATAC AGCGCCCTTG CAGGAGAGAA GGATTGGTGG AGTTTTTCAA 
GACCTGGTGG TGAACACCAG GCAAGATATG AAGCATGTTA AAGACTCAAA AACAGGTTCA 
GAGGGTACAG TGGTACAGCT ACTCGCCAAC CACTTCCGAG TGATATCTCG TCCTCAGTGG 
GTTGCATATA AATACAACGT TGACTACAAA CCAGACATAG AAGATGGAAA TCTCCGTACA 
ATTTTACTTG ATCAACATAG AAGGAAATTT GGAGAGCGCC ATATATTTGA TGGAAACTCT 
TTATTATTAT CTCGGCCACT AAAAGAGCGG AGAGTGGAAT GGTTGAGCAC AACCAAAGAC 
AAAAACATCG TGAAGATTAC AGTTGAGTTT TCCAAAGAAC TCACGCCCAC GTCGCCAGAT 
TGCCTACGCT ATTACAACAT TCTCTTTAGA AGAACTTTCA AGCTGCTGGA TTTTGAACAA 
GTTGGTCGCA ACTATTATAC CAAAAAGAAG GCCATTCAGT TATACCGTCA TGGTACCAGT 
TTGGAAATCT GGCTTGGTTA TGTTACTTCT GTTCTTCAAT ACGAAAACAG CATTACCCTC 
TGTGCCGATG TGAGCCACAA ACTGCTCCGA ATAGAAACTG CTTATGATTT CATAAAGAGA 
ACATCTGCCC AGGCCCAGAC AGGAAACATC CGAGAGGAAG TAACTAATAA ATTAATTGGA 
TCAATTGTTC TGACAAAATA CAACAACAAA ACCTACAGAG TAGATGATAT TGATTGGAAG 
CAGAATCCTG AAGACACATT TAACAAATCA GATGGCAGCA AAATCACCTA TATAGACTAC 
TACAGGCAGC AACATAAAGA AATTGTCACA GTGAAGAAAC AGCCACTTTT GGTCAGCCAG 
GGCAGATGGA AAAAGGGCCT AACGGGTACA CAACGTGAAC CTATCCTGCT GATTCCTCAG 
CTGTGCCACA TGACAGGTCT AACAGATGAA ATATGTAAAG ATTATAGCAT TGTGAAAGAA 
TTGGCTAAAC ATACAAGATT GAGTCCAAGA AGAAGGCATC ATACATTAAA AGAATTCATC 
AATACTCTAC AAGATAATAA AAAAGTACGA GAGTTACTTC AACTCTGGGA TTTGAAATTT 
GATACCAATT TTTTGTCCGT CCCGGGAAGA GTTTTGAAAA ACGCAAACAT CGTGCAAGGC 
AGAAGAATGG TTAAAGCCAA TTCACAAGGA GACTGGTCAA GAGAAATAAG AGAATTACCC 
TTACTTAATG CAATGCCACT ACATAGTTGG CTCATACTCT ATAGCAGGAG CAGTCACAGA 
GAAGCCATGT CCTTAAAGGG TCATCTACAG AGTGTCACAG CCCCCATGGG CATAACTATG 
AAACCAGCAG AAATGATTGA AGTAGATGGT GATGCTAACT CCTATATAGA CACATTACGG 
AAATATACTA GACCAACACT GCAGATGGTG ATTTGTATCC TGCCCAATGA TGACAAACGT 
AGATATGACA GCATAAAAAG ATACCTATGT ACCAAATGCC CAATTCCAAG CCAGTGTGTG 
GTGAAAAAGA CCTTAGAAAA AGTCCAGGCA AGGACCATCG TCACCAAGAT TGCCCAGCAG 
ATGAATTGCA AGATGGGAGG AGCCCTCTGG AAGGTGGAGA CAGACGTACA AAGAACAATG 
TTCGTTGGCA TTGATTGTTT CCACGATATC GTAAATCGAC AGAAATCAAT AGCAGGATTT 
GTTGCAAGTA CCAATGCTGA ATTAACAAAG TGGTACTCTC AATGTGTCAT CCAGAAAACA 
GGAGAAGAGC TTGTGAAAGA GCTGGAGATC TGCTTGAAAG CTGCCCTGGA TGTCTGGTGT 
AAAAACGAAT CATCGATGCC ACATTCTGTT ATTGTGTATC GGGATGGAGT GGGAGATGGT 
CAGCTTCAAG CATTGCTTGA CCATGAAGCG AAAAAGATGT CGACCTACTT AAAAACCATC 
TCTCCTAACA ATTTCACTCT AGCTTTCATT GTGGTGAAGA AACGAATAAA CACTAGATTT 
TTTCTTAAAC ATGGAAGCAA TTTTCAAAAT CCACCTCCAG GAACAGTTAT TGATGTAGAG 
TTGACTAGGA ATGAATGGTA TGACTTTTTT ATTGTGAGTC AGTCTGTGCA AGATGGGACT 
GTTACCCCCA CTCATTATAA CGTCATCTAT GACACGATTG GCTTGAGCCC AGATACAGTA 
CAGCGTTTAA CATATTGTCT ATGCCACATG TATTATAATT TGCCAGGCAT CATCCGAGTT 
CCAGCGCCTT GCCACTATGC CCACAAGCTG GCTTACCTCG TGGGGCAGTC CATTCACCAG 
GAACCGAATC GTTCCTTGTC AACTCGTCTC TTTTACCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of Piwil3 suppresses cell proliferation, migration and invasion in gastric cancer.
Cancer biomarkers : section A of Disease markers20(4)499-509(2017 Dec)
Jiang L,Wang WJ,Li ZW,Wang XZ

Expression of PIWIL3 in primary and metastatic melanoma.
Journal of cancer research and clinical oncology143(3)433-437(2017 Mar)
Gambichler T,Kohsik C,H?h AK,Lang K,K?fferlein HU,Br?ning T,Stockfleth E,St?cker M,Drei?igacker M,Sand M

Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.
Molecular and cellular biochemistry427(1-2)145-156(2017 Mar)
Sivagurunathan S,Palanisamy K,Arunachalam JP,Chidambaram S

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,D?ret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN

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PIWIL3 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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