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NGF cDNA ORF clone, Homo sapiens(Human)

Gene Symbol NGF
Entrez Gene ID 4803
Full Name nerve growth factor
Synonyms Beta-NGF,HSAN5,NGFB
General protein information
Preferred Names

nerve growth factor

Names

beta-nerve growth factor
nerve growth factor (beta polypeptide)
nerve growth factor, beta subunit

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1p13.2

Summary This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].
Disorder MIM:

162030

Disorder Html: Neuropathy, hereditary sensory and autonomic, type V, 608654 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_006710665.2 XP_006710728.1 beta-nerve growth factor isoform X1
XM_011541518.2 XP_011539820.1 beta-nerve growth factor isoform X1
NM_002506.2 NP_002497.2 beta-nerve growth factor precursor
XM_006710663.2 XP_006710726.1 beta-nerve growth factor isoform X1
XM_006710663.3 XP_006710726.1 beta-nerve growth factor isoform X2



Xenopus tropicalis (tropical clawed frog) ngf NP_001123396.1
Mus musculus (house mouse) Ngf NP_038637.1
Macaca mulatta (rhesus monkey) LOC711681 XP_001100522.2
Pan troglodytes (chimpanzee) NGF NP_001012439.1
Homo sapiens (human) NGF NP_002497.2
Rattus norvegicus (Norway rat) Ngf NP_001263984.1
Canis lupus familiaris (dog) NGF NP_001181879.1
Bos taurus (cattle) NGF NP_001092832.1
Gallus gallus (chicken) NGF XP_004935065.1


Related articles in PubMed

Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1/2 signaling in pancreatic cancer.
Xin B, He X, Wang J, Cai J, Wei W, Zhang T, Shen X
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]16(6)1005-1014(2016 Nov - Dec)

Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder.
Bilgiç A, Toker A, Işık Ü, Kılınç İ
European child & adolescent psychiatry26(3)355-363(2017 Mar)

Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity.
Ogłodek EA, Just MJ, Szromek AR, Araszkiewicz A
Pharmacological reports : PR68(5)945-51(2016 Oct)

Monocyte chemoattractant protein-1, transforming growth factor-beta1, nerve growth factor, resistin and hyaluronic acid as serum markers: comparison between recurrent acute and chronic pancreatitis.
Kamath MG, Pai CG, Kamath A, Kurien A
Hepatobiliary & pancreatic diseases international : HBPD INT15(2)209-15(2016 Apr)

Elevated Brain-Derived Neurotrophic Factor Correlates Negatively with Severity and Duration of Major Depressive Episodes.
Kheirouri S, Noorazar SG, Alizadeh M, Dana-Alamdari L
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology29(1)24-31(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a stage-related modulation of beta-NGF and its receptors in the inflammatory process of OA
Title: β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis.

Results indicate that NGF inhibited CRT translocation induced by mitoxantrone. NGF effect on CRT translocation could have consequences in immunotherapy, potentially lessening the effectiveness of this type of treatment.
Title: The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signaling pathway in epithelial ovarian cancer cells.

NGF stimulates generation of neurons, but not neuronal progenitors from embryonic stem cells and affects the proportion of specific types of neurons in cultures of differentiating embryonic stem cells.
Title: Effect of Nerve Growth Factor on Neural Differentiation of Mouse Embryonic Stem Cells.

BDNF and NGF serum levels are reduced in the early and moderate glaucoma stages, suggesting the possibility that both factors could be further investigated as potential circulating biomarkers for the early detection of glaucoma.
Title: Exploring Serum Levels of Brain Derived Neurotrophic Factor and Nerve Growth Factor Across Glaucoma Stages.

NGF attenuates these responses-both in vivo and in vitro. Therefore, NGF therapy may represent a novel approach for the management of diabetic keratopathy.
Title: Nerve Growth Factor Attenuates Apoptosis and Inflammation in the Diabetic Cornea.

The following NGF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NGF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25822 NM_002506.2
Latest version!
Homo sapiens nerve growth factor (NGF), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu25822 XM_006710663.3
Latest version!
Homo sapiens nerve growth factor (NGF), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu25822 XM_006710665.2
Latest version!
Homo sapiens nerve growth factor (beta polypeptide) (NGF), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu59274 XM_011541518.2
Latest version!
Homo sapiens nerve growth factor (NGF), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
View Old Accession Versions >>
OHu25822 XM_006710663.2 Homo sapiens nerve growth factor (beta polypeptide) (NGF), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25822
Clone ID Related Accession (Same CDS sequence) XM_006710665.2 , NM_002506.2 , XM_006710663.2 , XM_006710663.3
Accession Version NM_002506.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 726bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-27
Organism Homo sapiens(Human)
Product beta-nerve growth factor precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X52599.1, BC032517.2, CR541855.1 and BE045524.1. This sequence is a reference standard in the RefSeqGene project. On Jul 19, 2005 this sequence version replaced NM_002506.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X52599.1, BC032517.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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ATGTCCATGT TGTTCTACAC TCTGATCACA GCTTTTCTGA TCGGCATACA GGCGGAACCA 
CACTCAGAGA GCAATGTCCC TGCAGGACAC ACCATCCCCC AAGCCCACTG GACTAAACTT
CAGCATTCCC TTGACACTGC CCTTCGCAGA GCCCGCAGCG CCCCGGCAGC GGCGATAGCT
GCACGCGTGG CGGGGCAGAC CCGCAACATT ACTGTGGACC CCAGGCTGTT TAAAAAGCGG
CGACTCCGTT CACCCCGTGT GCTGTTTAGC ACCCAGCCTC CCCGTGAAGC TGCAGACACT
CAGGATCTGG ACTTCGAGGT CGGTGGTGCT GCCCCCTTCA ACAGGACTCA CAGGAGCAAG
CGGTCATCAT CCCATCCCAT CTTCCACAGG GGCGAATTCT CGGTGTGTGA CAGTGTCAGC
GTGTGGGTTG GGGATAAGAC CACCGCCACA GACATCAAGG GCAAGGAGGT GATGGTGTTG
GGAGAGGTGA ACATTAACAA CAGTGTATTC AAACAGTACT TTTTTGAGAC CAAGTGCCGG
GACCCAAATC CCGTTGACAG CGGGTGCCGG GGCATTGACT CAAAGCACTG GAACTCATAT
TGTACCACGA CTCACACCTT TGTCAAGGCG CTGACCATGG ATGGCAAGCA GGCTGCCTGG
CGGTTTATCC GGATAGATAC GGCCTGTGTG TGTGTGCTCA GCAGGAAGGC TGTGAGAAGA
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002497.2
CDS170..895
Misc Feature(1)419..421
Misc Feature(2)551..880
Exon (1)1..33
Exon (2)34..157
Exon (3)158..1049
Translation

Target ORF information:

RefSeq Version NM_002506.2
Organism Homo sapiens(Human)
Definition Homo sapiens nerve growth factor (NGF), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002506.2

ORF Insert Sequence:

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121
181
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361
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481
541
601
661
721
ATGTCCATGT TGTTCTACAC TCTGATCACA GCTTTTCTGA TCGGCATACA GGCGGAACCA 
CACTCAGAGA GCAATGTCCC TGCAGGACAC ACCATCCCCC AAGCCCACTG GACTAAACTT
CAGCATTCCC TTGACACTGC CCTTCGCAGA GCCCGCAGCG CCCCGGCAGC GGCGATAGCT
GCACGCGTGG CGGGGCAGAC CCGCAACATT ACTGTGGACC CCAGGCTGTT TAAAAAGCGG
CGACTCCGTT CACCCCGTGT GCTGTTTAGC ACCCAGCCTC CCCGTGAAGC TGCAGACACT
CAGGATCTGG ACTTCGAGGT CGGTGGTGCT GCCCCCTTCA ACAGGACTCA CAGGAGCAAG
CGGTCATCAT CCCATCCCAT CTTCCACAGG GGCGAATTCT CGGTGTGTGA CAGTGTCAGC
GTGTGGGTTG GGGATAAGAC CACCGCCACA GACATCAAGG GCAAGGAGGT GATGGTGTTG
GGAGAGGTGA ACATTAACAA CAGTGTATTC AAACAGTACT TTTTTGAGAC CAAGTGCCGG
GACCCAAATC CCGTTGACAG CGGGTGCCGG GGCATTGACT CAAAGCACTG GAACTCATAT
TGTACCACGA CTCACACCTT TGTCAAGGCG CTGACCATGG ATGGCAAGCA GGCTGCCTGG
CGGTTTATCC GGATAGATAC GGCCTGTGTG TGTGTGCTCA GCAGGAAGGC TGTGAGAAGA
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25822
Clone ID Related Accession (Same CDS sequence) XM_006710665.2 , NM_002506.2 , XM_006710663.2 , XM_006710663.3
Accession Version XM_006710665.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 726bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-12
Organism Homo sapiens(Human)
Product beta-nerve growth factor isoform X1
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCCATGT TGTTCTACAC TCTGATCACA GCTTTTCTGA TCGGCATACA GGCGGAACCA 
CACTCAGAGA GCAATGTCCC TGCAGGACAC ACCATCCCCC AAGCCCACTG GACTAAACTT
CAGCATTCCC TTGACACTGC CCTTCGCAGA GCCCGCAGCG CCCCGGCAGC GGCGATAGCT
GCACGCGTGG CGGGGCAGAC CCGCAACATT ACTGTGGACC CCAGGCTGTT TAAAAAGCGG
CGACTCCGTT CACCCCGTGT GCTGTTTAGC ACCCAGCCTC CCCGTGAAGC TGCAGACACT
CAGGATCTGG ACTTCGAGGT CGGTGGTGCT GCCCCCTTCA ACAGGACTCA CAGGAGCAAG
CGGTCATCAT CCCATCCCAT CTTCCACAGG GGCGAATTCT CGGTGTGTGA CAGTGTCAGC
GTGTGGGTTG GGGATAAGAC CACCGCCACA GACATCAAGG GCAAGGAGGT GATGGTGTTG
GGAGAGGTGA ACATTAACAA CAGTGTATTC AAACAGTACT TTTTTGAGAC CAAGTGCCGG
GACCCAAATC CCGTTGACAG CGGGTGCCGG GGCATTGACT CAAAGCACTG GAACTCATAT
TGTACCACGA CTCACACCTT TGTCAAGGCG CTGACCATGG ATGGCAAGCA GGCTGCCTGG
CGGTTTATCC GGATAGATAC GGCCTGTGTG TGTGTGCTCA GCAGGAAGGC TGTGAGAAGA
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006710728.1
Translation

Target ORF information:

RefSeq Version XM_006710665.2
Organism Homo sapiens(Human)
Definition Homo sapiens nerve growth factor (beta polypeptide) (NGF), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006710665.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCCATGT TGTTCTACAC TCTGATCACA GCTTTTCTGA TCGGCATACA GGCGGAACCA 
CACTCAGAGA GCAATGTCCC TGCAGGACAC ACCATCCCCC AAGCCCACTG GACTAAACTT
CAGCATTCCC TTGACACTGC CCTTCGCAGA GCCCGCAGCG CCCCGGCAGC GGCGATAGCT
GCACGCGTGG CGGGGCAGAC CCGCAACATT ACTGTGGACC CCAGGCTGTT TAAAAAGCGG
CGACTCCGTT CACCCCGTGT GCTGTTTAGC ACCCAGCCTC CCCGTGAAGC TGCAGACACT
CAGGATCTGG ACTTCGAGGT CGGTGGTGCT GCCCCCTTCA ACAGGACTCA CAGGAGCAAG
CGGTCATCAT CCCATCCCAT CTTCCACAGG GGCGAATTCT CGGTGTGTGA CAGTGTCAGC
GTGTGGGTTG GGGATAAGAC CACCGCCACA GACATCAAGG GCAAGGAGGT GATGGTGTTG
GGAGAGGTGA ACATTAACAA CAGTGTATTC AAACAGTACT TTTTTGAGAC CAAGTGCCGG
GACCCAAATC CCGTTGACAG CGGGTGCCGG GGCATTGACT CAAAGCACTG GAACTCATAT
TGTACCACGA CTCACACCTT TGTCAAGGCG CTGACCATGG ATGGCAAGCA GGCTGCCTGG
CGGTTTATCC GGATAGATAC GGCCTGTGTG TGTGTGCTCA GCAGGAAGGC TGTGAGAAGA
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25822
Clone ID Related Accession (Same CDS sequence) XM_006710665.2 , NM_002506.2 , XM_006710663.2 , XM_006710663.3
Accession Version XM_006710663.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 726bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2015-03-12
Organism Homo sapiens(Human)
Product beta-nerve growth factor isoform X1
Comment

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCCATGT TGTTCTACAC TCTGATCACA GCTTTTCTGA TCGGCATACA GGCGGAACCA 
CACTCAGAGA GCAATGTCCC TGCAGGACAC ACCATCCCCC AAGCCCACTG GACTAAACTT
CAGCATTCCC TTGACACTGC CCTTCGCAGA GCCCGCAGCG CCCCGGCAGC GGCGATAGCT
GCACGCGTGG CGGGGCAGAC CCGCAACATT ACTGTGGACC CCAGGCTGTT TAAAAAGCGG
CGACTCCGTT CACCCCGTGT GCTGTTTAGC ACCCAGCCTC CCCGTGAAGC TGCAGACACT
CAGGATCTGG ACTTCGAGGT CGGTGGTGCT GCCCCCTTCA ACAGGACTCA CAGGAGCAAG
CGGTCATCAT CCCATCCCAT CTTCCACAGG GGCGAATTCT CGGTGTGTGA CAGTGTCAGC
GTGTGGGTTG GGGATAAGAC CACCGCCACA GACATCAAGG GCAAGGAGGT GATGGTGTTG
GGAGAGGTGA ACATTAACAA CAGTGTATTC AAACAGTACT TTTTTGAGAC CAAGTGCCGG
GACCCAAATC CCGTTGACAG CGGGTGCCGG GGCATTGACT CAAAGCACTG GAACTCATAT
TGTACCACGA CTCACACCTT TGTCAAGGCG CTGACCATGG ATGGCAAGCA GGCTGCCTGG
CGGTTTATCC GGATAGATAC GGCCTGTGTG TGTGTGCTCA GCAGGAAGGC TGTGAGAAGA
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006710726.1
Translation

Target ORF information:

RefSeq Version XM_006710663.2
Organism Homo sapiens(Human)
Definition Homo sapiens nerve growth factor (beta polypeptide) (NGF), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006710663.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCCATGT TGTTCTACAC TCTGATCACA GCTTTTCTGA TCGGCATACA GGCGGAACCA 
CACTCAGAGA GCAATGTCCC TGCAGGACAC ACCATCCCCC AAGCCCACTG GACTAAACTT
CAGCATTCCC TTGACACTGC CCTTCGCAGA GCCCGCAGCG CCCCGGCAGC GGCGATAGCT
GCACGCGTGG CGGGGCAGAC CCGCAACATT ACTGTGGACC CCAGGCTGTT TAAAAAGCGG
CGACTCCGTT CACCCCGTGT GCTGTTTAGC ACCCAGCCTC CCCGTGAAGC TGCAGACACT
CAGGATCTGG ACTTCGAGGT CGGTGGTGCT GCCCCCTTCA ACAGGACTCA CAGGAGCAAG
CGGTCATCAT CCCATCCCAT CTTCCACAGG GGCGAATTCT CGGTGTGTGA CAGTGTCAGC
GTGTGGGTTG GGGATAAGAC CACCGCCACA GACATCAAGG GCAAGGAGGT GATGGTGTTG
GGAGAGGTGA ACATTAACAA CAGTGTATTC AAACAGTACT TTTTTGAGAC CAAGTGCCGG
GACCCAAATC CCGTTGACAG CGGGTGCCGG GGCATTGACT CAAAGCACTG GAACTCATAT
TGTACCACGA CTCACACCTT TGTCAAGGCG CTGACCATGG ATGGCAAGCA GGCTGCCTGG
CGGTTTATCC GGATAGATAC GGCCTGTGTG TGTGTGCTCA GCAGGAAGGC TGTGAGAAGA
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25822
Clone ID Related Accession (Same CDS sequence) XM_006710665.2 , NM_002506.2 , XM_006710663.2 , XM_006710663.3
Accession Version XM_006710663.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 726bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product beta-nerve growth factor isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006710663.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

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ATGTCCATGT TGTTCTACAC TCTGATCACA GCTTTTCTGA TCGGCATACA GGCGGAACCA 
CACTCAGAGA GCAATGTCCC TGCAGGACAC ACCATCCCCC AAGCCCACTG GACTAAACTT
CAGCATTCCC TTGACACTGC CCTTCGCAGA GCCCGCAGCG CCCCGGCAGC GGCGATAGCT
GCACGCGTGG CGGGGCAGAC CCGCAACATT ACTGTGGACC CCAGGCTGTT TAAAAAGCGG
CGACTCCGTT CACCCCGTGT GCTGTTTAGC ACCCAGCCTC CCCGTGAAGC TGCAGACACT
CAGGATCTGG ACTTCGAGGT CGGTGGTGCT GCCCCCTTCA ACAGGACTCA CAGGAGCAAG
CGGTCATCAT CCCATCCCAT CTTCCACAGG GGCGAATTCT CGGTGTGTGA CAGTGTCAGC
GTGTGGGTTG GGGATAAGAC CACCGCCACA GACATCAAGG GCAAGGAGGT GATGGTGTTG
GGAGAGGTGA ACATTAACAA CAGTGTATTC AAACAGTACT TTTTTGAGAC CAAGTGCCGG
GACCCAAATC CCGTTGACAG CGGGTGCCGG GGCATTGACT CAAAGCACTG GAACTCATAT
TGTACCACGA CTCACACCTT TGTCAAGGCG CTGACCATGG ATGGCAAGCA GGCTGCCTGG
CGGTTTATCC GGATAGATAC GGCCTGTGTG TGTGTGCTCA GCAGGAAGGC TGTGAGAAGA
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006710726.1
CDS63..788
Misc Feature(1)444..773
Translation

Target ORF information:

RefSeq Version XM_006710663.3
Organism Homo sapiens(Human)
Definition Homo sapiens nerve growth factor (NGF), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006710663.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGTCCATGT TGTTCTACAC TCTGATCACA GCTTTTCTGA TCGGCATACA GGCGGAACCA 
CACTCAGAGA GCAATGTCCC TGCAGGACAC ACCATCCCCC AAGCCCACTG GACTAAACTT
CAGCATTCCC TTGACACTGC CCTTCGCAGA GCCCGCAGCG CCCCGGCAGC GGCGATAGCT
GCACGCGTGG CGGGGCAGAC CCGCAACATT ACTGTGGACC CCAGGCTGTT TAAAAAGCGG
CGACTCCGTT CACCCCGTGT GCTGTTTAGC ACCCAGCCTC CCCGTGAAGC TGCAGACACT
CAGGATCTGG ACTTCGAGGT CGGTGGTGCT GCCCCCTTCA ACAGGACTCA CAGGAGCAAG
CGGTCATCAT CCCATCCCAT CTTCCACAGG GGCGAATTCT CGGTGTGTGA CAGTGTCAGC
GTGTGGGTTG GGGATAAGAC CACCGCCACA GACATCAAGG GCAAGGAGGT GATGGTGTTG
GGAGAGGTGA ACATTAACAA CAGTGTATTC AAACAGTACT TTTTTGAGAC CAAGTGCCGG
GACCCAAATC CCGTTGACAG CGGGTGCCGG GGCATTGACT CAAAGCACTG GAACTCATAT
TGTACCACGA CTCACACCTT TGTCAAGGCG CTGACCATGG ATGGCAAGCA GGCTGCCTGG
CGGTTTATCC GGATAGATAC GGCCTGTGTG TGTGTGCTCA GCAGGAAGGC TGTGAGAAGA
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu59274
Clone ID Related Accession (Same CDS sequence) XM_011541518.2
Accession Version XM_011541518.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 891bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product beta-nerve growth factor isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011541518.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

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781
841
ATGGCCTCAT CTAATGGACA CTTTAATGAA GTTTTGGCCA GTGGTCGTGC AGTCCAAGGG 
GCTGGATGGC ATGCTGGACC CAAGCTCAGC TCAGCGTCCG GACCCAATAA CAGTTTTACC
AAGGGAGCAG CTTTCTATCC TGGCCACACT GAGGTGCATA GCGTAATGTC CATGTTGTTC
TACACTCTGA TCACAGCTTT TCTGATCGGC ATACAGGCGG AACCACACTC AGAGAGCAAT
GTCCCTGCAG GACACACCAT CCCCCAAGCC CACTGGACTA AACTTCAGCA TTCCCTTGAC
ACTGCCCTTC GCAGAGCCCG CAGCGCCCCG GCAGCGGCGA TAGCTGCACG CGTGGCGGGG
CAGACCCGCA ACATTACTGT GGACCCCAGG CTGTTTAAAA AGCGGCGACT CCGTTCACCC
CGTGTGCTGT TTAGCACCCA GCCTCCCCGT GAAGCTGCAG ACACTCAGGA TCTGGACTTC
GAGGTCGGTG GTGCTGCCCC CTTCAACAGG ACTCACAGGA GCAAGCGGTC ATCATCCCAT
CCCATCTTCC ACAGGGGCGA ATTCTCGGTG TGTGACAGTG TCAGCGTGTG GGTTGGGGAT
AAGACCACCG CCACAGACAT CAAGGGCAAG GAGGTGATGG TGTTGGGAGA GGTGAACATT
AACAACAGTG TATTCAAACA GTACTTTTTT GAGACCAAGT GCCGGGACCC AAATCCCGTT
GACAGCGGGT GCCGGGGCAT TGACTCAAAG CACTGGAACT CATATTGTAC CACGACTCAC
ACCTTTGTCA AGGCGCTGAC CATGGATGGC AAGCAGGCTG CCTGGCGGTT TATCCGGATA
GATACGGCCT GTGTGTGTGT GCTCAGCAGG AAGGCTGTGA GAAGAGCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011539820.1
CDS3043..3933
Misc Feature(1)3589..3918
Translation

Target ORF information:

RefSeq Version XM_011541518.2
Organism Homo sapiens(Human)
Definition Homo sapiens nerve growth factor (NGF), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011541518.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCCTCAT CTAATGGACA CTTTAATGAA GTTTTGGCCA GTGGTCGTGC AGTCCAAGGG 
GCTGGATGGC ATGCTGGACC CAAGCTCAGC TCAGCGTCCG GACCCAATAA CAGTTTTACC
AAGGGAGCAG CTTTCTATCC TGGCCACACT GAGGTGCATA GCGTAATGTC CATGTTGTTC
TACACTCTGA TCACAGCTTT TCTGATCGGC ATACAGGCGG AACCACACTC AGAGAGCAAT
GTCCCTGCAG GACACACCAT CCCCCAAGCC CACTGGACTA AACTTCAGCA TTCCCTTGAC
ACTGCCCTTC GCAGAGCCCG CAGCGCCCCG GCAGCGGCGA TAGCTGCACG CGTGGCGGGG
CAGACCCGCA ACATTACTGT GGACCCCAGG CTGTTTAAAA AGCGGCGACT CCGTTCACCC
CGTGTGCTGT TTAGCACCCA GCCTCCCCGT GAAGCTGCAG ACACTCAGGA TCTGGACTTC
GAGGTCGGTG GTGCTGCCCC CTTCAACAGG ACTCACAGGA GCAAGCGGTC ATCATCCCAT
CCCATCTTCC ACAGGGGCGA ATTCTCGGTG TGTGACAGTG TCAGCGTGTG GGTTGGGGAT
AAGACCACCG CCACAGACAT CAAGGGCAAG GAGGTGATGG TGTTGGGAGA GGTGAACATT
AACAACAGTG TATTCAAACA GTACTTTTTT GAGACCAAGT GCCGGGACCC AAATCCCGTT
GACAGCGGGT GCCGGGGCAT TGACTCAAAG CACTGGAACT CATATTGTAC CACGACTCAC
ACCTTTGTCA AGGCGCTGAC CATGGATGGC AAGCAGGCTG CCTGGCGGTT TATCCGGATA
GATACGGCCT GTGTGTGTGT GCTCAGCAGG AAGGCTGTGA GAAGAGCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1/2 signaling in pancreatic cancer.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]16(6)1005-1014(2016 Nov - Dec)
Xin B,He X,Wang J,Cai J,Wei W,Zhang T,Shen X


book

Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder.
European child & adolescent psychiatry26(3)355-363(2017 Mar)
Bilgiç A,Toker A,Işık Ü,Kılınç İ


book

Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity.
Pharmacological reports : PR68(5)945-51(2016 Oct)
Ogłodek EA,Just MJ,Szromek AR,Araszkiewicz A


book

Monocyte chemoattractant protein-1, transforming growth factor-beta1, nerve growth factor, resistin and hyaluronic acid as serum markers: comparison between recurrent acute and chronic pancreatitis.
Hepatobiliary & pancreatic diseases international : HBPD INT15(2)209-15(2016 Apr)
Kamath MG,Pai CG,Kamath A,Kurien A


book

Elevated Brain-Derived Neurotrophic Factor Correlates Negatively with Severity and Duration of Major Depressive Episodes.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology29(1)24-31(2016 Mar)
Kheirouri S,Noorazar SG,Alizadeh M,Dana-Alamdari L


 
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