ATP1B3 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | ATP1B3 |
| Entrez Gene ID | 483 |
| Full Name | ATPase Na+/K+ transporting subunit beta 3 |
| Synonyms | ATPB-3,CD298 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001679.2 | NP_001670.1 | sodium/potassium-transporting ATPase subunit beta-3 |
| NM_001679.4 | NP_001670.1 | sodium/potassium-transporting ATPase subunit beta-3 |
| NM_001679.3 | NP_001670.1 | sodium/potassium-transporting ATPase subunit beta-3 |
| Xenopus tropicalis (tropical clawed frog) | atp1b3 | NP_989087.1 |
| Homo sapiens (human) | ATP1B3 | NP_001670.1 |
| Pan troglodytes (chimpanzee) | ATP1B3 | XP_001154579.2 |
| Bos taurus (cattle) | ATP1B3 | NP_001030470.1 |
| Gallus gallus (chicken) | ATP1B3 | NP_990866.1 |
| Danio rerio (zebrafish) | atp1b3a | NP_571296.1 |
| Canis lupus familiaris (dog) | ATP1B3 | XP_005634705.1 |
| ATP1B3 | XP_001107546.2 | |
| Danio rerio (zebrafish) | atp1b3b | NP_571745.1 |
| Mus musculus (house mouse) | Atp1b3 | NP_031528.1 |
| Rattus norvegicus (Norway rat) | Atp1b3 | NP_037045.1 |
Related articles in PubMed
ATP1B3: a virus-induced host factor against EV71 replication by up-regulating the production of type-I interferons.
Lu Y, Hou H, Wang F, Qiao L, Wang X, Yu J, Liu W, Sun Z
Virology49628-34(2016 09)
ATP1B3 Protein Modulates the Restriction of HIV-1 Production and Nuclear Factor ? Light Chain Enhancer of Activated B Cells (NF-?B) Activation by BST-2.
Nishitsuji H, Sugiyama R, Abe M, Takaku H
The Journal of biological chemistry291(9)4754-62(2016 Feb)
Identification and characterization of angiogenesis targets through proteomic profiling of endothelial cells in human cancer tissues.
Mesri M, Birse C, Heidbrink J, McKinnon K, Brand E, Bermingham CL, Feild B, Fitzhugh W, He T, Ruben S, Moore PA
PloS one8(11)e78885(2013)
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our study demonstrated that ATP1B3 inhibit EV71 replication by enhancing the production of type-I interferons, which could act as a potential therapeutic target in EV71 infection.
Title: ATP1B3: a virus-induced host factor against EV71 replication by up-regulating the production of type-I interferons.
Data suggest that ATP1B3 is binding partner of BST-2 and regulates stability of BST-2; ATP1B3 is co-factor that accelerates BST-2 degradation and reduces BST-2-mediated restriction of HIV-1 replication/tropism and NFkappaB activation.
Title: ATP1B3 Protein Modulates the Restriction of HIV-1 Production and Nuclear Factor ? Light Chain Enhancer of Activated B Cells (NF-?B) Activation by BST-2.
B7H3 and ATP1B3 are overexpressed in tumor endothelial cells, favoring an angiogenic phenotype.
Title: Identification and characterization of angiogenesis targets through proteomic profiling of endothelial cells in human cancer tissues.
Elevated Na+ -K+ -ATPase activity postexercise may contribute to reduced fatigue after training.
Title: Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.
These results evidenced that the beta3 subunit of Na, K ATPase is expressed on RBC membrane but the epitope recognized by mAb P-3E10 is hidden in normal RBCs. we showed the association of beta3 subunit and alpha subunit of Na, K ATPase.
Title: Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells.
The following ATP1B3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP1B3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu29398 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001679.2 , NM_001679.4 , NM_001679.3 | |
| Accession Version | NM_001679.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2015-03-14 | |
| Organism | Homo sapiens(Human) | |
| Product | sodium/potassium-transporting ATPase subunit beta-3 | |
| Comment | ||
1 | ATGACGAAGA ACGAGAAGAA GTCCCTCAAC CAGAGCCTGG CCGAGTGGAA GCTCTTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001670.1 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001679.2 |
ORF Insert Sequence:
1 | ATGACGAAGA ACGAGAAGAA GTCCCTCAAC CAGAGCCTGG CCGAGTGGAA GCTCTTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu29398 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001679.2 , NM_001679.4 , NM_001679.3 | |
| Accession Version | NM_001679.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-05 | |
| Organism | Homo sapiens(human) | |
| Product | sodium/potassium-transporting ATPase subunit beta-3 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK131061.1, AC112504.6, DB307448.1 and CN295803.1. On Nov 22, 2018 this sequence version replaced NM_001679.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.77974.1, SRR1660807.202974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000286371.8/ ENSP00000286371.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGACGAAGA ACGAGAAGAA GTCCCTCAAC CAGAGCCTGG CCGAGTGGAA GCTCTTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001670.1 |
| CDS | 160..999 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001679.4 |
ORF Insert Sequence:
1 | ATGACGAAGA ACGAGAAGAA GTCCCTCAAC CAGAGCCTGG CCGAGTGGAA GCTCTTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu29398 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001679.2 , NM_001679.4 , NM_001679.3 | |
| Accession Version | NM_001679.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-27 | |
| Organism | Homo sapiens(human) | |
| Product | sodium/potassium-transporting ATPase subunit beta-3 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY040306.1, AK131061.1, AC112504.6, DB307448.1 and CN295803.1. On Jun 15, 2016 this sequence version replaced NM_001679.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.24470.1, SRR1660807.202974.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGACGAAGA ACGAGAAGAA GTCCCTCAAC CAGAGCCTGG CCGAGTGGAA GCTCTTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001670.1 |
| CDS | 211..1050 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001679.3 |
ORF Insert Sequence:
1 | ATGACGAAGA ACGAGAAGAA GTCCCTCAAC CAGAGCCTGG CCGAGTGGAA GCTCTTCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
ATP1B3: a virus-induced host factor against EV71 replication by up-regulating the production of type-I interferons. |
|
ATP1B3 Protein Modulates the Restriction of HIV-1 Production and Nuclear Factor ? Light Chain Enhancer of Activated B Cells (NF-?B) Activation by BST-2. |
|
Identification and characterization of angiogenesis targets through proteomic profiling of endothelial cells in human cancer tissues. |
|
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. |