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NOTCH3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol NOTCH3
Entrez Gene ID 4854
Full Name notch 3
Synonyms CADASIL, CASIL, IMF2, LMNS
General protein information
Preferred Names
neurogenic locus notch homolog protein 3
Names
neurogenic locus notch homolog protein 3
Notch homolog 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.2-p13.1

Summary This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600276

Disorder Html: Cerebral arteriopathy with subcortical infarcts and

mRNA and Protein(s)

mRNA Protein Name
NM_000435 NP_000426 neurogenic locus notch homolog protein 3 precursor
XM_005259924 XP_005259981 neurogenic locus notch homolog protein 3 isoform X1



Homo sapiens (human) NOTCH3 NP_000426.2
Pan troglodytes (chimpanzee) NOTCH3 XP_003316212.1
Macaca mulatta (Rhesus monkey) NOTCH3 XP_002808222.1
Canis lupus familiaris (dog) NOTCH3 XP_005633258.1
Bos taurus (cattle) NOTCH3 XP_003586294.1
Mus musculus (house mouse) Notch3 NP_032742.1
Rattus norvegicus (Norway rat) Notch3 NP_064472.2
Xenopus (Silurana) tropicalis (western clawed frog) notch2 XP_002941531.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following NOTCH3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NOTCH3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu24165 NM_000435 Homo sapiens notch 3 (NOTCH3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $923.30
$1319.00
OHu51627 XM_005259924 PREDICTED: Homo sapiens notch 3 (NOTCH3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $1091.30
$1559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu24165
Clone ID Related Accession (Same CDS sequence) NM_000435
Accession Version NM_000435.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 6966bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 14-AUG-2015
Organism Homo sapiens (human)
Product neurogenic locus notch homolog protein 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U97669.1 and AC004663.1. This sequence is a reference standard in the RefSeqGene project. On Mar 28, 2007 this sequence version replaced gi:4557798. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U97669.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
5521
5581
5641
5701
5761
5821
5881
5941
6001
6061
6121
6181
6241
6301
6361
6421
6481
6541
6601
6661
6721
6781
6841
6901
6961
ATGGGGCCGG GGGCCCGTGG CCGCCGCCGC CGCCGTCGCC CGATGTCGCC GCCACCGCCA 
CCGCCACCCG TGCGGGCGCT GCCCCTGCTG CTGCTGCTAG CGGGGCCGGG GGCTGCAGCC
CCCCCTTGCC TGGACGGAAG CCCGTGTGCA AATGGAGGTC GTTGCACCCA GCTGCCCTCC
CGGGAGGCTG CCTGCCTGTG CCCGCCTGGC TGGGTGGGTG AGCGGTGTCA GCTGGAGGAC
CCCTGTCACT CAGGCCCCTG TGCTGGCCGT GGTGTCTGCC AGAGTTCAGT GGTGGCTGGC
ACCGCCCGAT TCTCATGCCG GTGCCCCCGT GGCTTCCGAG GCCCTGACTG CTCCCTGCCA
GATCCCTGCC TCAGCAGCCC TTGTGCCCAC GGTGCCCGCT GCTCAGTGGG GCCCGATGGA
CGCTTCCTCT GCTCCTGCCC ACCTGGCTAC CAGGGCCGCA GCTGCCGAAG CGACGTGGAT
GAGTGCCGGG TGGGTGAGCC CTGCCGCCAT GGTGGCACCT GCCTCAACAC ACCTGGCTCC
TTCCGCTGCC AGTGTCCAGC TGGCTACACA GGGCCACTAT GTGAGAACCC CGCGGTGCCC
TGTGCACCCT CACCATGCCG TAACGGGGGC ACCTGCAGGC AGAGTGGCGA CCTCACTTAC
GACTGTGCCT GTCTTCCTGG GTTTGAGGGT CAGAATTGTG AAGTGAACGT GGACGACTGT
CCAGGACACC GATGTCTCAA TGGGGGGACA TGCGTGGATG GCGTCAACAC CTATAACTGC
CAGTGCCCTC CTGAGTGGAC AGGCCAGTTC TGCACGGAGG ACGTGGATGA GTGTCAGCTG
CAGCCCAACG CCTGCCACAA TGGGGGTACC TGCTTCAACA CGCTGGGTGG CCACAGCTGC
GTGTGTGTCA ATGGCTGGAC AGGCGAGAGC TGCAGTCAGA ATATCGATGA CTGTGCCACA
GCCGTGTGCT TCCATGGGGC CACCTGCCAT GACCGCGTGG CTTCTTTCTA CTGTGCCTGC
CCCATGGGCA AGACTGGCCT CCTGTGTCAC CTGGATGACG CCTGTGTCAG CAACCCCTGC
CACGAGGATG CTATCTGTGA CACAAATCCG GTGAACGGCC GGGCCATTTG CACCTGTCCT
CCCGGCTTCA CGGGTGGGGC ATGTGACCAG GATGTGGACG AGTGCTCTAT CGGCGCCAAC
CCCTGCGAGC ACTTGGGCAG GTGCGTGAAC ACGCAGGGCT CCTTCCTGTG CCAGTGCGGT
CGTGGCTACA CTGGACCTCG CTGTGAGACC GATGTCAACG AGTGTCTGTC GGGGCCCTGC
CGAAACCAGG CCACGTGCCT CGACCGCATA GGCCAGTTCA CCTGTATCTG TATGGCAGGC
TTCACAGGAA CCTATTGCGA GGTGGACATT GACGAGTGTC AGAGTAGCCC CTGTGTCAAC
GGTGGGGTCT GCAAGGACCG AGTCAATGGC TTCAGCTGCA CCTGCCCCTC GGGCTTCAGC
GGCTCCACGT GTCAGCTGGA CGTGGACGAA TGCGCCAGCA CGCCCTGCAG GAATGGCGCC
AAATGCGTGG ACCAGCCCGA TGGCTACGAG TGCCGCTGTG CCGAGGGCTT TGAGGGCACG
CTGTGTGATC GCAACGTGGA CGACTGCTCC CCTGACCCAT GCCACCATGG TCGCTGCGTG
GATGGCATCG CCAGCTTCTC ATGTGCCTGT GCTCCTGGCT ACACGGGCAC ACGCTGCGAG
AGCCAGGTGG ACGAATGCCG CAGCCAGCCC TGCCGCCATG GCGGCAAATG CCTAGACCTG
GTGGACAAGT ACCTCTGCCG CTGCCCTTCT GGGACCACAG GTGTGAACTG CGAAGTGAAC
ATTGACGACT GTGCCAGCAA CCCCTGCACC TTTGGAGTCT GCCGTGATGG CATCAACCGC
TACGACTGTG TCTGCCAACC TGGCTTCACA GGGCCCCTTT GTAACGTGGA GATCAATGAG
TGTGCTTCCA GCCCATGCGG CGAGGGAGGT TCCTGTGTGG ATGGGGAAAA TGGCTTCCGC
TGCCTCTGCC CGCCTGGCTC CTTGCCCCCA CTCTGCCTCC CCCCGAGCCA TCCCTGTGCC
CATGAGCCCT GCAGTCACGG CATCTGCTAT GATGCACCTG GCGGGTTCCG CTGTGTGTGT
GAGCCTGGCT GGAGTGGCCC CCGCTGCAGC CAGAGCCTGG CCCGAGACGC CTGTGAGTCC
CAGCCGTGCA GGGCCGGTGG GACATGCAGC AGCGATGGAA TGGGTTTCCA CTGCACCTGC
CCGCCTGGTG TCCAGGGACG TCAGTGTGAA CTCCTCTCCC CCTGCACCCC GAACCCCTGT
GAGCATGGGG GCCGCTGCGA GTCTGCCCCT GGCCAGCTGC CTGTCTGCTC CTGCCCCCAG
GGCTGGCAAG GCCCACGATG CCAGCAGGAT GTGGACGAGT GTGCTGGCCC CGCACCCTGT
GGCCCTCATG GTATCTGCAC CAACCTGGCA GGGAGTTTCA GCTGCACCTG CCATGGAGGG
TACACTGGCC CTTCCTGCGA TCAGGACATC AATGACTGTG ACCCCAACCC ATGCCTGAAC
GGTGGCTCGT GCCAAGACGG CGTGGGCTCC TTTTCCTGCT CCTGCCTCCC TGGTTTCGCC
GGCCCACGAT GCGCCCGCGA TGTGGATGAG TGCCTGAGCA ACCCCTGCGG CCCGGGCACC
TGTACCGACC ACGTGGCCTC CTTCACCTGC ACCTGCCCGC CAGGCTACGG AGGCTTCCAC
TGCGAACAGG ACCTGCCCGA CTGCAGCCCC AGCTCCTGCT TCAATGGCGG GACCTGTGTG
GACGGCGTGA ACTCGTTCAG CTGCCTGTGC CGTCCCGGCT ACACAGGAGC CCACTGCCAA
CATGAGGCAG ACCCCTGCCT CTCGCGGCCC TGCCTACACG GGGGCGTCTG CAGCGCCGCC
CACCCTGGCT TCCGCTGCAC CTGCCTCGAG AGCTTCACGG GCCCGCAGTG CCAGACGCTG
GTGGATTGGT GCAGCCGCCA GCCTTGTCAA AACGGGGGTC GCTGCGTCCA GACTGGGGCC
TATTGCCTTT GTCCCCCTGG ATGGAGCGGA CGCCTCTGTG ACATCCGAAG CTTGCCCTGC
AGGGAGGCCG CAGCCCAGAT CGGGGTGCGG CTGGAGCAGC TGTGTCAGGC GGGTGGGCAG
TGTGTGGATG AAGACAGCTC CCACTACTGC GTGTGCCCAG AGGGCCGTAC TGGTAGCCAC
TGTGAGCAGG AGGTGGACCC CTGCTTGGCC CAGCCCTGCC AGCATGGGGG GACCTGCCGT
GGCTATATGG GGGGCTACAT GTGTGAGTGT CTTCCTGGCT ACAATGGTGA TAACTGTGAG
GACGACGTGG ACGAGTGTGC CTCCCAGCCC TGCCAGCACG GGGGTTCATG CATTGACCTC
GTGGCCCGCT ATCTCTGCTC CTGTCCCCCA GGAACGCTGG GGGTGCTCTG CGAGATTAAT
GAGGATGACT GCGGCCCAGG CCCACCGCTG GACTCAGGGC CCCGGTGCCT ACACAATGGC
ACCTGCGTGG ACCTGGTGGG TGGTTTCCGC TGCACCTGTC CCCCAGGATA CACTGGTTTG
CGCTGCGAGG CAGACATCAA TGAGTGTCGC TCAGGTGCCT GCCACGCGGC ACACACCCGG
GACTGCCTGC AGGACCCAGG CGGAGGTTTC CGTTGCCTTT GTCATGCTGG CTTCTCAGGT
CCTCGCTGTC AGACTGTCCT GTCTCCCTGC GAGTCCCAGC CATGCCAGCA TGGAGGCCAG
TGCCGTCCTA GCCCGGGTCC TGGGGGTGGG CTGACCTTCA CCTGTCACTG TGCCCAGCCG
TTCTGGGGTC CGCGTTGCGA GCGGGTGGCG CGCTCCTGCC GGGAGCTGCA GTGCCCGGTG
GGCGTCCCAT GCCAGCAGAC GCCCCGCGGG CCGCGCTGCG CCTGCCCCCC AGGGTTGTCG
GGACCCTCCT GCCGCAGCTT CCCGGGGTCG CCGCCGGGGG CCAGCAACGC CAGCTGCGCG
GCCGCCCCCT GTCTCCACGG GGGCTCCTGC CGCCCCGCGC CGCTCGCGCC CTTCTTCCGC
TGCGCTTGCG CGCAGGGCTG GACCGGGCCG CGCTGCGAGG CGCCCGCCGC GGCACCCGAG
GTCTCGGAGG AGCCGCGGTG CCCGCGCGCC GCCTGCCAGG CCAAGCGCGG GGACCAGCGC
TGCGACCGCG AGTGCAACAG CCCAGGCTGC GGCTGGGACG GCGGCGACTG CTCGCTGAGC
GTGGGCGACC CCTGGCGGCA ATGCGAGGCG CTGCAGTGCT GGCGCCTCTT CAACAACAGC
CGCTGCGACC CCGCCTGCAG CTCGCCCGCC TGCCTCTACG ACAACTTCGA CTGCCACGCC
GGTGGCCGCG AGCGCACTTG CAACCCGGTG TACGAGAAGT ACTGCGCCGA CCACTTTGCC
GACGGCCGCT GCGACCAGGG CTGCAACACG GAGGAGTGCG GCTGGGATGG GCTGGATTGT
GCCAGCGAGG TGCCGGCCCT GCTGGCCCGC GGCGTGCTGG TGCTCACAGT GCTGCTGCCG
CCAGAGGAGC TACTGCGTTC CAGCGCCGAC TTTCTGCAGC GGCTCAGCGC CATCCTGCGC
ACCTCGCTGC GCTTCCGCCT GGACGCGCAC GGCCAGGCCA TGGTCTTCCC TTACCACCGG
CCTAGTCCTG GCTCCGAACC CCGGGCCCGT CGGGAGCTGG CCCCCGAGGT GATCGGCTCG
GTAGTAATGC TGGAGATTGA CAACCGGCTC TGCCTGCAGT CGCCTGAGAA TGATCACTGC
TTCCCCGATG CCCAGAGCGC CGCTGACTAC CTGGGAGCGT TGTCAGCGGT GGAGCGCCTG
GACTTCCCGT ACCCACTGCG GGACGTGCGG GGGGAGCCGC TGGAGCCTCC AGAACCCAGC
GTCCCGCTGC TGCCACTGCT AGTGGCGGGC GCTGTCTTGC TGCTGGTCAT TCTCGTCCTG
GGTGTCATGG TGGCCCGGCG CAAGCGCGAG CACAGCACCC TCTGGTTCCC TGAGGGCTTC
TCACTGCACA AGGACGTGGC CTCTGGTCAC AAGGGCCGGC GGGAACCCGT GGGCCAGGAC
GCGCTGGGCA TGAAGAACAT GGCCAAGGGT GAGAGCCTGA TGGGGGAGGT GGCCACAGAC
TGGATGGACA CAGAGTGCCC AGAGGCCAAG CGGCTAAAGG TAGAGGAGCC AGGCATGGGG
GCTGAGGAGG CTGTGGATTG CCGTCAGTGG ACTCAACACC ATCTGGTTGC TGCTGACATC
CGCGTGGCAC CAGCCATGGC ACTGACACCA CCACAGGGCG ACGCAGATGC TGATGGCATG
GATGTCAATG TGCGTGGCCC AGATGGCTTC ACCCCGCTAA TGCTGGCTTC CTTCTGTGGG
GGGGCTCTGG AGCCAATGCC AACTGAAGAG GATGAGGCAG ATGACACATC AGCTAGCATC
ATCTCCGACC TGATCTGCCA GGGGGCTCAG CTTGGGGCAC GGACTGACCG TACTGGCGAG
ACTGCTTTGC ACCTGGCTGC CCGTTATGCC CGTGCTGATG CAGCCAAGCG GCTGCTGGAT
GCTGGGGCAG ACACCAATGC CCAGGACCAC TCAGGCCGCA CTCCCCTGCA CACAGCTGTC
ACAGCCGATG CCCAGGGTGT CTTCCAGATT CTCATCCGAA ACCGCTCTAC AGACTTGGAT
GCCCGCATGG CAGATGGCTC AACGGCACTG ATCCTGGCGG CCCGCCTGGC AGTAGAGGGC
ATGGTGGAAG AGCTCATCGC CAGCCATGCT GATGTCAATG CTGTGGATGA GCTTGGGAAA
TCAGCCTTAC ACTGGGCTGC GGCTGTGAAC AACGTGGAAG CCACTTTGGC CCTGCTCAAA
AATGGAGCCA ATAAGGACAT GCAGGATAGC AAGGAGGAGA CCCCCCTATT CCTGGCCGCC
CGCGAGGGCA GCTATGAGGC TGCCAAGCTG CTGTTGGACC ACTTTGCCAA CCGTGAGATC
ACCGACCACC TGGACAGGCT GCCGCGGGAC GTAGCCCAGG AGAGACTGCA CCAGGACATC
GTGCGCTTGC TGGATCAACC CAGTGGGCCC CGCAGCCCCC CCGGTCCCCA CGGCCTGGGG
CCTCTGCTCT GTCCTCCAGG GGCCTTCCTC CCTGGCCTCA AAGCGGCACA GTCGGGGTCC
AAGAAGAGCA GGAGGCCCCC CGGGAAGGCG GGGCTGGGGC CGCAGGGGCC CCGGGGGCGG
GGCAAGAAGC TGACGCTGGC CTGCCCGGGC CCCCTGGCTG ACAGCTCGGT CACGCTGTCG
CCCGTGGACT CGCTGGACTC CCCGCGGCCT TTCGGTGGGC CCCCTGCTTC CCCTGGTGGC
TTCCCCCTTG AGGGGCCCTA TGCAGCTGCC ACTGCCACTG CAGTGTCTCT GGCACAGCTT
GGTGGCCCAG GCCGGGCGGG TCTAGGGCGC CAGCCCCCTG GAGGATGTGT ACTCAGCCTG
GGCCTGCTGA ACCCTGTGGC TGTGCCCCTC GATTGGGCCC GGCTGCCCCC ACCTGCCCCT
CCAGGCCCCT CGTTCCTGCT GCCACTGGCG CCGGGACCCC AGCTGCTCAA CCCAGGGACC
CCCGTCTCCC CGCAGGAGCG GCCCCCGCCT TACCTGGCAG TCCCAGGACA TGGCGAGGAG
TACCCGGCGG CTGGGGCACA CAGCAGCCCC CCAAAGGCCC GCTTCCTGCG GGTTCCCAGT
GAGCACCCTT ACCTGACCCC ATCCCCCGAA TCCCCTGAGC ACTGGGCCAG CCCCTCACCT
CCCTCCCTCT CAGACTGGTC CGAATCCACG CCTAGCCCAG CCACTGCCAC TGGGGCCATG
GCCACCACCA CTGGGGCACT GCCTGCCCAG CCACTTCCCT TGTCTGTTCC CAGCTCCCTT
GCTCAGGCCC AGACCCAGCT GGGGCCCCAG CCGGAAGTTA CCCCCAAGAG GCAAGTGTTG
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000426.2
CDS77..7042
Misc Feature(1)548..661(+)
Misc Feature(2)548..604(+)
Misc Feature(3)782..892(+)
Misc Feature(4)782..835(+)
Misc Feature(5)896..1009(+)
Misc Feature(6)896..955(+)
Misc Feature(7)1016..1123(+)
Misc Feature(8)1016..1069(+)
Misc Feature(9)1247..1363(+)
Misc Feature(10)1247..1306(+)
Misc Feature(11)1367..1477(+)
Misc Feature(12)1367..1420(+)
Misc Feature(13)1481..1591(+)
Misc Feature(14)1481..1534(+)
Misc Feature(15)1595..1702(+)
Misc Feature(16)1595..1648(+)
Misc Feature(17)1709..1816(+)
Misc Feature(18)1709..1759(+)
Misc Feature(19)1823..1930(+)
Misc Feature(20)1829..1873(+)
Misc Feature(21)1934..2038(+)
Misc Feature(22)1934..1984(+)
Misc Feature(23)2048..>2134(+)
Misc Feature(24)2054..2098(+)
Misc Feature(25)2504..2614(+)
Misc Feature(26)2504..2560(+)
Misc Feature(27)2621..2728(+)
Misc Feature(28)2621..2674(+)
Misc Feature(29)2735..2842(+)
Misc Feature(30)2735..2785(+)
Misc Feature(31)2861..2956(+)
Misc Feature(32)3329..3436(+)
Misc Feature(33)3335..3379(+)
Misc Feature(34)3440..3550(+)
Misc Feature(35)3440..3493(+)
Misc Feature(36)3587..3685(+)
Misc Feature(37)4214..4327(+)
Misc Feature(38)4235..4357(+)
Misc Feature(39)4337..4450(+)
Misc Feature(40)4358..4450(+)
Misc Feature(41)4475..4591(+)
Misc Feature(42)4487..4576(+)
Misc Feature(43)4589..4756(+)
Misc Feature(44)4787..4792(+)
Misc Feature(45)4802..4993(+)
Misc Feature(46)4958..4960(+)
Misc Feature(47)5006..5068(+)
Misc Feature(48)5057..5059(+)
Misc Feature(49)5405..5755(+)
Misc Feature(50)5411..5752(+)
Misc Feature(51)5588..5677(+)
Misc Feature(52)5648..5815(+)
Misc Feature(53)5672..6052(+)
Misc Feature(54)5687..5779(+)
Misc Feature(55)5789..5878(+)
Misc Feature(56)5804..6082(+)
Misc Feature(57)5888..5977(+)
Misc Feature(58)5987..6076(+)
Misc Feature(59)6707..6895(+)
Exon (1)1..194
Gene:NOTCH3
Gene Synonym:
Exon (2)195..273
Gene:NOTCH3
Gene Synonym:
Exon (3)274..416
Gene:NOTCH3
Gene Synonym:
Exon (4)417..755
Gene:NOTCH3
Gene Synonym:
Exon (5)756..878
Gene:NOTCH3
Gene Synonym:
Exon (6)879..1112
Gene:NOTCH3
Gene Synonym:
Exon (7)1113..1268
Gene:NOTCH3
Gene Synonym:
Exon (8)1269..1454
Gene:NOTCH3
Gene Synonym:
Exon (9)1455..1568
Gene:NOTCH3
Gene Synonym:
Exon (10)1569..1682
Gene:NOTCH3
Gene Synonym:
Exon (11)1683..1916
Gene:NOTCH3
Gene Synonym:
Exon (12)1917..2027
Gene:NOTCH3
Gene Synonym:
Exon (13)2028..2220
Gene:NOTCH3
Gene Synonym:
Exon (14)2221..2372
Gene:NOTCH3
Gene Synonym:
Exon (15)2373..2486
Gene:NOTCH3
Gene Synonym:
Exon (16)2487..2642
Gene:NOTCH3
Gene Synonym:
Exon (17)2643..2868
Gene:NOTCH3
Gene Synonym:
Exon (18)2869..3070
Gene:NOTCH3
Gene Synonym:
Exon (19)3071..3218
Gene:NOTCH3
Gene Synonym:
Exon (20)3219..3403
Gene:NOTCH3
Gene Synonym:
Exon (21)3404..3536
Gene:NOTCH3
Gene Synonym:
Exon (22)3537..3794
Gene:NOTCH3
Gene Synonym:
Exon (23)3795..3913
Gene:NOTCH3
Gene Synonym:
Exon (24)3914..4479
Gene:NOTCH3
Gene Synonym:
Exon (25)4480..4812
Gene:NOTCH3
Gene Synonym:
Exon (26)4813..4967
Gene:NOTCH3
Gene Synonym:
Exon (27)4968..5190
Gene:NOTCH3
Gene Synonym:
Exon (28)5191..5275
Gene:NOTCH3
Gene Synonym:
Exon (29)5276..5438
Gene:NOTCH3
Gene Synonym:
Exon (30)5439..5743
Gene:NOTCH3
Gene Synonym:
Exon (31)5744..5891
Gene:NOTCH3
Gene Synonym:
Exon (32)5892..5989
Gene:NOTCH3
Gene Synonym:
Exon (33)5990..8071
Gene:NOTCH3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000435
Organism Homo sapiens (human)
Definition Homo sapiens notch 3 (NOTCH3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000435

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
5521
5581
5641
5701
5761
5821
5881
5941
6001
6061
6121
6181
6241
6301
6361
6421
6481
6541
6601
6661
6721
6781
6841
6901
6961
ATGGGGCCGG GGGCCCGTGG CCGCCGCCGC CGCCGTCGCC CGATGTCGCC GCCACCGCCA 
CCGCCACCCG TGCGGGCGCT GCCCCTGCTG CTGCTGCTAG CGGGGCCGGG GGCTGCAGCC
CCCCCTTGCC TGGACGGAAG CCCGTGTGCA AATGGAGGTC GTTGCACCCA GCTGCCCTCC
CGGGAGGCTG CCTGCCTGTG CCCGCCTGGC TGGGTGGGTG AGCGGTGTCA GCTGGAGGAC
CCCTGTCACT CAGGCCCCTG TGCTGGCCGT GGTGTCTGCC AGAGTTCAGT GGTGGCTGGC
ACCGCCCGAT TCTCATGCCG GTGCCCCCGT GGCTTCCGAG GCCCTGACTG CTCCCTGCCA
GATCCCTGCC TCAGCAGCCC TTGTGCCCAC GGTGCCCGCT GCTCAGTGGG GCCCGATGGA
CGCTTCCTCT GCTCCTGCCC ACCTGGCTAC CAGGGCCGCA GCTGCCGAAG CGACGTGGAT
GAGTGCCGGG TGGGTGAGCC CTGCCGCCAT GGTGGCACCT GCCTCAACAC ACCTGGCTCC
TTCCGCTGCC AGTGTCCAGC TGGCTACACA GGGCCACTAT GTGAGAACCC CGCGGTGCCC
TGTGCACCCT CACCATGCCG TAACGGGGGC ACCTGCAGGC AGAGTGGCGA CCTCACTTAC
GACTGTGCCT GTCTTCCTGG GTTTGAGGGT CAGAATTGTG AAGTGAACGT GGACGACTGT
CCAGGACACC GATGTCTCAA TGGGGGGACA TGCGTGGATG GCGTCAACAC CTATAACTGC
CAGTGCCCTC CTGAGTGGAC AGGCCAGTTC TGCACGGAGG ACGTGGATGA GTGTCAGCTG
CAGCCCAACG CCTGCCACAA TGGGGGTACC TGCTTCAACA CGCTGGGTGG CCACAGCTGC
GTGTGTGTCA ATGGCTGGAC AGGCGAGAGC TGCAGTCAGA ATATCGATGA CTGTGCCACA
GCCGTGTGCT TCCATGGGGC CACCTGCCAT GACCGCGTGG CTTCTTTCTA CTGTGCCTGC
CCCATGGGCA AGACTGGCCT CCTGTGTCAC CTGGATGACG CCTGTGTCAG CAACCCCTGC
CACGAGGATG CTATCTGTGA CACAAATCCG GTGAACGGCC GGGCCATTTG CACCTGTCCT
CCCGGCTTCA CGGGTGGGGC ATGTGACCAG GATGTGGACG AGTGCTCTAT CGGCGCCAAC
CCCTGCGAGC ACTTGGGCAG GTGCGTGAAC ACGCAGGGCT CCTTCCTGTG CCAGTGCGGT
CGTGGCTACA CTGGACCTCG CTGTGAGACC GATGTCAACG AGTGTCTGTC GGGGCCCTGC
CGAAACCAGG CCACGTGCCT CGACCGCATA GGCCAGTTCA CCTGTATCTG TATGGCAGGC
TTCACAGGAA CCTATTGCGA GGTGGACATT GACGAGTGTC AGAGTAGCCC CTGTGTCAAC
GGTGGGGTCT GCAAGGACCG AGTCAATGGC TTCAGCTGCA CCTGCCCCTC GGGCTTCAGC
GGCTCCACGT GTCAGCTGGA CGTGGACGAA TGCGCCAGCA CGCCCTGCAG GAATGGCGCC
AAATGCGTGG ACCAGCCCGA TGGCTACGAG TGCCGCTGTG CCGAGGGCTT TGAGGGCACG
CTGTGTGATC GCAACGTGGA CGACTGCTCC CCTGACCCAT GCCACCATGG TCGCTGCGTG
GATGGCATCG CCAGCTTCTC ATGTGCCTGT GCTCCTGGCT ACACGGGCAC ACGCTGCGAG
AGCCAGGTGG ACGAATGCCG CAGCCAGCCC TGCCGCCATG GCGGCAAATG CCTAGACCTG
GTGGACAAGT ACCTCTGCCG CTGCCCTTCT GGGACCACAG GTGTGAACTG CGAAGTGAAC
ATTGACGACT GTGCCAGCAA CCCCTGCACC TTTGGAGTCT GCCGTGATGG CATCAACCGC
TACGACTGTG TCTGCCAACC TGGCTTCACA GGGCCCCTTT GTAACGTGGA GATCAATGAG
TGTGCTTCCA GCCCATGCGG CGAGGGAGGT TCCTGTGTGG ATGGGGAAAA TGGCTTCCGC
TGCCTCTGCC CGCCTGGCTC CTTGCCCCCA CTCTGCCTCC CCCCGAGCCA TCCCTGTGCC
CATGAGCCCT GCAGTCACGG CATCTGCTAT GATGCACCTG GCGGGTTCCG CTGTGTGTGT
GAGCCTGGCT GGAGTGGCCC CCGCTGCAGC CAGAGCCTGG CCCGAGACGC CTGTGAGTCC
CAGCCGTGCA GGGCCGGTGG GACATGCAGC AGCGATGGAA TGGGTTTCCA CTGCACCTGC
CCGCCTGGTG TCCAGGGACG TCAGTGTGAA CTCCTCTCCC CCTGCACCCC GAACCCCTGT
GAGCATGGGG GCCGCTGCGA GTCTGCCCCT GGCCAGCTGC CTGTCTGCTC CTGCCCCCAG
GGCTGGCAAG GCCCACGATG CCAGCAGGAT GTGGACGAGT GTGCTGGCCC CGCACCCTGT
GGCCCTCATG GTATCTGCAC CAACCTGGCA GGGAGTTTCA GCTGCACCTG CCATGGAGGG
TACACTGGCC CTTCCTGCGA TCAGGACATC AATGACTGTG ACCCCAACCC ATGCCTGAAC
GGTGGCTCGT GCCAAGACGG CGTGGGCTCC TTTTCCTGCT CCTGCCTCCC TGGTTTCGCC
GGCCCACGAT GCGCCCGCGA TGTGGATGAG TGCCTGAGCA ACCCCTGCGG CCCGGGCACC
TGTACCGACC ACGTGGCCTC CTTCACCTGC ACCTGCCCGC CAGGCTACGG AGGCTTCCAC
TGCGAACAGG ACCTGCCCGA CTGCAGCCCC AGCTCCTGCT TCAATGGCGG GACCTGTGTG
GACGGCGTGA ACTCGTTCAG CTGCCTGTGC CGTCCCGGCT ACACAGGAGC CCACTGCCAA
CATGAGGCAG ACCCCTGCCT CTCGCGGCCC TGCCTACACG GGGGCGTCTG CAGCGCCGCC
CACCCTGGCT TCCGCTGCAC CTGCCTCGAG AGCTTCACGG GCCCGCAGTG CCAGACGCTG
GTGGATTGGT GCAGCCGCCA GCCTTGTCAA AACGGGGGTC GCTGCGTCCA GACTGGGGCC
TATTGCCTTT GTCCCCCTGG ATGGAGCGGA CGCCTCTGTG ACATCCGAAG CTTGCCCTGC
AGGGAGGCCG CAGCCCAGAT CGGGGTGCGG CTGGAGCAGC TGTGTCAGGC GGGTGGGCAG
TGTGTGGATG AAGACAGCTC CCACTACTGC GTGTGCCCAG AGGGCCGTAC TGGTAGCCAC
TGTGAGCAGG AGGTGGACCC CTGCTTGGCC CAGCCCTGCC AGCATGGGGG GACCTGCCGT
GGCTATATGG GGGGCTACAT GTGTGAGTGT CTTCCTGGCT ACAATGGTGA TAACTGTGAG
GACGACGTGG ACGAGTGTGC CTCCCAGCCC TGCCAGCACG GGGGTTCATG CATTGACCTC
GTGGCCCGCT ATCTCTGCTC CTGTCCCCCA GGAACGCTGG GGGTGCTCTG CGAGATTAAT
GAGGATGACT GCGGCCCAGG CCCACCGCTG GACTCAGGGC CCCGGTGCCT ACACAATGGC
ACCTGCGTGG ACCTGGTGGG TGGTTTCCGC TGCACCTGTC CCCCAGGATA CACTGGTTTG
CGCTGCGAGG CAGACATCAA TGAGTGTCGC TCAGGTGCCT GCCACGCGGC ACACACCCGG
GACTGCCTGC AGGACCCAGG CGGAGGTTTC CGTTGCCTTT GTCATGCTGG CTTCTCAGGT
CCTCGCTGTC AGACTGTCCT GTCTCCCTGC GAGTCCCAGC CATGCCAGCA TGGAGGCCAG
TGCCGTCCTA GCCCGGGTCC TGGGGGTGGG CTGACCTTCA CCTGTCACTG TGCCCAGCCG
TTCTGGGGTC CGCGTTGCGA GCGGGTGGCG CGCTCCTGCC GGGAGCTGCA GTGCCCGGTG
GGCGTCCCAT GCCAGCAGAC GCCCCGCGGG CCGCGCTGCG CCTGCCCCCC AGGGTTGTCG
GGACCCTCCT GCCGCAGCTT CCCGGGGTCG CCGCCGGGGG CCAGCAACGC CAGCTGCGCG
GCCGCCCCCT GTCTCCACGG GGGCTCCTGC CGCCCCGCGC CGCTCGCGCC CTTCTTCCGC
TGCGCTTGCG CGCAGGGCTG GACCGGGCCG CGCTGCGAGG CGCCCGCCGC GGCACCCGAG
GTCTCGGAGG AGCCGCGGTG CCCGCGCGCC GCCTGCCAGG CCAAGCGCGG GGACCAGCGC
TGCGACCGCG AGTGCAACAG CCCAGGCTGC GGCTGGGACG GCGGCGACTG CTCGCTGAGC
GTGGGCGACC CCTGGCGGCA ATGCGAGGCG CTGCAGTGCT GGCGCCTCTT CAACAACAGC
CGCTGCGACC CCGCCTGCAG CTCGCCCGCC TGCCTCTACG ACAACTTCGA CTGCCACGCC
GGTGGCCGCG AGCGCACTTG CAACCCGGTG TACGAGAAGT ACTGCGCCGA CCACTTTGCC
GACGGCCGCT GCGACCAGGG CTGCAACACG GAGGAGTGCG GCTGGGATGG GCTGGATTGT
GCCAGCGAGG TGCCGGCCCT GCTGGCCCGC GGCGTGCTGG TGCTCACAGT GCTGCTGCCG
CCAGAGGAGC TACTGCGTTC CAGCGCCGAC TTTCTGCAGC GGCTCAGCGC CATCCTGCGC
ACCTCGCTGC GCTTCCGCCT GGACGCGCAC GGCCAGGCCA TGGTCTTCCC TTACCACCGG
CCTAGTCCTG GCTCCGAACC CCGGGCCCGT CGGGAGCTGG CCCCCGAGGT GATCGGCTCG
GTAGTAATGC TGGAGATTGA CAACCGGCTC TGCCTGCAGT CGCCTGAGAA TGATCACTGC
TTCCCCGATG CCCAGAGCGC CGCTGACTAC CTGGGAGCGT TGTCAGCGGT GGAGCGCCTG
GACTTCCCGT ACCCACTGCG GGACGTGCGG GGGGAGCCGC TGGAGCCTCC AGAACCCAGC
GTCCCGCTGC TGCCACTGCT AGTGGCGGGC GCTGTCTTGC TGCTGGTCAT TCTCGTCCTG
GGTGTCATGG TGGCCCGGCG CAAGCGCGAG CACAGCACCC TCTGGTTCCC TGAGGGCTTC
TCACTGCACA AGGACGTGGC CTCTGGTCAC AAGGGCCGGC GGGAACCCGT GGGCCAGGAC
GCGCTGGGCA TGAAGAACAT GGCCAAGGGT GAGAGCCTGA TGGGGGAGGT GGCCACAGAC
TGGATGGACA CAGAGTGCCC AGAGGCCAAG CGGCTAAAGG TAGAGGAGCC AGGCATGGGG
GCTGAGGAGG CTGTGGATTG CCGTCAGTGG ACTCAACACC ATCTGGTTGC TGCTGACATC
CGCGTGGCAC CAGCCATGGC ACTGACACCA CCACAGGGCG ACGCAGATGC TGATGGCATG
GATGTCAATG TGCGTGGCCC AGATGGCTTC ACCCCGCTAA TGCTGGCTTC CTTCTGTGGG
GGGGCTCTGG AGCCAATGCC AACTGAAGAG GATGAGGCAG ATGACACATC AGCTAGCATC
ATCTCCGACC TGATCTGCCA GGGGGCTCAG CTTGGGGCAC GGACTGACCG TACTGGCGAG
ACTGCTTTGC ACCTGGCTGC CCGTTATGCC CGTGCTGATG CAGCCAAGCG GCTGCTGGAT
GCTGGGGCAG ACACCAATGC CCAGGACCAC TCAGGCCGCA CTCCCCTGCA CACAGCTGTC
ACAGCCGATG CCCAGGGTGT CTTCCAGATT CTCATCCGAA ACCGCTCTAC AGACTTGGAT
GCCCGCATGG CAGATGGCTC AACGGCACTG ATCCTGGCGG CCCGCCTGGC AGTAGAGGGC
ATGGTGGAAG AGCTCATCGC CAGCCATGCT GATGTCAATG CTGTGGATGA GCTTGGGAAA
TCAGCCTTAC ACTGGGCTGC GGCTGTGAAC AACGTGGAAG CCACTTTGGC CCTGCTCAAA
AATGGAGCCA ATAAGGACAT GCAGGATAGC AAGGAGGAGA CCCCCCTATT CCTGGCCGCC
CGCGAGGGCA GCTATGAGGC TGCCAAGCTG CTGTTGGACC ACTTTGCCAA CCGTGAGATC
ACCGACCACC TGGACAGGCT GCCGCGGGAC GTAGCCCAGG AGAGACTGCA CCAGGACATC
GTGCGCTTGC TGGATCAACC CAGTGGGCCC CGCAGCCCCC CCGGTCCCCA CGGCCTGGGG
CCTCTGCTCT GTCCTCCAGG GGCCTTCCTC CCTGGCCTCA AAGCGGCACA GTCGGGGTCC
AAGAAGAGCA GGAGGCCCCC CGGGAAGGCG GGGCTGGGGC CGCAGGGGCC CCGGGGGCGG
GGCAAGAAGC TGACGCTGGC CTGCCCGGGC CCCCTGGCTG ACAGCTCGGT CACGCTGTCG
CCCGTGGACT CGCTGGACTC CCCGCGGCCT TTCGGTGGGC CCCCTGCTTC CCCTGGTGGC
TTCCCCCTTG AGGGGCCCTA TGCAGCTGCC ACTGCCACTG CAGTGTCTCT GGCACAGCTT
GGTGGCCCAG GCCGGGCGGG TCTAGGGCGC CAGCCCCCTG GAGGATGTGT ACTCAGCCTG
GGCCTGCTGA ACCCTGTGGC TGTGCCCCTC GATTGGGCCC GGCTGCCCCC ACCTGCCCCT
CCAGGCCCCT CGTTCCTGCT GCCACTGGCG CCGGGACCCC AGCTGCTCAA CCCAGGGACC
CCCGTCTCCC CGCAGGAGCG GCCCCCGCCT TACCTGGCAG TCCCAGGACA TGGCGAGGAG
TACCCGGCGG CTGGGGCACA CAGCAGCCCC CCAAAGGCCC GCTTCCTGCG GGTTCCCAGT
GAGCACCCTT ACCTGACCCC ATCCCCCGAA TCCCCTGAGC ACTGGGCCAG CCCCTCACCT
CCCTCCCTCT CAGACTGGTC CGAATCCACG CCTAGCCCAG CCACTGCCAC TGGGGCCATG
GCCACCACCA CTGGGGCACT GCCTGCCCAG CCACTTCCCT TGTCTGTTCC CAGCTCCCTT
GCTCAGGCCC AGACCCAGCT GGGGCCCCAG CCGGAAGTTA CCCCCAAGAG GCAAGTGTTG
GCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu51627
Clone ID Related Accession (Same CDS sequence) XM_005259924
Accession Version XM_005259924.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 6810bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product neurogenic locus notch homolog protein 3 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011295.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578833288. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
5521
5581
5641
5701
5761
5821
5881
5941
6001
6061
6121
6181
6241
6301
6361
6421
6481
6541
6601
6661
6721
6781
ATGGGGCCGG GGGCCCGTGG CCGCCGCCGC CGCCGTCGCC CGATGTCGCC GCCACCGCCA 
CCGCCACCCG TGCGGGCGCT GCCCCTGCTG CTGCTGCTAG CGGGGCCGGG GGCTGCAGCC
CCCCCTTGCC TGGACGGAAG CCCGTGTGCA AATGGAGGTC GTTGCACCCA GCTGCCCTCC
CGGGAGGCTG CCTGCCTGTG CCCGCCTGGC TGGGTGGGTG AGCGGTGTCA GCTGGAGGAC
CCCTGTCACT CAGGCCCCTG TGCTGGCCGT GGTGTCTGCC AGAGTTCAGT GGTGGCTGGC
ACCGCCCGAT TCTCATGCCG GTGCCCCCGT GGCTTCCGAG GCCCTGACTG CTCCCTGCCA
GATCCCTGCC TCAGCAGCCC TTGTGCCCAC GGTGCCCGCT GCTCAGTGGG GCCCGATGGA
CGCTTCCTCT GCTCCTGCCC ACCTGGCTAC CAGGGCCGCA GCTGCCGAAG CGACGTGGAT
GAGTGCCGGG TGGGTGAGCC CTGCCGCCAT GGTGGCACCT GCCTCAACAC ACCTGGCTCC
TTCCGCTGCC AGTGTCCAGC TGGCTACACA GGGCCACTAT GTGAGAACCC CGCGGTGCCC
TGTGCACCCT CACCATGCCG TAACGGGGGC ACCTGCAGGC AGAGTGGCGA CCTCACTTAC
GACTGTGCCT GTCTTCCTGG GTTTGAGGGT CAGAATTGTG AAGTGAACGT GGACGACTGT
CCAGGACACC GATGTCTCAA TGGGGGGACA TGCGTGGATG GCGTCAACAC CTATAACTGC
CAGTGCCCTC CTGAGTGGAC AGGCCAGTTC TGCACGGAGG ACGTGGATGA GTGTCAGCTG
CAGCCCAACG CCTGCCACAA TGGGGGTACC TGCTTCAACA CGCTGGGTGG CCACAGCTGC
GTGTGTGTCA ATGGCTGGAC AGGCGAGAGC TGCAGTCAGA ATATCGATGA CTGTGCCACA
GCCGTGTGCT TCCATGGGGC CACCTGCCAT GACCGCGTGG CTTCTTTCTA CTGTGCCTGC
CCCATGGGCA AGACTGGCCT CCTGTGTCAC CTGGATGACG CCTGTGTCAG CAACCCCTGC
CACGAGGATG CTATCTGTGA CACAAATCCG GTGAACGGCC GGGCCATTTG CACCTGTCCT
CCCGGCTTCA CGGGTGGGGC ATGTGACCAG GATGTGGACG AGTGCTCTAT CGGCGCCAAC
CCCTGCGAGC ACTTGGGCAG GTGCGTGAAC ACGCAGGGCT CCTTCCTGTG CCAGTGCGGT
CGTGGCTACA CTGGACCTCG CTGTGAGACC GATGTCAACG AGTGTCTGTC GGGGCCCTGC
CGAAACCAGG CCACGTGCCT CGACCGCATA GGCCAGTTCA CCTGTATCTG TATGGCAGGC
TTCACAGGAA CCTATTGCGA GGTGGACATT GACGAGTGTC AGAGTAGCCC CTGTGTCAAC
GGTGGGGTCT GCAAGGACCG AGTCAATGGC TTCAGCTGCA CCTGCCCCTC GGGCTTCAGC
GGCTCCACGT GTCAGCTGGA CGTGGACGAA TGCGCCAGCA CGCCCTGCAG GAATGGCGCC
AAATGCGTGG ACCAGCCCGA TGGCTACGAG TGCCGCTGTG CCGAGGGCTT TGAGGGCACG
CTGTGTGATC GCAACGTGGA CGACTGCTCC CCTGACCCAT GCCACCATGG TCGCTGCGTG
GATGGCATCG CCAGCTTCTC ATGTGCCTGT GCTCCTGGCT ACACGGGCAC ACGCTGCGAG
AGCCAGGTGG ACGAATGCCG CAGCCAGCCC TGCCGCCATG GCGGCAAATG CCTAGACCTG
GTGGACAAGT ACCTCTGCCG CTGCCCTTCT GGGACCACAG GTGTGAACTG CGAAGTGAAC
ATTGACGACT GTGCCAGCAA CCCCTGCACC TTTGGAGTCT GCCGTGATGG CATCAACCGC
TACGACTGTG TCTGCCAACC TGGCTTCACA GGGCCCCTTT GTAACGTGGA GATCAATGAG
TGTGCTTCCA GCCCATGCGG CGAGGGAGGT TCCTGTGTGG ATGGGGAAAA TGGCTTCCGC
TGCCTCTGCC CGCCTGGCTC CTTGCCCCCA CTCTGCCTCC CCCCGAGCCA TCCCTGTGCC
CATGAGCCCT GCAGTCACGG CATCTGCTAT GATGCACCTG GCGGGTTCCG CTGTGTGTGT
GAGCCTGGCT GGAGTGGCCC CCGCTGCAGC CAGAGCCTGG CCCGAGACGC CTGTGAGTCC
CAGCCGTGCA GGGCCGGTGG GACATGCAGC AGCGATGGAA TGGGTTTCCA CTGCACCTGC
CCGCCTGGTG TCCAGGGACG TCAGTGTGAA CTCCTCTCCC CCTGCACCCC GAACCCCTGT
GAGCATGGGG GCCGCTGCGA GTCTGCCCCT GGCCAGCTGC CTGTCTGCTC CTGCCCCCAG
GGCTGGCAAG ACCCATGCCT GAACGGTGGC TCGTGCCAAG ACGGCGTGGG CTCCTTTTCC
TGCTCCTGCC TCCCTGGTTT CGCCGGCCCA CGATGCGCCC GCGATGTGGA TGAGTGCCTG
AGCAACCCCT GCGGCCCGGG CACCTGTACC GACCACGTGG CCTCCTTCAC CTGCACCTGC
CCGCCAGGCT ACGGAGGCTT CCACTGCGAA CAGGACCTGC CCGACTGCAG CCCCAGCTCC
TGCTTCAATG GCGGGACCTG TGTGGACGGC GTGAACTCGT TCAGCTGCCT GTGCCGTCCC
GGCTACACAG GAGCCCACTG CCAACATGAG GCAGACCCCT GCCTCTCGCG GCCCTGCCTA
CACGGGGGCG TCTGCAGCGC CGCCCACCCT GGCTTCCGCT GCACCTGCCT CGAGAGCTTC
ACGGGCCCGC AGTGCCAGAC GCTGGTGGAT TGGTGCAGCC GCCAGCCTTG TCAAAACGGG
GGTCGCTGCG TCCAGACTGG GGCCTATTGC CTTTGTCCCC CTGGATGGAG CGGACGCCTC
TGTGACATCC GAAGCTTGCC CTGCAGGGAG GCCGCAGCCC AGATCGGGGT GCGGCTGGAG
CAGCTGTGTC AGGCGGGTGG GCAGTGTGTG GATGAAGACA GCTCCCACTA CTGCGTGTGC
CCAGAGGGCC GTACTGGTAG CCACTGTGAG CAGGAGGTGG ACCCCTGCTT GGCCCAGCCC
TGCCAGCATG GGGGGACCTG CCGTGGCTAT ATGGGGGGCT ACATGTGTGA GTGTCTTCCT
GGCTACAATG GTGATAACTG TGAGGACGAC GTGGACGAGT GTGCCTCCCA GCCCTGCCAG
CACGGGGGTT CATGCATTGA CCTCGTGGCC CGCTATCTCT GCTCCTGTCC CCCAGGAACG
CTGGGGGTGC TCTGCGAGAT TAATGAGGAT GACTGCGGCC CAGGCCCACC GCTGGACTCA
GGGCCCCGGT GCCTACACAA TGGCACCTGC GTGGACCTGG TGGGTGGTTT CCGCTGCACC
TGTCCCCCAG GATACACTGG TTTGCGCTGC GAGGCAGACA TCAATGAGTG TCGCTCAGGT
GCCTGCCACG CGGCACACAC CCGGGACTGC CTGCAGGACC CAGGCGGAGG TTTCCGTTGC
CTTTGTCATG CTGGCTTCTC AGGTCCTCGC TGTCAGACTG TCCTGTCTCC CTGCGAGTCC
CAGCCATGCC AGCATGGAGG CCAGTGCCGT CCTAGCCCGG GTCCTGGGGG TGGGCTGACC
TTCACCTGTC ACTGTGCCCA GCCGTTCTGG GGTCCGCGTT GCGAGCGGGT GGCGCGCTCC
TGCCGGGAGC TGCAGTGCCC GGTGGGCGTC CCATGCCAGC AGACGCCCCG CGGGCCGCGC
TGCGCCTGCC CCCCAGGGTT GTCGGGACCC TCCTGCCGCA GCTTCCCGGG GTCGCCGCCG
GGGGCCAGCA ACGCCAGCTG CGCGGCCGCC CCCTGTCTCC ACGGGGGCTC CTGCCGCCCC
GCGCCGCTCG CGCCCTTCTT CCGCTGCGCT TGCGCGCAGG GCTGGACCGG GCCGCGCTGC
GAGGCGCCCG CCGCGGCACC CGAGGTCTCG GAGGAGCCGC GGTGCCCGCG CGCCGCCTGC
CAGGCCAAGC GCGGGGACCA GCGCTGCGAC CGCGAGTGCA ACAGCCCAGG CTGCGGCTGG
GACGGCGGCG ACTGCTCGCT GAGCGTGGGC GACCCCTGGC GGCAATGCGA GGCGCTGCAG
TGCTGGCGCC TCTTCAACAA CAGCCGCTGC GACCCCGCCT GCAGCTCGCC CGCCTGCCTC
TACGACAACT TCGACTGCCA CGCCGGTGGC CGCGAGCGCA CTTGCAACCC GGTGTACGAG
AAGTACTGCG CCGACCACTT TGCCGACGGC CGCTGCGACC AGGGCTGCAA CACGGAGGAG
TGCGGCTGGG ATGGGCTGGA TTGTGCCAGC GAGGTGCCGG CCCTGCTGGC CCGCGGCGTG
CTGGTGCTCA CAGTGCTGCT GCCGCCAGAG GAGCTACTGC GTTCCAGCGC CGACTTTCTG
CAGCGGCTCA GCGCCATCCT GCGCACCTCG CTGCGCTTCC GCCTGGACGC GCACGGCCAG
GCCATGGTCT TCCCTTACCA CCGGCCTAGT CCTGGCTCCG AACCCCGGGC CCGTCGGGAG
CTGGCCCCCG AGGTGATCGG CTCGGTAGTA ATGCTGGAGA TTGACAACCG GCTCTGCCTG
CAGTCGCCTG AGAATGATCA CTGCTTCCCC GATGCCCAGA GCGCCGCTGA CTACCTGGGA
GCGTTGTCAG CGGTGGAGCG CCTGGACTTC CCGTACCCAC TGCGGGACGT GCGGGGGGAG
CCGCTGGAGC CTCCAGAACC CAGCGTCCCG CTGCTGCCAC TGCTAGTGGC GGGCGCTGTC
TTGCTGCTGG TCATTCTCGT CCTGGGTGTC ATGGTGGCCC GGCGCAAGCG CGAGCACAGC
ACCCTCTGGT TCCCTGAGGG CTTCTCACTG CACAAGGACG TGGCCTCTGG TCACAAGGGC
CGGCGGGAAC CCGTGGGCCA GGACGCGCTG GGCATGAAGA ACATGGCCAA GGGTGAGAGC
CTGATGGGGG AGGTGGCCAC AGACTGGATG GACACAGAGT GCCCAGAGGC CAAGCGGCTA
AAGGTAGAGG AGCCAGGCAT GGGGGCTGAG GAGGCTGTGG ATTGCCGTCA GTGGACTCAA
CACCATCTGG TTGCTGCTGA CATCCGCGTG GCACCAGCCA TGGCACTGAC ACCACCACAG
GGCGACGCAG ATGCTGATGG CATGGATGTC AATGTGCGTG GCCCAGATGG CTTCACCCCG
CTAATGCTGG CTTCCTTCTG TGGGGGGGCT CTGGAGCCAA TGCCAACTGA AGAGGATGAG
GCAGATGACA CATCAGCTAG CATCATCTCC GACCTGATCT GCCAGGGGGC TCAGCTTGGG
GCACGGACTG ACCGTACTGG CGAGACTGCT TTGCACCTGG CTGCCCGTTA TGCCCGTGCT
GATGCAGCCA AGCGGCTGCT GGATGCTGGG GCAGACACCA ATGCCCAGGA CCACTCAGGC
CGCACTCCCC TGCACACAGC TGTCACAGCC GATGCCCAGG GTGTCTTCCA GATTCTCATC
CGAAACCGCT CTACAGACTT GGATGCCCGC ATGGCAGATG GCTCAACGGC ACTGATCCTG
GCGGCCCGCC TGGCAGTAGA GGGCATGGTG GAAGAGCTCA TCGCCAGCCA TGCTGATGTC
AATGCTGTGG ATGAGCTTGG GAAATCAGCC TTACACTGGG CTGCGGCTGT GAACAACGTG
GAAGCCACTT TGGCCCTGCT CAAAAATGGA GCCAATAAGG ACATGCAGGA TAGCAAGGAG
GAGACCCCCC TATTCCTGGC CGCCCGCGAG GGCAGCTATG AGGCTGCCAA GCTGCTGTTG
GACCACTTTG CCAACCGTGA GATCACCGAC CACCTGGACA GGCTGCCGCG GGACGTAGCC
CAGGAGAGAC TGCACCAGGA CATCGTGCGC TTGCTGGATC AACCCAGTGG GCCCCGCAGC
CCCCCCGGTC CCCACGGCCT GGGGCCTCTG CTCTGTCCTC CAGGGGCCTT CCTCCCTGGC
CTCAAAGCGG CACAGTCGGG GTCCAAGAAG AGCAGGAGGC CCCCCGGGAA GGCGGGGCTG
GGGCCGCAGG GGCCCCGGGG GCGGGGCAAG AAGCTGACGC TGGCCTGCCC GGGCCCCCTG
GCTGACAGCT CGGTCACGCT GTCGCCCGTG GACTCGCTGG ACTCCCCGCG GCCTTTCGGT
GGGCCCCCTG CTTCCCCTGG TGGCTTCCCC CTTGAGGGGC CCTATGCAGC TGCCACTGCC
ACTGCAGTGT CTCTGGCACA GCTTGGTGGC CCAGGCCGGG CGGGTCTAGG GCGCCAGCCC
CCTGGAGGAT GTGTACTCAG CCTGGGCCTG CTGAACCCTG TGGCTGTGCC CCTCGATTGG
GCCCGGCTGC CCCCACCTGC CCCTCCAGGC CCCTCGTTCC TGCTGCCACT GGCGCCGGGA
CCCCAGCTGC TCAACCCAGG GACCCCCGTC TCCCCGCAGG AGCGGCCCCC GCCTTACCTG
GCAGTCCCAG GACATGGCGA GGAGTACCCG GCGGCTGGGG CACACAGCAG CCCCCCAAAG
GCCCGCTTCC TGCGGGTTCC CAGTGAGCAC CCTTACCTGA CCCCATCCCC CGAATCCCCT
GAGCACTGGG CCAGCCCCTC ACCTCCCTCC CTCTCAGACT GGTCCGAATC CACGCCTAGC
CCAGCCACTG CCACTGGGGC CATGGCCACC ACCACTGGGG CACTGCCTGC CCAGCCACTT
CCCTTGTCTG TTCCCAGCTC CCTTGCTCAG GCCCAGACCC AGCTGGGGCC CCAGCCGGAA
GTTACCCCCA AGAGGCAAGT GTTGGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005259981.1
CDS58..6867
Misc Feature(1)529..642(+)
Misc Feature(2)529..585(+)
Misc Feature(3)763..873(+)
Misc Feature(4)763..816(+)
Misc Feature(5)877..990(+)
Misc Feature(6)877..936(+)
Misc Feature(7)997..1104(+)
Misc Feature(8)997..1050(+)
Misc Feature(9)1228..1344(+)
Misc Feature(10)1228..1287(+)
Misc Feature(11)1348..1458(+)
Misc Feature(12)1348..1401(+)
Misc Feature(13)1462..1572(+)
Misc Feature(14)1462..1515(+)
Misc Feature(15)1576..1683(+)
Misc Feature(16)1576..1629(+)
Misc Feature(17)1690..1797(+)
Misc Feature(18)1690..1740(+)
Misc Feature(19)1804..1911(+)
Misc Feature(20)1810..1854(+)
Misc Feature(21)1915..2019(+)
Misc Feature(22)1915..1965(+)
Misc Feature(23)2029..>2115(+)
Misc Feature(24)2035..2079(+)
Misc Feature(25)2467..2553(+)
Misc Feature(26)2560..2667(+)
Misc Feature(27)2560..2610(+)
Misc Feature(28)2686..2781(+)
Misc Feature(29)3154..3261(+)
Misc Feature(30)3160..3204(+)
Misc Feature(31)3265..3375(+)
Misc Feature(32)3265..3318(+)
Misc Feature(33)3412..3510(+)
Misc Feature(34)4039..4152(+)
Misc Feature(35)4162..4275(+)
Misc Feature(36)4312..4401(+)
Misc Feature(37)4414..4581(+)
Misc Feature(38)4627..4818(+)
Misc Feature(39)5230..5580(+)
Misc Feature(40)5236..5577(+)
Misc Feature(41)5473..5640(+)
Misc Feature(42)5497..5877(+)
Misc Feature(43)5629..5907(+)
Misc Feature(44)6532..6720(+)
Translation

Target ORF information:

RefSeq Version XM_005259924
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens notch 3 (NOTCH3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005259924

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
5521
5581
5641
5701
5761
5821
5881
5941
6001
6061
6121
6181
6241
6301
6361
6421
6481
6541
6601
6661
6721
6781
ATGGGGCCGG GGGCCCGTGG CCGCCGCCGC CGCCGTCGCC CGATGTCGCC GCCACCGCCA 
CCGCCACCCG TGCGGGCGCT GCCCCTGCTG CTGCTGCTAG CGGGGCCGGG GGCTGCAGCC
CCCCCTTGCC TGGACGGAAG CCCGTGTGCA AATGGAGGTC GTTGCACCCA GCTGCCCTCC
CGGGAGGCTG CCTGCCTGTG CCCGCCTGGC TGGGTGGGTG AGCGGTGTCA GCTGGAGGAC
CCCTGTCACT CAGGCCCCTG TGCTGGCCGT GGTGTCTGCC AGAGTTCAGT GGTGGCTGGC
ACCGCCCGAT TCTCATGCCG GTGCCCCCGT GGCTTCCGAG GCCCTGACTG CTCCCTGCCA
GATCCCTGCC TCAGCAGCCC TTGTGCCCAC GGTGCCCGCT GCTCAGTGGG GCCCGATGGA
CGCTTCCTCT GCTCCTGCCC ACCTGGCTAC CAGGGCCGCA GCTGCCGAAG CGACGTGGAT
GAGTGCCGGG TGGGTGAGCC CTGCCGCCAT GGTGGCACCT GCCTCAACAC ACCTGGCTCC
TTCCGCTGCC AGTGTCCAGC TGGCTACACA GGGCCACTAT GTGAGAACCC CGCGGTGCCC
TGTGCACCCT CACCATGCCG TAACGGGGGC ACCTGCAGGC AGAGTGGCGA CCTCACTTAC
GACTGTGCCT GTCTTCCTGG GTTTGAGGGT CAGAATTGTG AAGTGAACGT GGACGACTGT
CCAGGACACC GATGTCTCAA TGGGGGGACA TGCGTGGATG GCGTCAACAC CTATAACTGC
CAGTGCCCTC CTGAGTGGAC AGGCCAGTTC TGCACGGAGG ACGTGGATGA GTGTCAGCTG
CAGCCCAACG CCTGCCACAA TGGGGGTACC TGCTTCAACA CGCTGGGTGG CCACAGCTGC
GTGTGTGTCA ATGGCTGGAC AGGCGAGAGC TGCAGTCAGA ATATCGATGA CTGTGCCACA
GCCGTGTGCT TCCATGGGGC CACCTGCCAT GACCGCGTGG CTTCTTTCTA CTGTGCCTGC
CCCATGGGCA AGACTGGCCT CCTGTGTCAC CTGGATGACG CCTGTGTCAG CAACCCCTGC
CACGAGGATG CTATCTGTGA CACAAATCCG GTGAACGGCC GGGCCATTTG CACCTGTCCT
CCCGGCTTCA CGGGTGGGGC ATGTGACCAG GATGTGGACG AGTGCTCTAT CGGCGCCAAC
CCCTGCGAGC ACTTGGGCAG GTGCGTGAAC ACGCAGGGCT CCTTCCTGTG CCAGTGCGGT
CGTGGCTACA CTGGACCTCG CTGTGAGACC GATGTCAACG AGTGTCTGTC GGGGCCCTGC
CGAAACCAGG CCACGTGCCT CGACCGCATA GGCCAGTTCA CCTGTATCTG TATGGCAGGC
TTCACAGGAA CCTATTGCGA GGTGGACATT GACGAGTGTC AGAGTAGCCC CTGTGTCAAC
GGTGGGGTCT GCAAGGACCG AGTCAATGGC TTCAGCTGCA CCTGCCCCTC GGGCTTCAGC
GGCTCCACGT GTCAGCTGGA CGTGGACGAA TGCGCCAGCA CGCCCTGCAG GAATGGCGCC
AAATGCGTGG ACCAGCCCGA TGGCTACGAG TGCCGCTGTG CCGAGGGCTT TGAGGGCACG
CTGTGTGATC GCAACGTGGA CGACTGCTCC CCTGACCCAT GCCACCATGG TCGCTGCGTG
GATGGCATCG CCAGCTTCTC ATGTGCCTGT GCTCCTGGCT ACACGGGCAC ACGCTGCGAG
AGCCAGGTGG ACGAATGCCG CAGCCAGCCC TGCCGCCATG GCGGCAAATG CCTAGACCTG
GTGGACAAGT ACCTCTGCCG CTGCCCTTCT GGGACCACAG GTGTGAACTG CGAAGTGAAC
ATTGACGACT GTGCCAGCAA CCCCTGCACC TTTGGAGTCT GCCGTGATGG CATCAACCGC
TACGACTGTG TCTGCCAACC TGGCTTCACA GGGCCCCTTT GTAACGTGGA GATCAATGAG
TGTGCTTCCA GCCCATGCGG CGAGGGAGGT TCCTGTGTGG ATGGGGAAAA TGGCTTCCGC
TGCCTCTGCC CGCCTGGCTC CTTGCCCCCA CTCTGCCTCC CCCCGAGCCA TCCCTGTGCC
CATGAGCCCT GCAGTCACGG CATCTGCTAT GATGCACCTG GCGGGTTCCG CTGTGTGTGT
GAGCCTGGCT GGAGTGGCCC CCGCTGCAGC CAGAGCCTGG CCCGAGACGC CTGTGAGTCC
CAGCCGTGCA GGGCCGGTGG GACATGCAGC AGCGATGGAA TGGGTTTCCA CTGCACCTGC
CCGCCTGGTG TCCAGGGACG TCAGTGTGAA CTCCTCTCCC CCTGCACCCC GAACCCCTGT
GAGCATGGGG GCCGCTGCGA GTCTGCCCCT GGCCAGCTGC CTGTCTGCTC CTGCCCCCAG
GGCTGGCAAG ACCCATGCCT GAACGGTGGC TCGTGCCAAG ACGGCGTGGG CTCCTTTTCC
TGCTCCTGCC TCCCTGGTTT CGCCGGCCCA CGATGCGCCC GCGATGTGGA TGAGTGCCTG
AGCAACCCCT GCGGCCCGGG CACCTGTACC GACCACGTGG CCTCCTTCAC CTGCACCTGC
CCGCCAGGCT ACGGAGGCTT CCACTGCGAA CAGGACCTGC CCGACTGCAG CCCCAGCTCC
TGCTTCAATG GCGGGACCTG TGTGGACGGC GTGAACTCGT TCAGCTGCCT GTGCCGTCCC
GGCTACACAG GAGCCCACTG CCAACATGAG GCAGACCCCT GCCTCTCGCG GCCCTGCCTA
CACGGGGGCG TCTGCAGCGC CGCCCACCCT GGCTTCCGCT GCACCTGCCT CGAGAGCTTC
ACGGGCCCGC AGTGCCAGAC GCTGGTGGAT TGGTGCAGCC GCCAGCCTTG TCAAAACGGG
GGTCGCTGCG TCCAGACTGG GGCCTATTGC CTTTGTCCCC CTGGATGGAG CGGACGCCTC
TGTGACATCC GAAGCTTGCC CTGCAGGGAG GCCGCAGCCC AGATCGGGGT GCGGCTGGAG
CAGCTGTGTC AGGCGGGTGG GCAGTGTGTG GATGAAGACA GCTCCCACTA CTGCGTGTGC
CCAGAGGGCC GTACTGGTAG CCACTGTGAG CAGGAGGTGG ACCCCTGCTT GGCCCAGCCC
TGCCAGCATG GGGGGACCTG CCGTGGCTAT ATGGGGGGCT ACATGTGTGA GTGTCTTCCT
GGCTACAATG GTGATAACTG TGAGGACGAC GTGGACGAGT GTGCCTCCCA GCCCTGCCAG
CACGGGGGTT CATGCATTGA CCTCGTGGCC CGCTATCTCT GCTCCTGTCC CCCAGGAACG
CTGGGGGTGC TCTGCGAGAT TAATGAGGAT GACTGCGGCC CAGGCCCACC GCTGGACTCA
GGGCCCCGGT GCCTACACAA TGGCACCTGC GTGGACCTGG TGGGTGGTTT CCGCTGCACC
TGTCCCCCAG GATACACTGG TTTGCGCTGC GAGGCAGACA TCAATGAGTG TCGCTCAGGT
GCCTGCCACG CGGCACACAC CCGGGACTGC CTGCAGGACC CAGGCGGAGG TTTCCGTTGC
CTTTGTCATG CTGGCTTCTC AGGTCCTCGC TGTCAGACTG TCCTGTCTCC CTGCGAGTCC
CAGCCATGCC AGCATGGAGG CCAGTGCCGT CCTAGCCCGG GTCCTGGGGG TGGGCTGACC
TTCACCTGTC ACTGTGCCCA GCCGTTCTGG GGTCCGCGTT GCGAGCGGGT GGCGCGCTCC
TGCCGGGAGC TGCAGTGCCC GGTGGGCGTC CCATGCCAGC AGACGCCCCG CGGGCCGCGC
TGCGCCTGCC CCCCAGGGTT GTCGGGACCC TCCTGCCGCA GCTTCCCGGG GTCGCCGCCG
GGGGCCAGCA ACGCCAGCTG CGCGGCCGCC CCCTGTCTCC ACGGGGGCTC CTGCCGCCCC
GCGCCGCTCG CGCCCTTCTT CCGCTGCGCT TGCGCGCAGG GCTGGACCGG GCCGCGCTGC
GAGGCGCCCG CCGCGGCACC CGAGGTCTCG GAGGAGCCGC GGTGCCCGCG CGCCGCCTGC
CAGGCCAAGC GCGGGGACCA GCGCTGCGAC CGCGAGTGCA ACAGCCCAGG CTGCGGCTGG
GACGGCGGCG ACTGCTCGCT GAGCGTGGGC GACCCCTGGC GGCAATGCGA GGCGCTGCAG
TGCTGGCGCC TCTTCAACAA CAGCCGCTGC GACCCCGCCT GCAGCTCGCC CGCCTGCCTC
TACGACAACT TCGACTGCCA CGCCGGTGGC CGCGAGCGCA CTTGCAACCC GGTGTACGAG
AAGTACTGCG CCGACCACTT TGCCGACGGC CGCTGCGACC AGGGCTGCAA CACGGAGGAG
TGCGGCTGGG ATGGGCTGGA TTGTGCCAGC GAGGTGCCGG CCCTGCTGGC CCGCGGCGTG
CTGGTGCTCA CAGTGCTGCT GCCGCCAGAG GAGCTACTGC GTTCCAGCGC CGACTTTCTG
CAGCGGCTCA GCGCCATCCT GCGCACCTCG CTGCGCTTCC GCCTGGACGC GCACGGCCAG
GCCATGGTCT TCCCTTACCA CCGGCCTAGT CCTGGCTCCG AACCCCGGGC CCGTCGGGAG
CTGGCCCCCG AGGTGATCGG CTCGGTAGTA ATGCTGGAGA TTGACAACCG GCTCTGCCTG
CAGTCGCCTG AGAATGATCA CTGCTTCCCC GATGCCCAGA GCGCCGCTGA CTACCTGGGA
GCGTTGTCAG CGGTGGAGCG CCTGGACTTC CCGTACCCAC TGCGGGACGT GCGGGGGGAG
CCGCTGGAGC CTCCAGAACC CAGCGTCCCG CTGCTGCCAC TGCTAGTGGC GGGCGCTGTC
TTGCTGCTGG TCATTCTCGT CCTGGGTGTC ATGGTGGCCC GGCGCAAGCG CGAGCACAGC
ACCCTCTGGT TCCCTGAGGG CTTCTCACTG CACAAGGACG TGGCCTCTGG TCACAAGGGC
CGGCGGGAAC CCGTGGGCCA GGACGCGCTG GGCATGAAGA ACATGGCCAA GGGTGAGAGC
CTGATGGGGG AGGTGGCCAC AGACTGGATG GACACAGAGT GCCCAGAGGC CAAGCGGCTA
AAGGTAGAGG AGCCAGGCAT GGGGGCTGAG GAGGCTGTGG ATTGCCGTCA GTGGACTCAA
CACCATCTGG TTGCTGCTGA CATCCGCGTG GCACCAGCCA TGGCACTGAC ACCACCACAG
GGCGACGCAG ATGCTGATGG CATGGATGTC AATGTGCGTG GCCCAGATGG CTTCACCCCG
CTAATGCTGG CTTCCTTCTG TGGGGGGGCT CTGGAGCCAA TGCCAACTGA AGAGGATGAG
GCAGATGACA CATCAGCTAG CATCATCTCC GACCTGATCT GCCAGGGGGC TCAGCTTGGG
GCACGGACTG ACCGTACTGG CGAGACTGCT TTGCACCTGG CTGCCCGTTA TGCCCGTGCT
GATGCAGCCA AGCGGCTGCT GGATGCTGGG GCAGACACCA ATGCCCAGGA CCACTCAGGC
CGCACTCCCC TGCACACAGC TGTCACAGCC GATGCCCAGG GTGTCTTCCA GATTCTCATC
CGAAACCGCT CTACAGACTT GGATGCCCGC ATGGCAGATG GCTCAACGGC ACTGATCCTG
GCGGCCCGCC TGGCAGTAGA GGGCATGGTG GAAGAGCTCA TCGCCAGCCA TGCTGATGTC
AATGCTGTGG ATGAGCTTGG GAAATCAGCC TTACACTGGG CTGCGGCTGT GAACAACGTG
GAAGCCACTT TGGCCCTGCT CAAAAATGGA GCCAATAAGG ACATGCAGGA TAGCAAGGAG
GAGACCCCCC TATTCCTGGC CGCCCGCGAG GGCAGCTATG AGGCTGCCAA GCTGCTGTTG
GACCACTTTG CCAACCGTGA GATCACCGAC CACCTGGACA GGCTGCCGCG GGACGTAGCC
CAGGAGAGAC TGCACCAGGA CATCGTGCGC TTGCTGGATC AACCCAGTGG GCCCCGCAGC
CCCCCCGGTC CCCACGGCCT GGGGCCTCTG CTCTGTCCTC CAGGGGCCTT CCTCCCTGGC
CTCAAAGCGG CACAGTCGGG GTCCAAGAAG AGCAGGAGGC CCCCCGGGAA GGCGGGGCTG
GGGCCGCAGG GGCCCCGGGG GCGGGGCAAG AAGCTGACGC TGGCCTGCCC GGGCCCCCTG
GCTGACAGCT CGGTCACGCT GTCGCCCGTG GACTCGCTGG ACTCCCCGCG GCCTTTCGGT
GGGCCCCCTG CTTCCCCTGG TGGCTTCCCC CTTGAGGGGC CCTATGCAGC TGCCACTGCC
ACTGCAGTGT CTCTGGCACA GCTTGGTGGC CCAGGCCGGG CGGGTCTAGG GCGCCAGCCC
CCTGGAGGAT GTGTACTCAG CCTGGGCCTG CTGAACCCTG TGGCTGTGCC CCTCGATTGG
GCCCGGCTGC CCCCACCTGC CCCTCCAGGC CCCTCGTTCC TGCTGCCACT GGCGCCGGGA
CCCCAGCTGC TCAACCCAGG GACCCCCGTC TCCCCGCAGG AGCGGCCCCC GCCTTACCTG
GCAGTCCCAG GACATGGCGA GGAGTACCCG GCGGCTGGGG CACACAGCAG CCCCCCAAAG
GCCCGCTTCC TGCGGGTTCC CAGTGAGCAC CCTTACCTGA CCCCATCCCC CGAATCCCCT
GAGCACTGGG CCAGCCCCTC ACCTCCCTCC CTCTCAGACT GGTCCGAATC CACGCCTAGC
CCAGCCACTG CCACTGGGGC CATGGCCACC ACCACTGGGG CACTGCCTGC CCAGCCACTT
CCCTTGTCTG TTCCCAGCTC CCTTGCTCAG GCCCAGACCC AGCTGGGGCC CCAGCCGGAA
GTTACCCCCA AGAGGCAAGT GTTGGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Common NOTCH3 Variants and Cerebral Small-Vessel Disease
Stroke 46 (6), 1482-1487 (2015)
Rutten-Jacobs LC, Traylor M, Adib-Samii P, Thijs V, Sudlow C, Rothwell PM, Boncoraglio G, Dichgans M, Bevan S, Meschia J, Levi C, Rost NS, Rosand J, Hassan A and Markus HS.


book

NOTCH3 gene polymorphism is associated with the prognosis of gliomas in Chinese patients
Medicine (Baltimore) 94 (9), E482 (2015)
Shen Z, Hou X, Chen B, Chen P and Zhang Q.


book

Cysteine-sparing CADASIL mutations in NOTCH3 show proaggregatory properties in vitro
Stroke 46 (3), 786-792 (2015)
Wollenweber FA, Hanecker P, Bayer-Karpinska A, Malik R, Bazner H, Moreton F, Muir KW, Muller S, Giese A, Opherk C, Dichgans M, Haffner C and Duering M.


book

Notch signaling and ageing
Adv. Exp. Med. Biol. 822, 25-36 (2015)
Polychronidou E, Vlachakis D, Vlamos P, Baumann M and Kossida S.


book

CADASIL and autoimmunity: coexistence in a family with the R169C mutation at exon 4 of the NOTCH3 gene
Cerebrovasc. Dis. 38 (4), 302-307 (2014)
Paraskevas GP, Bougea A, Synetou M, Vassilopoulou S, Anagnostou E, Voumvourakis K, Iliopoulos A and Spengos K.


book

The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation
Genomics 24 (2), 253-258 (1994)
Larsson C, Lardelli M, White I and Lendahl U.


book

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3
Genomics 23 (2), 408-419 (1994)
Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H and Ikemura T.


book

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12
Nat. Genet. 3 (3), 256-259 (1993)
Tournier-Lasserve E, Joutel A, Melki J, Weissenbach J, Lathrop GM, Chabriat H, Mas JL, Cabanis EA, Baudrimont M, Maciazek J et al.


book

CADASIL
(in) Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Rutten,J. and Lesnik Oberstein,S.A.J.


book

Comparison of male and female kidney transplant survival rates
Transplantation 13 (5), 493-500 (1972)
Beleil,O.M., Mickey,M.R. and Terasaki,P.I.


 
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