Gene Symbol | NSF |
Entrez Gene ID | 4905 |
Full Name | N-ethylmaleimide sensitive factor, vesicle fusing ATPase |
Synonyms | SEC18,SKD2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » NSF cDNA ORF clone
Gene Symbol | NSF |
Entrez Gene ID | 4905 |
Full Name | N-ethylmaleimide sensitive factor, vesicle fusing ATPase |
Synonyms | SEC18,SKD2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_006178.3 | NP_006169.2 | vesicle-fusing ATPase |
NM_006178.4 | NP_006169.2 | vesicle-fusing ATPase |
Pan troglodytes (chimpanzee) | NSF | XP_511626.3 |
Canis lupus familiaris (dog) | NSF | XP_548044.2 |
Mus musculus (house mouse) | Nsf | NP_032766.2 |
Drosophila melanogaster (fruit fly) | comt | NP_001259506.1 |
Saccharomyces cerevisiae (baker's yeast) | SEC18 | NP_009636.3 |
Gallus gallus (chicken) | NSF | NP_001019627.1 |
Danio rerio (zebrafish) | nsfa | NP_001037793.1 |
Neurospora crassa | NCU03387 | XP_956834.1 |
Xenopus tropicalis (tropical clawed frog) | nsf | NP_001072788.1 |
Bos taurus (cattle) | NSF | XP_002696103.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012684 | XP_307148.3 |
Schizosaccharomyces pombe (fission yeast) | sec18 | NP_594690.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_02418 | XP_003709204.1 |
NSF | XP_002800596.1 | |
Caenorhabditis elegans (roundworm) | nsf-1 | NP_001076603.1 |
Caenorhabditis elegans (roundworm) | nsf-1 | NP_001076604.1 |
Homo sapiens (human) | NSF | NP_006169.2 |
Rattus norvegicus (Norway rat) | Nsf | NP_068516.1 |
Drosophila melanogaster (fruit fly) | Nsf2 | NP_788676.1 |
Kluyveromyces lactis | KLLA0C14520g | XP_452850.1 |
Eremothecium gossypii | AGOS_AER169C | NP_985027.1 |
Differential requirement for N-ethylmaleimide-sensitive factor in endosomal trafficking of transferrin receptor from anterograde trafficking of vesicular stomatitis virus glycoprotein G.
Fan J, Zhou X, Wang Y, Kuang C, Sun Y, Liu X, Toomre D, Xu Y
FEBS letters591(2)273-281(2017 01)
A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence.
Cabana-Dom?nguez J, Roncero C, Grau-L?pez L, Rodr?guez-Cintas L, Barral C, Abad AC, Erikson G, Wineinger NE, Torrico B, Arenas C, Casas M, Ribas?s M, Cormand B, Fern?ndez-Castillo N
Scientific reports631033(2016 Aug)
Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine.
Cipriano DJ, Jung J, Vivona S, Fenn TD, Brunger AT, Bryant Z
The Journal of biological chemistry288(32)23436-45(2013 Aug)
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
Couch FJ, Wang X, McGuffog L, Lee A, Olswold C, Kuchenbaecker KB, Soucy P, Fredericksen Z, Barrowdale D, Dennis J, Gaudet MM, Dicks E, Kosel M, Healey S, Sinilnikova OM, Lee A, Bacot F, Vincent D, Hogervorst FB, Peock S, Stoppa-Lyonnet D, Jakubowska A, , Radice P, Schmutzler RK, , Domchek SM, Piedmonte M, Singer CF, Friedman E, Thomassen M, , Hansen TV, Neuhausen SL, Szabo CI, Blanco I, Greene MH, Karlan BY, Garber J, Phelan CM, Weitzel JN, Montagna M, Olah E, Andrulis IL, Godwin AK, Yannoukakos D, Goldgar DE, Caldes T, Nevanlinna H, Osorio A, Terry MB, Daly MB, van Rensburg EJ, Hamann U, Ramus SJ, Toland AE, Caligo MA, Olopade OI, Tung N, Claes K, Beattie MS, Southey MC, Imyanitov EN, Tischkowitz M, Janavicius R, John EM, Kwong A, Diez O, Balma?a J, Barkardottir RB, Arun BK, Rennert G, Teo SH, Ganz PA, Campbell I, van der Hout AH, van Deurzen CH, Seynaeve C, G?mez Garcia EB, van Leeuwen FE, Meijers-Heijboer HE, Gille JJ, Ausems MG, Blok MJ, Ligtenberg MJ, Rookus MA, Devilee P, Verhoef S, van Os TA, Wijnen JT, , , Frost D, Ellis S, Fineberg E, Platte R, Evans DG, Izatt L, Eeles RA, Adlard J, Eccles DM, Cook J, Brewer C, Douglas F, Hodgson S, Morrison PJ, Side LE, Donaldson A, Houghton C, Rogers MT, Dorkins H, Eason J, Gregory H, McCann E, Murray A, Calender A, Hardouin A, Berthet P, Delnatte C, Nogues C, Lasset C, Houdayer C, Leroux D, Rouleau E, Prieur F, Damiola F, Sobol H, Coupier I, Venat-Bouvet L, Castera L, Gauthier-Villars M, L?on? M, Pujol P, Mazoyer S, Bignon YJ, , Z?owocka-Per?owska E, Gronwald J, Lubinski J, Durda K, Jaworska K, Huzarski T, Spurdle AB, Viel A, Peissel B, Bonanni B, Melloni G, Ottini L, Papi L, Varesco L, Tibiletti MG, Peterlongo P, Volorio S, Manoukian S, Pensotti V, Arnold N, Engel C, Deissler H, Gadzicki D, Gehrig A, Kast K, Rhiem K, Meindl A, Niederacher D, Ditsch N, Plendl H, Preisler-Adams S, Engert S, Sutter C, Varon-Mateeva R, Wappenschmidt B, Weber BH, Arver B, Stenmark-Askmalm M, Loman N, Rosenquist R, Einbeigi Z, Nathanson KL, Rebbeck TR, Blank SV, Cohn DE, Rodriguez GC, Small L, Friedlander M, Bae-Jump VL, Fink-Retter A, Rappaport C, Gschwantler-Kaulich D, Pfeiler G, Tea MK, Lindor NM, Kaufman B, Shimon Paluch S, Laitman Y, Skytte AB, Gerdes AM, Pedersen IS, Moeller ST, Kruse TA, Jensen UB, Vijai J, Sarrel K, Robson M, Kauff N, Mulligan AM, Glendon G, Ozcelik H, Ejlertsen B, Nielsen FC, J?nson L, Andersen MK, Ding YC, Steele L, Foretova L, Teul? A, Lazaro C, Brunet J, Pujana MA, Mai PL, Loud JT, Walsh C, Lester J, Orsulic S, Narod SA, Herzog J, Sand SR, Tognazzo S, Agata S, Vaszko T, Weaver J, Stavropoulou AV, Buys SS, Romero A, de la Hoya M, Aittom?ki K, Muranen TA, Duran M, Chung WK, Lasa A, Dorfling CM, Miron A, , Benitez J, Senter L, Huo D, Chan SB, Sokolenko AP, Chiquette J, Tihomirova L, Friebel TM, Agnarsson BA, Lu KH, Lejbkowicz F, James PA, Hall P, Dunning AM, Tessier D, Cunningham J, Slager SL, Wang C, Hart S, Stevens K, Simard J, Pastinen T, Pankratz VS, Offit K, Easton DF, Chenevix-Trench G, Antoniou AC,
PLoS genetics9(3)e1003212(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
NSF deficiency in HeLa cells barely affected cell viability, anterograde trafficking of vesicular stomatitis virus glycoprotein G and transferrin endocytosis.
Title: Differential requirement for N-ethylmaleimide-sensitive factor in endosomal trafficking of transferrin receptor from anterograde trafficking of vesicular stomatitis virus glycoprotein G.
a processive helicase-like mechanism for NSF in which approximately 1 residue is unwound for every hydrolyzed ATP molecule.
Title: Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine.
Single and multiple-marker analyses revealed a strong association between cocaine dependence and the NSF gene.
Title: Candidate pathway association study in cocaine dependence: the control of neurotransmitter release.
Knockdown of TRX1 increases the level of S-nitrosylated NSF, prolongs the inhibition of exocytosis, and suppresses leukocyte
Title: Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of 182 candidate genes in anorexia nervosa.
The following NSF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NSF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu55931 | |
Clone ID Related Accession (Same CDS sequence) | NM_006178.3 , NM_006178.4 | |
Accession Version | NM_006178.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Homo sapiens(human) | |
Product | vesicle-fusing ATPase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB460965.1, AK226078.1 and BC030613.2. On Jul 2, 2011 this sequence version replaced NM_006178.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF135168.1, SRR1660803.85589.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGGCC GGAGCATGCA AGCGGCAAGA TGTCCTACAG ATGAATTATC TTTAACCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006169.2 |
CDS | 108..2342 |
Translation |
Target ORF information:
Target ORF information:
|
NM_006178.3 |
1 | ATGGCGGGCC GGAGCATGCA AGCGGCAAGA TGTCCTACAG ATGAATTATC TTTAACCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu55931 | |
Clone ID Related Accession (Same CDS sequence) | NM_006178.3 , NM_006178.4 | |
Accession Version | NM_006178.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-29 | |
Organism | Homo sapiens(human) | |
Product | vesicle-fusing ATPase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB460965.1, AK226078.1 and BC030613.2. On May 17, 2019 this sequence version replaced NM_006178.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030613.2, SRR1660805.206957.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000398238.8/ ENSP00000381293.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## |
1 | ATGGCGGGCC GGAGCATGCA AGCGGCAAGA TGTCCTACAG ATGAATTATC TTTAACCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006169.2 |
CDS | 108..2342 |
Translation |
Target ORF information:
Target ORF information:
|
NM_006178.4 |
1 | ATGGCGGGCC GGAGCATGCA AGCGGCAAGA TGTCCTACAG ATGAATTATC TTTAACCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Differential requirement for N-ethylmaleimide-sensitive factor in endosomal trafficking of transferrin receptor from anterograde trafficking of vesicular stomatitis virus glycoprotein G. |
A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. |
Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine. |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. |