G0S2 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | G0S2 |
| Entrez Gene ID | 50486 |
| Full Name | G0/G1 switch 2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_015714.3 | NP_056529.1 | G0/G1 switch protein 2 |
| NM_015714.4 | NP_056529.1 | G0/G1 switch protein 2 |
| Homo sapiens (human) | G0S2 | NP_056529.1 |
| Rattus norvegicus (Norway rat) | G0s2 | NP_001009632.1 |
| Mus musculus (house mouse) | G0s2 | NP_032085.1 |
| Bos taurus (cattle) | G0S2 | NP_001179076.1 |
| Canis lupus familiaris (dog) | G0S2 | XP_005622384.1 |
| Pan troglodytes (chimpanzee) | G0S2 | XP_514164.1 |
Related articles in PubMed
Palmitate induces fat accumulation by activating C/EBP?-mediated G0S2 expression in HepG2 cells.
Zhao NQ, Li XY, Wang L, Feng ZL, Li XF, Wen YF, Han JX
World journal of gastroenterology23(43)7705-7715(2017 Nov)
G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux.
Zhang X, Heckmann BL, Campbell LE, Liu J
Biochimica et biophysica acta1862(10 Pt B)1146-1154(2017 10)
Activation of
Zhang F, Zhu YL, Deng WL, Zhu J, Zhang J
Journal of leukocyte biology101(3)655-664(2017 03)
G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer.
Yim CY, Bikorimana E, Khan E, Warzecha JM, Shin L, Rodriguez J, Dmitrovsky E, Freemantle SJ, Spinella MJ
Cell cycle (Georgetown, Tex.)16(21)2146-2155(2017)
Regulation of G0/G1 switch gene 2 (G0S2) expression in human adipose tissue.
Skopp A, May M, Janke J, Kielstein H, Wunder R, Flade-Kuthe R, Kuthe A, Jordan J, Engeli S
Archives of physiology and biochemistry122(2)47-53(2016)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
G0S2 functions as a master regulator of tissue-specific balance of TG storage vs. mobilization, partitioning of metabolic fuels between adipose and liver, and the whole-body adaptive energy response.
Title: G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux.
differences in G0S2 expression may explain depot-specific and obesity-associated differences in lipolysis on the molecular level
Title: Regulation of G0/G1 switch gene 2 (G0S2) expression in human adipose tissue.
Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 product (G0S2) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL).
Title: Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells.
Results indicate that G0S2 acts as a prosurvival molecule in endothelial cells.
Title: Lipolytic inhibitor G0/G1 switch gene 2 inhibits reactive oxygen species production and apoptosis in endothelial cells.
The following G0S2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the G0S2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu17003 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_015714.3 , NM_015714.4 | |
| Accession Version | NM_015714.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-29 | |
| Organism | Homo sapiens(human) | |
| Product | G0/G1 switch protein 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM788126.1 and AV709160.1. On Apr 10, 2008 this sequence version replaced NM_015714.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279845.6542.1, BC009694.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAAACGG TCCAGGAGCT GATCCCCCTG GCCAAGGAGA TGATGGCCCA GAAGCGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_056529.1 |
| CDS | 258..569 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_015714.3 |
ORF Insert Sequence:
1 | ATGGAAACGG TCCAGGAGCT GATCCCCCTG GCCAAGGAGA TGATGGCCCA GAAGCGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu17003 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_015714.3 , NM_015714.4 | |
| Accession Version | NM_015714.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-01 | |
| Organism | Homo sapiens(human) | |
| Product | G0/G1 switch protein 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM788126.1 and AV709160.1. On Nov 23, 2018 this sequence version replaced NM_015714.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.34592.1, SRR5189664.41709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367029.5/ ENSP00000355996.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGAAACGG TCCAGGAGCT GATCCCCCTG GCCAAGGAGA TGATGGCCCA GAAGCGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_056529.1 |
| CDS | 171..482 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_015714.4 |
ORF Insert Sequence:
1 | ATGGAAACGG TCCAGGAGCT GATCCCCCTG GCCAAGGAGA TGATGGCCCA GAAGCGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Palmitate induces fat accumulation by activating C/EBP?-mediated G0S2 expression in HepG2 cells. |
|
G0S2: A small giant controller of lipolysis and adipose-liver fatty acid flux. |
|
Activation of |
|
G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer. |
|
Regulation of G0/G1 switch gene 2 (G0S2) expression in human adipose tissue. |