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SERPINE1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol SERPINE1
Entrez Gene ID 5054
Full Name serpin family E member 1
Synonyms PAI,PAI-1,PAI1,PLANH1
General protein information
Preferred Names

serpin family E member 1

Names

plasminogen activator inhibitor 1
endothelial plasminogen activator inhibitor
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
serpin E1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

7

7q22.1

Summary This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Disorder MIM:

173360

Disorder Html: Plasminogen activator inhibitor, type I, 613329 (3); {Transcription

mRNA and Protein(s)

mRNA Protein Name
XM_017012260.1 XP_016867749.1 plasminogen activator inhibitor 1 isoform X1
NM_000602.4 NP_000593.1 plasminogen activator inhibitor 1 precursor



Pan troglodytes (chimpanzee) SERPINE1 XP_527841.3
Bos taurus (cattle) SERPINE1 NP_776562.1
Macaca mulatta (rhesus monkey) SERPINE1 XP_001107647.1
Canis lupus familiaris (dog) SERPINE1 NP_001184024.1
Xenopus tropicalis (tropical clawed frog) serpine1 XP_002941247.2
Mus musculus (house mouse) Serpine1 NP_032897.2
Rattus norvegicus (Norway rat) Serpine1 NP_036752.1
Anopheles gambiae (African malaria mosquito) SRPN1 XP_308847.4
Anopheles gambiae (African malaria mosquito) SRPN2 XP_308845.4
Homo sapiens (human) SERPINE1 NP_000593.1
Danio rerio (zebrafish) serpine1 NP_001108031.1
Anopheles gambiae (African malaria mosquito) SRPN3 XP_308846.4


Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway.
Wang X, Liu C, Wang J, Fan Y, Wang Z, Wang Y
Oncology reports37(2)747-753(2017 Feb)

Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population.
Gong ZH, Ji JF, Yang J, Xiang T, Zhou CK, Pan XL, Yao J
The Kaohsiung journal of medical sciences33(1)24-29(2017 Jan)

Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City.
Barajas-Castañeda LM, Cortés-Gutiérrez E, García-Rodríguez FM, Campos-Rodríguez R, Lara-Padilla E, Enríquez-Rincón F, Castro-Mussot ME, Figueroa-Arredondo P
Journal of immunology research20168519648(2016)

[Role of polymorphic markers for the genes of hemostasis and platelet receptors in liver fibrosis progression in patients with chronic hepatitis C].
Starostina EE, Samokhodskaya LM, Rozina TP, Krasnova TN, Yarovaya EB, Mukhin NA
Terapevticheskii arkhiv88(8)93-98(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the plasminogen activator urokinase (uPA)/plasminogen activator inhibitor 1 (PAI-1) ratios in prostate cancer (PCa) patients to be significantly higher than in benign prostatic hyperplasia (BPH) patients.
Title: Further evaluation of uPA and PAI-1 as biomarkers for prostatic diseases.

High PAI1 expression is associated with angiogenesis in hepatocellular carcinoma.
Title: HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma.

Plasma PAI-1 levels gradually increased as dementia progressed. The mean levels of plasma PAI-1 in patients with mild cognitive impairment and Alzheimer's disease patients were significantly higher than those of healthy controls.
Title: Plasminogen activator inhibitor-1 as an early potential diagnostic marker for Alzheimer's disease.

The PAI-1 level and 4G/5G polymorphism may not be a risk factor of arterial ischemic stroke in Thai children.
Title: Global fibrinolytic activity, PAI-1 level, and 4G/5G polymorphism in Thai children with arterial ischemic stroke.

Suggest that overexpressed SPP1, PAI and caveolin-1 were linked to carcinogenesis and progression, and thus they may serve as potential prognostic factors in oral squamous cell carcinoma.
Title: Prognostic and predictive values of SPP1, PAI and caveolin-1 in patients with oral squamous cell carcinoma.

The following SERPINE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27681 NM_000602.4
Latest version!
Homo sapiens serpin family E member 1 (SERPINE1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu97293 XM_017012260.1
Latest version!
Homo sapiens serpin family E member 1 (SERPINE1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27681
Clone ID Related Accession (Same CDS sequence) NM_000602.4
Accession Version NM_000602.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1209bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product plasminogen activator inhibitor 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CN309001.1, BC010860.1, M16006.1 and AI752990.1. This sequence is a reference standard in the RefSeqGene project. On Apr 5, 2012 this sequence version replaced NM_000602.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.170127.1, M16006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
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361
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481
541
601
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721
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961
1021
1081
1141
1201
ATGCAGATGT CTCCAGCCCT CACCTGCCTA GTCCTGGGCC TGGCCCTTGT CTTTGGTGAA 
GGGTCTGCTG TGCACCATCC CCCATCCTAC GTGGCCCACC TGGCCTCAGA CTTCGGGGTG
AGGGTGTTTC AGCAGGTGGC GCAGGCCTCC AAGGACCGCA ACGTGGTTTT CTCACCCTAT
GGGGTGGCCT CGGTGTTGGC CATGCTCCAG CTGACAACAG GAGGAGAAAC CCAGCAGCAG
ATTCAAGCAG CTATGGGATT CAAGATTGAT GACAAGGGCA TGGCCCCCGC CCTCCGGCAT
CTGTACAAGG AGCTCATGGG GCCATGGAAC AAGGATGAGA TCAGCACCAC AGACGCGATC
TTCGTCCAGC GGGATCTGAA GCTGGTCCAG GGCTTCATGC CCCACTTCTT CAGGCTGTTC
CGGAGCACGG TCAAGCAAGT GGACTTTTCA GAGGTGGAGA GAGCCAGATT CATCATCAAT
GACTGGGTGA AGACACACAC AAAAGGTATG ATCAGCAACT TGCTTGGGAA AGGAGCCGTG
GACCAGCTGA CACGGCTGGT GCTGGTGAAT GCCCTCTACT TCAACGGCCA GTGGAAGACT
CCCTTCCCCG ACTCCAGCAC CCACCGCCGC CTCTTCCACA AATCAGACGG CAGCACTGTC
TCTGTGCCCA TGATGGCTCA GACCAACAAG TTCAACTATA CTGAGTTCAC CACGCCCGAT
GGCCATTACT ACGACATCCT GGAACTGCCC TACCACGGGG ACACCCTCAG CATGTTCATT
GCTGCCCCTT ATGAAAAAGA GGTGCCTCTC TCTGCCCTCA CCAACATTCT GAGTGCCCAG
CTCATCAGCC ACTGGAAAGG CAACATGACC AGGCTGCCCC GCCTCCTGGT TCTGCCCAAG
TTCTCCCTGG AGACTGAAGT CGACCTCAGG AAGCCCCTAG AGAACCTGGG AATGACCGAC
ATGTTCAGAC AGTTTCAGGC TGACTTCACG AGTCTTTCAG ACCAAGAGCC TCTCCACGTC
GCGCAGGCGC TGCAGAAAGT GAAGATCGAG GTGAACGAGA GTGGCACGGT GGCCTCCTCA
TCCACAGCTG TCATAGTCTC AGCCCGCATG GCCCCCGAGG AGATCATCAT GGACAGACCC
TTCCTCTTTG TGGTCCGGCA CAACCCCACA GGAACAGTCC TTTTCATGGG CCAAGTGATG
GAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000593.1
CDS158..1366
Misc Feature(1)230..1363
Misc Feature(2)851..853
Misc Feature(3)1019..1021
Misc Feature(4)order(1220..1231,1280..1297)
Misc Feature(5)1235..1237
Misc Feature(6)1247..1249
Misc Feature(7)1262..1267
Misc Feature(8)1292..1294
Exon (1)1..156
Exon (2)157..428
Exon (3)429..662
Exon (4)663..857
Exon (5)858..1056
Exon (6)1057..1157
Exon (7)1158..1244
Exon (8)1245..1328
Exon (9)1329..3190
Translation

Target ORF information:

RefSeq Version NM_000602.4
Organism Homo sapiens(Human)
Definition Homo sapiens serpin family E member 1 (SERPINE1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000602.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCAGATGT CTCCAGCCCT CACCTGCCTA GTCCTGGGCC TGGCCCTTGT CTTTGGTGAA 
GGGTCTGCTG TGCACCATCC CCCATCCTAC GTGGCCCACC TGGCCTCAGA CTTCGGGGTG
AGGGTGTTTC AGCAGGTGGC GCAGGCCTCC AAGGACCGCA ACGTGGTTTT CTCACCCTAT
GGGGTGGCCT CGGTGTTGGC CATGCTCCAG CTGACAACAG GAGGAGAAAC CCAGCAGCAG
ATTCAAGCAG CTATGGGATT CAAGATTGAT GACAAGGGCA TGGCCCCCGC CCTCCGGCAT
CTGTACAAGG AGCTCATGGG GCCATGGAAC AAGGATGAGA TCAGCACCAC AGACGCGATC
TTCGTCCAGC GGGATCTGAA GCTGGTCCAG GGCTTCATGC CCCACTTCTT CAGGCTGTTC
CGGAGCACGG TCAAGCAAGT GGACTTTTCA GAGGTGGAGA GAGCCAGATT CATCATCAAT
GACTGGGTGA AGACACACAC AAAAGGTATG ATCAGCAACT TGCTTGGGAA AGGAGCCGTG
GACCAGCTGA CACGGCTGGT GCTGGTGAAT GCCCTCTACT TCAACGGCCA GTGGAAGACT
CCCTTCCCCG ACTCCAGCAC CCACCGCCGC CTCTTCCACA AATCAGACGG CAGCACTGTC
TCTGTGCCCA TGATGGCTCA GACCAACAAG TTCAACTATA CTGAGTTCAC CACGCCCGAT
GGCCATTACT ACGACATCCT GGAACTGCCC TACCACGGGG ACACCCTCAG CATGTTCATT
GCTGCCCCTT ATGAAAAAGA GGTGCCTCTC TCTGCCCTCA CCAACATTCT GAGTGCCCAG
CTCATCAGCC ACTGGAAAGG CAACATGACC AGGCTGCCCC GCCTCCTGGT TCTGCCCAAG
TTCTCCCTGG AGACTGAAGT CGACCTCAGG AAGCCCCTAG AGAACCTGGG AATGACCGAC
ATGTTCAGAC AGTTTCAGGC TGACTTCACG AGTCTTTCAG ACCAAGAGCC TCTCCACGTC
GCGCAGGCGC TGCAGAAAGT GAAGATCGAG GTGAACGAGA GTGGCACGGT GGCCTCCTCA
TCCACAGCTG TCATAGTCTC AGCCCGCATG GCCCCCGAGG AGATCATCAT GGACAGACCC
TTCCTCTTTG TGGTCCGGCA CAACCCCACA GGAACAGTCC TTTTCATGGG CCAAGTGATG
GAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu97293
Clone ID Related Accession (Same CDS sequence) XM_017012260.1
Accession Version XM_017012260.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1323bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product plasminogen activator inhibitor 1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCAGATGT CTCCAGCCCT CACCTGCCTA GTCCTGGGCC TGGCCCTTGT CTTTGGTGAA 
GGGTCTGCTG TGCACCATCC CCCATCCTAC GTGGCCCACC TGGCCTCAGA CTTCGGGGTG
AGGGTGTTTC AGCAGGTGGC GCAGGCCTCC AAGGACCGCA ACGTGGTTTT CTCACCCTAT
GGGGTGGCCT CGGTGTTGGC CATGCTCCAG CTGACAACAG GAGGAGAAAC CCAGCAGCAG
ATTCAAGCAG CTATGGGATT CAAGATTGAT GACAAGGGCA TGGCCCCCGC CCTCCGGCAT
CTGTACAAGG AGCTCATGGG GCCATGGAAC AAGGATGAGA TCAGCACCAC AGACGCGATC
TTCGTCCAGC GGGATCTGAA GCTGGTCCAG GGCTTCATGC CCCACTTCTT CAGGCTGTTC
CGGAGCACGG TCAAGCAAGT GGACTTTTCA GAGGTGGAGA GAGCCAGATT CATCATCAAT
GACTGGGTGA AGACACACAC AAAAGGTATG ATCAGCAACT TGCTTGGGAA AGGAGCCGTG
GACCAGCTGA CACGGCTGGT GCTGGTGAAT GCCCTCTACT TCAACGGCCA GTGGAAGACT
CCCTTCCCCG ACTCCAGCAC CCACCGCCGC CTCTTCCACA AATCAGACGG CAGCACTGTC
TCTGTGCCCA TGATGGCTCA GACCAACAAG TTCAACTATA CTGAGTTCAC CACGCCCGAT
GGCCATTACT ACGACATCCT GGAACTGCCC TACCACGGGG ACACCCTCAG CATGTTCATT
GCTGCCCCTT ATGAAAAAGA GGTGCCTCTC TCTGCCCTCA CCAACATTCT GAGTGCCCAG
CTCATCAGCC ACTGGAAAGG CAACATGACC AGGCTGCCCC GCCTCCTGGT TCTGCCCAAG
TTCTCCCTGG AGACTGAAGT CGACCTCAGG AAGCCCCTAG AGAACCTGGG AATGACCGAC
ATGTTCAGAC AGTTTCAGGC TGACTTCACG AGTCTTTCAG ACCAAGAGCC TCTCCACGTC
GCGCAGGCGC TGCAGAAAGT GAAGATCGAG GTGAACGAGA GTGGCACGGT GGCCTCCTCA
TCCACAGGTG AGTCTGGCTC AGGTGAGGCT CCACGGGTGT CGCCTCCATC GCCCTTCAGG
ATAACTGGTC CCCAGACCCG GAAAGGACCC CGCAGCCCTC TCGGCACAGA GCAGCTCTGT
CTGTGCTCAG CCATCACCCA CTCCCCACCT GTTTCTCAGC CTGGAAAACG GGCTTGGGAC
CATGGAACCC TGTTTCCTCG CCTGATGGCT CCTAAGTTCC CTGACTGTGA AAAGGCCTCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016867749.1
CDS160..1482
Translation

Target ORF information:

RefSeq Version XM_017012260.1
Organism Homo sapiens(Human)
Definition Homo sapiens serpin family E member 1 (SERPINE1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017012260.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCAGATGT CTCCAGCCCT CACCTGCCTA GTCCTGGGCC TGGCCCTTGT CTTTGGTGAA 
GGGTCTGCTG TGCACCATCC CCCATCCTAC GTGGCCCACC TGGCCTCAGA CTTCGGGGTG
AGGGTGTTTC AGCAGGTGGC GCAGGCCTCC AAGGACCGCA ACGTGGTTTT CTCACCCTAT
GGGGTGGCCT CGGTGTTGGC CATGCTCCAG CTGACAACAG GAGGAGAAAC CCAGCAGCAG
ATTCAAGCAG CTATGGGATT CAAGATTGAT GACAAGGGCA TGGCCCCCGC CCTCCGGCAT
CTGTACAAGG AGCTCATGGG GCCATGGAAC AAGGATGAGA TCAGCACCAC AGACGCGATC
TTCGTCCAGC GGGATCTGAA GCTGGTCCAG GGCTTCATGC CCCACTTCTT CAGGCTGTTC
CGGAGCACGG TCAAGCAAGT GGACTTTTCA GAGGTGGAGA GAGCCAGATT CATCATCAAT
GACTGGGTGA AGACACACAC AAAAGGTATG ATCAGCAACT TGCTTGGGAA AGGAGCCGTG
GACCAGCTGA CACGGCTGGT GCTGGTGAAT GCCCTCTACT TCAACGGCCA GTGGAAGACT
CCCTTCCCCG ACTCCAGCAC CCACCGCCGC CTCTTCCACA AATCAGACGG CAGCACTGTC
TCTGTGCCCA TGATGGCTCA GACCAACAAG TTCAACTATA CTGAGTTCAC CACGCCCGAT
GGCCATTACT ACGACATCCT GGAACTGCCC TACCACGGGG ACACCCTCAG CATGTTCATT
GCTGCCCCTT ATGAAAAAGA GGTGCCTCTC TCTGCCCTCA CCAACATTCT GAGTGCCCAG
CTCATCAGCC ACTGGAAAGG CAACATGACC AGGCTGCCCC GCCTCCTGGT TCTGCCCAAG
TTCTCCCTGG AGACTGAAGT CGACCTCAGG AAGCCCCTAG AGAACCTGGG AATGACCGAC
ATGTTCAGAC AGTTTCAGGC TGACTTCACG AGTCTTTCAG ACCAAGAGCC TCTCCACGTC
GCGCAGGCGC TGCAGAAAGT GAAGATCGAG GTGAACGAGA GTGGCACGGT GGCCTCCTCA
TCCACAGGTG AGTCTGGCTC AGGTGAGGCT CCACGGGTGT CGCCTCCATC GCCCTTCAGG
ATAACTGGTC CCCAGACCCG GAAAGGACCC CGCAGCCCTC TCGGCACAGA GCAGCTCTGT
CTGTGCTCAG CCATCACCCA CTCCCCACCT GTTTCTCAGC CTGGAAAACG GGCTTGGGAC
CATGGAACCC TGTTTCCTCG CCTGATGGCT CCTAAGTTCC CTGACTGTGA AAAGGCCTCC
TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN


book

Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway.
Oncology reports37(2)747-753(2017 Feb)
Wang X,Liu C,Wang J,Fan Y,Wang Z,Wang Y


book

Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population.
The Kaohsiung journal of medical sciences33(1)24-29(2017 Jan)
Gong ZH,Ji JF,Yang J,Xiang T,Zhou CK,Pan XL,Yao J


book

Overexpression of MMP-3 and uPA with Diminished PAI-1 Related to Metastasis in Ductal Breast Cancer Patients Attending a Public Hospital in Mexico City.
Journal of immunology research20168519648(2016)
Barajas-Castañeda LM,Cortés-Gutiérrez E,García-Rodríguez FM,Campos-Rodríguez R,Lara-Padilla E,Enríquez-Rincón F,Castro-Mussot ME,Figueroa-Arredondo P


book

[Role of polymorphic markers for the genes of hemostasis and platelet receptors in liver fibrosis progression in patients with chronic hepatitis C].
Terapevticheskii arkhiv88(8)93-98(2016)
Starostina EE,Samokhodskaya LM,Rozina TP,Krasnova TN,Yarovaya EB,Mukhin NA


 
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