×

GP6 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GP6
Entrez Gene ID 51206
Full Name glycoprotein VI platelet
Synonyms BDPLT11,GPIV,GPVI
General protein information
Preferred Names

glycoprotein VI platelet

Names

platelet glycoprotein VI
glycoprotein 6
platelet collagen receptor

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

19

19q13.42

Disorder MIM:

605546


mRNA and Protein(s)

mRNA Protein Name
NM_001256017.2 NP_001242946.2 platelet glycoprotein VI isoform 3 precursor
NM_016363.5 NP_057447.5 platelet glycoprotein VI isoform 2 precursor
NM_001083899.2 NP_001077368.2 platelet glycoprotein VI isoform 1 precursor



Canis lupus familiaris (dog) GP6 XP_005616212.1
Rattus norvegicus (Norway rat) Gp6 XP_003748805.2
Pan troglodytes (chimpanzee) GP6 XP_513024.3
Homo sapiens (human) GP6 NP_001242946.2
Mus musculus (house mouse) Gp6 NP_001156486.1


Related articles in PubMed

Elevated Soluble Platelet Glycoprotein VI Levels in Patients After Living Donor Liver Transplantation.
Takahashi N, Usui M, Naitoh K, Wada H, Mastsui T, Kobayashi T, Matsumoto T, Uemoto S, Isaji S
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis23(3)274-281(2017 Apr)

Associations between polymorphisms in coagulation-related genes and venous thromboembolism: A meta-analysis with trial sequential analysis.
Jiang J, Liu K, Zou J, Ma H, Yang H, Zhang X, Jiao Y
Medicine96(13)e6537(2017 Mar)

Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage.
Sokol J, Skerenova M, Biringer K, Lasabova Z, Stasko J, Kubisz P
Expert review of hematology8(6)863-8(2015 Dec)

Diagnostic and therapeutic potentials of platelet glycoprotein VI.
Bigalke B, Krämer BF, Seizer P, Fateh-Moghadam S, Gawaz M, Lindemann S
Seminars in thrombosis and hemostasis36(2)203-11(2010 Mar)

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.
Dumont B, Lasne D, Rothschild C, Bouabdelli M, Ollivier V, Oudin C, Ajzenberg N, Grandchamp B, Jandrot-Perrus M
Blood114(9)1900-3(2009 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Novel antithrombotic peptides derived from trowaglerix that acts through GPVI antagonism with greater safety-no severe bleeding.
Title: Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet.

plasma sGPVI levels are related to platelet activation in Living Donor Liver Transplantation. Although the plasma levels of sGPVI in the survivors increased after the operation, those in the nonsurvivors were high only on day 3.
Title: Elevated Soluble Platelet Glycoprotein VI Levels in Patients After Living Donor Liver Transplantation.

rs1613662 polymorphism has an important role in the development of venous thromboembolism in the white race
Title: Associations between polymorphisms in coagulation-related genes and venous thromboembolism: A meta-analysis with trial sequential analysis.

results support the idea that genetic variability of GP6 regulatory regions can be associated with platelet hyperaggregability - a possible cause of miscarriage
Title: Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage.

These results demonstrate that GP6 is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.
Title: Fibrin activates GPVI in human and mouse platelets.

The following GP6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GP6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu20368 NM_001083899.2
Latest version!
Homo sapiens glycoprotein VI platelet (GP6), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $363.30
$519.00
OHu20989 NM_001256017.2
Latest version!
Homo sapiens glycoprotein VI platelet (GP6), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu21878 NM_016363.5
Latest version!
Homo sapiens glycoprotein VI platelet (GP6), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20368
Clone ID Related Accession (Same CDS sequence) NM_001083899.2
Accession Version NM_001083899.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1863bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-09
Organism Homo sapiens(Human)
Product platelet glycoprotein VI isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB043821.1 and AC011476.8. This sequence is a reference standard in the RefSeqGene project. On Dec 6, 2013 this sequence version replaced NM_001083899.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB043821.1, BC069485.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG GAACCTCTGT GACCCCCAGC CGGTTACCAA CAGAACCACC TTCCCCGGTA
GCAGAATTCT CAGAAGCCAC CGCTGAACTG ACCGTCTCAT TCACAAACGA AGTCTTCACA
ACTGAGACTT CTAGGAGTAT CACCGCCAGT CCAAAGGAGT CAGACTCTCC AGCTGGTGAG
TCCTGCCCGC CAGTACTACA CCAAGGGCAA CCTGGTCCGG ATATGCCTCG GGGCTGTGAT
CCTAATAATC CTGGCGGGGT TTCTGGCAGA GGACTGGCAC AGCCGGAGGA AGCGCCTGCG
GCACAGGGGC AGGGCTGTGC AGAGGCCGCT TCCGCCCCTC CCGCCCCTCC CGCTGACCCG
GAAATCAAAC GGGGGTCAGG ATGGAGGCCG ACAGGATGTT CACAGCCGCG GGTTATGTTC
ATGACCGCTG AACCCCAGGC ACGGTCGTAT CCAAGGGAGG GATCATGGCA TGGGAGGCGA
CTCAAAGACT GGCGTGTGTG GAGCGTGGAA GCAGGAGGGC AGAGGCTACA GCTGTGGAAA
CGAGGCCATG CTGCCTCCTC CTGGTGTTCC ATCAGGGAGC CGTTCGGCCA GTGTCTGTCT
GTCTGTCTGC CTCTCTGTCT GAGGGCACCC TCCATTTGGG ATGGAAGGAA TCTGTGGAGA
CCCCATCCTC CTCCCTGCAC ACTGTGGATG ACATGGTACC CTGGCTGGAC CACATACTGG
CCTCTTTCTT CAACCTCTCT AATATGGGCT CCAGACGGAT CTCTAAGGTT CCCAGCTCTC
AGGGTTGACT CTGTTCCATC CTCTGTGCAA AATCCTCCCG TGCTTCCCTT TGGCCCTCTG
TGCTCTTGTC TGGTTTTCCC CAGAAACTCT CACCCTCACT CCATCTCCCA CTGCGGTCTA
ACAAATCTCC TTTCGTCTCT CAGAACGGGT CTTGCAGGCA GTTTGGGTAT GTCATTCATT
TTCCTTAGTG TAAAACTAGC ACGTTGCCCG CTTCCCTTCA CATTAGAAAA CAAGATCAGC
CTGTGCAACA TGGTGAAACC TCATCTCTAC CAACAAAACA AAAAAACACA AAAATTAGCC
AGGTGTGGTG GTGCATCCCT ATACTCCCAG CAACTCAGGG GGCTGAGGTG GGAGAATGGC
TTGAGCCTGG GAGGCAGAGG TTGCAGTGAG CTGAGATCAC ACCACTGCAC TCTAGCTCGG
GTGACGAAGC CTGACTTTGT CTCAAAAAAT ACAGGGATGA ATATGTCAAT TACCCTGATT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001077368.2
CDS29..1891
Misc Feature(1)20..22
Misc Feature(2)104..352
Misc Feature(3)order(206..208,293..295,314..316)
Misc Feature(4)365..634
Exon (1)1..62
Exon (2)63..95
Exon (3)96..353
Exon (4)354..638
Exon (5)639..692
Exon (6)693..752
Exon (7)753..807
Exon (8)808..2268
Translation

Target ORF information:

RefSeq Version NM_001083899.2
Organism Homo sapiens(Human)
Definition Homo sapiens glycoprotein VI platelet (GP6), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001083899.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG GAACCTCTGT GACCCCCAGC CGGTTACCAA CAGAACCACC TTCCCCGGTA
GCAGAATTCT CAGAAGCCAC CGCTGAACTG ACCGTCTCAT TCACAAACGA AGTCTTCACA
ACTGAGACTT CTAGGAGTAT CACCGCCAGT CCAAAGGAGT CAGACTCTCC AGCTGGTGAG
TCCTGCCCGC CAGTACTACA CCAAGGGCAA CCTGGTCCGG ATATGCCTCG GGGCTGTGAT
CCTAATAATC CTGGCGGGGT TTCTGGCAGA GGACTGGCAC AGCCGGAGGA AGCGCCTGCG
GCACAGGGGC AGGGCTGTGC AGAGGCCGCT TCCGCCCCTC CCGCCCCTCC CGCTGACCCG
GAAATCAAAC GGGGGTCAGG ATGGAGGCCG ACAGGATGTT CACAGCCGCG GGTTATGTTC
ATGACCGCTG AACCCCAGGC ACGGTCGTAT CCAAGGGAGG GATCATGGCA TGGGAGGCGA
CTCAAAGACT GGCGTGTGTG GAGCGTGGAA GCAGGAGGGC AGAGGCTACA GCTGTGGAAA
CGAGGCCATG CTGCCTCCTC CTGGTGTTCC ATCAGGGAGC CGTTCGGCCA GTGTCTGTCT
GTCTGTCTGC CTCTCTGTCT GAGGGCACCC TCCATTTGGG ATGGAAGGAA TCTGTGGAGA
CCCCATCCTC CTCCCTGCAC ACTGTGGATG ACATGGTACC CTGGCTGGAC CACATACTGG
CCTCTTTCTT CAACCTCTCT AATATGGGCT CCAGACGGAT CTCTAAGGTT CCCAGCTCTC
AGGGTTGACT CTGTTCCATC CTCTGTGCAA AATCCTCCCG TGCTTCCCTT TGGCCCTCTG
TGCTCTTGTC TGGTTTTCCC CAGAAACTCT CACCCTCACT CCATCTCCCA CTGCGGTCTA
ACAAATCTCC TTTCGTCTCT CAGAACGGGT CTTGCAGGCA GTTTGGGTAT GTCATTCATT
TTCCTTAGTG TAAAACTAGC ACGTTGCCCG CTTCCCTTCA CATTAGAAAA CAAGATCAGC
CTGTGCAACA TGGTGAAACC TCATCTCTAC CAACAAAACA AAAAAACACA AAAATTAGCC
AGGTGTGGTG GTGCATCCCT ATACTCCCAG CAACTCAGGG GGCTGAGGTG GGAGAATGGC
TTGAGCCTGG GAGGCAGAGG TTGCAGTGAG CTGAGATCAC ACCACTGCAC TCTAGCTCGG
GTGACGAAGC CTGACTTTGT CTCAAAAAAT ACAGGGATGA ATATGTCAAT TACCCTGATT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20989
Clone ID Related Accession (Same CDS sequence) NM_001256017.2
Accession Version NM_001256017.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 966bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-09
Organism Homo sapiens(Human)
Product platelet glycoprotein VI isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB043820.1 and AC011476.8. This sequence is a reference standard in the RefSeqGene project. On Dec 6, 2013 this sequence version replaced NM_001256017.1. Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB043820.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG AATTCTCAGA AGCCACCGCT GAACTGACCG TCTCATTCAC AAACGAAGTC
TTCACAACTG AGACTTCTAG GAGTATCACC GCCAGTCCAA AGGAGTCAGA CTCTCCAGCT
GGTCCTGCCC GCCAGTACTA CACCAAGGGC AACCTGGTCC GGATATGCCT CGGGGCTGTG
ATCCTAATAA TCCTGGCGGG GTTTCTGGCA GAGGACTGGC ACAGCCGGAG GAAGCGCCTG
CGGCACAGGG GCAGGGCTGT GCAGAGGCCG CTTCCGCCCC TCCCGCCCCT CCCGCTGACC
CGGAAATCAA ACGGGGGTCA GGATGGAGGC CGACAGGATG TTCACAGCCG CGGGTTATGT
TCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001242946.2
CDS29..994
Misc Feature(1)20..22
Misc Feature(2)104..352
Misc Feature(3)order(206..208,293..295,314..316)
Misc Feature(4)365..634
Exon (1)1..62
Exon (2)63..95
Exon (3)96..353
Exon (4)354..638
Exon (5)639..698
Exon (6)699..749
Exon (7)750..2210
Translation

Target ORF information:

RefSeq Version NM_001256017.2
Organism Homo sapiens(Human)
Definition Homo sapiens glycoprotein VI platelet (GP6), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001256017.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG AATTCTCAGA AGCCACCGCT GAACTGACCG TCTCATTCAC AAACGAAGTC
TTCACAACTG AGACTTCTAG GAGTATCACC GCCAGTCCAA AGGAGTCAGA CTCTCCAGCT
GGTCCTGCCC GCCAGTACTA CACCAAGGGC AACCTGGTCC GGATATGCCT CGGGGCTGTG
ATCCTAATAA TCCTGGCGGG GTTTCTGGCA GAGGACTGGC ACAGCCGGAG GAAGCGCCTG
CGGCACAGGG GCAGGGCTGT GCAGAGGCCG CTTCCGCCCC TCCCGCCCCT CCCGCTGACC
CGGAAATCAA ACGGGGGTCA GGATGGAGGC CGACAGGATG TTCACAGCCG CGGGTTATGT
TCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21878
Clone ID Related Accession (Same CDS sequence) NM_016363.5
Accession Version NM_016363.5 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1020bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-09
Organism Homo sapiens(Human)
Product platelet glycoprotein VI isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB043819.1 and AC011476.8. On Dec 6, 2013 this sequence version replaced NM_016363.4. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 2 which has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB043819.1, BC104832.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG GAACCTCTGT GACCCCCAGC CGGTTACCAA CAGAACCACC TTCCCCGGTA
GCAGAATTCT CAGAAGCCAC CGCTGAACTG ACCGTCTCAT TCACAAACGA AGTCTTCACA
ACTGAGACTT CTAGGAGTAT CACCGCCAGT CCAAAGGAGT CAGACTCTCC AGCTGGTCCT
GCCCGCCAGT ACTACACCAA GGGCAACCTG GTCCGGATAT GCCTCGGGGC TGTGATCCTA
ATAATCCTGG CGGGGTTTCT GGCAGAGGAC TGGCACAGCC GGAGGAAGCG CCTGCGGCAC
AGGGGCAGGG CTGTGCAGAG GCCGCTTCCG CCCCTCCCGC CCCTCCCGCT GACCCGGAAA
TCAAACGGGG GTCAGGATGG AGGCCGACAG GATGTTCACA GCCGCGGGTT ATGTTCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057447.5
CDS29..1048
Misc Feature(1)20..22
Misc Feature(2)104..352
Misc Feature(3)order(206..208,293..295,314..316)
Misc Feature(4)365..634
Misc Feature(5)830..892
Exon (1)1..62
Exon (2)63..95
Exon (3)96..353
Exon (4)354..638
Exon (5)639..692
Exon (6)693..752
Exon (7)753..803
Exon (8)804..2264
Translation

Target ORF information:

RefSeq Version NM_016363.5
Organism Homo sapiens(Human)
Definition Homo sapiens glycoprotein VI platelet (GP6), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016363.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG GAACCTCTGT GACCCCCAGC CGGTTACCAA CAGAACCACC TTCCCCGGTA
GCAGAATTCT CAGAAGCCAC CGCTGAACTG ACCGTCTCAT TCACAAACGA AGTCTTCACA
ACTGAGACTT CTAGGAGTAT CACCGCCAGT CCAAAGGAGT CAGACTCTCC AGCTGGTCCT
GCCCGCCAGT ACTACACCAA GGGCAACCTG GTCCGGATAT GCCTCGGGGC TGTGATCCTA
ATAATCCTGG CGGGGTTTCT GGCAGAGGAC TGGCACAGCC GGAGGAAGCG CCTGCGGCAC
AGGGGCAGGG CTGTGCAGAG GCCGCTTCCG CCCCTCCCGC CCCTCCCGCT GACCCGGAAA
TCAAACGGGG GTCAGGATGG AGGCCGACAG GATGTTCACA GCCGCGGGTT ATGTTCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Elevated Soluble Platelet Glycoprotein VI Levels in Patients After Living Donor Liver Transplantation.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis23(3)274-281(2017 Apr)
Takahashi N,Usui M,Naitoh K,Wada H,Mastsui T,Kobayashi T,Matsumoto T,Uemoto S,Isaji S


book

Associations between polymorphisms in coagulation-related genes and venous thromboembolism: A meta-analysis with trial sequential analysis.
Medicine96(13)e6537(2017 Mar)
Jiang J,Liu K,Zou J,Ma H,Yang H,Zhang X,Jiao Y


book

Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage.
Expert review of hematology8(6)863-8(2015 Dec)
Sokol J,Skerenova M,Biringer K,Lasabova Z,Stasko J,Kubisz P


book

Diagnostic and therapeutic potentials of platelet glycoprotein VI.
Seminars in thrombosis and hemostasis36(2)203-11(2010 Mar)
Bigalke B,Krämer BF,Seizer P,Fateh-Moghadam S,Gawaz M,Lindemann S


book

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.
Blood114(9)1900-3(2009 Aug)
Dumont B,Lasne D,Rothschild C,Bouabdelli M,Ollivier V,Oudin C,Ajzenberg N,Grandchamp B,Jandrot-Perrus M


 
*
*
*
*