MRPL51 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | MRPL51 |
| Entrez Gene ID | 51258 |
| Full Name | mitochondrial ribosomal protein L51 |
| Synonyms | CDA09,HSPC241,MRP64,bMRP64 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_016497.3 | NP_057581.2 | 39S ribosomal protein L51, mitochondrial |
| NM_016497.4 | NP_057581.2 | 39S ribosomal protein L51, mitochondrial |
| Bos taurus (cattle) | MRPL51 | NP_001094558.1 |
| Rattus norvegicus (Norway rat) | Mrpl51 | NP_001100091.1 |
| Homo sapiens (human) | MRPL51 | NP_057581.2 |
| Pan troglodytes (chimpanzee) | MRPL51 | XP_508954.2 |
| MRPL51 | XP_001105685.1 | |
| Canis lupus familiaris (dog) | MRPL51 | XP_003433522.1 |
| Mus musculus (house mouse) | Mrpl51 | NP_079871.1 |
| Gallus gallus (chicken) | MRPL51 | NP_001008675.1 |
| Danio rerio (zebrafish) | zgc:110255 | NP_001013494.1 |
| Xenopus tropicalis (tropical clawed frog) | mrpl51 | NP_001017085.1 |
Related articles in PubMed
Structures of the human mitochondrial ribosome in native states of assembly.
Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V
Nature structural & molecular biology24(10)866-869(2017 Oct)
Structure of the large ribosomal subunit from human mitochondria.
Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G, Scheres SHW, Ramakrishnan V
Science (New York, N.Y.)346(6210)718-722(2014 Nov)
Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes.
Haque ME, Elmore KB, Tripathy A, Koc H, Koc EC, Spremulli LL
The Journal of biological chemistry285(36)28353-62(2010 Sep)
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)
Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhang Z, Gerstein M
Genomics81(5)468-80(2003 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
The following MRPL51 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRPL51 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu30657 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_016497.3 , NM_016497.4 | |
| Accession Version | NM_016497.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-01 | |
| Organism | Homo sapiens(human) | |
| Product | 39S ribosomal protein L51, mitochondrial | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI856229.1, AF212248.1 and BC014329.1. On Mar 7, 2008 this sequence version replaced NM_016497.2. ##Evidence-Data-START## Transcript exon combination :: BI601503.1, SRR1163658.56398.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCAGGGA ACCTCTTATC CGGGGCAGGT AGGCGCCTGT GGGACTGGGT GCCTCTGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_057581.2 |
| CDS | 170..556 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_016497.3 |
ORF Insert Sequence:
1 | ATGGCAGGGA ACCTCTTATC CGGGGCAGGT AGGCGCCTGT GGGACTGGGT GCCTCTGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu30657 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_016497.3 , NM_016497.4 | |
| Accession Version | NM_016497.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-26 | |
| Organism | Homo sapiens(human) | |
| Product | 39S ribosomal protein L51, mitochondrial | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF212248.1, BC014329.1 and AC006064.10. On Nov 23, 2018 this sequence version replaced NM_016497.3. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.458397.1, SRR1660805.184931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000229238.5/ ENSP00000229238.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGCAGGGA ACCTCTTATC CGGGGCAGGT AGGCGCCTGT GGGACTGGGT GCCTCTGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_057581.2 |
| CDS | 127..513 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_016497.4 |
ORF Insert Sequence:
1 | ATGGCAGGGA ACCTCTTATC CGGGGCAGGT AGGCGCCTGT GGGACTGGGT GCCTCTGGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Structures of the human mitochondrial ribosome in native states of assembly. |
|
Structure of the large ribosomal subunit from human mitochondria. |
|
Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes. |
|
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. |
|
Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |