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MAGEC2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MAGEC2
Entrez Gene ID 51438
Full Name MAGE family member C2
Synonyms CT10,HCA587,MAGEE1
General protein information
Preferred Names

MAGE family member C2

Names

melanoma-associated antigen C2
MAGE-C2 antigen
MAGE-E1 antigen
cancer/testis antigen 10
hepatocellular cancer antigen 587
hepatocellular carcinoma-associated antigen 587
melanoma antigen family C, 2
melanoma antigen family C2
melanoma antigen, family E, 1, cancer/testis specific

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

X

Xq27.2

Summary This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009].
Disorder MIM:

300468


mRNA and Protein(s)

mRNA Protein Name
NM_016249.3 NP_057333.1 melanoma-associated antigen C2



Macaca mulatta (rhesus monkey) MAGEC2 XP_001085870.1
Homo sapiens (human) MAGEC2 NP_057333.1
Pan troglodytes (chimpanzee) MAGEC2 XP_003954152.1


Related articles in PubMed

The expression of MAGE-C1 and MAGE-C2 in breast cancer and their clinical significance.
Hou S, Sang M, Zhao L, Hou R, Shan B
American journal of surgery211(1)142-51(2016 Jan)

Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E.
Hao J, Song X, Wang J, Guo C, Li Y, Li B, Zhang Y, Yin Y
Oncotarget6(39)42028-39(2015 Dec)

Chromosomal aberrations of cancer-testis antigens in myeloma patients.
Curioni-Fontecedro A, Martin V, Vogetseder A, Knuth A, Moch H, Soldini D, Tinguely M
Hematological oncology33(3)159-63(2015 Sep)

Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.
Curioni-Fontecedro A, Pitocco R, Schoenewolf NL, Holzmann D, Soldini D, Dummer R, Calvieri S, Moch H, Mihic-Probst D, Fitsche A
BioMed research international2015432479(2015)

Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway.
Hao J, Shen R, Li Y, Zhang Y, Yin Y
Biochemical and biophysical research communications449(4)386-91(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our findings revealed a previously unrecognized regulation of STAT3 activation in tumor cells by cancer/testis antigen MAGEC2, and provided a molecular mechanism for the oncogenic activity of MAGEC2 in cancer cells.
Title: The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling.

our study provides a suitable cell model for exploring the biological functions of MAGEC2 in malignant cells, and sheds light on the molecular pathway by which MAGEC2 promotes tumor development.
Title: Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells.

The expressions of MAGE-C2 mRNA and MAGE-C2 protein were closely associated with stage, metastasis of lung cancer.
Title: [Expression and Clinical Significance of MAGE-C2 in Lung Adenocarcinoma].

High MAGE-C2 expression was found in 38.18% of triple negative breast cancer tissues and in 9.09% of adjacent tissues. High MAGE-C2 expression in TNBC patients was closely associated with tumor node metastasis and shorter survival time.
Title: Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer.

Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.
Title: Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E.

The following MAGEC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGEC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19550 NM_016249.3
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Homo sapiens MAGE family member C2 (MAGEC2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19550
Clone ID Related Accession (Same CDS sequence) NM_016249.3
Accession Version NM_016249.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1122bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product melanoma-associated antigen C2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013318.1, AF116194.1, BC005891.2, BP370466.1 and BM548987.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 3, 2011 this sequence version replaced XM_003403863.1, NM_016249.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP283302.1, BC013318.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCCTCCCG TTCCAGGCGT TCCATTCCGC AACGTTGACA ACGACTCCCC GACCTCAGTT 
GAGTTAGAAG ACTGGGTAGA TGCACAGCAT CCCACAGATG AGGAAGAGGA GGAAGCCTCC
TCCGCCTCTT CCACTTTGTA CTTAGTATTT TCCCCCTCTT CTTTCTCCAC ATCCTCTTCT
CTGATTCTTG GTGGTCCTGA GGAGGAGGAG GTGCCCTCTG GTGTGATACC AAATCTTACC
GAGAGCATTC CCAGTAGTCC TCCACAGGGT CCTCCACAGG GTCCTTCCCA GAGTCCTCTG
AGCTCCTGCT GCTCCTCTTT TTCATGGAGC TCATTCAGTG AGGAGTCCAG CAGCCAGAAA
GGGGAGGATA CAGGCACCTG TCAGGGCCTG CCAGACAGTG AGTCCTCTTT CACATATACA
CTAGATGAAA AGGTGGCCGA GTTAGTGGAG TTCCTGCTCC TCAAATACGA AGCAGAGGAG
CCTGTAACAG AGGCAGAGAT GCTGATGATT GTCATCAAGT ACAAAGATTA CTTTCCTGTG
ATACTCAAGA GAGCCCGTGA GTTCATGGAG CTTCTTTTTG GCCTTGCCCT GATAGAAGTG
GGCCCTGACC ACTTCTGTGT GTTTGCAAAC ACAGTAGGCC TCACCGATGA GGGTAGTGAT
GATGAGGGCA TGCCCGAGAA CAGCCTCCTG ATTATTATTC TGAGTGTGAT CTTCATAAAG
GGCAACTGTG CCTCTGAGGA GGTCATCTGG GAAGTGCTGA ATGCAGTAGG GGTATATGCT
GGGAGGGAGC ACTTCGTCTA TGGGGAGCCT AGGGAGCTCC TCACTAAAGT TTGGGTGCAG
GGACATTACC TGGAGTATCG GGAGGTGCCC CACAGTTCTC CTCCATATTA TGAATTCCTG
TGGGGTCCGA GAGCCCATTC AGAAAGCATC AAGAAGAAAG TACTAGAGTT TTTAGCCAAG
CTGAACAACA CTGTTCCTAG TTCCTTTCCA TCCTGGTACA AGGATGCTTT GAAAGATGTG
GAAGAGAGAG TCCAGGCCAC AATTGATACC GCAGATGATG CCACTGTCAT GGCCAGTGAA
AGCCTCAGTG TCATGTCCAG CAACGTCTCC TTTTCTGAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057333.1
CDS349..1470
Misc Feature(1)223..225
Misc Feature(2)751..1467
Misc Feature(3)<1033..1272
Exon (1)1..188
Exon (2)189..282
Exon (3)283..1994
Translation

Target ORF information:

RefSeq Version NM_016249.3
Organism Homo sapiens(Human)
Definition Homo sapiens MAGE family member C2 (MAGEC2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016249.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCCTCCCG TTCCAGGCGT TCCATTCCGC AACGTTGACA ACGACTCCCC GACCTCAGTT 
GAGTTAGAAG ACTGGGTAGA TGCACAGCAT CCCACAGATG AGGAAGAGGA GGAAGCCTCC
TCCGCCTCTT CCACTTTGTA CTTAGTATTT TCCCCCTCTT CTTTCTCCAC ATCCTCTTCT
CTGATTCTTG GTGGTCCTGA GGAGGAGGAG GTGCCCTCTG GTGTGATACC AAATCTTACC
GAGAGCATTC CCAGTAGTCC TCCACAGGGT CCTCCACAGG GTCCTTCCCA GAGTCCTCTG
AGCTCCTGCT GCTCCTCTTT TTCATGGAGC TCATTCAGTG AGGAGTCCAG CAGCCAGAAA
GGGGAGGATA CAGGCACCTG TCAGGGCCTG CCAGACAGTG AGTCCTCTTT CACATATACA
CTAGATGAAA AGGTGGCCGA GTTAGTGGAG TTCCTGCTCC TCAAATACGA AGCAGAGGAG
CCTGTAACAG AGGCAGAGAT GCTGATGATT GTCATCAAGT ACAAAGATTA CTTTCCTGTG
ATACTCAAGA GAGCCCGTGA GTTCATGGAG CTTCTTTTTG GCCTTGCCCT GATAGAAGTG
GGCCCTGACC ACTTCTGTGT GTTTGCAAAC ACAGTAGGCC TCACCGATGA GGGTAGTGAT
GATGAGGGCA TGCCCGAGAA CAGCCTCCTG ATTATTATTC TGAGTGTGAT CTTCATAAAG
GGCAACTGTG CCTCTGAGGA GGTCATCTGG GAAGTGCTGA ATGCAGTAGG GGTATATGCT
GGGAGGGAGC ACTTCGTCTA TGGGGAGCCT AGGGAGCTCC TCACTAAAGT TTGGGTGCAG
GGACATTACC TGGAGTATCG GGAGGTGCCC CACAGTTCTC CTCCATATTA TGAATTCCTG
TGGGGTCCGA GAGCCCATTC AGAAAGCATC AAGAAGAAAG TACTAGAGTT TTTAGCCAAG
CTGAACAACA CTGTTCCTAG TTCCTTTCCA TCCTGGTACA AGGATGCTTT GAAAGATGTG
GAAGAGAGAG TCCAGGCCAC AATTGATACC GCAGATGATG CCACTGTCAT GGCCAGTGAA
AGCCTCAGTG TCATGTCCAG CAACGTCTCC TTTTCTGAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The expression of MAGE-C1 and MAGE-C2 in breast cancer and their clinical significance.
American journal of surgery211(1)142-51(2016 Jan)
Hou S,Sang M,Zhao L,Hou R,Shan B


book

Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E.
Oncotarget6(39)42028-39(2015 Dec)
Hao J,Song X,Wang J,Guo C,Li Y,Li B,Zhang Y,Yin Y


book

Chromosomal aberrations of cancer-testis antigens in myeloma patients.
Hematological oncology33(3)159-63(2015 Sep)
Curioni-Fontecedro A,Martin V,Vogetseder A,Knuth A,Moch H,Soldini D,Tinguely M


book

Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.
BioMed research international2015432479(2015)
Curioni-Fontecedro A,Pitocco R,Schoenewolf NL,Holzmann D,Soldini D,Dummer R,Calvieri S,Moch H,Mihic-Probst D,Fitsche A


book

Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway.
Biochemical and biophysical research communications449(4)386-91(2014 Jul)
Hao J,Shen R,Li Y,Zhang Y,Yin Y


 
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