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MAGEC2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAGEC2
Entrez Gene ID 51438
Full Name melanoma antigen family C2
Synonyms CT10, HCA587, MAGEE1
General protein information
Preferred Names
melanoma-associated antigen C2
Names
melanoma-associated antigen C2
MAGE-C2 antigen
MAGE-E1 antigen
cancer/testis antigen 10
hepatocellular cancer antigen 587
hepatocellular carcinoma-associated antigen 587
melanoma antigen, family E, 1, cancer/testis specific
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq27

Summary This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

300468


mRNA and Protein(s)

mRNA Protein Name
NM_016249 NP_057333 melanoma-associated antigen C2


Homo sapiens (human) MAGEC2 NP_057333.1
Pan troglodytes (chimpanzee) MAGEC2 XP_003954152.1
Macaca mulatta (Rhesus monkey) MAGEC2 XP_001085870.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MAGEC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAGEC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19550 NM_016249 Homo sapiens melanoma antigen family C, 2 (MAGEC2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19550
Clone ID Related Accession (Same CDS sequence) NM_016249
Accession Version NM_016249.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1122bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product melanoma-associated antigen C2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC013318.1, AF116194.1, BC005891.2, BP370466.1 and BM548987.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 3, 2011 this sequence version replaced gi:341914970, gi:29337297. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013318.1, AF151378.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCCTCCCG TTCCAGGCGT TCCATTCCGC AACGTTGACA ACGACTCCCC GACCTCAGTT 
GAGTTAGAAG ACTGGGTAGA TGCACAGCAT CCCACAGATG AGGAAGAGGA GGAAGCCTCC
TCCGCCTCTT CCACTTTGTA CTTAGTATTT TCCCCCTCTT CTTTCTCCAC ATCCTCTTCT
CTGATTCTTG GTGGTCCTGA GGAGGAGGAG GTGCCCTCTG GTGTGATACC AAATCTTACC
GAGAGCATTC CCAGTAGTCC TCCACAGGGT CCTCCACAGG GTCCTTCCCA GAGTCCTCTG
AGCTCCTGCT GCTCCTCTTT TTCATGGAGC TCATTCAGTG AGGAGTCCAG CAGCCAGAAA
GGGGAGGATA CAGGCACCTG TCAGGGCCTG CCAGACAGTG AGTCCTCTTT CACATATACA
CTAGATGAAA AGGTGGCCGA GTTAGTGGAG TTCCTGCTCC TCAAATACGA AGCAGAGGAG
CCTGTAACAG AGGCAGAGAT GCTGATGATT GTCATCAAGT ACAAAGATTA CTTTCCTGTG
ATACTCAAGA GAGCCCGTGA GTTCATGGAG CTTCTTTTTG GCCTTGCCCT GATAGAAGTG
GGCCCTGACC ACTTCTGTGT GTTTGCAAAC ACAGTAGGCC TCACCGATGA GGGTAGTGAT
GATGAGGGCA TGCCCGAGAA CAGCCTCCTG ATTATTATTC TGAGTGTGAT CTTCATAAAG
GGCAACTGTG CCTCTGAGGA GGTCATCTGG GAAGTGCTGA ATGCAGTAGG GGTATATGCT
GGGAGGGAGC ACTTCGTCTA TGGGGAGCCT AGGGAGCTCC TCACTAAAGT TTGGGTGCAG
GGACATTACC TGGAGTATCG GGAGGTGCCC CACAGTTCTC CTCCATATTA TGAATTCCTG
TGGGGTCCGA GAGCCCATTC AGAAAGCATC AAGAAGAAAG TACTAGAGTT TTTAGCCAAG
CTGAACAACA CTGTTCCTAG TTCCTTTCCA TCCTGGTACA AGGATGCTTT GAAAGATGTG
GAAGAGAGAG TCCAGGCCAC AATTGATACC GCAGATGATG CCACTGTCAT GGCCAGTGAA
AGCCTCAGTG TCATGTCCAG CAACGTCTCC TTTTCTGAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057333.1
CDS349..1470
Misc Feature(1)223..225(+)
Misc Feature(2)751..1467(+)
Misc Feature(3)790..1290(+)
Exon (1)1..188
Gene:MAGEC2
Gene Synonym:
Exon (2)189..282
Gene:MAGEC2
Gene Synonym:
Exon (3)283..1994
Gene:MAGEC2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_016249
Organism Homo sapiens (human)
Definition Homo sapiens melanoma antigen family C, 2 (MAGEC2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016249

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCCTCCCG TTCCAGGCGT TCCATTCCGC AACGTTGACA ACGACTCCCC GACCTCAGTT 
GAGTTAGAAG ACTGGGTAGA TGCACAGCAT CCCACAGATG AGGAAGAGGA GGAAGCCTCC
TCCGCCTCTT CCACTTTGTA CTTAGTATTT TCCCCCTCTT CTTTCTCCAC ATCCTCTTCT
CTGATTCTTG GTGGTCCTGA GGAGGAGGAG GTGCCCTCTG GTGTGATACC AAATCTTACC
GAGAGCATTC CCAGTAGTCC TCCACAGGGT CCTCCACAGG GTCCTTCCCA GAGTCCTCTG
AGCTCCTGCT GCTCCTCTTT TTCATGGAGC TCATTCAGTG AGGAGTCCAG CAGCCAGAAA
GGGGAGGATA CAGGCACCTG TCAGGGCCTG CCAGACAGTG AGTCCTCTTT CACATATACA
CTAGATGAAA AGGTGGCCGA GTTAGTGGAG TTCCTGCTCC TCAAATACGA AGCAGAGGAG
CCTGTAACAG AGGCAGAGAT GCTGATGATT GTCATCAAGT ACAAAGATTA CTTTCCTGTG
ATACTCAAGA GAGCCCGTGA GTTCATGGAG CTTCTTTTTG GCCTTGCCCT GATAGAAGTG
GGCCCTGACC ACTTCTGTGT GTTTGCAAAC ACAGTAGGCC TCACCGATGA GGGTAGTGAT
GATGAGGGCA TGCCCGAGAA CAGCCTCCTG ATTATTATTC TGAGTGTGAT CTTCATAAAG
GGCAACTGTG CCTCTGAGGA GGTCATCTGG GAAGTGCTGA ATGCAGTAGG GGTATATGCT
GGGAGGGAGC ACTTCGTCTA TGGGGAGCCT AGGGAGCTCC TCACTAAAGT TTGGGTGCAG
GGACATTACC TGGAGTATCG GGAGGTGCCC CACAGTTCTC CTCCATATTA TGAATTCCTG
TGGGGTCCGA GAGCCCATTC AGAAAGCATC AAGAAGAAAG TACTAGAGTT TTTAGCCAAG
CTGAACAACA CTGTTCCTAG TTCCTTTCCA TCCTGGTACA AGGATGCTTT GAAAGATGTG
GAAGAGAGAG TCCAGGCCAC AATTGATACC GCAGATGATG CCACTGTCAT GGCCAGTGAA
AGCCTCAGTG TCATGTCCAG CAACGTCTCC TTTTCTGAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair
J. Invest. Dermatol. 133 (3), 759-767 (2013)
Bhatia N, Xiao TZ, Rosenthal KA, Siddiqui IA, Thiyagarajan S, Smart B, Meng Q, Zuleger CL, Mukhtar H, Kenney SC, Albertini MR and Jack Longley B.


book

MAGE-C1/CT7 and MAGE-C2/CT10 are frequently expressed in multiple myeloma and can be explored in combined immunotherapy for this malignancy
Cancer Immunol. Immunother. 62 (1), 191-195 (2013)
de Carvalho F, Alves VL, Braga WM, Xavier CV Jr and Colleoni GW.


book

Analysis of the processing of seven human tumor antigens by intermediate proteasomes
J. Immunol. 189 (7), 3538-3547 (2012)
Guillaume B, Stroobant V, Bousquet-Dubouch MP, Colau D, Chapiro J, Parmentier N, Dalet A and Van den Eynde BJ.


book

Genetically distinct subsets within ANCA-associated vasculitis
N. Engl. J. Med. 367 (3), 214-223 (2012)
Lyons PA, Rayner TF, Trivedi S, Holle JU, Watts RA, Jayne DR, Baslund B, Brenchley P, Bruchfeld A, Chaudhry AN, Cohen Tervaert JW, Deloukas P, Feighery C, Gross WL, Guillevin L, Gunnarsson I, Harper L, Hruskova Z, Little MA, Martorana D, Neumann T, Ohlsson S, Padmanabhan S, Pusey CD, Salama AD, Sanders JS, Savage CO, Segelmark M, Stegeman CA, Tesar V, Vaglio A, Wieczorek S, Wilde B, Zwerina J, Rees AJ, Clayton DG and Smith KG.


book

MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression
PLoS ONE 6 (8), E23747 (2011)
Xiao TZ, Bhatia N, Urrutia R, Lomberk GA, Simpson A and Longley BJ.


book

Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies
J. Immunol. 169 (2), 1102-1109 (2002)
Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW and Chen WF.


book

Structural characterization and chromosomal localization of the MAGE-E1 gene
Gene 277 (1-2), 129-137 (2001)
Kawano Y, Sasaki M, Nakahira K, Yoshimine T, Shimizu K, Wada H and Ikenaka K.


book

MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma
Cancer Res. 61 (12), 4809-4814 (2001)
Sasaki M, Nakahira K, Kawano Y, Katakura H, Yoshimine T, Shimizu K, Kim SU and Ikenaka K.


book

MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression
Int. J. Cancer 87 (1), 55-60 (2000)
Lucas S, De Plaen E and Boon T.


book

CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis
Int. J. Cancer 85 (5), 726-732 (2000)
Gure AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ and Chen YT.


 
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