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PRRX2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol PRRX2
Entrez Gene ID 51450
Full Name paired related homeobox 2
Synonyms PMX2,PRX2
General protein information
Preferred Names

paired related homeobox 2

Names

paired mesoderm homeobox protein 2
PRX-2
paired-like homeodomain protein PRX2
paired-related homeobox protein 2
testicular tissue protein Li 148
testicular tissue protein Li 160

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

9

9q34.11

Summary The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008].
Disorder MIM:

604675


mRNA and Protein(s)

mRNA Protein Name
NM_016307.3 NP_057391.1 paired mesoderm homeobox protein 2
XM_017014803.1 XP_016870292.1 paired mesoderm homeobox protein 2 isoform X1



Macaca mulatta (rhesus monkey) PRRX2 XP_001107634.1
Mus musculus (house mouse) Prrx2 NP_033142.2
Gallus gallus (chicken) PRRX2 XP_415476.3
Homo sapiens (human) PRRX2 NP_057391.1
Pan troglodytes (chimpanzee) PRRX2 XP_520310.2
Rattus norvegicus (Norway rat) Prrx2 NP_001099209.1
Xenopus tropicalis (tropical clawed frog) prrx2 XP_002940803.1
Canis lupus familiaris (dog) PRRX2 XP_548419.3
Bos taurus (cattle) PRRX2 XP_002691720.3


Related articles in PubMed

Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study.
Nagy P, Karton A, Betz A, Peskin AV, Pace P, O'Reilly RJ, Hampton MB, Radom L, Winterbourn CC
The Journal of biological chemistry286(20)18048-55(2011 May)

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PloS one5(7)e11493(2010 Jul)

Web-based, participant-driven studies yield novel genetic associations for common traits.
Eriksson N, Macpherson JM, Tung JY, Hon LS, Naughton B, Saxonov S, Avey L, Wojcicki A, Pe'er I, Mountain J
PLoS genetics6(6)e1000993(2010 Jun)

Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis.
Tokutomi Y, Araki N, Kataoka K, Yamamoto E, Kim-Mitsuyama S
Biochemical and biophysical research communications364(4)822-30(2007 Dec)

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M
Nucleic acids research34(6)1735-44(2006)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that upregulation of PRRX2 may be a mechanism contributing to TGF-beta-induced invasion and epithelial mesenchymal transition in breast cancer.
Title: PRRX2 as a novel TGF-β-induced factor enhances invasion and migration in mammary epithelial cell and correlates with poor prognosis in breast cancer.

Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study.
Title: Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

Valsartan, a selective Ang II type 1 (AT1) receptor blocker, and N-acetylcysteine, an antioxidant, inhibited both of these modifications, indicating the contribution of AT1 receptor and reactive oxygen species to oxidation of Prx2.
Title: Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis.

Encodes homeobox transcription factors that are expressed during vasculogenesis.
Title: Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes.

The following PRRX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRRX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu30413 NM_016307.3
Latest version!
Homo sapiens paired related homeobox 2 (PRRX2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu98689 XM_017014803.1
Latest version!
Homo sapiens paired related homeobox 2 (PRRX2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00

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2-4 Clone 40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu30413
Clone ID Related Accession (Same CDS sequence) NM_016307.3
Accession Version NM_016307.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 762bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-06
Organism Homo sapiens(Human)
Product paired mesoderm homeobox protein 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014645.1. On Nov 25, 2003 this sequence version replaced NM_016307.2. ##Evidence-Data-START## Transcript exon combination :: BC014645.1, AF061970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGACAGCG CGGCCGCCGC CTTCGCCCTG GACAAGCCGG CGCTGGGCCC GGGGCCGCCG 
CCGCCTCCAC CCGCGCTGGG GCCCGGCGAC TGCGCCCAGG CGCGCAAGAA CTTCTCGGTG
AGCCACCTCC TGGACCTGGA AGAGGTGGCG GCGGCCGGGC GGCTGGCGGC GCGCCCCGGG
GCCAGGGCCG AGGCGCGGGA GGGCGCAGCA CGGGAGCCGT CCGGGGGCAG CAGCGGCAGC
GAGGCGGCGC CGCAGGATGG TGAGTGTCCC AGCCCGGGGC GCGGTAGCGC CGCCAAGCGG
AAGAAGAAGC AGCGGCGGAA CCGCACCACG TTCAACAGCA GCCAACTGCA GGCGCTGGAG
CGCGTGTTCG AGCGCACGCA CTACCCCGAC GCCTTTGTGC GCGAGGAGCT TGCCCGGCGC
GTCAACCTCA GCGAGGCGCG CGTTCAGGTC TGGTTTCAGA ACCGCCGCGC CAAGTTCCGC
AGGAATGAAA GGGCCATGCT GGCCAGCCGC TCTGCCTCGC TGCTCAAGTC CTACAGCCAG
GAGGCCGCCA TCGAGCAGCC CGTGGCTCCC CGGCCCACCG CCCTGAGTCC AGATTATCTC
TCCTGGACAG CCTCGTCCCC CTACAGCACA GTGCCACCCT ACAGCCCTGG GAGCTCAGGC
CCCGCAACCC CAGGGGTCAA CATGGCCAAC AGCATCGCCA GCCTCCGTCT CAAGGCCAAG
GAGTTCAGCC TGCACCACAG CCAGGTGCCT ACGGTGAACT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057391.1
CDS228..989
Misc Feature(1)552..707
Misc Feature(2)order(555..557,675..677,684..689,696..698)
Misc Feature(3)903..956
Misc Feature(4)915..956
Exon (1)1..486
Exon (2)487..674
Exon (3)675..853
Exon (4)854..1311
Translation

Target ORF information:

RefSeq Version NM_016307.3
Organism Homo sapiens(Human)
Definition Homo sapiens paired related homeobox 2 (PRRX2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016307.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGACAGCG CGGCCGCCGC CTTCGCCCTG GACAAGCCGG CGCTGGGCCC GGGGCCGCCG 
CCGCCTCCAC CCGCGCTGGG GCCCGGCGAC TGCGCCCAGG CGCGCAAGAA CTTCTCGGTG
AGCCACCTCC TGGACCTGGA AGAGGTGGCG GCGGCCGGGC GGCTGGCGGC GCGCCCCGGG
GCCAGGGCCG AGGCGCGGGA GGGCGCAGCA CGGGAGCCGT CCGGGGGCAG CAGCGGCAGC
GAGGCGGCGC CGCAGGATGG TGAGTGTCCC AGCCCGGGGC GCGGTAGCGC CGCCAAGCGG
AAGAAGAAGC AGCGGCGGAA CCGCACCACG TTCAACAGCA GCCAACTGCA GGCGCTGGAG
CGCGTGTTCG AGCGCACGCA CTACCCCGAC GCCTTTGTGC GCGAGGAGCT TGCCCGGCGC
GTCAACCTCA GCGAGGCGCG CGTTCAGGTC TGGTTTCAGA ACCGCCGCGC CAAGTTCCGC
AGGAATGAAA GGGCCATGCT GGCCAGCCGC TCTGCCTCGC TGCTCAAGTC CTACAGCCAG
GAGGCCGCCA TCGAGCAGCC CGTGGCTCCC CGGCCCACCG CCCTGAGTCC AGATTATCTC
TCCTGGACAG CCTCGTCCCC CTACAGCACA GTGCCACCCT ACAGCCCTGG GAGCTCAGGC
CCCGCAACCC CAGGGGTCAA CATGGCCAAC AGCATCGCCA GCCTCCGTCT CAAGGCCAAG
GAGTTCAGCC TGCACCACAG CCAGGTGCCT ACGGTGAACT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu98689
Clone ID Related Accession (Same CDS sequence) XM_017014803.1
Accession Version XM_017014803.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 582bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product paired mesoderm homeobox protein 2 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGGGCCCAC TTCACAGGGA AACAGGCCCA GAGAGGAGCG GTCACAGGCT CAAAGTCACA 
GAGCTGGGAT GTGGAGAAGG TGAGTGTCCC AGCCCGGGGC GCGGTAGCGC CGCCAAGCGG
AAGAAGAAGC AGCGGCGGAA CCGCACCACG TTCAACAGCA GCCAACTGCA GGCGCTGGAG
CGCGTGTTCG AGCGCACGCA CTACCCCGAC GCCTTTGTGC GCGAGGAGCT TGCCCGGCGC
GTCAACCTCA GCGAGGCGCG CGTTCAGGTC TGGTTTCAGA ACCGCCGCGC CAAGTTCCGC
AGGAATGAAA GGGCCATGCT GGCCAGCCGC TCTGCCTCGC TGCTCAAGTC CTACAGCCAG
GAGGCCGCCA TCGAGCAGCC CGTGGCTCCC CGGCCCACCG CCCTGAGTCC AGATTATCTC
TCCTGGACAG CCTCGTCCCC CTACAGCACA GTGCCACCCT ACAGCCCTGG GAGCTCAGGC
CCCGCAACCC CAGGGGTCAA CATGGCCAAC AGCATCGCCA GCCTCCGTCT CAAGGCCAAG
GAGTTCAGCC TGCACCACAG CCAGGTGCCT ACGGTGAACT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016870292.1
CDS16..597
Translation

Target ORF information:

RefSeq Version XM_017014803.1
Organism Homo sapiens(Human)
Definition Homo sapiens paired related homeobox 2 (PRRX2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017014803.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGGCCCAC TTCACAGGGA AACAGGCCCA GAGAGGAGCG GTCACAGGCT CAAAGTCACA 
GAGCTGGGAT GTGGAGAAGG TGAGTGTCCC AGCCCGGGGC GCGGTAGCGC CGCCAAGCGG
AAGAAGAAGC AGCGGCGGAA CCGCACCACG TTCAACAGCA GCCAACTGCA GGCGCTGGAG
CGCGTGTTCG AGCGCACGCA CTACCCCGAC GCCTTTGTGC GCGAGGAGCT TGCCCGGCGC
GTCAACCTCA GCGAGGCGCG CGTTCAGGTC TGGTTTCAGA ACCGCCGCGC CAAGTTCCGC
AGGAATGAAA GGGCCATGCT GGCCAGCCGC TCTGCCTCGC TGCTCAAGTC CTACAGCCAG
GAGGCCGCCA TCGAGCAGCC CGTGGCTCCC CGGCCCACCG CCCTGAGTCC AGATTATCTC
TCCTGGACAG CCTCGTCCCC CTACAGCACA GTGCCACCCT ACAGCCCTGG GAGCTCAGGC
CCCGCAACCC CAGGGGTCAA CATGGCCAAC AGCATCGCCA GCCTCCGTCT CAAGGCCAAG
GAGTTCAGCC TGCACCACAG CCAGGTGCCT ACGGTGAACT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study.
The Journal of biological chemistry286(20)18048-55(2011 May)
Nagy P,Karton A,Betz A,Peskin AV,Pace P,O'Reilly RJ,Hampton MB,Radom L,Winterbourn CC


book

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
PloS one5(7)e11493(2010 Jul)
Jugessur A,Shi M,Gjessing HK,Lie RT,Wilcox AJ,Weinberg CR,Christensen K,Boyles AL,Daack-Hirsch S,Nguyen TT,Christiansen L,Lidral AC,Murray JC


book

Web-based, participant-driven studies yield novel genetic associations for common traits.
PLoS genetics6(6)e1000993(2010 Jun)
Eriksson N,Macpherson JM,Tung JY,Hon LS,Naughton B,Saxonov S,Avey L,Wojcicki A,Pe'er I,Mountain J


book

Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis.
Biochemical and biophysical research communications364(4)822-30(2007 Dec)
Tokutomi Y,Araki N,Kataoka K,Yamamoto E,Kim-Mitsuyama S


book

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
Nucleic acids research34(6)1735-44(2006)
Wissmüller S,Kosian T,Wolf M,Finzsch M,Wegner M


 
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