Gene Symbol | GET4 |
Entrez Gene ID | 51608 |
Full Name | golgi to ER traffic protein 4 |
Synonyms | C7orf20,CEE,CGI-20,TRC35 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » GET4 cDNA ORF clone
Gene Symbol | GET4 |
Entrez Gene ID | 51608 |
Full Name | golgi to ER traffic protein 4 |
Synonyms | C7orf20,CEE,CGI-20,TRC35 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_015949.3 | NP_057033.2 | Golgi to ER traffic protein 4 homolog |
NM_015949.2 | NP_057033.2 | Golgi to ER traffic protein 4 homolog |
Danio rerio (zebrafish) | get4 | NP_001186836.1 |
Bos taurus (cattle) | GET4 | NP_001069993.1 |
Mus musculus (house mouse) | Get4 | NP_080545.2 |
Rattus norvegicus (Norway rat) | Get4 | NP_001156792.1 |
Drosophila melanogaster (fruit fly) | CG9853 | NP_649464.1 |
Arabidopsis thaliana (thale cress) | AT5G63220 | NP_201127.2 |
Gallus gallus (chicken) | GET4 | NP_001006159.1 |
Pan troglodytes (chimpanzee) | GET4 | XP_518924.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000119 | XP_311026.4 |
Kluyveromyces lactis | KLLA0F20295g | XP_455991.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_08069 | XP_003715022.1 |
Neurospora crassa | NCU01190 | XP_961556.1 |
Xenopus tropicalis (tropical clawed frog) | get4 | NP_001016708.1 |
Homo sapiens (human) | GET4 | NP_057033.2 |
Canis lupus familiaris (dog) | GET4 | XP_003639138.2 |
Saccharomyces cerevisiae (baker's yeast) | GET4 | NP_014807.3 |
Schizosaccharomyces pombe (fission yeast) | get4 | NP_587883.1 |
Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.
Mock JY, Xu Y, Ye Y, Clemons WM Jr
Proceedings of the National Academy of Sciences of the United States of America114(44)11679-11684(2017 Oct)
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
Mock JY, Chartron JW, Zaslaver M, Xu Y, Ye Y, Clemons WM Jr
Proceedings of the National Academy of Sciences of the United States of America112(1)106-11(2015 Jan)
Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.
Gristick HB, Rao M, Chartron JW, Rome ME, Shan SO, Clemons WM Jr
Nature structural & molecular biology21(5)437-42(2014 May)
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M, Iakoucheva LM
Nature communications53650(2014 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Both TRC35 and Ubl4A have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex.
Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
The crystal structure of the Get3-Get4-Get5 complex in an ATP-bound state is presented.
Title: Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.
Data indicate that BCL2-associated athanogene 6 (BAG6) appears to be the central component for the process, as depletion of BAG6 leads to the loss of both UBL4A and GET4 proteins and resistance to cell killing by DNA-damaging agents.
Title: Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.
Data indicate that the Bag6-Ubl4A-Trc35 complex is localized to the endoplasmic reticulum (ER) membrane to regulate ER-associated degradation (ERAD).
Title: A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.
SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.
Title: SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.
The following GET4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GET4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu29871 | |
Clone ID Related Accession (Same CDS sequence) | NM_015949.3 , NM_015949.2 | |
Accession Version | NM_015949.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-10 | |
Organism | Homo sapiens(human) | |
Product | Golgi to ER traffic protein 4 homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM843540.1, AL133014.1, BG109419.1, BM980767.1 and AC073957.7. On Nov 23, 2018 this sequence version replaced NM_015949.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.723831.1, SRR3476690.64852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000265857.8/ ENSP00000265857.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCGGCGG CGGCGGCGAT GGCCGAGCAG GAGAGCGCCC GGAACGGCGG CCGCAACCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057033.2 |
CDS | 93..1076 |
Translation |
Target ORF information:
Target ORF information:
|
NM_015949.3 |
1 | ATGGCGGCGG CGGCGGCGAT GGCCGAGCAG GAGAGCGCCC GGAACGGCGG CCGCAACCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu29871 | |
Clone ID Related Accession (Same CDS sequence) | NM_015949.3 , NM_015949.2 | |
Accession Version | NM_015949.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-30 | |
Organism | Homo sapiens(human) | |
Product | Golgi to ER traffic protein 4 homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM843540.1, AL133014.1, BG109419.1 and BM980767.1. On or before Mar 4, 2006 this sequence version replaced XM_946077.1, XM_946078.1, XM_946079.1, XM_946080.1, XM_946081.1, XM_946082.1, XM_942533.1, XM_946083.1, NM_015949.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK023560.1, SRR1803611.139726.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGG CGGCGGCGAT GGCCGAGCAG GAGAGCGCCC GGAACGGCGG CCGCAACCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057033.2 |
CDS | 93..1076 |
Translation |
Target ORF information:
Target ORF information:
|
NM_015949.2 |
1 | ATGGCGGCGG CGGCGGCGAT GGCCGAGCAG GAGAGCGCCC GGAACGGCGG CCGCAACCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35. |
Architecture of the human interactome defines protein communities and disease networks. |
Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. |
Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4. |
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. |