Gene Symbol | CIAO2B |
Entrez Gene ID | 51647 |
Full Name | family with sequence similarity 96 member B |
Synonyms | CGI-128,CIA2B,MIP18 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » CIAO2B cDNA ORF clone
Gene Symbol | CIAO2B |
Entrez Gene ID | 51647 |
Full Name | family with sequence similarity 96 member B |
Synonyms | CGI-128,CIA2B,MIP18 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_016062.3 | NP_057146.1 | mitotic spindle-associated MMXD complex subunit MIP18 |
NM_016062.4 | NP_057146.1 | cytosolic iron-sulfur assembly component 2B |
Canis lupus familiaris (dog) | FAM96B | XP_005620920.1 |
Rattus norvegicus (Norway rat) | Fam96b | NP_001138326.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005422 | XP_315430.3 |
Schizosaccharomyces pombe (fission yeast) | SPAC144.16 | NP_594677.1 |
Caenorhabditis elegans (roundworm) | F45G2.10 | NP_499777.1 |
Kluyveromyces lactis | KLLA0F24332g | XP_456164.1 |
Bos taurus (cattle) | FAM96B | NP_001179967.1 |
Saccharomyces cerevisiae (baker's yeast) | CIA2 | NP_011990.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03615 | XP_003716279.1 |
Oryza sativa (rice) | Os04g0595200 | NP_001053732.1 |
Homo sapiens (human) | FAM96B | NP_057146.1 |
Pan troglodytes (chimpanzee) | FAM96B | XP_001160459.1 |
Mus musculus (house mouse) | Fam96b | NP_081029.1 |
Gallus gallus (chicken) | FAM96B | XP_414150.1 |
Danio rerio (zebrafish) | fam96b | NP_001002449.1 |
Drosophila melanogaster (fruit fly) | CG7949 | NP_648416.1 |
Eremothecium gossypii | AGOS_AGR343W | NP_987009.1 |
Arabidopsis thaliana (thale cress) | AT1G68310 | NP_001154457.1 |
Xenopus tropicalis (tropical clawed frog) | fam96b | NP_001128276.1 |
Neurospora crassa | NCU02573 | XP_965704.1 |
Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.
Upadhyay AS, Stehling O, Panayiotou C, R?sser R, Lill R, ?verby AK
The Journal of biological chemistry292(33)13879-13889(2017 08)
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins.
Odermatt DC, Gari K
Cell reports18(6)1434-1443(2017 Feb)
Identification of FAM96B as a novel prelamin A binding partner.
Xiong XD, Wang J, Zheng H, Jing X, Liu Z, Zhou Z, Liu X
Biochemical and biophysical research communications440(1)20-4(2013 Oct)
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Stehling O, Mascarenhas J, Vashisht AA, Sheftel AD, Niggemeyer B, R?sser R, Pierik AJ, Wohlschlegel JA, Lill R
Cell metabolism18(2)187-98(2013 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that CIA2B and MMS19 physically interact with C-terminus of viperin/RSAD2; CIAO1 appears to function as primary viperin-interacting protein; CIA2A binds to N-terminus of viperin in CIAO1-, CIA2B-, and MMS19-independent fashion. (CIA2B = metallochaperone CIA2B/FAM96B; MMS19 = transcription factor MMS19; CIAO1 = cytosolic iron-sulfur assembly component 1; CIA2A = metallochaperone CIA2A/Fam96a)
Title: Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.
Co-localization experiments by fluorescent confocal microscopy revealed that FAM96B colocalized with prelamin A in HEK-293 cells.
Title: Identification of FAM96B as a novel prelamin A binding partner.
CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization.
Title: Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
Title: The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
these findings suggest that FAM96B acts as a regulator of E2-2 through the control of its protein expression.
Title: Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2.
The following CIAO2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CIAO2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu15220 | |
Clone ID Related Accession (Same CDS sequence) | NM_016062.3 , NM_016062.4 | |
Accession Version | NM_016062.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-10 | |
Organism | Homo sapiens(human) | |
Product | mitotic spindle-associated MMXD complex subunit MIP18 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA270099.1, AF151886.1 and BQ955804.1. On Jan 24, 2012 this sequence version replaced NM_016062.2. Transcript Variant: This variant (1) represents the shortest transcript but encodes the supported protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.616714.1, SRR1163658.369371.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTAGGCG GCGGCGGGGT CGGCGGCGGC CTCCTGGAGA ATGCCAACCC CCTCATCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057146.1 |
CDS | 60..551 |
Translation |
Target ORF information:
Target ORF information:
|
NM_016062.3 |
1 | ATGGTAGGCG GCGGCGGGGT CGGCGGCGGC CTCCTGGAGA ATGCCAACCC CCTCATCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu15220 | |
Clone ID Related Accession (Same CDS sequence) | NM_016062.3 , NM_016062.4 | |
Accession Version | NM_016062.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 492bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | cytosolic iron-sulfur assembly component 2B | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA270099.1 and AF151886.1. On Nov 22, 2018 this sequence version replaced NM_016062.3. Transcript Variant: This variant (1) represents the shortest transcript but encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.204834.1, ERR279834.8284.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000422424.7/ ENSP00000387471.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGTAGGCG GCGGCGGGGT CGGCGGCGGC CTCCTGGAGA ATGCCAACCC CCTCATCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_057146.1 |
CDS | 39..530 |
Translation |
Target ORF information:
Target ORF information:
|
NM_016062.4 |
1 | ATGGTAGGCG GCGGCGGGGT CGGCGGCGGC CTCCTGGAGA ATGCCAACCC CCTCATCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. |
Architecture of the human interactome defines protein communities and disease networks. |
The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins. |
Identification of FAM96B as a novel prelamin A binding partner. |
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. |