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PF4V1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PF4V1
Entrez Gene ID 5197
Full Name platelet factor 4 variant 1
Synonyms CXCL4L1, CXCL4V1, PF4-ALT, PF4A, SCYB4V1
General protein information
Preferred Names
platelet factor 4 variant
Names
platelet factor 4 variant
PF4alt
PF4var1
C-X-C motif chemokine 4
platelet factor 4, variant 1 (PF4-like)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12-q21

Summary lac of sum
Disorder MIM:

173461


mRNA and Protein(s)

mRNA Protein Name
NM_002620 NP_002611 platelet factor 4 variant precursor



Homo sapiens (human) PF4V1 NP_002611.1
Pan troglodytes (chimpanzee) PF4V1 XP_001156146.1
Macaca mulatta (Rhesus monkey) PF4V1 XP_001102971.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PF4V1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PF4V1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25445
NM_002620 Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25445
Clone ID Related Accession (Same CDS sequence) NM_002620
Accession Version NM_002620.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 315bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product platelet factor 4 variant precursor
Comment PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M26167.1. On Mar 7, 2006 this sequence version replaced gi:4505734. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC130653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144333, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
ATGAGCTCCG CAGCCAGGTC CCGCCTCACC CGCGCCACCC GCCAGGAGAT GCTGTTCTTG 
GCGTTGCTGC TCCTGCCAGT TGTGGTCGCC TTCGCCAGAG CTGAAGCTGA AGAAGATGGG
GACCTGCAGT GCCTGTGTGT GAAGACCACC TCCCAGGTCC GTCCCAGGCA CATCACCAGC
CTGGAGGTGA TCAAGGCCGG ACCCCACTGC CCCACTGCCC AACTCATAGC CACGCTGAAG
AATGGGAGGA AAATTTGCTT GGATCTGCAA GCCCTGCTGT ACAAGAAAAT CATTAAGGAA
CATTTGGAGA GTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002611.1
CDS68..382
Misc Feature(1)188..364(+)
Misc Feature(2)188..355(+)
Misc Feature(3)188..196(+)
Misc Feature(4)191..361(+)
Misc Feature(5)191..319(+)
Misc Feature(6)194..205(+)
Misc Feature(7)200..241(+)
Misc Feature(8)206..322(+)
Misc Feature(9)227..361(+)
Misc Feature(10)233..319(+)
Misc Feature(11)239..361(+)
Misc Feature(12)266..274(+)
Misc Feature(13)266..274(+)
Misc Feature(14)305..313(+)
Misc Feature(15)350..370(+)
Exon (1)1..167
Gene:PF4V1
Gene Synonym:
Exon (2)168..294
Gene:PF4V1
Gene Synonym:
Exon (3)295..741
Gene:PF4V1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002620
Organism Homo sapiens (human)
Definition Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002620

ORF Insert Sequence:

1
61
121
181
241
301
ATGAGCTCCG CAGCCAGGTC CCGCCTCACC CGCGCCACCC GCCAGGAGAT GCTGTTCTTG 
GCGTTGCTGC TCCTGCCAGT TGTGGTCGCC TTCGCCAGAG CTGAAGCTGA AGAAGATGGG
GACCTGCAGT GCCTGTGTGT GAAGACCACC TCCCAGGTCC GTCCCAGGCA CATCACCAGC
CTGGAGGTGA TCAAGGCCGG ACCCCACTGC CCCACTGCCC AACTCATAGC CACGCTGAAG
AATGGGAGGA AAATTTGCTT GGATCTGCAA GCCCTGCTGT ACAAGAAAAT CATTAAGGAA
CATTTGGAGA GTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

CXCL4L1-fibstatin cooperation inhibits tumor angiogenesis, lymphangiogenesis and metastasis
Microvasc. Res. 89, 25-33 (2013)
Prats AC, Van den Berghe L, Rayssac A, Ainaoui N, Morfoisse F, Pujol F, Legonidec S, Bikfalvi A, Prats H, Pyronnet S and Garmy-Susini B.


book

Alternative C-terminal helix orientation alters chemokine function: structure of the anti-angiogenic chemokine, CXCL4L1
J. Biol. Chem. 288 (19), 13522-13533 (2013)
Kuo JH, Chen YP, Liu JS, Dubrac A, Quemener C, Prats H, Bikfalvi A, Wu WG and Sue SC.


book

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature 491 (7422), 119-124 (2012)
Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and Cho JH.


book

PF-4var/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function
PLoS ONE 7 (2), E31343 (2012)
De Sutter J, Van de Veire NR, Struyf S, Philippe J, De Buyzere M and Van Damme J.


book

The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer
Cytokine Growth Factor Rev. 22 (1), 1-18 (2011)
Vandercappellen J, Van Damme J and Struyf S.


book

Modulation of cystic fibrosis lung disease by variants in interleukin-8
Genes Immun. 9 (6), 501-508 (2008)
Hillian AD, Londono D, Dunn JM, Goddard KA, Pace RG, Knowles MR and Drumm ML.


book

Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis
Circ. Res. 95 (9), 855-857 (2004)
Struyf S, Burdick MD, Proost P, Van Damme J and Strieter RM.


book

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides
Nat. Biotechnol. 21 (5), 566-569 (2003)
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR and Vandekerckhove J.


book

Structural and functional comparison of the genes for human platelet factor 4 and PF4alt
Blood 76 (2), 336-344 (1990)
Eisman R, Surrey S, Ramachandran B, Schwartz E and Poncz M.


book

Identification and characterization of PF4varl, a human gene variant of platelet factor 4
Mol. Cell. Biol. 9 (4), 1445-1451 (1989)
Green CJ, Charles RS, Edwards BF and Johnson PH.


 
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