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PGAM2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol PGAM2
Entrez Gene ID 5224
Full Name phosphoglycerate mutase 2
Synonyms GSD10,PGAM-M,PGAMM
General protein information
Preferred Names

phosphoglycerate mutase 2

Names

phosphoglycerate mutase 2
BPG-dependent PGAM 2
muscle-specific phosphoglycerate mutase
phosphoglycerate mutase 2 (muscle)
phosphoglycerate mutase isozyme M

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

7

7p13

Summary Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009].
Disorder MIM:

612931

Disorder Html: Glycogen storage disease X, 261670 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000290.3 NP_000281.2 phosphoglycerate mutase 2



Bos taurus (cattle) PGAM2 NP_001033200.1
Pan troglodytes (chimpanzee) PGAM2 XP_001143059.1
Canis lupus familiaris (dog) PGAM2 XP_532718.2
Mus musculus (house mouse) Pgam2 NP_061358.1
Kluyveromyces lactis KLLA0E11859g XP_454486.1
Eremothecium gossypii AGOS_ACR056W NP_983459.2
Xenopus tropicalis (tropical clawed frog) pgam2 NP_001005665.1
Danio rerio (zebrafish) pgam2 NP_957318.1
Homo sapiens (human) PGAM2 NP_000281.2
Rattus norvegicus (Norway rat) Pgam2 NP_059024.1
Saccharomyces cerevisiae (baker's yeast) GPM1 NP_012770.1
Drosophila melanogaster (fruit fly) Pglym87 NP_652041.2
Macaca mulatta (rhesus monkey) PGAM2 XP_001116220.1


Related articles in PubMed

Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase.
Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan KL, Lei QY, Xiong Y
Cancer research74(13)3630-42(2014 Jul)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene.
Hadjigeorgiou GM, Kawashima N, Bruno C, Andreu AL, Sue CM, Rigden DJ, Kawashima A, Shanske S, DiMauro S
Neuromuscular disorders : NMD9(6-7)399-402(1999 Oct)

The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency.
Tsujino S, Shanske S, Sakoda S, Fenichel G, DiMauro S
American journal of human genetics52(3)472-7(1993 Mar)

Human muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy.
DiMauro S, Miranda AF, Khan S, Gitlin K, Friedman R
Science (New York, N.Y.)212(4500)1277-9(1981 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PGAM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGAM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19214
NM_000290.3
Latest version!
Homo sapiens phosphoglycerate mutase 2 (PGAM2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19214
Clone ID Related Accession (Same CDS sequence) NM_000290.3
Accession Version NM_000290.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 762bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product phosphoglycerate mutase 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT002473.1 and BC001904.1. This sequence is a reference standard in the RefSeqGene project. On Sep 25, 2009 this sequence version replaced NM_000290.2. ##Evidence-Data-START## Transcript exon combination :: BC001904.1, SRR1803614.210160.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCACTC ACCGCCTCGT GATGGTCCGG CACGGCGAGA GCACATGGAA CCAGGAGAAC 
CGTTTCTGTG GCTGGTTCGA TGCAGAGCTG AGTGAAAAGG GGACCGAGGA GGCCAAGCGG
GGAGCCAAGG CCATCAAGGA TGCCAAGATG GAGTTTGACA TCTGCTACAC GTCAGTGCTG
AAGCGGGCCA TCCGCACCCT CTGGGCCATC CTGGACGGCA CGGACCAGAT GTGGCTGCCT
GTGGTGCGCA CTTGGCGCCT CAATGAGCGG CATTACGGGG GCCTCACAGG CCTCAACAAG
GCAGAAACGG CCGCCAAGCA CGGGGAGGAG CAGGTGAAGA TCTGGAGGCG CTCCTTCGAC
ATCCCGCCGC CCCCGATGGA CGAGAAGCAC CCCTACTACA ACTCCATTAG CAAGGAGCGT
CGGTACGCAG GCCTGAAGCC CGGGGAACTC CCCACCTGCG AGAGCCTCAA GGACACCATT
GCCCGGGCCC TGCCCTTCTG GAACGAGGAG ATTGTTCCCC AGATCAAGGC CGGCAAGCGA
GTGCTCATTG CAGCCCACGG GAACAGCCTG CGGGGCATTG TCAAGCACCT GGAAGGGATG
TCAGACCAGG CGATCATGGA GCTGAACCTG CCCACGGGGA TCCCCATTGT GTATGAGCTG
AACAAGGAGC TGAAGCCCAC CAAGCCCATG CAGTTCCTGG GTGATGAGGA AACGGTGCGG
AAGGCCATGG AGGCTGTGGC TGCCCAGGGC AAGGCCAAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000281.2
CDS59..820
Misc Feature(1)65..67
Misc Feature(2)68..811
Misc Feature(3)order(86..91,242..244,614..619)
Misc Feature(4)86..109
Misc Feature(5)98..100
Misc Feature(6)125..130
Misc Feature(7)323..334
Misc Feature(8)404..409
Misc Feature(9)410..412
Misc Feature(10)452..454
Misc Feature(11)455..457
Misc Feature(12)461..463
Misc Feature(13)512..514
Misc Feature(14)614..616
Misc Feature(15)617..622
Exon (1)1..472
Exon (2)473..653
Exon (3)654..857
Translation

Target ORF information:

RefSeq Version NM_000290.3
Organism Homo sapiens(Human)
Definition Homo sapiens phosphoglycerate mutase 2 (PGAM2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000290.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCACTC ACCGCCTCGT GATGGTCCGG CACGGCGAGA GCACATGGAA CCAGGAGAAC 
CGTTTCTGTG GCTGGTTCGA TGCAGAGCTG AGTGAAAAGG GGACCGAGGA GGCCAAGCGG
GGAGCCAAGG CCATCAAGGA TGCCAAGATG GAGTTTGACA TCTGCTACAC GTCAGTGCTG
AAGCGGGCCA TCCGCACCCT CTGGGCCATC CTGGACGGCA CGGACCAGAT GTGGCTGCCT
GTGGTGCGCA CTTGGCGCCT CAATGAGCGG CATTACGGGG GCCTCACAGG CCTCAACAAG
GCAGAAACGG CCGCCAAGCA CGGGGAGGAG CAGGTGAAGA TCTGGAGGCG CTCCTTCGAC
ATCCCGCCGC CCCCGATGGA CGAGAAGCAC CCCTACTACA ACTCCATTAG CAAGGAGCGT
CGGTACGCAG GCCTGAAGCC CGGGGAACTC CCCACCTGCG AGAGCCTCAA GGACACCATT
GCCCGGGCCC TGCCCTTCTG GAACGAGGAG ATTGTTCCCC AGATCAAGGC CGGCAAGCGA
GTGCTCATTG CAGCCCACGG GAACAGCCTG CGGGGCATTG TCAAGCACCT GGAAGGGATG
TCAGACCAGG CGATCATGGA GCTGAACCTG CCCACGGGGA TCCCCATTGT GTATGAGCTG
AACAAGGAGC TGAAGCCCAC CAAGCCCATG CAGTTCCTGG GTGATGAGGA AACGGTGCGG
AAGGCCATGG AGGCTGTGGC TGCCCAGGGC AAGGCCAAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase.
Cancer research74(13)3630-42(2014 Jul)
Xu Y,Li F,Lv L,Li T,Zhou X,Deng CX,Guan KL,Lei QY,Xiong Y


book

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballescà JL,Oliva R


book

Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene.
Neuromuscular disorders : NMD9(6-7)399-402(1999 Oct)
Hadjigeorgiou GM,Kawashima N,Bruno C,Andreu AL,Sue CM,Rigden DJ,Kawashima A,Shanske S,DiMauro S


book

The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency.
American journal of human genetics52(3)472-7(1993 Mar)
Tsujino S,Shanske S,Sakoda S,Fenichel G,DiMauro S


book

Human muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy.
Science (New York, N.Y.)212(4500)1277-9(1981 Jun)
DiMauro S,Miranda AF,Khan S,Gitlin K,Friedman R


 
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