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SERPINE2 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol SERPINE2
Entrez Gene ID 5270
Full Name serpin family E member 2
Synonyms GDN,GDNPF,PI-7,PI7,PN-1,PN1,PNI
General protein information
Preferred Names

serpin family E member 2

Names

glia-derived nexin
glial-derived neurite promoting factor
peptidase inhibitor 7
protease nexin I
serpin E2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

2

2q36.1
Summary This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Disorder MIM:

177010


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001136528.1 NP_001130000.1 glia-derived nexin isoform b precursor
XM_005246641.2 XP_005246698.1 glia-derived nexin isoform X1
XM_005246642.2 XP_005246699.1 glia-derived nexin isoform X1
NM_001136530.1 NP_001130002.1 glia-derived nexin isoform c precursor
NM_001136528.2 NP_001130000.1 glia-derived nexin isoform b precursor
XM_017004331.1 XP_016859820.1 glia-derived nexin isoform X3
XM_017004329.1 XP_016859818.1 glia-derived nexin isoform X2
XM_017004332.1 XP_016859821.1 glia-derived nexin isoform X3
NM_006216.3 NP_006207.1 glia-derived nexin isoform a precursor
XM_017004330.1 XP_016859819.1 glia-derived nexin isoform X2
XM_017004332.2 XP_016859821.1 glia-derived nexin isoform X3

Pathways from BioSystems


Homologies


Homo sapiens (human) SERPINE2 NP_001130002.1
Pan troglodytes (chimpanzee) SERPINE2 XP_001167141.2
Xenopus tropicalis (tropical clawed frog) serpine2 NP_988931.2
Mus musculus (house mouse) Serpine2 NP_033281.1
Rattus norvegicus (Norway rat) Serpine2 NP_062070.1
Danio rerio (zebrafish) serpine2 NP_956478.1
SERPINE2 XP_001109037.2
Bos taurus (cattle) SERPINE2 NP_777094.1
Gallus gallus (chicken) SERPINE2 NP_001077389.1
Canis lupus familiaris (dog) SERPINE2 XP_005640777.1

Gene Ontology


Bibliography

Related articles in PubMed

A slow-cycling subpopulation of melanoma cells with highly invasive properties.
Perego M, Maurer M, Wang JX, Shaffer S, M?ller AC, Parapatics K, Li L, Hristova D, Shin S, Keeney F, Liu S, Xu X, Raj A, Jensen JK, Bennett KL, Wagner SN, Somasundaram R, Herlyn M
Oncogene37(3)302-312(2018 Jan)

ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.
Langer EM, Kendsersky ND, Daniel CJ, Kuziel GM, Pelz C, Murphy KM, Capecchi MR, Sears RC
Oncogene(2017 Oct)

Comparison of two neurotrophic serpins reveals a small fragment with cell survival activity.
Winokur PN, Subramanian P, Bullock JL, Arocas V, Becerra SP
Molecular vision23372-384(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results indicate that SERPINE2 and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
Title: Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer.

high expression of SerpinE2 in osteosarcoma stimulates cell proliferation, promotes drugresistance, and results in poor survival by regulating CDK4 and cyclin D1.
Title: SerpinE2 promotes multiple cell proliferation and drug resistance in osteosarcoma.

Single nucleotide polymorphisms in EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population.
Title: Exploring the interaction among EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population.

We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005).
Title: Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.

together, these data demonstrate that SERPINE2 might prevent cartilage catabolism by inhibiting the expression of MMP-13, one of the most relevant collagenases, involved in cartilage breakdown in OA.
Title: SERPINE2 Inhibits IL-1?-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-?B/AP-1 Pathways.

The following SERPINE2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINE2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu16659 NM_001136528.2
Latest version!		 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
OHu17944 NM_006216.3
Latest version!		 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu16659 XM_017004331.1
Latest version!		 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
OHu16659 XM_017004332.2
Latest version!		 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
OHu17944 XM_005246642.2
Latest version!		 Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu17944 XM_017004329.1
Latest version!		 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu17944 XM_017004330.1
Latest version!		 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu16481 NM_001136530.1
Latest version!		 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu36360 XM_005246641.2
Latest version!		 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
View Old Accession Versions >>
OHu16659 NM_001136528.1 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
OHu16659 XM_017004332.1 Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu16659
Clone ID Related Accession (Same CDS sequence) NM_001136528.1 , NM_001136528.2 , XM_017004331.1 , XM_017004332.1 , XM_017004332.2
Accession Version NM_001136528.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1194bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-07-03
Organism Homo sapiens(human)
Product glia-derived nexin isoform b precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC366668.1, AK225823.1, AC073641.3, AI754402.1 and DB325994.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.240949.1, SRR1660805.157452.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

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ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001130000.1
CDS244..1437
Translation

Target ORF information:

RefSeq Version NM_001136528.1
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001136528.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16659
Clone ID Related Accession (Same CDS sequence) NM_001136528.1 , NM_001136528.2 , XM_017004331.1 , XM_017004332.1 , XM_017004332.2
Accession Version NM_001136528.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1194bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-29
Organism Homo sapiens(human)
Product glia-derived nexin isoform b precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK225823.1, AC073641.3, AI754402.1 and DB325994.1. On Aug 7, 2019 this sequence version replaced NM_001136528.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.157452.1, SRR1660809.176396.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
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361
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481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001130000.1
CDS211..1404
Translation

Target ORF information:

RefSeq Version NM_001136528.2
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001136528.2

ORF Insert Sequence:

1
61
121
181
241
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361
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481
541
601
661
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841
901
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1081
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ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17944
Clone ID Related Accession (Same CDS sequence) XM_005246642.2 , XM_017004329.1 , NM_006216.3 , XM_017004330.1
Accession Version NM_006216.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1197bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-06
Organism Homo sapiens(human)
Product glia-derived nexin isoform a precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC366668.1, BC015663.2, BX360097.2, AI754402.1 and DB325994.1. This sequence is a reference standard in the RefSeqGene project. On Nov 4, 2008 this sequence version replaced NM_006216.2. Transcript Variant: This variant (1) encodes isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.12678.1, SRR1660807.52910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145245, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
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721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAACAGGG TCAGAAAACC TCCATGTTTC TCATATCTTG 
CAAAAAGCAA AAATTGAAGT CAGTGAAGAT GGAACCAAAG CTTCAGCAGC AACAACTGCA 
ATTCTCATTG CAAGATCATC GCCTCCCTGG TTTATAGTAG ACAGACCTTT TCTGTTTTTC 
ATCCGACATA ATCCTACAGG TGCTGTGTTA TTCATGGGGC AGATAAACAA ACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006207.1
CDS244..1440
Translation

Target ORF information:

RefSeq Version NM_006216.3
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_006216.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAACAGGG TCAGAAAACC TCCATGTTTC TCATATCTTG 
CAAAAAGCAA AAATTGAAGT CAGTGAAGAT GGAACCAAAG CTTCAGCAGC AACAACTGCA 
ATTCTCATTG CAAGATCATC GCCTCCCTGG TTTATAGTAG ACAGACCTTT TCTGTTTTTC 
ATCCGACATA ATCCTACAGG TGCTGTGTTA TTCATGGGGC AGATAAACAA ACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16659
Clone ID Related Accession (Same CDS sequence) NM_001136528.1 , NM_001136528.2 , XM_017004331.1 , XM_017004332.1 , XM_017004332.2
Accession Version XM_017004331.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1194bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product glia-derived nexin isoform X3
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016859820.1
CDS225..1418
Translation

Target ORF information:

RefSeq Version XM_017004331.1
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017004331.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16659
Clone ID Related Accession (Same CDS sequence) NM_001136528.1 , NM_001136528.2 , XM_017004331.1 , XM_017004332.1 , XM_017004332.2
Accession Version XM_017004332.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1194bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product glia-derived nexin isoform X3
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016859821.1
CDS62..1255
Translation

Target ORF information:

RefSeq Version XM_017004332.1
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017004332.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16659
Clone ID Related Accession (Same CDS sequence) NM_001136528.1 , NM_001136528.2 , XM_017004331.1 , XM_017004332.1 , XM_017004332.2
Accession Version XM_017004332.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1194bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product glia-derived nexin isoform X3
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017004332.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016859821.1
CDS61..1254
Translation

Target ORF information:

RefSeq Version XM_017004332.2
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017004332.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAAGGTCA GAAAACCTCC ATGTTTCTCA TATCTTGCAA 
AAAGCAAAAA TTGAAGTCAG TGAAGATGGA ACCAAAGCTT CAGCAGCAAC AACTGCAATT 
CTCATTGCAA GATCATCGCC TCCCTGGTTT ATAGTAGACA GACCTTTTCT GTTTTTCATC 
CGACATAATC CTACAGGTGC TGTGTTATTC ATGGGGCAGA TAAACAAACC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17944
Clone ID Related Accession (Same CDS sequence) XM_005246642.2 , XM_017004329.1 , NM_006216.3 , XM_017004330.1
Accession Version XM_005246642.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1197bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-03-11
Organism Homo sapiens(Human)
Product glia-derived nexin isoform X1
Comment 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAACAGGG TCAGAAAACC TCCATGTTTC TCATATCTTG 
CAAAAAGCAA AAATTGAAGT CAGTGAAGAT GGAACCAAAG CTTCAGCAGC AACAACTGCA 
ATTCTCATTG CAAGATCATC GCCTCCCTGG TTTATAGTAG ACAGACCTTT TCTGTTTTTC 
ATCCGACATA ATCCTACAGG TGCTGTGTTA TTCATGGGGC AGATAAACAA ACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005246699.1
Translation

Target ORF information:

RefSeq Version XM_005246642.2
Organism Homo sapiens(Human)
Definition Homo sapiens serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005246642.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAACAGGG TCAGAAAACC TCCATGTTTC TCATATCTTG 
CAAAAAGCAA AAATTGAAGT CAGTGAAGAT GGAACCAAAG CTTCAGCAGC AACAACTGCA 
ATTCTCATTG CAAGATCATC GCCTCCCTGG TTTATAGTAG ACAGACCTTT TCTGTTTTTC 
ATCCGACATA ATCCTACAGG TGCTGTGTTA TTCATGGGGC AGATAAACAA ACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17944
Clone ID Related Accession (Same CDS sequence) XM_005246642.2 , XM_017004329.1 , NM_006216.3 , XM_017004330.1
Accession Version XM_017004329.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1197bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product glia-derived nexin isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAACAGGG TCAGAAAACC TCCATGTTTC TCATATCTTG 
CAAAAAGCAA AAATTGAAGT CAGTGAAGAT GGAACCAAAG CTTCAGCAGC AACAACTGCA 
ATTCTCATTG CAAGATCATC GCCTCCCTGG TTTATAGTAG ACAGACCTTT TCTGTTTTTC 
ATCCGACATA ATCCTACAGG TGCTGTGTTA TTCATGGGGC AGATAAACAA ACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016859818.1
CDS225..1421
Translation

Target ORF information:

RefSeq Version XM_017004329.1
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017004329.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAACAGGG TCAGAAAACC TCCATGTTTC TCATATCTTG 
CAAAAAGCAA AAATTGAAGT CAGTGAAGAT GGAACCAAAG CTTCAGCAGC AACAACTGCA 
ATTCTCATTG CAAGATCATC GCCTCCCTGG TTTATAGTAG ACAGACCTTT TCTGTTTTTC 
ATCCGACATA ATCCTACAGG TGCTGTGTTA TTCATGGGGC AGATAAACAA ACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17944
Clone ID Related Accession (Same CDS sequence) XM_005246642.2 , XM_017004329.1 , NM_006216.3 , XM_017004330.1
Accession Version XM_017004330.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1197bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product glia-derived nexin isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAACAGGG TCAGAAAACC TCCATGTTTC TCATATCTTG 
CAAAAAGCAA AAATTGAAGT CAGTGAAGAT GGAACCAAAG CTTCAGCAGC AACAACTGCA 
ATTCTCATTG CAAGATCATC GCCTCCCTGG TTTATAGTAG ACAGACCTTT TCTGTTTTTC 
ATCCGACATA ATCCTACAGG TGCTGTGTTA TTCATGGGGC AGATAAACAA ACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016859819.1
CDS62..1258
Translation

Target ORF information:

RefSeq Version XM_017004330.1
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017004330.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGAACTGGC ATCTCCCCCT CTTCCTCTTG GCCTCTGTGA CGCTGCCTTC CATCTGCTCC 
CACTTCAATC CTCTGTCTCT CGAGGAACTA GGCTCCAACA CGGGGATCCA GGTTTTCAAT 
CAGATTGTGA AGTCGAGGCC TCATGACAAC ATCGTGATCT CTCCCCATGG GATTGCGTCG 
GTCCTGGGGA TGCTTCAGCT GGGGGCGGAC GGCAGGACCA AGAAGCAGCT CGCCATGGTG 
ATGAGATACG GCGTAAATGG AGTTGGTAAA ATATTAAAGA AGATCAACAA GGCCATCGTC 
TCCAAGAAGA ATAAAGACAT TGTGACAGTG GCTAACGCCG TGTTTGTTAA GAATGCCTCT 
GAAATTGAAG TGCCTTTTGT TACAAGGAAC AAAGATGTGT TCCAGTGTGA GGTCCGGAAT 
GTGAACTTTG AGGATCCAGC CTCTGCCTGT GATTCCATCA ATGCATGGGT TAAAAATGAA 
ACCAGGGATA TGATTGACAA TCTGCTGTCC CCAGATCTTA TTGATGGTGT GCTCACCAGA 
CTGGTCCTCG TCAACGCAGT GTATTTCAAG GGTCTGTGGA AATCACGGTT CCAACCCGAG 
AACACAAAGA AACGCACTTT CGTGGCAGCC GACGGGAAAT CCTATCAAGT GCCAATGCTG 
GCCCAGCTCT CCGTGTTCCG GTGTGGGTCG ACAAGTGCCC CCAATGATTT ATGGTACAAC 
TTCATTGAAC TGCCCTACCA CGGGGAAAGC ATCAGCATGC TGATTGCACT GCCGACTGAG 
AGCTCCACTC CGCTGTCTGC CATCATCCCA CACATCAGCA CCAAGACCAT AGACAGCTGG 
ATGAGCATCA TGGTGCCCAA GAGGGTGCAG GTGATCCTGC CCAAGTTCAC AGCTGTAGCA 
CAAACAGATT TGAAGGAGCC GCTGAAAGTT CTTGGCATTA CTGACATGTT TGATTCATCA 
AAGGCAAATT TTGCAAAAAT AACAACAGGG TCAGAAAACC TCCATGTTTC TCATATCTTG 
CAAAAAGCAA AAATTGAAGT CAGTGAAGAT GGAACCAAAG CTTCAGCAGC AACAACTGCA 
ATTCTCATTG CAAGATCATC GCCTCCCTGG TTTATAGTAG ACAGACCTTT TCTGTTTTTC 
ATCCGACATA ATCCTACAGG TGCTGTGTTA TTCATGGGGC AGATAAACAA ACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16481
Clone ID Related Accession (Same CDS sequence) NM_001136530.1
Accession Version NM_001136530.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1230bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-06
Organism Homo sapiens(human)
Product glia-derived nexin isoform c precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC304261.1, AK295564.1, BX360097.2, AI754402.1 and DB325994.1. Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct N-terminus and is longer than isoform a. CCDS Note: This CCDS representation is supported by the mRNA AK295564.1. It contains an alternative 5' exon compared to other variants at this locus, as represented by CCDS2460.1 and CCDS46526.1. It should be noted that the annotated start codon in this CCDS has a weak Kozak signal and is only conserved among primate species. It is possible that leaky scanning by ribosomes could occur to allow a downstream start codon to be used at least some of the time. The downstream start codon has a stronger Kozak signal and is much better conserved, and it would result in a protein that is 12 aa shorter at the N-terminus. There is no experimental evidence indicating which start codon is preferentially used by this variant in vivo. Signal peptides can be predicted for both the longer and shorter N-termini (cleavage following aa 31 or aa 19, respectively), but it should be noted that the probability of signal peptide occurrence is reduced for the longer N-terminus, as predicted by SignalP 3.0 and Phobius. It is unknown if a signal peptide is cleaved from the longer protein in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.123330.1, SRR1660803.201569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAGTGACT GCAGGTCGTC CTTGGTGGAA GGAACCATGA ACTGGCATCT CCCCCTCTTC 
CTCTTGGCCT CTGTGACGCT GCCTTCCATC TGCTCCCACT TCAATCCTCT GTCTCTCGAG 
GAACTAGGCT CCAACACGGG GATCCAGGTT TTCAATCAGA TTGTGAAGTC GAGGCCTCAT 
GACAACATCG TGATCTCTCC CCATGGGATT GCGTCGGTCC TGGGGATGCT TCAGCTGGGG 
GCGGACGGCA GGACCAAGAA GCAGCTCGCC ATGGTGATGA GATACGGCGT AAATGGAGTT 
GGTAAAATAT TAAAGAAGAT CAACAAGGCC ATCGTCTCCA AGAAGAATAA AGACATTGTG 
ACAGTGGCTA ACGCCGTGTT TGTTAAGAAT GCCTCTGAAA TTGAAGTGCC TTTTGTTACA 
AGGAACAAAG ATGTGTTCCA GTGTGAGGTC CGGAATGTGA ACTTTGAGGA TCCAGCCTCT 
GCCTGTGATT CCATCAATGC ATGGGTTAAA AATGAAACCA GGGATATGAT TGACAATCTG 
CTGTCCCCAG ATCTTATTGA TGGTGTGCTC ACCAGACTGG TCCTCGTCAA CGCAGTGTAT 
TTCAAGGGTC TGTGGAAATC ACGGTTCCAA CCCGAGAACA CAAAGAAACG CACTTTCGTG 
GCAGCCGACG GGAAATCCTA TCAAGTGCCA ATGCTGGCCC AGCTCTCCGT GTTCCGGTGT 
GGGTCGACAA GTGCCCCCAA TGATTTATGG TACAACTTCA TTGAACTGCC CTACCACGGG 
GAAAGCATCA GCATGCTGAT TGCACTGCCG ACTGAGAGCT CCACTCCGCT GTCTGCCATC 
ATCCCACACA TCAGCACCAA GACCATAGAC AGCTGGATGA GCATCATGGT GCCCAAGAGG 
GTGCAGGTGA TCCTGCCCAA GTTCACAGCT GTAGCACAAA CAGATTTGAA GGAGCCGCTG 
AAAGTTCTTG GCATTACTGA CATGTTTGAT TCATCAAAGG CAAATTTTGC AAAAATAACA 
AGGTCAGAAA ACCTCCATGT TTCTCATATC TTGCAAAAAG CAAAAATTGA AGTCAGTGAA 
GATGGAACCA AAGCTTCAGC AGCAACAACT GCAATTCTCA TTGCAAGATC ATCGCCTCCC 
TGGTTTATAG TAGACAGACC TTTTCTGTTT TTCATCCGAC ATAATCCTAC AGGTGCTGTG 
TTATTCATGG GGCAGATAAA CAAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001130002.1
CDS138..1367
Translation

Target ORF information:

RefSeq Version NM_001136530.1
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001136530.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAGTGACT GCAGGTCGTC CTTGGTGGAA GGAACCATGA ACTGGCATCT CCCCCTCTTC 
CTCTTGGCCT CTGTGACGCT GCCTTCCATC TGCTCCCACT TCAATCCTCT GTCTCTCGAG 
GAACTAGGCT CCAACACGGG GATCCAGGTT TTCAATCAGA TTGTGAAGTC GAGGCCTCAT 
GACAACATCG TGATCTCTCC CCATGGGATT GCGTCGGTCC TGGGGATGCT TCAGCTGGGG 
GCGGACGGCA GGACCAAGAA GCAGCTCGCC ATGGTGATGA GATACGGCGT AAATGGAGTT 
GGTAAAATAT TAAAGAAGAT CAACAAGGCC ATCGTCTCCA AGAAGAATAA AGACATTGTG 
ACAGTGGCTA ACGCCGTGTT TGTTAAGAAT GCCTCTGAAA TTGAAGTGCC TTTTGTTACA 
AGGAACAAAG ATGTGTTCCA GTGTGAGGTC CGGAATGTGA ACTTTGAGGA TCCAGCCTCT 
GCCTGTGATT CCATCAATGC ATGGGTTAAA AATGAAACCA GGGATATGAT TGACAATCTG 
CTGTCCCCAG ATCTTATTGA TGGTGTGCTC ACCAGACTGG TCCTCGTCAA CGCAGTGTAT 
TTCAAGGGTC TGTGGAAATC ACGGTTCCAA CCCGAGAACA CAAAGAAACG CACTTTCGTG 
GCAGCCGACG GGAAATCCTA TCAAGTGCCA ATGCTGGCCC AGCTCTCCGT GTTCCGGTGT 
GGGTCGACAA GTGCCCCCAA TGATTTATGG TACAACTTCA TTGAACTGCC CTACCACGGG 
GAAAGCATCA GCATGCTGAT TGCACTGCCG ACTGAGAGCT CCACTCCGCT GTCTGCCATC 
ATCCCACACA TCAGCACCAA GACCATAGAC AGCTGGATGA GCATCATGGT GCCCAAGAGG 
GTGCAGGTGA TCCTGCCCAA GTTCACAGCT GTAGCACAAA CAGATTTGAA GGAGCCGCTG 
AAAGTTCTTG GCATTACTGA CATGTTTGAT TCATCAAAGG CAAATTTTGC AAAAATAACA 
AGGTCAGAAA ACCTCCATGT TTCTCATATC TTGCAAAAAG CAAAAATTGA AGTCAGTGAA 
GATGGAACCA AAGCTTCAGC AGCAACAACT GCAATTCTCA TTGCAAGATC ATCGCCTCCC 
TGGTTTATAG TAGACAGACC TTTTCTGTTT TTCATCCGAC ATAATCCTAC AGGTGCTGTG 
TTATTCATGG GGCAGATAAA CAAACCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu36360
Clone ID Related Accession (Same CDS sequence) XM_005246641.2
Accession Version XM_005246641.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1233bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product glia-derived nexin isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005246641.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAGTGACT GCAGGTCGTC CTTGGTGGAA GGAACCATGA ACTGGCATCT CCCCCTCTTC 
CTCTTGGCCT CTGTGACGCT GCCTTCCATC TGCTCCCACT TCAATCCTCT GTCTCTCGAG 
GAACTAGGCT CCAACACGGG GATCCAGGTT TTCAATCAGA TTGTGAAGTC GAGGCCTCAT 
GACAACATCG TGATCTCTCC CCATGGGATT GCGTCGGTCC TGGGGATGCT TCAGCTGGGG 
GCGGACGGCA GGACCAAGAA GCAGCTCGCC ATGGTGATGA GATACGGCGT AAATGGAGTT 
GGTAAAATAT TAAAGAAGAT CAACAAGGCC ATCGTCTCCA AGAAGAATAA AGACATTGTG 
ACAGTGGCTA ACGCCGTGTT TGTTAAGAAT GCCTCTGAAA TTGAAGTGCC TTTTGTTACA 
AGGAACAAAG ATGTGTTCCA GTGTGAGGTC CGGAATGTGA ACTTTGAGGA TCCAGCCTCT 
GCCTGTGATT CCATCAATGC ATGGGTTAAA AATGAAACCA GGGATATGAT TGACAATCTG 
CTGTCCCCAG ATCTTATTGA TGGTGTGCTC ACCAGACTGG TCCTCGTCAA CGCAGTGTAT 
TTCAAGGGTC TGTGGAAATC ACGGTTCCAA CCCGAGAACA CAAAGAAACG CACTTTCGTG 
GCAGCCGACG GGAAATCCTA TCAAGTGCCA ATGCTGGCCC AGCTCTCCGT GTTCCGGTGT 
GGGTCGACAA GTGCCCCCAA TGATTTATGG TACAACTTCA TTGAACTGCC CTACCACGGG 
GAAAGCATCA GCATGCTGAT TGCACTGCCG ACTGAGAGCT CCACTCCGCT GTCTGCCATC 
ATCCCACACA TCAGCACCAA GACCATAGAC AGCTGGATGA GCATCATGGT GCCCAAGAGG 
GTGCAGGTGA TCCTGCCCAA GTTCACAGCT GTAGCACAAA CAGATTTGAA GGAGCCGCTG 
AAAGTTCTTG GCATTACTGA CATGTTTGAT TCATCAAAGG CAAATTTTGC AAAAATAACA 
ACAGGGTCAG AAAACCTCCA TGTTTCTCAT ATCTTGCAAA AAGCAAAAAT TGAAGTCAGT 
GAAGATGGAA CCAAAGCTTC AGCAGCAACA ACTGCAATTC TCATTGCAAG ATCATCGCCT 
CCCTGGTTTA TAGTAGACAG ACCTTTTCTG TTTTTCATCC GACATAATCC TACAGGTGCT 
GTGTTATTCA TGGGGCAGAT AAACAAACCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005246698.1
CDS297..1529
Translation

Target ORF information:

RefSeq Version XM_005246641.2
Organism Homo sapiens(human)
Definition Homo sapiens serpin family E member 2 (SERPINE2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005246641.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAGTGACT GCAGGTCGTC CTTGGTGGAA GGAACCATGA ACTGGCATCT CCCCCTCTTC 
CTCTTGGCCT CTGTGACGCT GCCTTCCATC TGCTCCCACT TCAATCCTCT GTCTCTCGAG 
GAACTAGGCT CCAACACGGG GATCCAGGTT TTCAATCAGA TTGTGAAGTC GAGGCCTCAT 
GACAACATCG TGATCTCTCC CCATGGGATT GCGTCGGTCC TGGGGATGCT TCAGCTGGGG 
GCGGACGGCA GGACCAAGAA GCAGCTCGCC ATGGTGATGA GATACGGCGT AAATGGAGTT 
GGTAAAATAT TAAAGAAGAT CAACAAGGCC ATCGTCTCCA AGAAGAATAA AGACATTGTG 
ACAGTGGCTA ACGCCGTGTT TGTTAAGAAT GCCTCTGAAA TTGAAGTGCC TTTTGTTACA 
AGGAACAAAG ATGTGTTCCA GTGTGAGGTC CGGAATGTGA ACTTTGAGGA TCCAGCCTCT 
GCCTGTGATT CCATCAATGC ATGGGTTAAA AATGAAACCA GGGATATGAT TGACAATCTG 
CTGTCCCCAG ATCTTATTGA TGGTGTGCTC ACCAGACTGG TCCTCGTCAA CGCAGTGTAT 
TTCAAGGGTC TGTGGAAATC ACGGTTCCAA CCCGAGAACA CAAAGAAACG CACTTTCGTG 
GCAGCCGACG GGAAATCCTA TCAAGTGCCA ATGCTGGCCC AGCTCTCCGT GTTCCGGTGT 
GGGTCGACAA GTGCCCCCAA TGATTTATGG TACAACTTCA TTGAACTGCC CTACCACGGG 
GAAAGCATCA GCATGCTGAT TGCACTGCCG ACTGAGAGCT CCACTCCGCT GTCTGCCATC 
ATCCCACACA TCAGCACCAA GACCATAGAC AGCTGGATGA GCATCATGGT GCCCAAGAGG 
GTGCAGGTGA TCCTGCCCAA GTTCACAGCT GTAGCACAAA CAGATTTGAA GGAGCCGCTG 
AAAGTTCTTG GCATTACTGA CATGTTTGAT TCATCAAAGG CAAATTTTGC AAAAATAACA 
ACAGGGTCAG AAAACCTCCA TGTTTCTCAT ATCTTGCAAA AAGCAAAAAT TGAAGTCAGT 
GAAGATGGAA CCAAAGCTTC AGCAGCAACA ACTGCAATTC TCATTGCAAG ATCATCGCCT 
CCCTGGTTTA TAGTAGACAG ACCTTTTCTG TTTTTCATCC GACATAATCC TACAGGTGCT 
GTGTTATTCA TGGGGCAGAT AAACAAACCC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

A slow-cycling subpopulation of melanoma cells with highly invasive properties.
Oncogene37(3)302-312(2018 Jan)
Perego M,Maurer M,Wang JX,Shaffer S,M?ller AC,Parapatics K,Li L,Hristova D,Shin S,Keeney F,Liu S,Xu X,Raj A,Jensen JK,Bennett KL,Wagner SN,Somasundaram R,Herlyn M


book

ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.
Oncogene(2017 Oct)
Langer EM,Kendsersky ND,Daniel CJ,Kuziel GM,Pelz C,Murphy KM,Capecchi MR,Sears RC


book

Comparison of two neurotrophic serpins reveals a small fragment with cell survival activity.
Molecular vision23372-384(2017)
Winokur PN,Subramanian P,Bullock JL,Arocas V,Becerra SP